Penicillium simplicissimum IFM53375
Species
KNApSAcK Entry
| Organism name | Penicillium simplicissimum IFM53375 |
|---|---|
| Genus | Penicillium |
| Family | Trichocomaceae |
| Kingdom | Fungi |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Penicillium |
|---|---|
| Linked NCBI taxonomy ID | 5073 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Aspergillaceae |
|---|---|
| ID | 1131492 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Fungi |
|---|---|
| ID | 4751 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00016737
|
Penicillide
/ Vermixocin A |
CHEMBL325752
CHEMBL1482850 |
C077329
|
6 / 3 / 1 | No. 1537 |
|
||
|
C00016738
|
Purpactin A
/ Vermixocin B |
CHEMBL116226
CHEMBL1374574 |
C068086
|
13 / 10 / 5 | No. 1537 |
|
||
|
C00031341
|
Secopenicillide A
/ (-)-Secopenicillide A |
No. 1537 |
|
|||||
|
C00031342
|
Secopenicillide B
/ (-)-Secopenicillide B |
No. 1537 |
|
|||||
|
C00023666
|
Altenusin
|
CHEMBL483531
|
C095643
|
47 / 45 / 41 | No. 2383 |
|
Human Protein / Gene in interactions
55 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9Y253 | DNA polymerase eta | Enzyme | C00016737 C00016738 C00023666 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00016737 C00023666 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00016738 C00023666 | 4 / 3 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00016737 C00023666 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00016737 C00016738 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00016738 C00023666 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00016737 C00016738 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00016738 C00023666 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00016737 C00016738 | 2 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00016738 C00023666 | 0 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00023666 | 5 / 9 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00023666 | 1 / 8 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00023666 | 1 / 1 |
| P54760 | Ephrin type-B receptor 4 | Eph | C00023666 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00023666 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00023666 | 0 / 0 |
| P11413 | Glucose-6-phosphate 1-dehydrogenase | Enzyme | C00023666 | 1 / 2 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00023666 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00023666 | 4 / 2 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00023666 | 0 / 0 |
| O14965 | Aurora kinase A | Aur | C00023666 | 0 / 0 |
| Q02763 | Angiopoietin-1 receptor | Tie | C00023666 | 1 / 1 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00023666 | 7 / 3 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00023666 | 1 / 1 |
| O60285 | NUAK family SNF1-like kinase 1 | CAMK serine/threonine protein kinase NUAK subfamily | C00023666 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00023666 | 0 / 0 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00023666 | 5 / 4 |
| O00444 | Serine/threonine-protein kinase PLK4 | PLK serine/threonine protein kinase subfamily | C00023666 | 0 / 0 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00023666 | 5 / 1 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00023666 | 0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00023666 | 0 / 0 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00023666 | 1 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00023666 | 2 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00023666 | 0 / 0 |
| P35916 | Vascular endothelial growth factor receptor 3 | Vegfr | C00023666 | 2 / 1 |
| P41279 | Mitogen-activated protein kinase kinase kinase 8 | Ste11 | C00023666 | 0 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00023666 | 0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00023666 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00023666 | 4 / 1 |
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00023666 | 1 / 3 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00016738 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00023666 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00023666 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00016738 | 1 / 1 |
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00023666 | 1 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00023666 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00023666 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00023666 | 0 / 0 |
| O00167 | Eyes absent homolog 2 | Enzyme | C00016738 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00023666 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00016738 | 1 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00016738 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00023666 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00023666 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00023666 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (48)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300908 | Anemia, nonspherocytic hemolytic, due to g6pd deficiency |
P11413
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #114480 | Breast cancer |
P31749
|
| #114500 | Colorectal cancer; crc |
P31749
P84022 |
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #246200 | Donohue syndrome |
P06213
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #602089 | Hemangioma, capillary infantile |
P35916
P35968 |
| #114550 | Hepatocellular carcinoma |
P08581
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
P36888 |
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P00533
P04626 |
| #153100 | Lymphedema, hereditary, ia |
P35916
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P04626
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #176920 | Proteus syndrome |
P31749
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #600195 | Venous malformations, multiple cutaneous and mucosal; vmcm |
Q02763
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (42)
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P08581 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P09619 (related) P11802 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00026 | Endometrial Cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P08581 (related) |
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00015 | Malignant pleural mesothelioma |
P08069
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00021 | Renal cell carcinoma |
P08581
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00101 | Other phagocyte defects |
P11413
(related)
|
| H00668 | Anemia due to disorders of glutathione metabolism |
P11413
(related)
|
| H00038 | Malignant melanoma |
P11802
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00535 | Lymphedemas |
P35916
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00531 | Venous malformations |
Q02763
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|