Species

KNApSAcK Entry

Organism name Chaetomium chiversii
Genus Chaetomium
Family Chaetomiaceae
Kingdom Fungi

NCBI taxonomy

Entry

Linked NCBI taxonomy name Chaetomium chiversii
Linked NCBI taxonomy ID 155873
Linked level species

Family

Family in NCBI taxonomy Chaetomiaceae
ID 35718

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00039177 External link 512 Eugenetin
No. 719
C00040142 External link 512 Radicicol
/ (+)-Radicicol
CHEMBL414883
CHEMBL453974
CHEMBL453386
CHEMBL1596863
C035359
44 / 27 / 24 6 / 0 No. 981
C00038727 External link 512 Chaetochiversin B
/ (+)-Chaetochiversin B
No. 2234
C00038726 External link 512 Chaetochiversin A
/ (+)-Chaetochiversin A
No. 2234
C00038728 External link 512 Chaetochromin A
CHEMBL162783
CHEMBL1099258
CHEMBL1096606
C032678
41 / 23 / 13 No. 8470

Human Protein / Gene in interactions

66 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q13148 TAR DNA-binding protein 43 Unclassified protein C00038728 C00040142 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00038728 C00040142 1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00038728 C00040142 0 / 0
Q99700 Ataxin-2 Unclassified protein C00038728 C00040142 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00038728 C00040142 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00038728 C00040142 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00038728 C00040142 4 / 3
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00038728 C00040142 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00038728 C00040142 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00038728 C00040142 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00038728 C00040142 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00038728 C00040142 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00038728 C00040142 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00038728 C00040142 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00038728 C00040142 0 / 0
O75496 Geminin Unclassified protein C00038728 C00040142 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00038728 C00040142 2 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00038728 C00040142 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00038728 C00040142 2 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00038728 0 / 0
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily C00040142 0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily C00040142 0 / 0
P07332 Tyrosine-protein kinase Fes/Fps Fer C00040142 0 / 0
P39748 Flap endonuclease 1 Enzyme C00038728 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00038728 0 / 0
P16152 Carbonyl reductase [NADPH] 1 Enzyme C00040142 0 / 0
O00444 Serine/threonine-protein kinase PLK4 PLK serine/threonine protein kinase subfamily C00040142 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00040142 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00038728 3 / 1
P37840 Alpha-synuclein Unclassified protein C00040142 4 / 2
Q99683 Mitogen-activated protein kinase kinase kinase 5 Ste11 C00040142 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00038728 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00038728 0 / 0
O75828 Carbonyl reductase [NADPH] 3 Enzyme C00040142 0 / 0
P98073 Enteropeptidase Enzyme C00038728 1 / 1
Q16659 Mitogen-activated protein kinase 6 CMGC serine/threonine protein kinase ERK3 subfamily C00040142 0 / 0
P52564 Dual specificity mitogen-activated protein kinase kinase 6 Ste7 C00040142 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00038728 0 / 0
O14976 Cyclin-G-associated kinase NAK serine/threonine protein kinase subfamily C00040142 0 / 0
O94804 Serine/threonine-protein kinase 10 STE serine/threonine protein kinase SLK subfamily C00040142 1 / 0
P16298 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Ser_Thr C00038728 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00040142 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00038728 1 / 1
Q9H2G2 STE20-like serine/threonine-protein kinase STE serine/threonine protein kinase SLK subfamily C00040142 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00040142 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00038728 0 / 0
P06746 DNA polymerase beta Enzyme C00038728 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00038728 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00038728 0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 C00040142 0 / 0
Q96P20 NACHT, LRR and PYD domains-containing protein 3 Unclassified protein C00040142 3 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00040142 0 / 3
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 C00040142 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00040142 0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim C00040142 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00038728 2 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00038728 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00038728 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00038728 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00038728 1 / 1
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00038728 0 / 0
O00255 Menin Unclassified protein C00040142 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00040142 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00038728 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00038728 2 / 1
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00040142 0 / 0

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00040142
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00040142
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00040142
3303 HSPA1A, HSP70-1, HSP70-1A, HSP70I, HSP72, HSPA1 heat shock 70kDa protein 1A C00040142
3757 KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 C00040142
5241 PGR, NR3C3, PR progesterone receptor C00040142

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#607115 Cinca syndrome; cinca Q96P20
#114500 Colorectal cancer; crc P84022
Q14191
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#226200 Enterokinase deficiency P98073
#120100 Familial cold autoinflammatory syndrome 1; fcas1 Q96P20
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#191900 Muckle-wells syndrome; mws Q96P20
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#273300 Testicular germ cell tumor; tgct O94804
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (28)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00988 Enterokinase deficiency P98073 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00282 Cryopyrin associated periodic syndrome (CAPS) Q96P20 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)