KNApSAcK Metabolite C00041878
Metabolite
KNApSAcK Entry
| id | C00041878 |
|---|---|
| Name | Spinosyn A / (-)-Spinosyn A |
| CAS RN | 131929-60-7 |
| Standard InChI | InChI=1S/C41H65NO10/c1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C41H65NO10/c1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5644 |
Link
ChEMBL
| By standard InChI | CHEMBL501411 |
|---|---|
| By standard InChI Main Layer | CHEMBL501411 CHEMBL1874717 |
KEGG
| By LinkDB | C11054 |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Pseudonocardiaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Saccharopolyspora spinosa | 60894 | Pseudonocardiaceae | Bacteria |
Human Protein / Gene in interaction
7 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL1874717 |
CHEMBL1794524
(1)
CHEMBL1794552
(1)
|
0 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | CHEMBL1874717 |
CHEMBL1794371
(1)
CHEMBL1794471
(1)
|
0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL1874717 |
CHEMBL1794339
(1)
|
2 / 3 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | CHEMBL1874717 |
CHEMBL1794293
(1)
|
5 / 3 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL1874717 |
CHEMBL1794364
(1)
CHEMBL1794542
(1)
|
1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL1874717 |
CHEMBL2114890
(1)
|
0 / 0 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL1874717 |
CHEMBL1794321
(1)
CHEMBL1794560
(1)
|
3 / 4 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (11)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #601665 | Obesity |
P37231
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (11)
| KEGG | disease name | UniProt |
|---|---|---|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|