PCIDB

KNApSAcK Metabolite C00041598

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00041598
Name	Indole-3-methanol
CAS RN	700-06-1
Standard InChI	InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2
Standard InChI (Main Layer)	InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2

Cluster

Phytochemical cluster	No. 4
KCF-S cluster	No. 710

Link

ChEMBL

By standard InChI	CHEMBL155625
By standard InChI Main Layer	CHEMBL155625

KEGG

By LinkDB

CTD

By CAS RN	C016517

Species

Summary

Plant class

class name	count

Family

family name	count
Chalinidae	1

List (1)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Haliclona oculata	6058	Chalinidae		Metazoa

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	CHEMBL155625	CHEMBL1794585 (1)	0 / 0
O75496	Geminin	Unclassified protein	CHEMBL155625	CHEMBL2114843 (1)	0 / 0
P10145	Interleukin-8	Secreted protein	CHEMBL155625	CHEMBL2114835 (1)	0 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	CHEMBL155625	CHEMBL2114842 (1)	0 / 0
P03372	Estrogen receptor	NR3A1	CHEMBL155625	CHEMBL1794542 (1)	1 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	CHEMBL155625	CHEMBL2114890 (1)	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	CHEMBL155625	CHEMBL1738442 (1)	0 / 0

CTD interaction (124)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
C016517	5243	ABCB1 ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	indole-3-carbinol results in decreased expression of ABCB1	decreases expression		16082211
C016517	9429	ABCG2 ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1	ATP-binding cassette, sub-family G (WHITE), member 2	indole-3-carbinol results in increased expression of ABCG2 mRNA	increases expression	mRNA	17077187
C016517	196	AHR bHLHe76	aryl hydrocarbon receptor	indole-3-carbinol binds to and results in increased activity of AHR protein	affects binding / increases activity	protein	9407059
C016517	196	AHR bHLHe76	aryl hydrocarbon receptor	[indole-3-carbinol co-treated with DDT] results in increased expression of AHR mRNA	affects cotreatment / increases expression	mRNA	17311112
C016517	196	AHR bHLHe76	aryl hydrocarbon receptor	indole-3-carbinol promotes the reaction [AHR protein binds to BRCA1 protein]	affects binding / increases reaction	protein	18259752
C016517	196	AHR bHLHe76	aryl hydrocarbon receptor	indole-3-carbinol results in increased expression of AHR mRNA	increases expression	mRNA	17311112
C016517	367	AR AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM	androgen receptor	indole-3-carbinol results in decreased activity of AR protein	decreases activity	protein	16082211
C016517	581	BAX BCL2L4	BCL2-associated X protein	indole-3-carbinol results in increased expression of BAX	increases expression		16082211
C016517	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BCL2 protein]	decreases reaction / increases expression	protein	15811958
C016517	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	indole-3-carbinol results in decreased expression of BCL2	decreases expression		16082211
C016517	597	BCL2A1 ACC-1 ACC-2 BCL2L5 BFL1 GRS HBPA1	BCL2-related protein A1	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]	decreases reaction / increases expression	protein	15811958
C016517	598	BCL2L1 BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS	BCL2-like 1	indole-3-carbinol results in decreased expression of BCL2L1	decreases expression		16082211
C016517	329	BIRC2 API1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1	baculoviral IAP repeat containing 2	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]	decreases reaction / increases expression	protein	15811958
C016517	330	BIRC3 AIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2	baculoviral IAP repeat containing 3	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]	decreases reaction / increases expression	protein	15811958
C016517	332	BIRC5 API4 EPR-1	baculoviral IAP repeat containing 5	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]	decreases reaction / increases expression	protein	15811958
C016517	332	BIRC5 API4 EPR-1	baculoviral IAP repeat containing 5	indole-3-carbinol results in decreased expression of BIRC5	decreases expression		16082211
C016517	672	BRCA1 BRCAI BRCC1 BROVCA1 IRIS PNCA4 PPP1R53 PSCP RNF53	breast cancer 1, early onset	BRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]	decreases reaction / increases activity / increases reaction	protein	11110848
C016517	672	BRCA1 BRCAI BRCC1 BROVCA1 IRIS PNCA4 PPP1R53 PSCP RNF53	breast cancer 1, early onset	[indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA1 protein	affects cotreatment / increases expression	protein	16434996
