Alternaria alternata
Species
KNApSAcK Entry
| Organism name | Alternaria alternata |
|---|---|
| Genus | Alternaria |
| Family | Dothideomycetes |
| Kingdom | Fungi |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Alternaria alternata |
|---|---|
| Linked NCBI taxonomy ID | 5599 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Pleosporaceae |
|---|---|
| ID | 28556 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Fungi |
|---|---|
| ID | 4751 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003652
|
Ergosterol
/ Ergosta-5,7,22-trien-3beta-ol |
CHEMBL222608
CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225 |
D004875
|
12 / 14 / 11 | No. 111 | No. 11 |
|
|
|
C00033559
|
3,5-Caffeoyl quinic acid
/ 3,5-di-O-Caffeoylquinic acid / (-)-3,5-Dicaffeoyl quinic acid |
CHEMBL441250
CHEMBL249447 |
2 / 0 / 0 | No. 518 | No. 6 |
|
||
|
C00023758
|
Ergosta-4,6,8(14),22-tetraen-3-one
|
CHEMBL1801892
CHEMBL2040598 |
C015860
|
No. 768 |
|
|||
|
C00000134
|
(s)-(+)-Abscisic acid
/ 2,4-Pentadienoic acid |
CHEMBL288040
CHEMBL379808 CHEMBL1318134 CHEMBL1469719 CHEMBL1741460 CHEMBL1965138 |
D000040
|
10 / 9 / 10 | No. 1435 | No. 38 |
|
|
|
C00023666
|
Altenusin
|
CHEMBL483531
|
C095643
|
47 / 45 / 41 | No. 2383 |
|
||
|
C00002350
|
Maculosin
/ Cyclo(L-tyrosyl-L-proline) / L-Proline-L-tyrosine anhydride |
CHEMBL359788
CHEMBL510756 CHEMBL1980823 |
C085319
|
2 / 1 / 0 | No. 2431 |
|
||
|
C00023667
|
Dehydroaltenusin
|
CHEMBL594151
|
1 / 1 / 1 | No. 2465 |
|
|||
|
C00036682
|
ACTG toxin A
|
No. 5095 |
|
|||||
|
C00036683
|
ACTG toxin B
|
No. 5095 |
|
|||||
|
C00024781
|
AK-toxin I
|
No. 5683 |
|
|||||
|
C00024782
|
AK-toxin II
|
C089064
|
No. 5683 |
|
Human Protein / Gene in interactions
68 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000134 C00003652 | 1 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003652 C00023666 | 4 / 3 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000134 C00003652 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000134 C00003652 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000134 C00003652 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000134 C00003652 | 0 / 1 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00023666 | 5 / 9 |
| O14965 | Aurora kinase A | Aur | C00023666 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00023666 | 4 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000134 | 3 / 2 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00023666 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00023666 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00023666 | 0 / 0 |
| O00444 | Serine/threonine-protein kinase PLK4 | PLK serine/threonine protein kinase subfamily | C00023666 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00023666 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003652 | 2 / 3 |
| Q15746 | Myosin light chain kinase, smooth muscle | Mlck | C00023667 | 1 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003652 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00023666 | 1 / 1 |
| P54760 | Ephrin type-B receptor 4 | Eph | C00023666 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00023666 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00023666 | 0 / 0 |
| P11413 | Glucose-6-phosphate 1-dehydrogenase | Enzyme | C00023666 | 1 / 2 |
| O75496 | Geminin | Unclassified protein | C00023666 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00033559 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00000134 | 0 / 0 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00023666 | 0 / 0 |
| Q02763 | Angiopoietin-1 receptor | Tie | C00023666 | 1 / 1 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00023666 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00023666 | 1 / 1 |
| O60285 | NUAK family SNF1-like kinase 1 | CAMK serine/threonine protein kinase NUAK subfamily | C00023666 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00023666 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003652 | 0 / 0 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00023666 | 5 / 4 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00023666 | 1 / 1 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00023666 | 5 / 1 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00023666 | 0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00023666 | 0 / 0 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00023666 | 1 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00023666 | 2 / 3 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002350 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00023666 | 0 / 0 |
| P35916 | Vascular endothelial growth factor receptor 3 | Vegfr | C00023666 | 2 / 1 |
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00023666 | 1 / 3 |
| P41279 | Mitogen-activated protein kinase kinase kinase 8 | Ste11 | C00023666 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000134 | 1 / 1 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002350 | 0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00023666 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003652 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00023666 | 4 / 1 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00033559 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00023666 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00023666 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00023666 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00023666 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003652 | 5 / 1 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00023666 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000134 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000134 | 3 / 4 |
| P31939 | Bifunctional purine biosynthesis protein PURH | Enzyme | C00003652 | 1 / 1 |
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00023666 | 1 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00023666 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00023666 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00023666 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00023666 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00023666 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00023666 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00023666 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (64)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #608688 | Aicar transformylase/imp cyclohydrolase deficiency |
P31939
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #300908 | Anemia, nonspherocytic hemolytic, due to g6pd deficiency |
P11413
|
| #613780 | Aortic aneurysm, familial thoracic 7; aat7 |
Q15746
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #114480 | Breast cancer |
P31749
|
| #114500 | Colorectal cancer; crc |
P31749
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #246200 | Donohue syndrome |
P06213
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #143500 | Gilbert syndrome |
P22309
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #602089 | Hemangioma, capillary infantile |
P35916
P35968 |
| #114550 | Hepatocellular carcinoma |
P08581
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
P36888 |
| #211980 | Lung cancer |
P00533
P04626 |
| #153100 | Lymphedema, hereditary, ia |
P35916
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P04626
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #176920 | Proteus syndrome |
P31749
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #600195 | Venous malformations, multiple cutaneous and mucosal; vmcm |
Q02763
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (56)
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P08581 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P09619 (related) P11802 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) |
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P08581 (related) |
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00015 | Malignant pleural mesothelioma |
P08069
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00021 | Renal cell carcinoma |
P08581
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00101 | Other phagocyte defects |
P11413
(related)
|
| H00668 | Anemia due to disorders of glutathione metabolism |
P11413
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00038 | Malignant melanoma |
P11802
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00966 | AICA-ribosiduria |
P31939
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00535 | Lymphedemas |
P35916
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00531 | Venous malformations |
Q02763
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
Q15746
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|