PCIDB

KNApSAcK Metabolite C00040436

Metabolite

KNApSAcK Entry

id C00040436
Name Talaroflavone
CAS RN 130838-22-1
Standard InChI InChI=1S/C14H12O6/c1-6-3-10(16)12(17)14(6)8-4-7(19-2)5-9(15)11(8)13(18)20-14/h3-5,12,15,17H,1-2H3
Standard InChI (Main Layer) InChI=1S/C14H12O6/c1-6-3-10(16)12(17)14(6)8-4-7(19-2)5-9(15)11(8)13(18)20-14/h3-5,12,15,17H,1-2H3

Cluster

Phytochemical cluster
KCF-S cluster No. 5993

Link

ChEMBL

By standard InChI CHEMBL408995
By standard InChI Main Layer CHEMBL408995

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count

Family

family name count
Pleosporaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Alternaria sp. 5598 Pleosporaceae Fungi

Human Protein / Gene in interaction

30 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P08069 Insulin-like growth factor 1 receptor TK tyrosine-protein kinase INSR subfamily CHEMBL408995 CHEMBL962870 (1)
1 / 3
O14965 Aurora kinase A Aur CHEMBL408995 CHEMBL966176 (1)
0 / 0
P68400 Casein kinase II subunit alpha Ck2 CHEMBL408995 CHEMBL962879 (1)
0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL408995 CHEMBL966179 (1)
0 / 0
O00444 Serine/threonine-protein kinase PLK4 PLK serine/threonine protein kinase subfamily CHEMBL408995 CHEMBL966209 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL408995 CHEMBL962866 (1)
1 / 11
P11387 DNA topoisomerase 1 Isomerase CHEMBL408995 CHEMBL921895 (1)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL408995 CHEMBL962874 (1)
1 / 1
P54760 Ephrin type-B receptor 4 Eph CHEMBL408995 CHEMBL962867 (1)
0 / 0
Q05397 Focal adhesion kinase 1 Fak CHEMBL408995 CHEMBL962869 (1)
0 / 0
Q02763 Angiopoietin-1 receptor Tie CHEMBL408995 CHEMBL965366 (1)
1 / 1
Q9UGP5 DNA polymerase lambda Enzyme CHEMBL408995 CHEMBL934560 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL408995 CHEMBL934562 (1)
1 / 1
O60285 NUAK family SNF1-like kinase 1 CAMK serine/threonine protein kinase NUAK subfamily CHEMBL408995 CHEMBL966175 (1)
0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily CHEMBL408995 CHEMBL962875 (1)
5 / 4
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL408995 CHEMBL962868 (1)
5 / 10
P09619 Platelet-derived growth factor receptor beta Pdgfr CHEMBL408995 CHEMBL962877 (1)
5 / 1
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL408995 CHEMBL962871 (1)
0 / 0
Q96GD4 Aurora kinase B Aur CHEMBL408995 CHEMBL966177 (1)
0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr CHEMBL408995 CHEMBL962872 (1)
1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL408995 CHEMBL962876 (1)
2 / 3
P35916 Vascular endothelial growth factor receptor 3 Vegfr CHEMBL408995 CHEMBL962873 (1)
2 / 1
P41279 Mitogen-activated protein kinase kinase kinase 8 Ste11 CHEMBL408995 CHEMBL966181 (1)
0 / 0
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily CHEMBL408995 CHEMBL962878 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL408995 CHEMBL966174 (1)
4 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL408995 CHEMBL934563 (1)
0 / 0
P28340 DNA polymerase delta catalytic subunit Transferase CHEMBL408995 CHEMBL921883 (1)
2 / 0
O14746 Telomerase reverse transcriptase Enzyme CHEMBL408995 CHEMBL921892 (1)
5 / 5
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family CHEMBL408995 CHEMBL966180 (1)
1 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL408995 CHEMBL934564 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (34)

OMIM preferred title UniProt
#609135 Aplastic anemia O14746
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#114480 Breast cancer P31749
#612591 Colorectal cancer, susceptibility to, 10; crcs10 P28340
#114500 Colorectal cancer; crc P31749
#615109 Cowden syndrome 6; cws6 P31749
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#246200 Donohue syndrome P06213
#613989 Dyskeratosis congenita, autosomal dominant, 2; dkca2 O14746
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#137800 Glioma susceptibility 1; glm1 P04626
#602089 Hemangioma, capillary infantile P35916
P35968
#114550 Hepatocellular carcinoma P08581
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#270450 Insulin-like growth factor i, resistance to P08069
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#601626 Leukemia, acute myeloid; aml P09619
P36888
#211980 Lung cancer P00533
P04626
#153100 Lymphedema, hereditary, ia P35916
#615381 Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome; mdpl P28340
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#615134 Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 O14746
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#167000 Ovarian cancer P04626
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#176920 Proteus syndrome P31749
#614742 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 O14746
#178500 Pulmonary fibrosis, idiopathic; ipf O14746
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#600195 Venous malformations, multiple cutaneous and mucosal; vmcm Q02763
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (31)

KEGG disease name UniProt
H00764 Cri du chat syndrome O14746 (related)
H01132 Aplastic anemia (AA) O14746 (related)
H01299 Idiopathic pulmonary fibrosis O14746 (related)
H00022 Bladder cancer O14746 (marker)
P00533 (related)
P04626 (related)
H00024 Prostate cancer O14746 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P08581 (related)
H00028 Choriocarcinoma P00533 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
P11802 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P09619 (related)
P11802 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00019 Pancreatic cancer P04626 (related)
H00026 Endometrial Cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P08581 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00015 Malignant pleural mesothelioma P08069 (related)
H00050 Synovial sarcoma P08069 (related)
H01274 Growth delay due to insulin-like growth factor I resistance P08069 (related)
H00021 Renal cell carcinoma P08581 (related)
H00038 Malignant melanoma P11802 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00535 Lymphedemas P35916 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00531 Venous malformations Q02763 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)