C016517	672	BRCA1 BRCAI BRCC1 BROVCA1 IRIS PNCA4 PPP1R53 PSCP RNF53	breast cancer 1, early onset	indole-3-carbinol promotes the reaction [AHR protein binds to BRCA1 protein]	affects binding / increases reaction	protein	18259752
C016517	672	BRCA1 BRCAI BRCC1 BROVCA1 IRIS PNCA4 PPP1R53 PSCP RNF53	breast cancer 1, early onset	indole-3-carbinol results in increased expression of BRCA1 mRNA	increases expression	mRNA	16434996
C016517	672	BRCA1 BRCAI BRCC1 BROVCA1 IRIS PNCA4 PPP1R53 PSCP RNF53	breast cancer 1, early onset	indole-3-carbinol results in increased expression of BRCA1 protein	increases expression	protein	11110848 16434996
C016517	675	BRCA2 BRCC2 BROVCA2 FACD FAD FAD1 FANCB FANCD FANCD1 GLM3 PNCA2	breast cancer 2, early onset	[indole-3-carbinol co-treated with Genistein] results in increased expression of BRCA2 protein	affects cotreatment / increases expression	protein	16434996
C016517	675	BRCA2 BRCC2 BROVCA2 FACD FAD FAD1 FANCB FANCD FANCD1 GLM3 PNCA2	breast cancer 2, early onset	indole-3-carbinol results in increased expression of BRCA2 mRNA	increases expression	mRNA	16434996
C016517	675	BRCA2 BRCC2 BROVCA2 FACD FAD FAD1 FANCB FANCD FANCD1 GLM3 PNCA2	breast cancer 2, early onset	indole-3-carbinol results in increased expression of BRCA2 protein	increases expression	protein	16434996
C016517	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	indole-3-carbinol results in increased activity of CASP3 protein	increases activity	protein	16082211
C016517	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	indole-3-carbinol results in increased cleavage of and results in increased activity of CASP3 protein	increases activity / increases cleavage	protein	20335513
C016517	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	indole-3-carbinol results in increased activity of CASP9 protein	increases activity	protein	16082211
C016517	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	indole-3-carbinol results in increased cleavage of and results in increased activity of CASP9 protein	increases activity / increases cleavage	protein	20335513
C016517	595	CCND1 BCL1 D11S287E PRAD1 U21B31	cyclin D1	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of CCND1 protein]	decreases reaction / increases expression	protein	15811958
C016517	595	CCND1 BCL1 D11S287E PRAD1 U21B31	cyclin D1	indole-3-carbinol results in decreased expression of CCND1	decreases expression		16082211
C016517	898	CCNE1 CCNE	cyclin E1	indole-3-carbinol affects the localization of CCNE1 protein	affects localization	protein	15611077
C016517	898	CCNE1 CCNE	cyclin E1	indole-3-carbinol affects the localization of [CDK2 protein binds to CCNE1 protein alternative form]	affects binding / affects localization	protein	15611077
C016517	898	CCNE1 CCNE	cyclin E1	indole-3-carbinol promotes the reaction [CDK2 protein binds to CCNE1 protein alternative form]	affects binding / increases reaction	protein	15611077
C016517	898	CCNE1 CCNE	cyclin E1	indole-3-carbinol results in decreased expression of CCNE1	decreases expression		16082211
C016517	1017	CDK2 p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	indole-3-carbinol affects the localization of CDK2 protein	affects localization	protein	15611077
C016517	1017	CDK2 p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	indole-3-carbinol affects the localization of [CDK2 protein binds to CCNE1 protein alternative form]	affects binding / affects localization	protein	15611077
C016517	1017	CDK2 p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	indole-3-carbinol analog results in decreased activity of CDK2 protein	decreases activity	protein	18023427 20570586
C016517	1017	CDK2 p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	indole-3-carbinol promotes the reaction [CDK2 protein binds to CCNE1 protein alternative form]	affects binding / increases reaction	protein	15611077
C016517	1017	CDK2 p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	indole-3-carbinol results in decreased activity of CDK2 protein	decreases activity	protein	15611077
C016517	1017	CDK2 p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	indole-3-carbinol results in decreased expression of CDK2	decreases expression		16082211
C016517	1019	CDK4 CMM3 PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	indole-3-carbinol analog results in decreased activity of CDK4 protein	decreases activity	protein	20570586
C016517	1019	CDK4 CMM3 PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	indole-3-carbinol analog results in increased expression of CDK4 protein	increases expression	protein	20570586
