PCIDB

KNApSAcK Metabolite C00038728

Metabolite

KNApSAcK Entry

id C00038728
Name Chaetochromin A
CAS RN 75514-37-3
Standard InChI InChI=1S/C30H26O10/c1-9-11(3)39-19-5-13-21(15(31)7-17(33)23(13)29(37)25(19)27(9)35)22-14-6-20-26(28(36)10(2)12(4)40-20)30(38)24(14)18(34)8-16(22)32/h5-12,31-34,37-38H,1-4H3
Standard InChI (Main Layer) InChI=1S/C30H26O10/c1-9-11(3)39-19-5-13-21(15(31)7-17(33)23(13)29(37)25(19)27(9)35)22-14-6-20-26(28(36)10(2)12(4)40-20)30(38)24(14)18(34)8-16(22)32/h5-12,31-34,37-38H,1-4H3

Cluster

Phytochemical cluster
KCF-S cluster No. 8470

Link

ChEMBL

By standard InChI CHEMBL162783
By standard InChI Main Layer CHEMBL162783 CHEMBL1099258 CHEMBL1096606

KEGG

By LinkDB

CTD

By CAS RN C032678

Species

Summary

Plant class

class name count

Family

family name count
Chaetomiaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Chaetomium chiversii 155873 Chaetomiaceae Fungi

Human Protein / Gene in interaction

41 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL162783 CHEMBL1614529 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL162783 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL162783 CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL162783 CHEMBL1794499 (1)
2 / 0
P06746 DNA polymerase beta Enzyme CHEMBL162783 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL162783 CHEMBL1614076 (1) CHEMBL1614103 (1)
CHEMBL1614031 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL162783 CHEMBL1794585 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL162783 CHEMBL1614474 (1) CHEMBL1738493 (1)
CHEMBL1738375 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL162783 CHEMBL1613776 (1)
3 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL162783 CHEMBL1794311 (1)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL162783 CHEMBL1614458 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL162783 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL162783 CHEMBL1738606 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL162783 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL162783 CHEMBL2114780 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL162783 CHEMBL1613838 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL162783 CHEMBL2114788 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL162783 CHEMBL1794569 (1)
1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL162783 CHEMBL1614280 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL162783 CHEMBL1794401 (1)
0 / 0
P98073 Enteropeptidase Enzyme CHEMBL162783 CHEMBL1738398 (1)
1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL162783 CHEMBL1963863 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL162783 CHEMBL1614521 (1)
0 / 0
P16298 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Ser_Thr CHEMBL162783 CHEMBL867617 (1)
0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL162783 CHEMBL1614342 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL162783 CHEMBL1738588 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL162783 CHEMBL1794483 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL162783 CHEMBL1614052 (1)
1 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL162783 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL162783 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL162783 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL162783 CHEMBL1738184 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL162783 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL162783 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL162783 CHEMBL1613829 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL162783 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL162783 CHEMBL1614364 (1)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL162783 CHEMBL2354311 (1)
1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL162783 CHEMBL2114738 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL162783 CHEMBL2114796 (1)
2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL162783 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (23)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114500 Colorectal cancer; crc P84022
Q14191
#226200 Enterokinase deficiency P98073
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (13)

KEGG disease name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00988 Enterokinase deficiency P98073 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)