PCIDB

KNApSAcK Metabolite C00040340

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00040340
Name	Spatozoate
CAS RN	85-68-7
Standard InChI	InChI=1S/C19H20O4/c1-2-3-13-22-18(20)16-11-7-8-12-17(16)19(21)23-14-15-9-5-4-6-10-15/h4-12H,2-3,13-14H2,1H3
Standard InChI (Main Layer)	InChI=1S/C19H20O4/c1-2-3-13-22-18(20)16-11-7-8-12-17(16)19(21)23-14-15-9-5-4-6-10-15/h4-12H,2-3,13-14H2,1H3

Cluster

Phytochemical cluster
KCF-S cluster	No. 6955

Link

ChEMBL

By standard InChI	CHEMBL1450327
By standard InChI Main Layer	CHEMBL1450327

KEGG

By LinkDB	C14211

CTD

By CAS RN	C027561

Species

Summary

Plant class

class name	count

Family

family name	count
Dictyotaceae	1

List (1)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Spatoglossum variabile	157006	Dictyotaceae		Eukaryota

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	CHEMBL1450327	CHEMBL1738312 (1)	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	CHEMBL1450327	CHEMBL1794573 (1)	2 / 2
P16473	Thyrotropin receptor	Glycohormone receptor	CHEMBL1450327	CHEMBL1614281 (1) CHEMBL1614361 (1)	3 / 2
P10828	Thyroid hormone receptor beta	NR1A2	CHEMBL1450327	CHEMBL1794399 (1)	3 / 1
P00352	Retinal dehydrogenase 1	Enzyme	CHEMBL1450327	CHEMBL1614458 (1)	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	CHEMBL1450327	CHEMBL2114788 (1)	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	CHEMBL1450327	CHEMBL1614280 (1)	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	CHEMBL1450327	CHEMBL1794401 (1)	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	CHEMBL1450327	CHEMBL1794510 (2)	5 / 3
P28482	Mitogen-activated protein kinase 1	Erk	CHEMBL1450327	CHEMBL1613808 (1)	0 / 0
P03372	Estrogen receptor	NR3A1	CHEMBL1450327	CHEMBL1794364 (2)	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	CHEMBL1450327	CHEMBL1614108 (1) CHEMBL1613886 (1)	0 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	CHEMBL1450327	CHEMBL1737991 (1)	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	CHEMBL1450327	CHEMBL2114890 (1)	0 / 0
P10275	Androgen receptor	NR3C4	CHEMBL1450327	CHEMBL1794321 (1)	3 / 4
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	CHEMBL1450327	CHEMBL1614364 (1)	1 / 1

CTD interaction (91)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of AHR mRNA]	decreases reaction / increases expression	mRNA	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of AHR protein]	decreases reaction / increases expression	protein	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	AHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT mRNA]	decreases reaction / increases expression	mutant form	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	AHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT protein]	decreases reaction / increases expression	mutant form	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	AHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP1B1 mRNA]	decreases reaction / increases expression	mutant form	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	AHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP1B1 protein]	decreases reaction / increases expression	mutant form	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	butylbenzyl phthalate affects the localization of AHR protein	affects localization	protein	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	butylbenzyl phthalate binds to and results in increased activity of AHR protein	affects binding / increases activity	protein	23220035
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	butylbenzyl phthalate promotes the reaction [AHR protein binds to ARNT protein]	affects binding / increases reaction	protein	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	butylbenzyl phthalate promotes the reaction [AHR protein binds to CYP1B1 promoter]	affects binding / increases reaction	protein	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	butylbenzyl phthalate results in increased expression of AHR mRNA	increases expression	mRNA	22138065
C027561	196	AHR bHLHe76	aryl hydrocarbon receptor	butylbenzyl phthalate results in increased expression of AHR protein	increases expression	protein	22138065
C027561	207	AKT1 AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	butylbenzyl phthalate results in increased phosphorylation of AKT1 protein	increases phosphorylation	protein	22552774
C027561	207	AKT1 AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of AKT1 protein]	decreases reaction / increases phosphorylation	protein	22552774
C027561	367	AR AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM	androgen receptor	butylbenzyl phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]	affects binding / decreases reaction / increases activity	protein	15840436 20943248
C027561	367	AR AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM	androgen receptor	butylbenzyl phthalate results in decreased activity of AR protein	decreases activity	protein	9846162
C027561	405	ARNT HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2	aryl hydrocarbon receptor nuclear translocator	3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT mRNA]	decreases reaction / increases expression	mRNA	22138065
C027561	405	ARNT HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2	aryl hydrocarbon receptor nuclear translocator	3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT protein]	decreases reaction / increases expression	protein	22138065
C027561	405	ARNT HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2	aryl hydrocarbon receptor nuclear translocator	AHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT mRNA]	decreases reaction / increases expression	mRNA	22138065
C027561	405	ARNT HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2	aryl hydrocarbon receptor nuclear translocator	AHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT protein]	decreases reaction / increases expression	protein	22138065
C027561	405	ARNT HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2	aryl hydrocarbon receptor nuclear translocator	butylbenzyl phthalate promotes the reaction [AHR protein binds to ARNT protein]	affects binding / increases reaction	protein	22138065
C027561	405	ARNT HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2	aryl hydrocarbon receptor nuclear translocator	butylbenzyl phthalate results in increased expression of ARNT mRNA	increases expression	mRNA	22138065
C027561	405	ARNT HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2	aryl hydrocarbon receptor nuclear translocator	butylbenzyl phthalate results in increased expression of ARNT protein	increases expression	protein	22138065
C027561	9915	ARNT2 bHLHe1	aryl-hydrocarbon receptor nuclear translocator 2	1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [butylbenzyl phthalate results in decreased expression of ARNT2 mRNA]	decreases expression / decreases reaction	mRNA	21771643
C027561	9915	ARNT2 bHLHe1	aryl-hydrocarbon receptor nuclear translocator 2	butylbenzyl phthalate results in decreased expression of ARNT2 mRNA	decreases expression	mRNA	21771643
C027561	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	butylbenzyl phthalate results in increased expression of CASP3 protein alternative form	increases expression	protein	23220035
C027561	999	CDH1 Arc-1 CD324 CDHE ECAD LCAM UVO	cadherin 1, type 1, E-cadherin (epithelial)	butylbenzyl phthalate results in decreased expression of CDH1 protein	decreases expression	protein	22552774
C027561	1499	CTNNB1 CTNNB MRD19 armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	butylbenzyl phthalate affects the localization of CTNNB1 protein	affects localization	protein	22552774
C027561	1499	CTNNB1 CTNNB MRD19 armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate affects the localization of CTNNB1 protein]	affects localization / decreases reaction	protein	22552774
C027561	1499	CTNNB1 CTNNB MRD19 armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	trichostatin A inhibits the reaction [butylbenzyl phthalate affects the localization of CTNNB1 protein]	affects localization / decreases reaction	protein	22552774
C027561	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	butylbenzyl phthalate results in increased expression of CYP1A1 protein	increases expression	protein	22138065
C027561	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP1B1 mRNA]	decreases reaction / increases expression	mRNA	22138065
C027561	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP1B1 protein]	decreases reaction / increases expression	protein	22138065
C027561	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	AHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP1B1 mRNA]	decreases reaction / increases expression	mRNA	22138065
C027561	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	AHR mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP1B1 protein]	decreases reaction / increases expression	protein	22138065
C027561	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	butylbenzyl phthalate promotes the reaction [AHR protein binds to CYP1B1 promoter]	affects binding / increases reaction	promoter	22138065
C027561	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	butylbenzyl phthalate results in increased expression of CYP1B1 mRNA	increases expression	mRNA	22138065
C027561	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	butylbenzyl phthalate results in increased expression of CYP1B1 protein	increases expression	protein	22138065
C027561	1956	EGFR ERBB ERBB1 HER1 PIG61 mENA	epidermal growth factor receptor (EC:2.7.10.1)	butylbenzyl phthalate results in increased phosphorylation of EGFR protein	increases phosphorylation	protein	22552774
C027561	1956	EGFR ERBB ERBB1 HER1 PIG61 mENA	epidermal growth factor receptor (EC:2.7.10.1)	fulvestrant inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of EGFR protein]	decreases reaction / increases phosphorylation	protein	22552774
C027561	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	butylbenzyl phthalate binds to and results in increased activity of ESR1 protein	affects binding / increases activity	protein	15840436
C027561	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	butylbenzyl phthalate binds to ESR1 protein	affects binding	protein	19913605 20822795 22467034
C027561	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	butylbenzyl phthalate results in decreased methylation of ESR1 gene	decreases methylation	gene	22949852
C027561	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	butylbenzyl phthalate results in decreased methylation of ESR1 promoter	decreases methylation	promoter	16326419
C027561	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	Tamoxifen inhibits the reaction [butylbenzyl phthalate binds to and results in increased activity of ESR1 protein]	affects binding / decreases reaction / increases activity	protein	15840436