C016517	1019	CDK4 CMM3 PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	indole-3-carbinol results in decreased expression of CDK4	decreases expression		16082211
C016517	1021	CDK6 PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter]	affects binding / decreases reaction	promoter	20570586
C016517	1021	CDK6 PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	indole-3-carbinol analog results in decreased activity of CDK6 promoter	decreases activity	promoter	18023427
C016517	1021	CDK6 PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	indole-3-carbinol analog results in decreased activity of CDK6 protein	decreases activity	protein	20570586
C016517	1021	CDK6 PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	indole-3-carbinol analog results in decreased expression of CDK6 mRNA	decreases expression	mRNA	18023427
C016517	1021	CDK6 PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	indole-3-carbinol analog results in decreased expression of CDK6 protein	decreases expression	protein	20570586
C016517	1021	CDK6 PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	indole-3-carbinol analog results in increased expression of CDK6 mRNA	increases expression	mRNA	20570586
C016517	1021	CDK6 PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	indole-3-carbinol results in decreased expression of CDK6	decreases expression		16082211
C016517	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	indole-3-carbinol analog results in increased expression of CDKN1A protein	increases expression	protein	20570586
C016517	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	indole-3-carbinol results in increased expression of CDKN1A	increases expression		16082211
C016517	1026	CDKN1A CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	indole-3-carbinol results in increased expression of CDKN1A mRNA	increases expression	mRNA	17311112 18025290
C016517	1027	CDKN1B CDKN4 KIP1 MEN1B MEN4 P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	indole-3-carbinol analog results in increased expression of CDKN1B protein	increases expression	protein	20570586
C016517	1027	CDKN1B CDKN4 KIP1 MEN1B MEN4 P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	indole-3-carbinol results in increased expression of CDKN1B	increases expression		16082211
C016517	1030	CDKN2B CDK4I INK4B MTS2 P15 TP15 p15INK4b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	indole-3-carbinol results in increased expression of CDKN2B	increases expression		16082211
C016517	8837	CFLAR CASH CASP8AP1 CLARP Casper FLAME FLAME-1 FLAME1 FLIP I-FLICE MRIT c-FLIP c-FLIPL c-FLIPR c-FLIPS	CASP8 and FADD-like apoptosis regulator	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of CFLAR protein]	decreases reaction / increases expression	protein	15811958
C016517	8837	CFLAR CASH CASP8AP1 CLARP Casper FLAME FLAME-1 FLAME1 FLIP I-FLICE MRIT c-FLIP c-FLIPL c-FLIPR c-FLIPS	CASP8 and FADD-like apoptosis regulator	indole-3-carbinol results in decreased expression of CFLAR	decreases expression		16082211
C016517	1147	CHUK IKBKA IKK-alpha IKK1 IKKA NFKBIKA TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	indole-3-carbinol inhibits the reaction [TNF protein results in increased activity of CHUK protein]	decreases reaction / increases activity	protein	15811958
C016517	1509	CTSD CLN10 CPSD	cathepsin D (EC:3.4.23.5)	indole-3-carbinol results in decreased expression of CTSD protein	decreases expression	protein	11110848
C016517	54205	CYCS CYC HCS THC4	cytochrome c, somatic	indole-3-carbinol affects the localization of CYCS protein	affects localization	protein	16082211
C016517	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1A1 mRNA	affects cotreatment / increases expression	mRNA	17311112
C016517	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	indole-3-carbinol results in increased expression of CYP1A1 mRNA	increases expression	mRNA	15890477 17311112
C016517	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	indole-3-carbinol results in increased expression of CYP1A1 protein	increases expression	protein	15890477
C016517	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1B1 mRNA	affects cotreatment / increases expression	mRNA	17311112
C016517	1545	CYP1B1 CP1B CYPIB1 GLC3A P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	indole-3-carbinol results in increased expression of CYP1B1 mRNA	increases expression	mRNA	15890477 17311112
C016517	1956	EGFR ERBB ERBB1 HER1 PIG61 mENA	epidermal growth factor receptor (EC:2.7.10.1)	indole-3-carbinol results in decreased expression of EGFR protein	decreases expression	protein	18025290
