Spatoglossum variabile
Species
KNApSAcK Entry
| Organism name | Spatoglossum variabile |
|---|---|
| Genus | Spatoglossum |
| Family | Dictyotaceae |
| Kingdom | Chromalveolata |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Spatoglossum |
|---|---|
| Linked NCBI taxonomy ID | 157006 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Dictyotaceae |
|---|---|
| ID | 2874 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Eukaryota |
|---|---|
| ID | 2759 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00040631
|
Varninasterol
/ (-)-Varninasterol |
No. 53 | No. 11 |
|
||||
|
C00003653
|
Fucosterol
/ (24R)24-Ethylcholesta-5,24(28)-dien-3beta-ol |
CHEMBL519971
CHEMBL1836654 |
C015896
|
No. 53 | No. 11 |
|
||
|
C00030754
|
Methyl gallate
/ Methyl 3,4,5-trihydroxybenzoate |
CHEMBL65675
|
C052082
|
16 / 15 / 13 | No. 1722 |
|
||
|
C00002714
|
Apiol
/ Apiole / Parsley apiole |
CHEMBL1560118
|
3 / 0 / 1 | No. 1917 | No. 6 |
|
||
|
C00014661
|
4'-Chloroaurone
|
CHEMBL596254
|
2 / 1 / 1 | No. 6650 |
|
|||
|
C00040340
|
Spatozoate
|
CHEMBL1450327
|
C027561
|
16 / 18 / 15 | 25 / 3 | No. 6955 |
|
|
|
C00014662
|
4'-Chloro-2-hydroxyaurone
|
No. 8746 |
|
Human Protein / Gene in interactions
31 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00030754 C00040340 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00030754 C00040340 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002714 C00040340 | 0 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00030754 C00040340 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00030754 C00040340 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00030754 C00040340 | 1 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00030754 | 11 / 10 |
| P55789 | FAD-linked sulfhydryl oxidase ALR | Enzyme | C00030754 | 1 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00040340 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00030754 | 1 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00040340 | 3 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00014661 | 1 / 1 |
| P02768 | Serum albumin | Secreted protein | C00030754 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00040340 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00030754 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00030754 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00030754 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00030754 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002714 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00040340 | 5 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00040340 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00040340 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002714 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00040340 | 2 / 2 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00014661 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00030754 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00040340 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00040340 | 3 / 4 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00030754 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00030754 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00040340 | 0 / 0 |
25 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00040340
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00040340
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00040340
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00040340
|
| 9915 | ARNT2, bHLHe1 | aryl-hydrocarbon receptor nuclear translocator 2 |
C00040340
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00040340
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00040340
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00040340
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00040340
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00040340
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00040340
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00040340
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00040340
|
| 2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00040340
|
| 10013 | HDAC6, CPBHM, HD6 | histone deacetylase 6 (EC:3.5.1.98) |
C00040340
|
| 3855 | KRT7, CK7, K2C7, K7, SCL | keratin 7 |
C00040340
|
| 27074 | LAMP3, CD208, DC_LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403 | lysosomal-associated membrane protein 3 |
C00040340
|
| 51176 | LEF1, LEF-1, TCF10, TCF1ALPHA, TCF7L3 | lymphoid enhancer-binding factor 1 |
C00040340
|
| 6528 | SLC5A5, NIS, TDH1 | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
C00040340
|
| 6714 | SRC, ASV, SRC1, c-SRC, p60-Src | v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) |
C00040340
|
| 6925 | TCF4, E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, TCF-4, bHLHb19 | transcription factor 4 |
C00040340
|
| 7020 | TFAP2A, AP-2, AP-2alpha, AP2TF, BOFS, TFAP2 | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
C00040340
|
| 7070 | THY1, CD90 | Thy-1 cell surface antigen |
C00040340
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00040340
|
| 7431 | VIM, CTRCT30 | vimentin |
C00040340
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (33)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613076 | Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay |
P55789
|
| #601665 | Obesity |
P37231
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (27)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|