C027561	2100	ESR2 ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2	estrogen receptor 2 (ER beta)	butylbenzyl phthalate binds to and results in decreased activity of ESR2 protein	affects binding / decreases activity	protein	15840436
C027561	2100	ESR2 ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2	estrogen receptor 2 (ER beta)	butylbenzyl phthalate binds to and results in increased activity of ESR2 protein	affects binding / increases activity	protein	15840436
C027561	2100	ESR2 ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2	estrogen receptor 2 (ER beta)	butylbenzyl phthalate binds to ESR2 protein	affects binding	protein	19913605
C027561	2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	butylbenzyl phthalate results in increased phosphorylation of GSK3B protein	increases phosphorylation	protein	22552774
C027561	2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of GSK3B protein]	decreases reaction / increases phosphorylation	protein	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]	affects binding / increases reaction	promoter	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	[butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]] which results in increased expression of HDAC6 mRNA	affects binding / increases expression / increases reaction	mRNA / promoter	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	butylbenzyl phthalate results in increased expression of HDAC6 mRNA	increases expression	mRNA	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	butylbenzyl phthalate results in increased expression of HDAC6 protein	increases expression	protein	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate affects the localization of CTNNB1 protein]	affects localization / decreases reaction	mutant form	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]	affects binding / decreases reaction / increases reaction	mutant form	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in decreased expression of KRT7 protein]	decreases expression / decreases reaction	mutant form	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of VIM protein]	decreases reaction / increases expression	mutant form	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of AKT1 protein]	decreases reaction / increases phosphorylation	mutant form	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of GSK3B protein]	decreases reaction / increases phosphorylation	mutant form	22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	HDAC6 results in increased susceptibility to butylbenzyl phthalate	increases response to substance		22552774
C027561	10013	HDAC6 CPBHM HD6	histone deacetylase 6 (EC:3.5.1.98)	TFAP2A mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of HDAC6 protein]	decreases reaction / increases expression	protein	22552774
C027561	3855	KRT7 CK7 K2C7 K7 SCL	keratin 7	butylbenzyl phthalate results in decreased expression of KRT7 protein	decreases expression	protein	22552774
C027561	3855	KRT7 CK7 K2C7 K7 SCL	keratin 7	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in decreased expression of KRT7 protein]	decreases expression / decreases reaction	protein	22552774
C027561	27074	LAMP3 CD208 DC_LAMP DC-LAMP DCLAMP LAMP LAMP-3 TSC403	lysosomal-associated membrane protein 3	butylbenzyl phthalate results in decreased expression of LAMP3 mRNA	decreases expression	mRNA	20678512
C027561	51176	LEF1 LEF-1 TCF10 TCF1ALPHA TCF7L3	lymphoid enhancer-binding factor 1	butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]	affects binding / increases reaction	protein	22552774
C027561	51176	LEF1 LEF-1 TCF10 TCF1ALPHA TCF7L3	lymphoid enhancer-binding factor 1	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]	affects binding / decreases reaction / increases reaction	protein	22552774
C027561	51176	LEF1 LEF-1 TCF10 TCF1ALPHA TCF7L3	lymphoid enhancer-binding factor 1	trichostatin A inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]	affects binding / decreases reaction / increases reaction	protein	22552774
C027561	6528	SLC5A5 NIS TDH1	solute carrier family 5 (sodium/iodide cotransporter), member 5	butylbenzyl phthalate results in increased expression of SLC5A5 mRNA	increases expression	mRNA	16257484
C027561	6714	SRC ASV SRC1 c-SRC p60-Src	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2)	butylbenzyl phthalate results in increased phosphorylation of SRC protein	increases phosphorylation	protein	22552774
C027561	6714	SRC ASV SRC1 c-SRC p60-Src	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2)	fulvestrant inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of SRC protein]	decreases reaction / increases phosphorylation	protein	22552774
C027561	6925	TCF4 E2-2 ITF-2 ITF2 PTHS SEF-2 SEF2 SEF2-1 SEF2-1A SEF2-1B TCF-4 bHLHb19	transcription factor 4	butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]	affects binding / increases reaction	protein	22552774
C027561	6925	TCF4 E2-2 ITF-2 ITF2 PTHS SEF-2 SEF2 SEF2-1 SEF2-1A SEF2-1B TCF-4 bHLHb19	transcription factor 4	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]	affects binding / decreases reaction / increases reaction	protein	22552774
C027561	6925	TCF4 E2-2 ITF-2 ITF2 PTHS SEF-2 SEF2 SEF2-1 SEF2-1A SEF2-1B TCF-4 bHLHb19	transcription factor 4	trichostatin A inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]	affects binding / decreases reaction / increases reaction	protein	22552774
C027561	7020	TFAP2A AP-2 AP-2alpha AP2TF BOFS TFAP2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	butylbenzyl phthalate affects the localization of TFAP2A protein	affects localization	protein	22552774
C027561	7020	TFAP2A AP-2 AP-2alpha AP2TF BOFS TFAP2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]	affects binding / increases reaction	protein	22552774
C027561	7020	TFAP2A AP-2 AP-2alpha AP2TF BOFS TFAP2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	[butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]] which results in increased expression of HDAC6 mRNA	affects binding / increases expression / increases reaction	protein	22552774
C027561	7020	TFAP2A AP-2 AP-2alpha AP2TF BOFS TFAP2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]	affects localization / decreases reaction	protein	22552774
C027561	7020	TFAP2A AP-2 AP-2alpha AP2TF BOFS TFAP2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	TFAP2A mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of HDAC6 protein]	decreases reaction / increases expression	mutant form	22552774
C027561	7020	TFAP2A AP-2 AP-2alpha AP2TF BOFS TFAP2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	tyrphostin AG 1478 inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]	affects localization / decreases reaction	protein	22552774
C027561	7070	THY1 CD90	Thy-1 cell surface antigen	butylbenzyl phthalate results in increased expression of THY1 protein	increases expression	protein	22552774
C027561	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]	decreases reaction / increases secretion	protein	18252963
C027561	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]	decreases reaction / increases secretion	protein	18252963
C027561	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	butylbenzyl phthalate results in increased secretion of VEGFA protein	increases secretion	protein	18252963
C027561	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	SB 203580 inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]	decreases reaction / increases secretion	protein	18252963
C027561	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	wortmannin inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]	decreases reaction / increases secretion	protein	18252963
C027561	7431	VIM CTRCT30	vimentin	butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]	affects binding / increases reaction	protein	22552774
C027561	7431	VIM CTRCT30	vimentin	butylbenzyl phthalate results in increased expression of VIM protein	increases expression	protein	22552774
C027561	7431	VIM CTRCT30	vimentin	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]	affects binding / decreases reaction / increases reaction	protein	22552774
C027561	7431	VIM CTRCT30	vimentin	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of VIM protein]	decreases reaction / increases expression	protein	22552774
C027561	7431	VIM CTRCT30	vimentin	trichostatin A inhibits the reaction [butylbenzyl phthalate promotes the reaction [[TCF4 protein binds to LEF1 protein] which binds to VIM protein]]	affects binding / decreases reaction / increases reaction	protein	22552774