C016517	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	BRCA1 protein promotes the reaction [indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]	decreases reaction / increases activity / increases reaction	protein	11110848
C016517	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	indole-3-carbinol analog results in decreased expression of ESR1 protein	decreases expression	protein	20570586
C016517	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	indole-3-carbinol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]	decreases reaction / increases activity	protein	11110848 16434996
C016517	9518	GDF15 GDF-15 MIC-1 MIC1 NAG-1 PDF PLAB PTGFB	growth differentiation factor 15	[indole-3-carbinol co-treated with resveratrol] results in increased expression of GDF15	affects cotreatment / increases expression		15670751
C016517	9518	GDF15 GDF-15 MIC-1 MIC1 NAG-1 PDF PLAB PTGFB	growth differentiation factor 15	indole-3-carbinol results in increased expression of GDF15	increases expression		15670751
C016517	3551	IKBKB IKK-beta IKK2 IKKB NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	indole-3-carbinol inhibits the reaction [TNF protein results in increased activity of IKBKB protein]	decreases reaction / increases activity	protein	15811958
C016517	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	indole-3-carbinol inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15811958
C016517	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	indole-3-carbinol inhibits the reaction [IL1B protein results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15811958
C016517	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	indole-3-carbinol results in increased expression of IL6 mRNA	increases expression	mRNA	18025290
C016517	4318	MMP9 CLG4B GELB MANDP2 MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]	decreases reaction / increases expression	protein	15811958
C016517	4582	MUC1 CA_15-3 CD227 EMA H23AG KL-6 MAM6 MCKD1 MUC-1 MUC-1/SEC MUC-1/X MUC1/ZD PEM PEMT PUM	mucin 1, cell surface associated	indole-3-carbinol results in decreased expression of MUC1 mRNA	decreases expression	mRNA	15027113
C016517	4582	MUC1 CA_15-3 CD227 EMA H23AG KL-6 MAM6 MCKD1 MUC-1 MUC-1/SEC MUC-1/X MUC1/ZD PEM PEMT PUM	mucin 1, cell surface associated	indole-3-carbinol results in decreased expression of MUC1 protein	decreases expression	protein	15027113
C016517	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	indole-3-carbinol results in decreased activity of NFE2L2 protein	decreases activity	protein	16082211
C016517	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	indole-3-carbinol inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15811958
C016517	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	indole-3-carbinol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15811958
C016517	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	indole-3-carbinol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15811958
C016517	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	indole-3-carbinol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15811958
C016517	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	indole-3-carbinol results in decreased activity of NFKB1 protein	decreases activity	protein	15811958 16082211
C016517	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	indole-3-carbinol inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]	decreases reaction / increases degradation	protein	15811958
C016517	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	indole-3-carbinol inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]	decreases reaction / increases phosphorylation	protein	15811958
C016517	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	indole-3-carbinol inhibits the reaction [TNF protein results in increased ubiquitination of NFKBIA protein]	decreases reaction / increases ubiquitination	protein	15811958
C016517	142	PARP1 ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	indole-3-carbinol promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]	increases cleavage / increases reaction	protein	15811958
C016517	5328	PLAU ATF BDPLT5 QPD UPA URK u-PA	plasminogen activator, urokinase (EC:3.4.21.73)	indole-3-carbinol results in increased expression of PLAU mRNA	increases expression	mRNA	18025290
C016517	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	15811958
C016517	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	indole-3-carbinol inhibits the reaction [IL1B protein results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15811958
C016517	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	indole-3-carbinol inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15811958
C016517	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	indole-3-carbinol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15811958
C016517	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	indole-3-carbinol inhibits the reaction [TNF protein affects the localization of RELA protein]	affects localization / decreases reaction	protein	15811958
C016517	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	indole-3-carbinol inhibits the reaction [TNF protein results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15811958
C016517	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	indole-3-carbinol results in decreased activity of RELA protein	decreases activity	protein	15811958 16082211
C016517	6667	SP1	Sp1 transcription factor	indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter]	affects binding / decreases reaction	protein	20570586
C016517	6667	SP1	Sp1 transcription factor	indole-3-carbinol results in decreased activity of SP1 protein	decreases activity	protein	16082211
C016517	7031	TFF1 BCEI D21S21 HP1.A HPS2 pNR-2 pS2	trefoil factor 1	indole-3-carbinol results in decreased expression of TFF1 protein	decreases expression	protein	11110848
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein affects the localization of RELA protein]	affects localization / decreases reaction	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased activity of CHUK protein]	decreases reaction / increases activity	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased activity of IKBKB protein]	decreases reaction / increases activity	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]	decreases reaction / increases activity	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased activity of RELA protein]	decreases reaction / increases activity	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]	decreases reaction / increases degradation	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BCL2 protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of CCND1 protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of CFLAR protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of XIAP protein]	decreases reaction / increases expression	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]	decreases reaction / increases phosphorylation	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol inhibits the reaction [TNF protein results in increased ubiquitination of NFKBIA protein]	decreases reaction / increases ubiquitination	protein	15811958
C016517	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	indole-3-carbinol promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]	increases cleavage / increases reaction	protein	15811958
C016517	7185	TRAF1 EBI6 MGC:10353	TNF receptor-associated factor 1	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]	decreases reaction / increases expression	protein	15811958
C016517	7431	VIM CTRCT30	vimentin	indole-3-carbinol results in decreased expression of VIM protein	decreases expression	protein	18025290
C016517	331	XIAP API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3	X-linked inhibitor of apoptosis	indole-3-carbinol inhibits the reaction [TNF protein results in increased expression of XIAP protein]	decreases reaction / increases expression	protein	15811958
C016517	331	XIAP API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3	X-linked inhibitor of apoptosis	indole-3-carbinol results in decreased expression of XIAP	decreases expression		16082211

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM	preferred title	UniProt
#615363	Estrogen resistance; estrr	P03372

KEGG DISEASE (1)

KEGG	disease name	UniProt
H00026	Endometrial Cancer	P03372 (marker)

Diseases related to CTD interactions

7 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D001943	C016517	Breast Neoplasms	therapeutic	16082211 20570586
D008064	C016517	Lipidoses	marker/mechanism	22328411
D008113	C016517	Liver Neoplasms	marker/mechanism	21396975
D008114	C016517	Liver Neoplasms, Experimental	marker/mechanism	22659510
D008201	C016517	Lymphangiectasis, Intestinal	marker/mechanism	22328411
D011472	C016517	Prostatitis	therapeutic	21427997
D002583	C016517	Uterine Cervical Neoplasms	therapeutic	16082211

KNApSAcK Metabolite C00041598

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (1)

* NCBI

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

CTD interaction (124)

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

KEGG DISEASE (1)

Diseases related to CTD interactions

7 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases