PCIDB

KNApSAcK Metabolite C00023666

Metabolite

KNApSAcK Entry

id C00023666
Name Altenusin
CAS RN 31186-12-6
Standard InChI InChI=1S/C15H14O6/c1-7-3-11(16)12(17)6-9(7)10-4-8(21-2)5-13(18)14(10)15(19)20/h3-6,16-18H,1-2H3,(H,19,20)
Standard InChI (Main Layer) InChI=1S/C15H14O6/c1-7-3-11(16)12(17)6-9(7)10-4-8(21-2)5-13(18)14(10)15(19)20/h3-6,16-18H,1-2H3,(H,19,20)

Cluster

Phytochemical cluster
KCF-S cluster No. 2383

Link

ChEMBL

By standard InChI CHEMBL483531
By standard InChI Main Layer CHEMBL483531

KEGG

By LinkDB

CTD

By CAS RN C095643

Human Protein / Gene in interaction

47 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL483531 CHEMBL1614529 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL483531 CHEMBL1738312 (1)
0 / 0
P08069 Insulin-like growth factor 1 receptor TK tyrosine-protein kinase INSR subfamily CHEMBL483531 CHEMBL962870 (1)
1 / 3
P06746 DNA polymerase beta Enzyme CHEMBL483531 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL483531 CHEMBL1614076 (1)
1 / 1
O14965 Aurora kinase A Aur CHEMBL483531 CHEMBL966176 (1)
0 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL483531 CHEMBL2354282 (1)
4 / 2
P68400 Casein kinase II subunit alpha Ck2 CHEMBL483531 CHEMBL962879 (1)
0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL483531 CHEMBL966179 (1)
0 / 0
O00444 Serine/threonine-protein kinase PLK4 PLK serine/threonine protein kinase subfamily CHEMBL483531 CHEMBL966209 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL483531 CHEMBL962866 (1)
1 / 11
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL483531 CHEMBL962874 (1)
1 / 1
P54760 Ephrin type-B receptor 4 Eph CHEMBL483531 CHEMBL962867 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL483531 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL483531 CHEMBL1738606 (1)
0 / 0
P11413 Glucose-6-phosphate 1-dehydrogenase Enzyme CHEMBL483531 CHEMBL1737961 (1)
1 / 2
O75496 Geminin Unclassified protein CHEMBL483531 CHEMBL2114843 (1)
0 / 0
Q05397 Focal adhesion kinase 1 Fak CHEMBL483531 CHEMBL962869 (1)
0 / 0
Q02763 Angiopoietin-1 receptor Tie CHEMBL483531 CHEMBL965366 (1)
1 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL483531 CHEMBL2114810 (1)
7 / 3
Q9Y253 DNA polymerase eta Enzyme CHEMBL483531 CHEMBL1794569 (1)
1 / 1
O60285 NUAK family SNF1-like kinase 1 CAMK serine/threonine protein kinase NUAK subfamily CHEMBL483531 CHEMBL966175 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL483531 CHEMBL1794401 (1)
0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily CHEMBL483531 CHEMBL962875 (1)
5 / 4
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL483531 CHEMBL962868 (1)
5 / 10
P09619 Platelet-derived growth factor receptor beta Pdgfr CHEMBL483531 CHEMBL962877 (1)
5 / 1
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL483531 CHEMBL962871 (1)
0 / 0
Q96GD4 Aurora kinase B Aur CHEMBL483531 CHEMBL966177 (1)
0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr CHEMBL483531 CHEMBL962872 (1)
1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL483531 CHEMBL962876 (1)
2 / 3
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL483531 CHEMBL1614521 (1)
0 / 0
P35916 Vascular endothelial growth factor receptor 3 Vegfr CHEMBL483531 CHEMBL962873 (1)
2 / 1
P41279 Mitogen-activated protein kinase kinase kinase 8 Ste11 CHEMBL483531 CHEMBL966181 (1)
0 / 0
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily CHEMBL483531 CHEMBL962878 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL483531 CHEMBL966174 (1)
4 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL483531 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL483531 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL483531 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL483531 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family CHEMBL483531 CHEMBL966180 (1)
1 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL483531 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL483531 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL483531 CHEMBL1613829 (1) CHEMBL1794433 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL483531 CHEMBL1738442 (1)
0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL483531 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL483531 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL483531 CHEMBL2114738 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (45)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#300908 Anemia, nonspherocytic hemolytic, due to g6pd deficiency P11413
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#114480 Breast cancer P31749
#114500 Colorectal cancer; crc P31749
#615109 Cowden syndrome 6; cws6 P31749
#127750 Dementia, lewy body; dlb P37840
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#246200 Donohue syndrome P06213
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#137800 Glioma susceptibility 1; glm1 P04626
#232300 Glycogen storage disease ii P10253
#602089 Hemangioma, capillary infantile P35916
P35968
#114550 Hepatocellular carcinoma P08581
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#270450 Insulin-like growth factor i, resistance to P08069
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#601626 Leukemia, acute myeloid; aml P09619
P36888
#211980 Lung cancer P00533
P04626
#153100 Lymphedema, hereditary, ia P35916
#174800 Mccune-albright syndrome; mas P63092
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P04626
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#176920 Proteus syndrome P31749
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#600195 Venous malformations, multiple cutaneous and mucosal; vmcm Q02763
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (41)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P08581 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
P11802 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P09619 (related)
P11802 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00019 Pancreatic cancer P04626 (related)
H00026 Endometrial Cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P08581 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00015 Malignant pleural mesothelioma P08069 (related)
H00050 Synovial sarcoma P08069 (related)
H01274 Growth delay due to insulin-like growth factor I resistance P08069 (related)
H00021 Renal cell carcinoma P08581 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00101 Other phagocyte defects P11413 (related)
H00668 Anemia due to disorders of glutathione metabolism P11413 (related)
H00038 Malignant melanoma P11802 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00535 Lymphedemas P35916 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00531 Venous malformations Q02763 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)