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM	preferred title	UniProt
#300068	Androgen insensitivity syndrome; ais	P10275
#312300	Androgen insensitivity, partial; pais	P10275
%606641	Body mass index; bmi	P37231
#609338	Carotid intimal medial thickness 1	P37231
#615363	Estrogen resistance; estrr	P03372
#137800	Glioma susceptibility 1; glm1	P37231
#603373	Hyperthyroidism, familial gestational	P16473
#609152	Hyperthyroidism, nonautoimmune	P16473
#275200	Hypothyroidism, congenital, nongoitrous, 1; chng1	P16473
#604367	Lipodystrophy, familial partial, type 3; fpld3	P37231
#613688	Long qt syndrome 2; lqt2	Q12809
#601665	Obesity	P37231
#609620	Short qt syndrome 1; sqt1	Q12809
#313200	Spinal and bulbar muscular atrophy, x-linked 1; smax1	P10275
#607250	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1	Q9NUW8
#188570	Thyroid hormone resistance, generalized, autosomal dominant; grth	P10828
#274300	Thyroid hormone resistance, generalized, autosomal recessive; grth	P10828
#145650	Thyroid hormone resistance, selective pituitary; prth	P10828

KEGG DISEASE (15)

KEGG	disease name	UniProt
H00026	Endometrial Cancer	P03372 (marker)
H00036	Osteosarcoma	P08684 (marker)
H00024	Prostate cancer	P10275 (related)
H00062	Spinal and bulbar muscular atrophy (SBMA)	P10275 (related)
H00608	46,XY disorders of sex development (Disorders in androgen synthesis or action)	P10275 (related)
H00609	46,XY disorders of sex development (Other)	P10275 (related)
H00249	Thyroid hormone resistance syndrome	P10828 (related)
H00250	Congenital nongoitrous hypothyroidism (CHNG)	P16473 (related)
H01269	Congenital hyperthyroidism	P16473 (related)
H00032	Thyroid cancer	P37231 (related)
H00409	Type II diabetes mellitus	P37231 (related)
H00420	Familial partial lipodystrophy (FPL)	P37231 (related)
H00720	Long QT syndrome	Q12809 (related)
H00725	Short QT syndrome	Q12809 (related)
H00063	Spinocerebellar ataxia (SCA)	Q9NUW8 (related)

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D009336	C027561	Necrosis	marker/mechanism	22138065
D009362	C027561	Neoplasm Metastasis	marker/mechanism	22552774
D011041	C027561	Poisoning	marker/mechanism	23220035

KNApSAcK Metabolite C00040340

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (1)

* NCBI

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

CTD interaction (91)

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

KEGG DISEASE (15)

Diseases related to CTD interactions

3 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases