Alternaria sp.
Species
KNApSAcK Entry
| Organism name | Alternaria sp. |
|---|---|
| Genus | Alternaria |
| Family | Dothideomycetes |
| Kingdom | Fungi |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Alternaria |
|---|---|
| Linked NCBI taxonomy ID | 5598 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Pleosporaceae |
|---|---|
| ID | 28556 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Fungi |
|---|---|
| ID | 4751 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (15)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00023663
|
Alternariol
/ 3,4',5-Trihydroxy-6'-methyl-dibenzo[a]pyrone |
CHEMBL519982
|
C005197
|
23 / 26 / 26 | 6 / 0 | No. 54 | No. 17 |
|
|
C00018905
|
Enniatin B
|
CHEMBL469036
|
19 / 22 / 23 | No. 859 |
|
|||
|
C00018907
|
Enniatin A1
|
No. 859 |
|
|||||
|
C00018906
|
Enniatin B1
|
CHEMBL446318
|
No. 859 |
|
||||
|
C00038417
|
Altertoxin I
|
CHEMBL521470
|
C050233
|
23 / 26 / 26 | No. 1896 |
|
||
|
C00038203
|
2,5-Dimethyl-7-hydroxychromone
|
CHEMBL509319
|
No. 1920 |
|
||||
|
C00023666
|
Altenusin
|
CHEMBL483531
|
C095643
|
47 / 45 / 41 | No. 2383 |
|
||
|
C00038416
|
Altenuene
|
CHEMBL482025
CHEMBL482026 CHEMBL1079573 |
C040005
|
No. 2465 |
|
|||
|
C00048234
|
Xanalteric acid I
/ (-)-Xanalteric acid I |
CHEMBL1082048
|
No. 5402 |
|
||||
|
C00048235
|
Xanalteric acid II
/ (+)-Xanalteric acid II |
CHEMBL1079563
|
No. 5402 |
|
||||
|
C00040436
|
Talaroflavone
|
CHEMBL408995
|
30 / 34 / 31 | No. 5993 |
|
|||
|
C00047716
|
Alternarian acid
|
CHEMBL1081907
|
No. 6879 |
|
||||
|
C00023713
|
Alternaric acid
|
No. 7166 |
|
|||||
|
C00047717
|
Alternarienonic acid
|
CHEMBL519395
|
23 / 26 / 26 | No. 8005 |
|
|||
|
C00001554
|
Tenuazonic acid
|
No. 8799 |
|
Human Protein / Gene in interactions
66 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O60285 | NUAK family SNF1-like kinase 1 | CAMK serine/threonine protein kinase NUAK subfamily | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00023663 C00023666 C00038417 C00040436 C00047717 | 5 / 4 |
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00023663 C00023666 C00038417 C00040436 C00047717 | 1 / 3 |
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00023663 C00023666 C00038417 C00040436 C00047717 | 1 / 3 |
| Q02763 | Angiopoietin-1 receptor | Tie | C00023663 C00023666 C00038417 C00040436 C00047717 | 1 / 1 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00023663 C00023666 C00038417 C00040436 C00047717 | 4 / 1 |
| O14965 | Aurora kinase A | Aur | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| P41279 | Mitogen-activated protein kinase kinase kinase 8 | Ste11 | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| O00444 | Serine/threonine-protein kinase PLK4 | PLK serine/threonine protein kinase subfamily | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00023663 C00023666 C00038417 C00040436 C00047717 | 1 / 8 |
| P35916 | Vascular endothelial growth factor receptor 3 | Vegfr | C00023663 C00023666 C00038417 C00040436 C00047717 | 2 / 1 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00023663 C00023666 C00038417 C00040436 C00047717 | 1 / 1 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00023663 C00023666 C00038417 C00040436 C00047717 | 5 / 1 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00023663 C00023666 C00038417 C00040436 C00047717 | 5 / 9 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00023663 C00023666 C00038417 C00040436 C00047717 | 2 / 3 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00023663 C00023666 C00038417 C00040436 C00047717 | 1 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| P54760 | Ephrin type-B receptor 4 | Eph | C00023663 C00023666 C00038417 C00040436 C00047717 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00018905 C00023666 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00018905 C00023666 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00023666 C00040436 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00018905 C00023666 | 7 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00023666 C00040436 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00023666 C00040436 | 1 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00018905 C00023666 | 4 / 3 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00023666 | 0 / 0 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00040436 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00018905 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00018905 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00018905 | 2 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00018905 | 1 / 1 |
| P11413 | Glucose-6-phosphate 1-dehydrogenase | Enzyme | C00023666 | 1 / 2 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00023666 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00023666 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00040436 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00023666 | 4 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00018905 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00018905 | 0 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00018905 | 1 / 4 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00023666 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00023666 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00018905 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00023666 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00023666 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00023666 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00018905 | 0 / 0 |
| P28340 | DNA polymerase delta catalytic subunit | Transferase | C00040436 | 2 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00040436 | 5 / 5 |
| Q99700 | Ataxin-2 | Unclassified protein | C00018905 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00023666 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00023666 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00023666 | 0 / 0 |
| O00167 | Eyes absent homolog 2 | Enzyme | C00018905 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00023666 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00018905 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00018905 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00018905 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00023666 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00023666 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00023666 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00018905 | 0 / 3 |
6 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00023663
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00023663
|
| 2938 | GSTA1, GST2, GSTA1-1, GTH1 | glutathione S-transferase alpha 1 (EC:2.5.1.18) |
C00023663
|
| 2939 | GSTA2, GST2, GSTA2-2, GTA2, GTH2 | glutathione S-transferase alpha 2 (EC:2.5.1.18) |
C00023663
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00023663
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00023663
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (61)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300908 | Anemia, nonspherocytic hemolytic, due to g6pd deficiency |
P11413
|
| #609135 | Aplastic anemia |
O14746
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #114480 | Breast cancer |
P31749
|
| #612591 | Colorectal cancer, susceptibility to, 10; crcs10 |
P28340
|
| #114500 | Colorectal cancer; crc |
P31749
P84022 |
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #246200 | Donohue syndrome |
P06213
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #602089 | Hemangioma, capillary infantile |
P35916
P35968 |
| #114550 | Hepatocellular carcinoma |
P08581
|
| #143100 | Huntington disease; hd |
P42858
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
P36888 |
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P00533
P04626 |
| #153100 | Lymphedema, hereditary, ia |
P35916
|
| #615381 | Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome; mdpl |
P28340
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P04626
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #176920 | Proteus syndrome |
P31749
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #600195 | Venous malformations, multiple cutaneous and mucosal; vmcm |
Q02763
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (61)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
P00533 (related) P04626 (related) |
| H00024 | Prostate cancer |
O14746
(marker)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P08581 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P09619 (related) P11802 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00026 | Endometrial Cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P08581 (related) |
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00015 | Malignant pleural mesothelioma |
P08069
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00021 | Renal cell carcinoma |
P08581
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00101 | Other phagocyte defects |
P11413
(related)
|
| H00668 | Anemia due to disorders of glutathione metabolism |
P11413
(related)
|
| H00038 | Malignant melanoma |
P11802
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00535 | Lymphedemas |
P35916
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00531 | Venous malformations |
Q02763
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
Q13315
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00094 | DNA repair defects |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|