Haliclona oculata

• Index
• Plant Species
• Metabolite list (7)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Haliclona oculata
Genus
Family
Kingdom

---

NCBI taxonomy

Entry

Linked NCBI taxonomy name	Haliclona oculata
Linked NCBI taxonomy ID	6058
Linked level	species

Family

Family in NCBI taxonomy	Chalinidae
ID	6056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Metazoa
ID	33208

Plant class

Plant class
ID

Metabolite list (7)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00041598	Indole-3-methanol	CHEMBL155625	C016517	7 / 1 / 1	50 / 7	No. 710	No. 4
C00041260	2-Ethoxycarbonyl-24-ethyl-2beta-hydroxy-A-nor-cholesta-5-en-4-one / (-)-2-Ethoxycarbonyl-24-ethyl-2beta-hydroxy-A-nor-cholesta-5-en-4-one					No. 2236
C00000113	Indole-3-carboxylic acid	CHEMBL387527	C012382	1 / 3 / 4		No. 3632
C00000112	Indole-3-carboxaldehyde / 1H-Indole-3-carboxaldehyde	CHEMBL147741	C012381	2 / 1 / 1		No. 4314
C00041286	6-Hydroxyindole-3-carboxaldehyde					No. 6145
C00041709	Oculatol / (+)-Oculatol					No. 6342
C00041710	Oculatolide / (+)-Oculatolide					No. 7250

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00041598	0 / 0
P12268	Inosine-5'-monophosphate dehydrogenase 2	Oxidoreductase	C00000112	0 / 0
O75496	Geminin	Unclassified protein	C00041598	0 / 0
P10145	Interleukin-8	Secreted protein	C00041598	0 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00041598	0 / 0
P00374	Dihydrofolate reductase	Oxidoreductase	C00000112	1 / 1
P03372	Estrogen receptor	NR3A1	C00041598	1 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00041598	0 / 0
P10275	Androgen receptor	NR3C4	C00000113	3 / 4
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00041598	0 / 0

50 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00041598
9429	ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1	ATP-binding cassette, sub-family G (WHITE), member 2	C00041598
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00041598
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00041598
581	BAX, BCL2L4	BCL2-associated X protein	C00041598
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00041598
597	BCL2A1, ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1	BCL2-related protein A1	C00041598
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00041598
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00041598
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00041598
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00041598
672	BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53	breast cancer 1, early onset	C00041598
675	BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2	breast cancer 2, early onset	C00041598
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00041598
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00041598
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00041598
898	CCNE1, CCNE	cyclin E1	C00041598
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00041598
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00041598
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00041598
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00041598
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00041598
1030	CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	C00041598
8837	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS	CASP8 and FADD-like apoptosis regulator	C00041598
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00041598
1509	CTSD, CLN10, CPSD	cathepsin D (EC:3.4.23.5)	C00041598
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00041598
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00041598
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00041598
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00041598
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00041598
9518	GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB	growth differentiation factor 15	C00041598
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00041598
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00041598
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00041598
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00041598
4582	MUC1, CA_15-3, CD227, EMA, H23AG, KL-6, MAM6, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM	mucin 1, cell surface associated	C00041598
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00041598
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00041598
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00041598
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00041598
5328	PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA	plasminogen activator, urokinase (EC:3.4.21.73)	C00041598
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00041598
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00041598
6667	SP1	Sp1 transcription factor	C00041598
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00041598
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00041598
7185	TRAF1, EBI6, MGC:10353	TNF receptor-associated factor 1	C00041598
7431	VIM, CTRCT30	vimentin	C00041598
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00041598

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions