PCIDB

KNApSAcK Metabolite C00042470

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00042470
Name	D-Glucose
CAS RN	50-99-7
Standard InChI	InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6+/m0/s1
Standard InChI (Main Layer)	InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2

Cluster

Phytochemical cluster
KCF-S cluster	No. 1384

Link

ChEMBL

By standard InChI
By standard InChI Main Layer	CHEMBL1206211

KEGG

By LinkDB	C00031

CTD

By CAS RN	D005947

Species

Summary

Plant class

class name	count
asterids	1

Family

family name	count
Rubiaceae	1

List (1)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Morinda citrifolia	43522	Rubiaceae	asterids	Viridiplantae

Human Protein / Gene in interaction

CTD interaction (861)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
D005947	5243	ABCB1 ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	Glucose results in decreased expression of ABCB1 protein	decreases expression	protein	22363694
D005947	31	ACACA ACAC ACACAD ACC ACC1 ACCA	acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14)	Glucose results in decreased phosphorylation of ACACA protein	decreases phosphorylation	protein	18482975 19071085
D005947	31	ACACA ACAC ACACAD ACC ACC1 ACCA	acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14)	PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]]	decreases phosphorylation / decreases reaction / increases reaction	protein	18482975
D005947	31	ACACA ACAC ACACAD ACC ACC1 ACCA	acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14)	[Pyruvic Acid co-treated with Glucose] results in increased phosphorylation of ACACA protein	affects cotreatment / increases phosphorylation	protein	19071085
D005947	31	ACACA ACAC ACACAD ACC ACC1 ACCA	acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14)	SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]	decreases phosphorylation / decreases reaction	protein	18482975
D005947	1636	ACE ACE1 CD143 DCP DCP1 ICH MVCD3	angiotensin I converting enzyme (EC:3.4.15.1)	Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein]	decreases reaction / increases expression	protein	16452552
D005947	1636	ACE ACE1 CD143 DCP DCP1 ICH MVCD3	angiotensin I converting enzyme (EC:3.4.15.1)	Glucose results in increased expression of ACE protein	increases expression	protein	16452552
D005947	59	ACTA2 AAT6 ACTSA MYMY5	actin, alpha 2, smooth muscle, aorta	[Glucose co-treated with TGFB1 protein] results in increased expression of ACTA2 protein	affects cotreatment / increases expression	protein	21829520
D005947	59	ACTA2 AAT6 ACTSA MYMY5	actin, alpha 2, smooth muscle, aorta	Glucose results in increased expression of ACTA2 protein	increases expression	protein	21829520
D005947	59	ACTA2 AAT6 ACTSA MYMY5	actin, alpha 2, smooth muscle, aorta	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of ACTA2 protein]	affects cotreatment / increases expression / increases reaction	protein	21829520
D005947	59	ACTA2 AAT6 ACTSA MYMY5	actin, alpha 2, smooth muscle, aorta	MAPK14 protein promotes the reaction [Glucose results in increased expression of ACTA2 protein]	increases expression / increases reaction	protein	21829520
D005947	60	ACTB BRWS1 PS1TP5BP1	actin, beta	Glucose deficiency results in decreased expression of ACTB protein	decreases expression	protein	22314686
D005947	177	AGER RAGE	advanced glycosylation end product-specific receptor	Glucose results in increased expression of AGER mRNA	increases expression	mRNA	19557821
D005947	177	AGER RAGE	advanced glycosylation end product-specific receptor	Luteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	177	AGER RAGE	advanced glycosylation end product-specific receptor	Quercetin inhibits the reaction [Glucose results in increased expression of AGER mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	177	AGER RAGE	advanced glycosylation end product-specific receptor	Rutin inhibits the reaction [Glucose results in increased expression of AGER mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	(3,4-dihydroxyphenylamino)-2-imidazoline inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Enalaprilat inhibits the reaction [Glucose results in increased expression of AGT protein]	decreases reaction / increases expression	protein	16452552
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]	increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]	increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Glucose promotes the reaction [AGT protein results in increased expression of FOSL1 mRNA]	increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]	increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]	increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]	increases phosphorylation / increases reaction	protein	15677497
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Glucose results in increased expression of AGT protein	increases expression	protein	16452552
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Rotenone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Simvastatin promotes the reaction [Glucose promotes the reaction [AGT protein results in increased expression of PTGS2 mRNA]]	increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	[valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]	affects cotreatment / decreases reaction / increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	[valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]	affects cotreatment / decreases reaction / increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]	decreases reaction / increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]]	decreases reaction / increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]	decreases reaction / increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]	decreases reaction / increases expression / increases reaction	protein	19225232
D005947	183	AGT ANHU SERPINA8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	185	AGTR1 AG2S AGTR1A AGTR1B AT1 AT1AR AT1B AT1BR AT1R AT2R1 AT2R1A AT2R1B HAT1R	angiotensin II receptor, type 1	Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein]	decreases reaction / increases expression	protein	16452552
D005947	185	AGTR1 AG2S AGTR1A AGTR1B AT1 AT1AR AT1B AT1BR AT1R AT2R1 AT2R1A AT2R1B HAT1R	angiotensin II receptor, type 1	Glucose results in increased expression of AGTR1 protein	increases expression	protein	16452552
D005947	196	AHR bHLHe76	aryl hydrocarbon receptor	4,7-phenanthroline inhibits the reaction [AHR promotes the reaction [Tetrachlorodibenzodioxin results in decreased uptake of Glucose]]	decreases reaction / decreases uptake / increases reaction		8738555
D005947	196	AHR bHLHe76	aryl hydrocarbon receptor	AHR promotes the reaction [Tetrachlorodibenzodioxin results in decreased uptake of Glucose]	decreases uptake / increases reaction		8738555
D005947	196	AHR bHLHe76	aryl hydrocarbon receptor	alpha-naphthoflavone inhibits the reaction [AHR promotes the reaction [Tetrachlorodibenzodioxin results in decreased uptake of Glucose]]	decreases reaction / decreases uptake / increases reaction		8738555
D005947	207	AKT1 AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]	decreases phosphorylation / decreases reaction	protein	21333731
D005947	207	AKT1 AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	Glucose results in decreased phosphorylation of AKT1 protein	decreases phosphorylation	protein	21333731
D005947	207	AKT1 AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	Glucose results in increased phosphorylation of AKT1 protein	increases phosphorylation	protein	21333731
D005947	207	AKT1 AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	Metformin inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]	decreases reaction / increases phosphorylation	protein	16385087
D005947	207	AKT1 AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]	decreases phosphorylation / decreases reaction	protein	21333731
D005947	213	ALB PRO0883 PRO0903 PRO1341	albumin	Glucose results in decreased uptake of ALB protein	decreases uptake	protein	16313995
D005947	213	ALB PRO0883 PRO0903 PRO1341	albumin	Glucose results in increased metabolism of ALB protein	increases metabolic processing	protein	12434198
D005947	213	ALB PRO0883 PRO0903 PRO1341	albumin	[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein	affects cotreatment / increases glycation	protein	12196478
D005947	213	ALB PRO0883 PRO0903 PRO1341	albumin	Phlorhizin inhibits the reaction [Glucose results in decreased uptake of ALB protein]	decreases reaction / decreases uptake	protein	16313995
D005947	213	ALB PRO0883 PRO0903 PRO1341	albumin	pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein]	affects cotreatment / decreases reaction / increases glycation	protein	12196478
D005947	219	ALDH1B1 ALDH5 ALDHX	aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)	Glucose deficiency results in increased expression of ALDH1B1 protein	increases expression	protein	22314686
D005947	405	ARNT HIF-1-beta HIF-1beta HIF1-beta HIF1B HIF1BETA TANGO bHLHe2	aryl hydrocarbon receptor nuclear translocator	Glucose promotes the reaction [[ARNT protein binds to G6PC promoter] which results in increased expression of G6PC mRNA]	affects binding / increases expression / increases reaction	protein	15767253
D005947	440	ASNS TS11	asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4)	Glucose affects the expression of ASNS mRNA	affects expression	mRNA	17409444
D005947	476	ATP1A1	ATPase, Na+/K+ transporting, alpha 1 polypeptide (EC:3.6.3.9)	Glucose results in decreased expression of and results in decreased activity of ATP1A1 protein	decreases activity / decreases expression	protein	22162761
D005947	476	ATP1A1	ATPase, Na+/K+ transporting, alpha 1 polypeptide (EC:3.6.3.9)	INS protein inhibits the reaction [Glucose results in decreased expression of ATP1A1 protein]	decreases expression / decreases reaction	protein	22162761
D005947	581	BAX BCL2L4	BCL2-associated X protein	NDRG2 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]	affects cotreatment / increases expression / increases reaction	protein	23451161
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	Catechin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	epigallocatechin gallate inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	Gliclazide inhibits the reaction [Glucose results in decreased expression of BCL2 protein]	decreases expression / decreases reaction	protein	18088078
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	Glucose results in decreased expression of BCL2 protein	decreases expression	protein	18088078
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	Glucose results in increased degradation of and results in decreased expression of BCL2 protein	decreases expression / increases degradation	protein	19557821
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]	decreases expression / decreases reaction	protein	18088078
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	[[NS 1619 co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]] which results in decreased expression of BCL2 protein	affects binding / affects cotreatment / decreases expression / increases activity	protein	21413024
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	Quercetin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	[[Tamoxifen co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]] which results in decreased expression of BCL2 protein	affects binding / affects cotreatment / decreases expression / increases activity	protein	21413024
D005947	650	BMP2 BDA2 BMP2A	bone morphogenetic protein 2	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of BMP2 mRNA]	decreases expression / decreases reaction	mRNA	19924377
D005947	650	BMP2 BDA2 BMP2A	bone morphogenetic protein 2	Glucose results in decreased expression of BMP2 mRNA	decreases expression	mRNA	19924377
D005947	650	BMP2 BDA2 BMP2A	bone morphogenetic protein 2	tin mesoporphyrin promotes the reaction [Glucose results in decreased expression of BMP2 mRNA]	decreases expression / increases reaction	mRNA	19924377
D005947	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	Gliclazide inhibits the reaction [Glucose results in increased expression of CASP3 protein]	decreases reaction / increases expression	protein	18088078
D005947	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	[Glucose deficiency co-treated with Acetylcysteine] results in increased activity of CASP3 protein	affects cotreatment / increases activity	protein	17309078
D005947	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	[Glucose deficiency co-treated with CAT] results in increased activity of CASP3 protein	affects cotreatment / increases activity	protein	17309078
D005947	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	[Glucose deficiency co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP3 protein	affects cotreatment / increases activity	protein	17309078
D005947	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	Glucose results in increased activity of CASP3 protein	increases activity	protein	19767878 19892008
D005947	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	Glucose results in increased expression of CASP3 protein	increases expression	protein	18088078
D005947	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of CASP3 protein]	decreases reaction / increases expression	protein	18088078
D005947	836	CASP3 CPP32 CPP32B SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	rosiglitazone inhibits the reaction [Glucose results in increased activity of CASP3 protein]	decreases reaction / increases activity	protein	19767878
D005947	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	[Glucose deficiency co-treated with Acetylcysteine] results in increased activity of CASP9 protein	affects cotreatment / increases activity	protein	17309078
D005947	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	[Glucose deficiency co-treated with CAT] results in increased activity of CASP9 protein	affects cotreatment / increases activity	protein	17309078
D005947	842	CASP9 APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	[Glucose deficiency co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP9 protein	affects cotreatment / increases activity	protein	17309078
D005947	847	CAT	catalase (EC:1.11.1.6)	CAT inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein]	affects folding / decreases reaction		17309078
D005947	847	CAT	catalase (EC:1.11.1.6)	CAT inhibits the reaction [Glucose deficiency results in increased activity of MAPK14 protein]	decreases reaction / increases activity		17309078
D005947	847	CAT	catalase (EC:1.11.1.6)	CAT inhibits the reaction [Glucose deficiency results in increased activity of MAPK1 protein]	decreases reaction / increases activity		17309078
D005947	847	CAT	catalase (EC:1.11.1.6)	CAT inhibits the reaction [Glucose deficiency results in increased activity of MAPK3 protein]	decreases reaction / increases activity		17309078
D005947	847	CAT	catalase (EC:1.11.1.6)	CAT inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]	decreases reaction / increases degradation		17309078
D005947	847	CAT	catalase (EC:1.11.1.6)	[Glucose deficiency co-treated with CAT] affects the localization of ENDOG protein	affects cotreatment / affects localization		17309078
D005947	847	CAT	catalase (EC:1.11.1.6)	[Glucose deficiency co-treated with CAT] results in increased activity of CASP3 protein	affects cotreatment / increases activity		17309078
D005947	847	CAT	catalase (EC:1.11.1.6)	[Glucose deficiency co-treated with CAT] results in increased activity of CASP9 protein	affects cotreatment / increases activity		17309078
D005947	847	CAT	catalase (EC:1.11.1.6)	[Glucose deficiency co-treated with CAT] results in increased cleavage of PARP1 protein	affects cotreatment / increases cleavage		17309078
D005947	857	CAV1 BSCL3 CGL3 MSTP085 PPH3 VIP21 CAV	caveolin 1, caveolae protein, 22kDa	EGF protein inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA]	decreases expression / decreases reaction	mRNA	19816600
D005947	857	CAV1 BSCL3 CGL3 MSTP085 PPH3 VIP21 CAV	caveolin 1, caveolae protein, 22kDa	Glucose results in decreased expression of CAV1 mRNA	decreases expression	mRNA	19816600
D005947	857	CAV1 BSCL3 CGL3 MSTP085 PPH3 VIP21 CAV	caveolin 1, caveolae protein, 22kDa	Glucose results in decreased expression of CAV1 protein	decreases expression	protein	19816600
D005947	857	CAV1 BSCL3 CGL3 MSTP085 PPH3 VIP21 CAV	caveolin 1, caveolae protein, 22kDa	Simvastatin inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA]	decreases expression / decreases reaction	mRNA	19816600
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	19132243
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CCL2 protein]	decreases reaction / increases expression	protein	19132243
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 protein]	decreases reaction / increases expression	protein	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Aspirin inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	CCL2 mRNA affects the reaction [Glucose results in increased expression of CTGF protein]	affects reaction / increases expression	mRNA	21367880
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	chromic chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	17665966
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	chromium nicotinic acid complex inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	17665966
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	16600694 19132243
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Clofibrate inhibits the reaction [Glucose results in increased expression of CCL2 protein]	decreases reaction / increases expression	protein	16600694 19132243
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Clofibrate inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	diphenyleneiodonium inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Fenofibrate inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	16600694 19132243
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Fenofibrate inhibits the reaction [Glucose results in increased expression of CCL2 protein]	decreases reaction / increases expression	protein	16600694 19132243
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Fenofibrate inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Glucose inhibits the reaction [Fructose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	19158351
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]	increases expression / increases reaction	mRNA	19225232
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Glucose results in increased expression of CCL2 mRNA	increases expression	mRNA	16143069 16600694 17655880 19132243 19225232 21367880
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Glucose results in increased expression of CCL2 protein	increases expression	protein	16600694 17655880 19132243
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Glucose results in increased secretion of CCL2 protein	increases secretion	protein	16600694 17665966
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	HTS 466284 inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	21367880
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	isoangustone A inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	21367880
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	picolinic acid inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	17665966
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	psicose inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	17655880
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	psicose inhibits the reaction [Glucose results in increased expression of CCL2 protein]	decreases reaction / increases expression	protein	17655880
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	SB 203580 inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	16143069 17655880 19132243
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	SB 203580 inhibits the reaction [Glucose results in increased expression of CCL2 protein]	decreases reaction / increases expression	protein	19132243
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Selenium inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	16143069
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]	decreases reaction / increases expression	mRNA	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased secretion of CCL2 protein]	decreases reaction / increases secretion	protein	16600694
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	[valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]	affects cotreatment / decreases reaction / increases expression / increases reaction	mRNA	19225232
D005947	6347	CCL2 GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF	chemokine (C-C motif) ligand 2	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]	decreases reaction / increases expression / increases reaction	mRNA	19225232
D005947	929	CD14	CD14 molecule	CD14 protein affects the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]	affects reaction / increases reaction / increases secretion	protein	18180316
D005947	929	CD14	CD14 molecule	Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]	decreases reaction / increases expression / increases reaction	protein	18180316
D005947	929	CD14	CD14 molecule	Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]	increases expression / increases reaction	protein	18180316
D005947	999	CDH1 Arc-1 CD324 CDHE ECAD LCAM UVO	cadherin 1, type 1, E-cadherin (epithelial)	[Glucose co-treated with TGFB1 protein] results in decreased expression of CDH1 protein	affects cotreatment / decreases expression	protein	21829520
D005947	999	CDH1 Arc-1 CD324 CDHE ECAD LCAM UVO	cadherin 1, type 1, E-cadherin (epithelial)	Glucose results in decreased expression of CDH1 protein	decreases expression	protein	21829520
D005947	999	CDH1 Arc-1 CD324 CDHE ECAD LCAM UVO	cadherin 1, type 1, E-cadherin (epithelial)	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in decreased expression of CDH1 protein]	affects cotreatment / decreases expression / increases reaction	protein	21829520
D005947	999	CDH1 Arc-1 CD324 CDHE ECAD LCAM UVO	cadherin 1, type 1, E-cadherin (epithelial)	MAPK14 protein promotes the reaction [Glucose results in decreased expression of CDH1 protein]	decreases expression / increases reaction	protein	21829520
D005947	634	CEACAM1 BGP BGP1 BGPI	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of CEACAM1 mRNA]	decreases expression / decreases reaction	mRNA	19924377
D005947	634	CEACAM1 BGP BGP1 BGPI	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased secretion of CEACAM1 protein]	decreases reaction / decreases secretion	protein	19924377
D005947	634	CEACAM1 BGP BGP1 BGPI	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	Glucose results in decreased expression of CEACAM1 mRNA	decreases expression	mRNA	19924377
D005947	634	CEACAM1 BGP BGP1 BGPI	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	Glucose results in decreased secretion of CEACAM1 protein	decreases secretion	protein	19924377
D005947	1152	CKB B-CK CKBB	creatine kinase, brain (EC:2.7.3.2)	Glucose inhibits the reaction [daidzein results in increased activity of CKB protein]	decreases reaction / increases activity	protein	16621514
D005947	1152	CKB B-CK CKBB	creatine kinase, brain (EC:2.7.3.2)	Glucose inhibits the reaction [Dihydrotestosterone results in increased activity of CKB protein]	decreases reaction / increases activity	protein	16621514
D005947	1152	CKB B-CK CKBB	creatine kinase, brain (EC:2.7.3.2)	Glucose inhibits the reaction [Estradiol results in increased activity of CKB protein]	decreases reaction / increases activity	protein	16621514
D005947	1152	CKB B-CK CKBB	creatine kinase, brain (EC:2.7.3.2)	Glucose inhibits the reaction [Genistein results in increased activity of CKB protein]	decreases reaction / increases activity	protein	16621514
D005947	1152	CKB B-CK CKBB	creatine kinase, brain (EC:2.7.3.2)	Glucose results in increased activity of CKB protein	increases activity	protein	16621514
D005947	1278	COL1A2 OI4	collagen, type I, alpha 2	Glucose results in increased expression of COL1A2 mRNA	increases expression	mRNA	17199790
D005947	1278	COL1A2 OI4	collagen, type I, alpha 2	troglitazone inhibits the reaction [Glucose results in increased expression of COL1A2 mRNA]	decreases reaction / increases expression	mRNA	17199790
D005947	1490	CTGF CCN2 HCS24 IGFBP8 NOV2	connective tissue growth factor	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CTGF protein]	decreases reaction / increases expression	protein	19369054
D005947	1490	CTGF CCN2 HCS24 IGFBP8 NOV2	connective tissue growth factor	bisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of CTGF mRNA]	decreases reaction / increases expression	mRNA	10026205
D005947	1490	CTGF CCN2 HCS24 IGFBP8 NOV2	connective tissue growth factor	Cadmium inhibits the reaction [Glucose results in increased expression of CTGF protein]	decreases reaction / increases expression	protein	19369054
D005947	1490	CTGF CCN2 HCS24 IGFBP8 NOV2	connective tissue growth factor	CCL2 mRNA affects the reaction [Glucose results in increased expression of CTGF protein]	affects reaction / increases expression	protein	21367880
D005947	1490	CTGF CCN2 HCS24 IGFBP8 NOV2	connective tissue growth factor	Glucose results in increased expression of CTGF mRNA	increases expression	mRNA	10026205
D005947	1490	CTGF CCN2 HCS24 IGFBP8 NOV2	connective tissue growth factor	Glucose results in increased expression of CTGF protein	increases expression	protein	19369054 21367880
D005947	1490	CTGF CCN2 HCS24 IGFBP8 NOV2	connective tissue growth factor	SB 203580 inhibits the reaction [Glucose results in increased expression of CTGF protein]	decreases reaction / increases expression	protein	19369054
D005947	1490	CTGF CCN2 HCS24 IGFBP8 NOV2	connective tissue growth factor	Zinc inhibits the reaction [Glucose results in increased expression of CTGF protein]	decreases reaction / increases expression	protein	19369054
D005947	1508	CTSB APPS CPSB	cathepsin B (EC:3.4.22.1)	Melatonin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CTSB protein]	affects cotreatment / decreases reaction / increases expression	protein	21392095
D005947	1508	CTSB APPS CPSB	cathepsin B (EC:3.4.22.1)	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CTSB protein	affects cotreatment / increases expression	protein	21392095
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]	decreases reaction / increases expression	mRNA	19132243
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]	decreases reaction / increases expression	protein	19132243
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	Clofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]	decreases reaction / increases expression	mRNA	19132243
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	Clofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]	decreases reaction / increases expression	protein	19132243
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	Fenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]	decreases reaction / increases expression	mRNA	19132243
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	Fenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]	decreases reaction / increases expression	protein	19132243
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	Glucose results in increased expression of CX3CL1 mRNA	increases expression	mRNA	19132243
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	Glucose results in increased expression of CX3CL1 protein	increases expression	protein	19132243
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	SB 203580 inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]	decreases reaction / increases expression	mRNA	19132243
D005947	6376	CX3CL1 ABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin	chemokine (C-X3-C motif) ligand 1	SB 203580 inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]	decreases reaction / increases expression	protein	19132243
D005947	1535	CYBA p22-PHOX	cytochrome b-245, alpha polypeptide	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA protein]]	decreases reaction / increases expression	protein	17916771
D005947	1535	CYBA p22-PHOX	cytochrome b-245, alpha polypeptide	Glucose results in increased expression of CYBA protein	increases expression	protein	17916771 18088078
D005947	1535	CYBA p22-PHOX	cytochrome b-245, alpha polypeptide	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of CYBA protein]	decreases reaction / increases expression	protein	18088078
D005947	1535	CYBA p22-PHOX	cytochrome b-245, alpha polypeptide	rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA protein]	decreases reaction / increases expression	protein	17916771
D005947	1536	CYBB AMCBX2 CGD GP91-1 GP91-PHOX GP91PHOX NOX2 p91-PHOX	cytochrome b-245, beta polypeptide	acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of CYBB protein]	decreases reaction / increases activity / increases expression	protein	19878672
D005947	1536	CYBB AMCBX2 CGD GP91-1 GP91-PHOX GP91PHOX NOX2 p91-PHOX	cytochrome b-245, beta polypeptide	Glucose results in increased expression of and results in increased activity of CYBB protein	increases activity / increases expression	protein	19878672
D005947	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	Glucose results in increased expression of CYP1A1 mRNA	increases expression	mRNA	21682256
D005947	1543	CYP1A1 AHH AHRR CP11 CYP1 P1-450 P450-C P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	Polyphenols promotes the reaction [Glucose results in increased expression of CYP1A1 mRNA]	increases expression / increases reaction	mRNA	21682256
D005947	1616	DAXX BING2 DAP6 EAP1	death-domain associated protein	Glucose deficiency affects the localization of DAXX protein	affects localization	protein	14505347
D005947	1616	DAXX BING2 DAP6 EAP1	death-domain associated protein	Glucose deficiency promotes the reaction [DAXX protein binds to MAP3K5 protein]	affects binding / increases reaction	protein	14505347
D005947	8527	DGKD DGKdelta dgkd-2	diacylglycerol kinase, delta 130kDa (EC:2.7.1.107)	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Glucose affects the localization of DGKD protein alternative form]	affects localization / decreases reaction	protein	22974639
D005947	8527	DGKD DGKdelta dgkd-2	diacylglycerol kinase, delta 130kDa (EC:2.7.1.107)	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of DGKD protein alternative form]	affects localization / decreases reaction	protein	22974639
D005947	8527	DGKD DGKdelta dgkd-2	diacylglycerol kinase, delta 130kDa (EC:2.7.1.107)	Glucose affects the localization of DGKD protein alternative form	affects localization	protein	22974639
D005947	1906	EDN1 ET1 HDLCQ7 PPET1	endothelin 1	carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	decreases reaction / increases expression	mRNA	16428915
D005947	1906	EDN1 ET1 HDLCQ7 PPET1	endothelin 1	carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]	decreases reaction / increases expression	protein	16428915
D005947	1906	EDN1 ET1 HDLCQ7 PPET1	endothelin 1	Glucose results in increased expression of EDN1 mRNA	increases expression	mRNA	16428915 20960276
D005947	1906	EDN1 ET1 HDLCQ7 PPET1	endothelin 1	Glucose results in increased expression of EDN1 protein	increases expression	protein	16428915
D005947	1906	EDN1 ET1 HDLCQ7 PPET1	endothelin 1	resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	decreases reaction / increases expression	mRNA	20960276
D005947	1950	EGF HOMG4 URG	epidermal growth factor	EGF protein inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA]	decreases expression / decreases reaction	protein	19816600
D005947	1950	EGF HOMG4 URG	epidermal growth factor	EGF protein promotes the reaction [Glucose results in increased expression of TGFA mRNA]	increases expression / increases reaction	protein	8638660
D005947	1950	EGF HOMG4 URG	epidermal growth factor	Glucose promotes the reaction [EGF protein results in increased expression of TGFA mRNA]	increases expression / increases reaction	protein	8638660
D005947	1958	EGR1 AT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225	early growth response 1	Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]	increases expression / increases reaction	mRNA	19225232
D005947	1958	EGR1 AT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225	early growth response 1	Glucose results in increased expression of EGR1 mRNA	increases expression	mRNA	19225232
D005947	1958	EGR1 AT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225	early growth response 1	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]]	decreases reaction / increases expression / increases reaction	mRNA	19225232
D005947	2021	ENDOG	endonuclease G	[Glucose deficiency co-treated with Acetylcysteine] affects the localization of ENDOG protein	affects cotreatment / affects localization	protein	17309078
D005947	2021	ENDOG	endonuclease G	[Glucose deficiency co-treated with CAT] affects the localization of ENDOG protein	affects cotreatment / affects localization	protein	17309078
D005947	2021	ENDOG	endonuclease G	[Glucose deficiency co-treated with Tetradecanoylphorbol Acetate] affects the localization of ENDOG protein	affects cotreatment / affects localization	protein	17309078
D005947	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	Glucose results in decreased expression of ESR1 mRNA	decreases expression	mRNA	16621514
D005947	2099	ESR1 ER ESR ESRA ESTRR Era NR3A1	estrogen receptor 1	Glucose results in increased expression of ESR1 mRNA	increases expression	mRNA	16621514
D005947	2100	ESR2 ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2	estrogen receptor 2 (ER beta)	Glucose results in decreased expression of ESR2 mRNA	decreases expression	mRNA	16621514
D005947	2100	ESR2 ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2	estrogen receptor 2 (ER beta)	Glucose results in increased expression of ESR2 mRNA	increases expression	mRNA	16621514
D005947	355	FAS ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6	Fas cell surface death receptor	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of FAS mRNA]]	decreases reaction / increases expression	mRNA	23319015
D005947	355	FAS ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6	Fas cell surface death receptor	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of FAS protein]]	decreases reaction / increases expression	protein	23319015
D005947	355	FAS ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6	Fas cell surface death receptor	Glucose results in increased expression of FAS mRNA	increases expression	mRNA	23319015
D005947	355	FAS ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6	Fas cell surface death receptor	Glucose results in increased expression of FAS protein	increases expression	protein	23319015
D005947	355	FAS ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6	Fas cell surface death receptor	platycodin D inhibits the reaction [Glucose results in increased expression of FAS mRNA]	decreases reaction / increases expression	mRNA	23319015
D005947	355	FAS ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6	Fas cell surface death receptor	platycodin D inhibits the reaction [Glucose results in increased expression of FAS protein]	decreases reaction / increases expression	protein	23319015
D005947	355	FAS ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6	Fas cell surface death receptor	STO 609 inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of FAS mRNA]]	decreases reaction / increases expression	mRNA	23319015
D005947	2194	FASN FAS OA-519 SDR27X1	fatty acid synthase (EC:2.3.1.85 2.3.1.38 2.3.1.39 2.3.1.41 3.1.2.14 4.2.1.59 1.1.1.100 1.3.1.39)	Glucose results in increased expression of FASN protein	increases expression	protein	18482975
D005947	2194	FASN FAS OA-519 SDR27X1	fatty acid synthase (EC:2.3.1.85 2.3.1.38 2.3.1.39 2.3.1.41 3.1.2.14 4.2.1.59 1.1.1.100 1.3.1.39)	[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides	increases abundance / increases expression	protein	18482975
D005947	2194	FASN FAS OA-519 SDR27X1	fatty acid synthase (EC:2.3.1.85 2.3.1.38 2.3.1.39 2.3.1.41 3.1.2.14 4.2.1.59 1.1.1.100 1.3.1.39)	PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]]	decreases reaction / increases expression / increases reaction	protein	18482975
D005947	2194	FASN FAS OA-519 SDR27X1	fatty acid synthase (EC:2.3.1.85 2.3.1.38 2.3.1.39 2.3.1.41 3.1.2.14 4.2.1.59 1.1.1.100 1.3.1.39)	[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides]	decreases reaction / increases abundance / increases activity / increases expression	protein	18482975
D005947	2194	FASN FAS OA-519 SDR27X1	fatty acid synthase (EC:2.3.1.85 2.3.1.38 2.3.1.39 2.3.1.41 3.1.2.14 4.2.1.59 1.1.1.100 1.3.1.39)	SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]	decreases reaction / increases expression	protein	18482975
D005947	26291	FGF21	fibroblast growth factor 21	FGF21 protein affects the uptake of Glucose	affects uptake	protein	15902306
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Glucose results in increased expression of FN1 mRNA]	decreases reaction / increases expression	mRNA	15086456
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Glucose results in increased secretion of FN1 protein]	decreases reaction / increases secretion	protein	15086456
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	acetovanillone inhibits the reaction [Glucose results in increased secretion of FN1 protein]	decreases reaction / increases secretion	protein	15086456
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	alpha-Tocopherol inhibits the reaction [Glucose results in increased expression of and results in increased secretion of FN1 protein]	decreases reaction / increases expression / increases secretion	protein	9225831
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	bosentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]	decreases reaction / increases expression	mRNA	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	bosentan inhibits the reaction [Glucose results in increased expression of FN1 protein]	decreases reaction / increases expression	protein	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	BQ 788 inhibits the reaction [Glucose results in increased expression of FN1 mRNA]	decreases reaction / increases expression	mRNA	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	calphostin C inhibits the reaction [Glucose results in increased secretion of FN1 protein]	decreases reaction / increases secretion	protein	15086456
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	chelerythrine inhibits the reaction [Glucose results in increased expression of FN1 protein]	decreases reaction / increases expression	protein	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]	decreases reaction / increases expression	mRNA	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein]	decreases reaction / increases expression	protein	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	diphenyleneiodonium inhibits the reaction [Glucose results in increased secretion of FN1 protein]	decreases reaction / increases secretion	protein	15086456
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein]	decreases reaction / increases secretion	protein	21829520
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	[Glucose results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased secretion of FN1 protein	increases abundance / increases expression / increases secretion	protein	15086456
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	Glucose results in increased expression of and results in increased secretion of FN1 protein	increases expression / increases secretion	protein	9225831 15086456
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	Glucose results in increased expression of FN1 mRNA	increases expression	mRNA	12388107 15086456 17199790
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	Glucose results in increased secretion of FN1 protein	increases secretion	protein	16320596 21829520
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	Indomethacin inhibits the reaction [Glucose results in increased secretion of FN1 protein]	decreases reaction / increases secretion	protein	16320596
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	MAPK14 protein promotes the reaction [Glucose results in increased secretion of FN1 protein]	increases reaction / increases secretion	protein	21829520
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased expression of FN1 mRNA]	decreases reaction / increases expression	mRNA	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased expression of FN1 protein]	decreases reaction / increases expression	protein	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	Rotenone inhibits the reaction [Glucose results in increased secretion of FN1 protein]	decreases reaction / increases secretion	protein	15086456
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	sitaxsentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]	decreases reaction / increases expression	mRNA	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	SN50 peptide inhibits the reaction [Glucose results in increased expression of FN1 mRNA]	decreases reaction / increases expression	mRNA	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	SN50 peptide inhibits the reaction [Glucose results in increased expression of FN1 protein]	decreases reaction / increases expression	protein	12388107
D005947	2335	FN1 CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF	fibronectin 1	troglitazone inhibits the reaction [Glucose results in increased expression of FN1 mRNA]	decreases reaction / increases expression	mRNA	17199790
D005947	2348	FOLR1 FBP FOLR	folate receptor 1 (adult)	Glucose results in decreased expression of FOLR1 mRNA	decreases expression	mRNA	19616087
D005947	2353	FOS AP-1 C-FOS p55	FBJ murine osteosarcoma viral oncogene homolog	[Glucose co-treated with Lipopolysaccharides] results in increased expression of FOS protein	affects cotreatment / increases expression	protein	18180316
D005947	8061	FOSL1 FRA FRA1 fra-1	FOS-like antigen 1	Glucose promotes the reaction [AGT protein results in increased expression of FOSL1 mRNA]	increases expression / increases reaction	mRNA	19225232
D005947	8061	FOSL1 FRA FRA1 fra-1	FOS-like antigen 1	Glucose results in increased expression of FOSL1 mRNA	increases expression	mRNA	19225232
D005947	2538	G6PC G6PC1 G6PT GSD1 GSD1a	glucose-6-phosphatase, catalytic subunit (EC:3.1.3.9)	Glucose promotes the reaction [[ARNT protein binds to G6PC promoter] which results in increased expression of G6PC mRNA]	affects binding / increases expression / increases reaction	mRNA / promoter	15767253
D005947	2538	G6PC G6PC1 G6PT GSD1 GSD1a	glucose-6-phosphatase, catalytic subunit (EC:3.1.3.9)	Glucose results in increased stability of and results in increased expression of G6PC mRNA	increases expression / increases stability	mRNA	15767253
D005947	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	Glucose results in increased expression of GAPDH mRNA	increases expression	mRNA	7826318
D005947	2597	GAPDH G3PD GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]	decreases activity / decreases reaction / increases chemical synthesis	protein	11050244
D005947	2641	GCG GLP1 GLP2 GRPP	glucagon	Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GCG protein]	decreases abundance / decreases reaction / increases secretion	protein	838844
D005947	2688	GH1 GH GH-N GHN IGHD1B hGH-N	growth hormone 1	GH1 protein promotes the reaction [Glucose results in increased phosphorylation of TBC1D4 protein]	increases phosphorylation / increases reaction	protein	21559284
D005947	2688	GH1 GH GH-N GHN IGHD1B hGH-N	growth hormone 1	Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein]	decreases abundance / decreases reaction / increases secretion	protein	838844
D005947	2697	GJA1 AVSD3 CMDR CX43 DFNB38 GJAL HLHS1 HSS ODDD	gap junction protein, alpha 1, 43kDa	Glucose results in decreased expression of GJA1 protein	decreases expression	protein	20578705
D005947	2697	GJA1 AVSD3 CMDR CX43 DFNB38 GJAL HLHS1 HSS ODDD	gap junction protein, alpha 1, 43kDa	Glucose results in increased degradation of GJA1 protein	increases degradation	protein	20578705
D005947	2697	GJA1 AVSD3 CMDR CX43 DFNB38 GJAL HLHS1 HSS ODDD	gap junction protein, alpha 1, 43kDa	resveratrol inhibits the reaction [Glucose results in increased degradation of GJA1 protein]	decreases reaction / increases degradation	protein	20578705
D005947	2720	GLB1 EBP ELNR1 MPS4B	galactosidase, beta 1 (EC:3.2.1.23)	Glucose results in increased expression of GLB1 protein	increases expression	protein	17075048
D005947	26585	GREM1 CKTSF1B1 DAND2 DRM GREMLIN IHG-2	gremlin 1, DAN family BMP antagonist	Glucose results in increased expression of GREM1 mRNA	increases expression	mRNA	10026205 10744662
D005947	2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose	affects cotreatment / decreases chemical synthesis / increases expression / increases phosphorylation	protein	22062806
D005947	2936	GSR	glutathione reductase (EC:1.8.1.7)	[Ascorbic Acid co-treated with GSR protein] affects the metabolism of Glucose	affects cotreatment / affects metabolic processing	protein	1901343
D005947	2936	GSR	glutathione reductase (EC:1.8.1.7)	[Doxorubicin co-treated with GSR protein] affects the metabolism of Glucose	affects cotreatment / affects metabolic processing	protein	1901343
D005947	2936	GSR	glutathione reductase (EC:1.8.1.7)	[Nitrofurantoin co-treated with GSR protein] affects the metabolism of Glucose	affects cotreatment / affects metabolic processing	protein	1901343
D005947	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]	decreases expression / decreases reaction	protein	21333731
D005947	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glucose promotes the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]	increases expression / increases reaction	mRNA	19924377
D005947	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glucose promotes the reaction [tin mesoporphyrin results in increased expression of HMOX1 mRNA]	increases expression / increases reaction	mRNA	19924377
D005947	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glucose results in decreased activity of HMOX1 promoter	decreases activity	promoter	14766238
D005947	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glucose results in decreased expression of HMOX1 protein	decreases expression	protein	21333731
D005947	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	Glucose results in increased expression of HMOX1 protein	increases expression	protein	21333731
D005947	3162	HMOX1 HMOX1D HO-1 HSP32 bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	rosiglitazone inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]	decreases expression / decreases reaction	protein	21333731
D005947	6927	HNF1A HNF-1A HNF1 IDDM20 LFB1 MODY3 TCF-1 TCF1	HNF1 homeobox A	HNF1A gene mutant form affects the susceptibility to Glucose	affects response to substance	gene	15787664
D005947	3172	HNF4A HNF4 HNF4a7 HNF4a8 HNF4a9 HNF4alpha MODY MODY1 NR2A1 NR2A21 TCF TCF14	hepatocyte nuclear factor 4, alpha	Cerulenin inhibits the reaction [Glucose results in decreased expression of HNF4A mRNA]	decreases expression / decreases reaction	mRNA	17992261
D005947	3172	HNF4A HNF4 HNF4a7 HNF4a8 HNF4a9 HNF4alpha MODY MODY1 NR2A1 NR2A21 TCF TCF14	hepatocyte nuclear factor 4, alpha	Glucose affects the reaction [HNF4A protein binds to SHBG promoter]	affects binding / affects reaction	protein	17992261
D005947	3172	HNF4A HNF4 HNF4a7 HNF4a8 HNF4a9 HNF4alpha MODY MODY1 NR2A1 NR2A21 TCF TCF14	hepatocyte nuclear factor 4, alpha	Glucose results in decreased expression of HNF4A mRNA	decreases expression	mRNA	17992261
D005947	3309	HSPA5 BIP GRP78 MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Glucose deficiency results in increased expression of HSPA5 mRNA	increases expression	mRNA	12147617
D005947	3309	HSPA5 BIP GRP78 MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Glucose results in increased expression of HSPA5 mRNA	increases expression	mRNA	16380481
D005947	3329	HSPD1 CPN60 GROEL HLD4 HSP-60 HSP60 HSP65 HuCHA60 SPG13	heat shock 60kDa protein 1 (chaperonin)	Glucose deficiency results in decreased expression of HSPD1 protein	decreases expression	protein	17855661
D005947	3329	HSPD1 CPN60 GROEL HLD4 HSP-60 HSP60 HSP65 HuCHA60 SPG13	heat shock 60kDa protein 1 (chaperonin)	Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of HSPD1 protein]	decreases expression / decreases reaction	protein	17855661
D005947	3375	IAPP DAP IAP	islet amyloid polypeptide	IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]	decreases reaction / increases secretion	protein	16204373
D005947	3375	IAPP DAP IAP	islet amyloid polypeptide	rosiglitazone inhibits the reaction [IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]]	decreases reaction / increases secretion	protein	16204373
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Glucose results in increased expression of ICAM1]	decreases reaction / increases expression		22074828
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	Glucose results in increased expression of ICAM1	increases expression		22074828
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	Glucose results in increased expression of ICAM1 mRNA	increases expression	mRNA	21682256
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	Glucose results in increased expression of ICAM1 protein	increases expression	protein	21367880 21373835
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]	decreases reaction / increases expression		22074828
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	HTS 466284 inhibits the reaction [Glucose results in increased expression of ICAM1 protein]	decreases reaction / increases expression	protein	21367880
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	isoangustone A inhibits the reaction [Glucose results in increased expression of ICAM1 protein]	decreases reaction / increases expression	protein	21367880
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	naringin inhibits the reaction [Glucose results in increased expression of ICAM1]	decreases reaction / increases expression		22074828
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	Polyphenols inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]	decreases reaction / increases expression	mRNA	21682256
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	resveratrol inhibits the reaction [Glucose results in increased expression of ICAM1]	decreases reaction / increases expression		22074828
D005947	3383	ICAM1 BB2 CD54 P3.58	intercellular adhesion molecule 1	rimonabant inhibits the reaction [Glucose results in increased expression of ICAM1 protein]	decreases reaction / increases expression	protein	21373835
D005947	3480	IGF1R CD221 IGFIR IGFR JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	Glucose results in increased expression of IGF1R mRNA	increases expression	mRNA	7826318
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Catechin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Catechin inhibits the reaction [Glucose results in increased expression of IL1B protein]	decreases reaction / increases expression	protein	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of IL1B protein]	decreases reaction / increases expression	protein	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	[Glucose co-treated with Lipopolysaccharides] results in decreased expression of IL1B protein	affects cotreatment / decreases expression	protein	20200188
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	[Glucose co-treated with Pam(3)CSK(4) peptide] results in decreased expression of IL1B protein	affects cotreatment / decreases expression	protein	20200188
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Glucose results in increased expression of IL1B mRNA	increases expression	mRNA	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Glucose results in increased expression of IL1B protein	increases expression	protein	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Luteolin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Luteolin inhibits the reaction [Glucose results in increased expression of IL1B protein]	decreases reaction / increases expression	protein	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Quercetin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Quercetin inhibits the reaction [Glucose results in increased expression of IL1B protein]	decreases reaction / increases expression	protein	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Rutin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	3553	IL1B IL-1 IL1-BETA IL1F2	interleukin 1, beta	Rutin inhibits the reaction [Glucose results in increased expression of IL1B protein]	decreases reaction / increases expression	protein	19557821
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	chromic chloride inhibits the reaction [Glucose results in increased secretion of IL6 protein]	decreases reaction / increases secretion	protein	17665966
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	chromic chloride promotes the reaction [Estradiol inhibits the reaction [Glucose results in increased secretion of IL6 protein]]	decreases reaction / increases reaction / increases secretion	protein	15528032
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	chromium nicotinic acid complex inhibits the reaction [Glucose results in increased secretion of IL6 protein]	decreases reaction / increases secretion	protein	17665966
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Estradiol inhibits the reaction [Glucose results in increased secretion of IL6 protein]	decreases reaction / increases secretion	protein	15528032
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Glucose results in increased expression of IL6 mRNA	increases expression	mRNA	21682256
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Glucose results in increased expression of IL6 protein	increases expression	protein	20578705
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Glucose results in increased secretion of and results in increased expression of IL6 protein	increases expression / increases secretion	protein	21682256
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Glucose results in increased secretion of IL6 protein	increases secretion	protein	15528032 17665966
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	picolinic acid inhibits the reaction [Glucose results in increased secretion of IL6 protein]	decreases reaction / increases secretion	protein	17665966
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Polyphenols inhibits the reaction [Glucose results in increased expression of IL6 mRNA]	decreases reaction / increases expression	mRNA	21682256
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Polyphenols inhibits the reaction [Glucose results in increased expression of IL6 protein]	decreases reaction / increases expression	protein	21682256
D005947	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	resveratrol inhibits the reaction [Glucose results in increased expression of IL6 protein]	decreases reaction / increases expression	protein	20578705
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	chromic chloride inhibits the reaction [Glucose results in increased secretion of IL8 protein]	decreases reaction / increases secretion	protein	17665966
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	chromium nicotinic acid complex inhibits the reaction [Glucose results in increased secretion of IL8 protein]	decreases reaction / increases secretion	protein	17665966
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glucose results in increased expression of IL8 mRNA	increases expression	mRNA	21682256
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glucose results in increased expression of IL8 protein	increases expression	protein	20578705
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glucose results in increased secretion of and results in increased expression of IL8 protein	increases expression / increases secretion	protein	21682256
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glucose results in increased secretion of IL8 protein	increases secretion	protein	17665966
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	picolinic acid inhibits the reaction [Glucose results in increased secretion of IL8 protein]	decreases reaction / increases secretion	protein	17665966
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Polyphenols inhibits the reaction [Glucose results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	21682256
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Polyphenols inhibits the reaction [Glucose results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	21682256
D005947	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	resveratrol inhibits the reaction [Glucose results in increased expression of IL8 protein]	decreases reaction / increases expression	protein	20578705
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]	decreases reaction / increases secretion	protein	14625208
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]	affects binding / decreases reaction	promoter	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in increased expression of INS mRNA]	decreases reaction / increases expression	mRNA	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in increased expression of INS protein]	decreases reaction / increases expression	protein	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	3-aminobenzamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]	affects binding / decreases reaction	promoter	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	3-aminobenzamide inhibits the reaction [Glucose results in increased expression of INS mRNA]	decreases reaction / increases expression	mRNA	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	3-aminobenzamide inhibits the reaction [Glucose results in increased expression of INS protein]	decreases reaction / increases expression	protein	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]	decreases reaction / increases reaction / increases secretion	protein	21163946
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Acetylcysteine inhibits the reaction [Glucose results in increased expression of INS protein]	decreases reaction / increases expression	protein	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	17192482
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Arachidonic Acid promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	17192482
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	arachidonyltrifluoromethane inhibits the reaction [Glucose results in increased secretion of INS protein]	decreases reaction / increases secretion	protein	17192482
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	baicalein promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	17192482
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]	decreases reaction / decreases secretion	protein	15642492
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	[chromic chloride results in increased activity of INS protein modified form] which results in increased import of Glucose	increases activity / increases import	protein	17965850
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Dexamethasone inhibits the reaction [INS protein results in increased uptake of Glucose]	decreases reaction / increases uptake	protein	18328801
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein]	decreases reaction / decreases secretion	protein	16452552
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]	decreases reaction / increases secretion	protein	14625208
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	[Glucose co-treated with INS protein] affects the localization of PDX1 protein	affects cotreatment / affects localization	protein	11574405
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	[Glucose co-treated with sodium arsenite] results in increased secretion of INS protein	affects cotreatment / increases secretion	protein	20100676
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Glucose inhibits the reaction [INS protein results in increased chemical synthesis of Glycogen]	decreases reaction / increases chemical synthesis	protein	15864539
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]	decreases reaction / increases secretion	protein	20960276
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Glucose results in decreased chemical synthesis of INS protein	decreases chemical synthesis	protein	20520763
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Glucose results in decreased secretion of INS protein	decreases secretion	protein	15642492 16452552
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Glucose results in increased activity of INS promoter	increases activity	promoter	16489446
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Glucose results in increased secretion of INS protein	increases secretion	protein	838844 9032110 10430617 15153144 15531508 16204373 17192482 18167556 18347054 19188863 20100676 21163946 22242153
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	[Glyburide co-treated with Glucose] results in increased expression of INS protein	affects cotreatment / increases expression	protein	11305519
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein]	decreases reaction / decreases secretion	protein	15642492
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	GW8510 promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	22242153
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]	decreases reaction / increases secretion	protein	16204373
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	INS protein inhibits the reaction [Glucose results in decreased expression of ATP1A1 protein]	decreases expression / decreases reaction	protein	22162761
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	INS protein mutant form results in decreased uptake of and results in decreased oxidation of Glucose	decreases oxidation / decreases uptake	protein	3511099
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	INS protein results in increased secretion of Glucose	increases secretion	protein	14625208
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	INS protein results in increased uptake of Glucose	increases uptake	protein	15277403 18328801 19531641
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein]	decreases reaction / increases secretion	protein	10430617
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Metformin promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	15531508
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	MIR133A affects the reaction [Glucose results in decreased chemical synthesis of INS protein]	affects reaction / decreases chemical synthesis	protein	20520763
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	17192482
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Niacinamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]	affects binding / decreases reaction	promoter	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Niacinamide inhibits the reaction [Glucose results in increased expression of INS mRNA]	decreases reaction / increases expression	mRNA	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Niacinamide inhibits the reaction [Glucose results in increased expression of INS protein]	decreases reaction / increases expression	protein	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	NKX6-1 protein promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	18347054
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	palmitoyl trifluoromethyl ketone inhibits the reaction [Glucose results in increased secretion of INS protein]	decreases reaction / increases secretion	protein	17192482
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Quercetin inhibits the reaction [Glucose results in increased expression of INS protein]	decreases reaction / increases expression	protein	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]	decreases reaction / increases secretion	protein	20960276
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	21163946
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	rosiglitazone inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]	decreases reaction / increases secretion	protein	14625208
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	rosiglitazone inhibits the reaction [IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]]	decreases reaction / increases secretion	protein	16204373
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	rosiglitazone promotes the reaction [INS protein results in increased uptake of Glucose]	increases reaction / increases uptake	protein	15277403
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Saquinavir inhibits the reaction [INS protein results in increased import of Glucose]	decreases reaction / increases import	protein	11786383
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	[SB 203580 co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects cotreatment / affects localization / decreases reaction	protein	11574405
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]	affects reaction / decreases reaction / increases secretion	protein	20960276
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]	decreases reaction / increases reaction / increases secretion	protein	21163946
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	SLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	16984975
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	sodium arsenite inhibits the reaction [Glucose results in increased secretion of INS protein]	decreases reaction / increases secretion	protein	20100676
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein]	decreases reaction / increases expression	protein	16505238
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]	decreases reaction / increases uptake	protein	7956951
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]]	decreases reaction / increases uptake	protein	7956951
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	UCP3 protein promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	18167556
D005947	3630	INS IDDM2 ILPR IRDN MODY10	insulin	[wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects cotreatment / affects localization / decreases reaction	protein	11574405
D005947	3643	INSR CD220 HHF5	insulin receptor (EC:2.7.10.1)	Glucose results in decreased degradation of INSR mRNA	decreases degradation	mRNA	7826318
D005947	3643	INSR CD220 HHF5	insulin receptor (EC:2.7.10.1)	Glucose results in increased expression of INSR mRNA	increases expression	mRNA	7826318
D005947	3643	INSR CD220 HHF5	insulin receptor (EC:2.7.10.1)	Glucose results in increased phosphorylation of INSR protein	increases phosphorylation	protein	7826318
D005947	3667	IRS1 HIRS-1	insulin receptor substrate 1	Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein]	affects binding / increases reaction	protein	10430617
D005947	3667	IRS1 HIRS-1	insulin receptor substrate 1	Glucose results in increased phosphorylation of IRS1 protein	increases phosphorylation	protein	10430617
D005947	3667	IRS1 HIRS-1	insulin receptor substrate 1	IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein]	decreases reaction / increases secretion	protein	10430617
D005947	8660	IRS2 IRS-2	insulin receptor substrate 2	Glucose results in increased phosphorylation of IRS2 protein	increases phosphorylation	protein	10430617
D005947	3674	ITGA2B BDPLT16 BDPLT2 CD41 CD41B GP2B GPIIb GT GTA HPA3	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]]	decreases reaction / increases expression	protein	18413191
D005947	3690	ITGB3 BDPLT16 BDPLT2 CD61 GP3A GPIIIa GT	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]	decreases reaction / increases expression	protein	18413191
D005947	3717	JAK2 JTK10 THCYT3	Janus kinase 2 (EC:2.7.10.2)	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	3717	JAK2 JTK10 THCYT3	Janus kinase 2 (EC:2.7.10.2)	(3,4-dihydroxyphenylamino)-2-imidazoline inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	3717	JAK2 JTK10 THCYT3	Janus kinase 2 (EC:2.7.10.2)	acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	3717	JAK2 JTK10 THCYT3	Janus kinase 2 (EC:2.7.10.2)	Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]	increases phosphorylation / increases reaction	protein	15677497
D005947	3717	JAK2 JTK10 THCYT3	Janus kinase 2 (EC:2.7.10.2)	Rotenone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	3717	JAK2 JTK10 THCYT3	Janus kinase 2 (EC:2.7.10.2)	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]	decreases reaction / increases phosphorylation / increases reaction	protein	15677497
D005947	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of JUN protein]	decreases reaction / increases phosphorylation	protein	19132243
D005947	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	Aspirin inhibits the reaction [Glucose results in increased expression of JUN protein]	decreases reaction / increases expression	protein	16600694
D005947	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	Clofibrate inhibits the reaction [Glucose results in increased expression of JUN protein]	decreases reaction / increases expression	protein	16600694
D005947	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	Fenofibrate inhibits the reaction [Glucose results in increased expression of JUN protein]	decreases reaction / increases expression	protein	16600694
D005947	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	[Glucose co-treated with Lipopolysaccharides] results in increased expression of JUN protein	affects cotreatment / increases expression	protein	18180316
D005947	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	Glucose results in increased expression of JUN protein	increases expression	protein	16600694
D005947	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	Glucose results in increased phosphorylation of JUN protein	increases phosphorylation	protein	19132243
D005947	3725	JUN AP-1 AP1 c-Jun	jun proto-oncogene	SB 203580 inhibits the reaction [Glucose results in increased phosphorylation of JUN protein]	decreases reaction / increases phosphorylation	protein	19132243
D005947	3778	KCNMA1 BKTM KCa1.1 MaxiK SAKCA SLO SLO-ALPHA SLO1 bA205K10.1 mSLO1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]	affects binding / decreases activity	protein	21413024
D005947	3778	KCNMA1 BKTM KCa1.1 MaxiK SAKCA SLO SLO-ALPHA SLO1 bA205K10.1 mSLO1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	[NS 1619 co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]	affects binding / affects cotreatment / increases activity	protein	21413024
D005947	3778	KCNMA1 BKTM KCa1.1 MaxiK SAKCA SLO SLO-ALPHA SLO1 bA205K10.1 mSLO1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	[[NS 1619 co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]] which results in decreased expression of BCL2 protein	affects binding / affects cotreatment / decreases expression / increases activity	protein	21413024
D005947	3778	KCNMA1 BKTM KCa1.1 MaxiK SAKCA SLO SLO-ALPHA SLO1 bA205K10.1 mSLO1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	[Tamoxifen co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]	affects binding / affects cotreatment / increases activity	protein	21413024
D005947	3778	KCNMA1 BKTM KCa1.1 MaxiK SAKCA SLO SLO-ALPHA SLO1 bA205K10.1 mSLO1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	[[Tamoxifen co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]] which results in decreased expression of BCL2 protein	affects binding / affects cotreatment / decreases expression / increases activity	protein	21413024
D005947	3778	KCNMA1 BKTM KCa1.1 MaxiK SAKCA SLO SLO-ALPHA SLO1 bA205K10.1 mSLO1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	[Tetraethylammonium co-treated with Glucose] results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]	affects binding / affects cotreatment / decreases activity	protein	21413024
D005947	3779	KCNMB1 BKbeta1 K(VCA)beta SLO-BETA hbeta1 hslo-beta k(VCA)beta-1 slo-beta-1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]	affects binding / decreases activity	protein	21413024
D005947	3779	KCNMB1 BKbeta1 K(VCA)beta SLO-BETA hbeta1 hslo-beta k(VCA)beta-1 slo-beta-1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	[NS 1619 co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]	affects binding / affects cotreatment / increases activity	protein	21413024
D005947	3779	KCNMB1 BKbeta1 K(VCA)beta SLO-BETA hbeta1 hslo-beta k(VCA)beta-1 slo-beta-1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	[[NS 1619 co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]] which results in decreased expression of BCL2 protein	affects binding / affects cotreatment / decreases expression / increases activity	protein	21413024
D005947	3779	KCNMB1 BKbeta1 K(VCA)beta SLO-BETA hbeta1 hslo-beta k(VCA)beta-1 slo-beta-1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	[Tamoxifen co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]	affects binding / affects cotreatment / increases activity	protein	21413024
D005947	3779	KCNMB1 BKbeta1 K(VCA)beta SLO-BETA hbeta1 hslo-beta k(VCA)beta-1 slo-beta-1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	[[Tamoxifen co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]] which results in decreased expression of BCL2 protein	affects binding / affects cotreatment / decreases expression / increases activity	protein	21413024
D005947	3779	KCNMB1 BKbeta1 K(VCA)beta SLO-BETA hbeta1 hslo-beta k(VCA)beta-1 slo-beta-1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	[Tetraethylammonium co-treated with Glucose] results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]	affects binding / affects cotreatment / decreases activity	protein	21413024
D005947	7071	KLF10 EGR-alpha EGRA TIEG TIEG1	Kruppel-like factor 10	Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]	increases expression / increases reaction	mRNA	19225232
D005947	7071	KLF10 EGR-alpha EGRA TIEG TIEG1	Kruppel-like factor 10	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]	decreases reaction / increases expression / increases reaction	mRNA	19225232
D005947	54474	KRT20 CD20 CK-20 CK20 K20 KRT21	keratin 20	[Glucose co-treated with TGFB1 protein] results in decreased expression of KRT20 protein	affects cotreatment / decreases expression	protein	21829520
D005947	54474	KRT20 CD20 CK-20 CK20 K20 KRT21	keratin 20	Glucose results in decreased expression of KRT20 mRNA	decreases expression	mRNA	21829520
D005947	54474	KRT20 CD20 CK-20 CK20 K20 KRT21	keratin 20	Glucose results in decreased expression of KRT20 protein	decreases expression	protein	21829520
D005947	54474	KRT20 CD20 CK-20 CK20 K20 KRT21	keratin 20	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in decreased expression of KRT20 protein]	affects cotreatment / decreases expression / increases reaction	protein	21829520
D005947	54474	KRT20 CD20 CK-20 CK20 K20 KRT21	keratin 20	MAPK14 protein promotes the reaction [Glucose results in decreased expression of KRT20 mRNA]	decreases expression / increases reaction	mRNA	21829520
D005947	54474	KRT20 CD20 CK-20 CK20 K20 KRT21	keratin 20	MAPK14 protein promotes the reaction [Glucose results in decreased expression of KRT20 protein]	decreases expression / increases reaction	protein	21829520
D005947	3920	LAMP2 CD107b LAMP-2 LAMPB LGP110	lysosomal-associated membrane protein 2	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of LAMP2 protein	affects cotreatment / increases expression	protein	21392095
D005947	3945	LDHB LDH-B LDH-H LDHBD TRG-5	lactate dehydrogenase B (EC:1.1.1.27)	LDHB protein affects the metabolism of Glucose	affects metabolic processing	protein	23437403
D005947	3952	LEP LEPD OB OBS	leptin	Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]	increases chemical synthesis / increases reaction	protein	11342529
D005947	3952	LEP LEPD OB OBS	leptin	Glucose results in increased susceptibility to LEP protein	increases response to substance	protein	11342529
D005947	3952	LEP LEPD OB OBS	leptin	LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]	increases chemical synthesis / increases reaction	protein	11342529
D005947	3976	LIF CDF DIA HILDA MLPLI	leukemia inhibitory factor	Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]	increases expression / increases reaction	mRNA	19225232
D005947	3976	LIF CDF DIA HILDA MLPLI	leukemia inhibitory factor	Glucose results in increased expression of LIF mRNA	increases expression	mRNA	19225232
D005947	3976	LIF CDF DIA HILDA MLPLI	leukemia inhibitory factor	[valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]	affects cotreatment / decreases reaction / increases expression / increases reaction	mRNA	19225232
D005947	3976	LIF CDF DIA HILDA MLPLI	leukemia inhibitory factor	valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]	decreases reaction / increases expression / increases reaction	mRNA	19225232
D005947	4023	LPL HDLCQ11 LIPD	lipoprotein lipase (EC:3.1.1.34)	LPL protein promotes the reaction [Fatty Acids results in increased uptake of Glucose]	increases reaction / increases uptake	protein	20628023
D005947	389692	MAFA RIPE3b1 hMafA	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]	affects binding / decreases reaction	protein	16505238
D005947	389692	MAFA RIPE3b1 hMafA	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	3-aminobenzamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]	affects binding / decreases reaction	protein	16505238
D005947	389692	MAFA RIPE3b1 hMafA	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	Niacinamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]	affects binding / decreases reaction	protein	16505238
D005947	4217	MAP3K5 ASK1 MAPKKK5 MEKK5	mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)	Glucose deficiency promotes the reaction [DAXX protein binds to MAP3K5 protein]	affects binding / increases reaction	protein	14505347
D005947	4217	MAP3K5 ASK1 MAPKKK5 MEKK5	mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)	Glucose results in increased expression of MAP3K5 protein	increases expression	protein	16731828
D005947	4217	MAP3K5 ASK1 MAPKKK5 MEKK5	mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25)	Glucose results in increased phosphorylation of and results in increased activity of MAP3K5 protein	increases activity / increases phosphorylation	protein	16731828
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Catechin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	CAT inhibits the reaction [Glucose deficiency results in increased activity of MAPK1 protein]	decreases reaction / increases activity	protein	17309078
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	epigallocatechin gallate inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Glucose deficiency results in increased activity of MAPK1 protein	increases activity	protein	17309078
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Glucose results in decreased phosphorylation of MAPK1 protein	decreases phosphorylation	protein	20200188
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Glucose results in increased phosphorylation of and results in increased activity of MAPK1 protein	increases activity / increases phosphorylation	protein	22162761
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Glucose results in increased phosphorylation of MAPK1 protein	increases phosphorylation	protein	18057711 19557821
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Heparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]	decreases reaction / increases phosphorylation	protein	18057711
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Quercetin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5594	MAPK1 ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	Tetradecanoylphorbol Acetate inhibits the reaction [Glucose deficiency results in increased activity of MAPK1 protein]	decreases reaction / increases activity	protein	17309078
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	CAT inhibits the reaction [Glucose deficiency results in increased activity of MAPK14 protein]	decreases reaction / increases activity	protein	17309078
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	Glucose deficiency results in increased activity of MAPK14 protein	increases activity	protein	17309078
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	Glucose results in decreased phosphorylation of MAPK14 protein	decreases phosphorylation	protein	20200188
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in decreased expression of CDH1 protein]	affects cotreatment / decreases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in decreased expression of KRT20 protein]	affects cotreatment / decreases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of ACTA2 protein]	affects cotreatment / increases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of VIM protein]	affects cotreatment / increases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [Glucose results in decreased expression of CDH1 protein]	decreases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [Glucose results in decreased expression of KRT20 mRNA]	decreases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [Glucose results in decreased expression of KRT20 protein]	decreases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [Glucose results in increased expression of ACTA2 protein]	increases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [Glucose results in increased expression of SNAI1 mRNA]	increases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [Glucose results in increased expression of VIM mRNA]	increases expression / increases reaction	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	MAPK14 protein promotes the reaction [Glucose results in increased secretion of FN1 protein]	increases reaction / increases secretion	protein	21829520
D005947	1432	MAPK14 CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	Tetradecanoylphorbol Acetate inhibits the reaction [Glucose deficiency results in increased activity of MAPK14 protein]	decreases reaction / increases activity	protein	17309078
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Catechin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	CAT inhibits the reaction [Glucose deficiency results in increased activity of MAPK3 protein]	decreases reaction / increases activity	protein	17309078
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	epigallocatechin gallate inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Glucose deficiency results in increased activity of MAPK3 protein	increases activity	protein	17309078
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Glucose results in decreased phosphorylation of MAPK3 protein	decreases phosphorylation	protein	20200188
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Glucose results in increased phosphorylation of and results in increased activity of MAPK3 protein	increases activity / increases phosphorylation	protein	22162761
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Glucose results in increased phosphorylation of MAPK3 protein	increases phosphorylation	protein	18057711 19557821
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Heparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]	decreases reaction / increases phosphorylation	protein	18057711
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Quercetin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]	decreases reaction / increases phosphorylation	protein	19557821
D005947	5595	MAPK3 ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	Tetradecanoylphorbol Acetate inhibits the reaction [Glucose deficiency results in increased activity of MAPK3 protein]	decreases reaction / increases activity	protein	17309078
D005947	5599	MAPK8 JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	Glucose deficiency results in increased activity of and results in increased phosphorylation of MAPK8 protein	increases activity / increases phosphorylation	protein	14505347
D005947	100314030			Glucose results in increased expression of MIR133A mRNA	increases expression	mRNA	20520763
D005947	100314030			MIR133A affects the reaction [Glucose results in decreased chemical synthesis of INS protein]	affects reaction / decreases chemical synthesis		20520763
D005947	387164			Glucose results in decreased expression of MIR146 mRNA	decreases expression	mRNA	20520763
D005947	406938	MIR146A MIRN146 MIRN146A miR-146a miRNA146A	microRNA 146a	Glucose results in increased expression of MIR146A mRNA	increases expression	mRNA	21682256
D005947	406938	MIR146A MIRN146 MIRN146A miR-146a miRNA146A	microRNA 146a	Polyphenols inhibits the reaction [Glucose results in increased expression of MIR146A mRNA]	decreases reaction / increases expression	mRNA	21682256
D005947	406940	MIR148A MIRN148 MIRN148A hsa-mir-148	microRNA 148a	Glucose results in decreased expression of MIR148A mRNA	decreases expression	mRNA	21682256
D005947	4312	MMP1 CLG CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	CD14 protein affects the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]	affects reaction / increases reaction / increases secretion	protein	18180316
D005947	4323	MMP14 MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS	matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80)	Glucose results in decreased expression of MMP14 protein	decreases expression	protein	21367880
D005947	4323	MMP14 MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS	matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80)	isoangustone A inhibits the reaction [Glucose results in decreased expression of MMP14 protein]	decreases expression / decreases reaction	protein	21367880
D005947	4609	MYC MRTL MYCC bHLHe39 c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	Glucose affects the reaction [Dexamethasone results in increased expression of MYC mRNA]	affects reaction / increases expression	mRNA	2558650
D005947	4609	MYC MRTL MYCC bHLHe39 c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	Glucose affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of MYC mRNA]	affects reaction / increases expression	mRNA	2558650
D005947	10135	NAMPT 1110035O14Rik PBEF PBEF1 VF VISFATIN	nicotinamide phosphoribosyltransferase (EC:2.4.2.12)	Glucose results in decreased expression of NAMPT mRNA	decreases expression	mRNA	20068143
D005947	8775	NAPA SNAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	Glucose deficiency results in decreased expression of NAPA protein	decreases expression	protein	22314686
D005947	653361	NCF1 NCF1A NOXO2 SH3PXD1A p47phox	neutrophil cytosolic factor 1	acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of NCF1 protein]	decreases reaction / increases activity / increases expression	protein	19878672
D005947	653361	NCF1 NCF1A NOXO2 SH3PXD1A p47phox	neutrophil cytosolic factor 1	bisindolylmaleimide I inhibits the reaction [Glucose affects the localization of NCF1 protein]	affects localization / decreases reaction	protein	17916771
D005947	653361	NCF1 NCF1A NOXO2 SH3PXD1A p47phox	neutrophil cytosolic factor 1	Glucose affects the localization of NCF1 protein	affects localization	protein	17916771
D005947	653361	NCF1 NCF1A NOXO2 SH3PXD1A p47phox	neutrophil cytosolic factor 1	Glucose results in increased expression of and results in increased activity of NCF1 protein	increases activity / increases expression	protein	19878672
D005947	653361	NCF1 NCF1A NOXO2 SH3PXD1A p47phox	neutrophil cytosolic factor 1	Glucose results in increased expression of NCF1 protein	increases expression	protein	18088078
D005947	653361	NCF1 NCF1A NOXO2 SH3PXD1A p47phox	neutrophil cytosolic factor 1	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of NCF1 protein]	decreases reaction / increases expression	protein	18088078
D005947	653361	NCF1 NCF1A NOXO2 SH3PXD1A p47phox	neutrophil cytosolic factor 1	PRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose affects the localization of NCF1 protein]]	affects localization / affects reaction / decreases reaction	protein	17916771
D005947	653361	NCF1 NCF1A NOXO2 SH3PXD1A p47phox	neutrophil cytosolic factor 1	rosiglitazone inhibits the reaction [Glucose affects the localization of NCF1 protein]	affects localization / decreases reaction	protein	17916771
D005947	57447	NDRG2 SYLD	NDRG family member 2	NDRG2 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]	affects cotreatment / increases expression / increases reaction	protein	23451161
D005947	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]]	decreases expression / decreases reaction	protein	21333731
D005947	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	Glucose results in decreased expression of NFE2L2 protein	decreases expression	protein	21333731
D005947	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	Glucose results in increased expression of NFE2L2	increases expression		20103708
D005947	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	Glucose results in increased expression of NFE2L2 protein	increases expression	protein	21333731
D005947	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	rosiglitazone inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]	decreases expression / decreases reaction	protein	21333731
D005947	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Glucose results in increased expression of NFKB1 mRNA	increases expression	mRNA	21682256
D005947	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Glucose results in increased expression of NFKB1 protein	increases expression	protein	18180316
D005947	4790	NFKB1 EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Polyphenols inhibits the reaction [Glucose results in increased expression of NFKB1 mRNA]	decreases reaction / increases expression	mRNA	21682256
D005947	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of NFKBIA protein]	decreases reaction / increases phosphorylation	protein	19132243
D005947	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	Catechin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	epigallocatechin gallate inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	Glucose results in increased degradation of and results in decreased expression of NFKBIA protein	decreases expression / increases degradation	protein	19557821
D005947	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	Glucose results in increased phosphorylation of NFKBIA protein	increases phosphorylation	protein	19132243
D005947	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	Quercetin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein]	decreases expression / decreases reaction / increases degradation	protein	19557821
D005947	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	SB 203580 inhibits the reaction [Glucose results in increased phosphorylation of NFKBIA protein]	decreases reaction / increases phosphorylation	protein	19132243
D005947	4825	NKX6-1 NKX6.1 NKX6A	NK6 homeobox 1	NKX6-1 protein promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	18347054
D005947	4842	NOS1 IHPS1 N-NOS NC-NOS NOS bNOS nNOS	nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)	Glucose deficiency results in decreased expression of NOS1 protein	decreases expression	protein	17855661
D005947	4842	NOS1 IHPS1 N-NOS NC-NOS NOS bNOS nNOS	nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)	Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of NOS1 protein]	decreases expression / decreases reaction	protein	17855661
D005947	4843	NOS2 HEP-NOS INOS NOS NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	Glucose results in increased expression of NOS2 mRNA	increases expression	mRNA	22363694
D005947	4843	NOS2 HEP-NOS INOS NOS NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	Glucose results in increased expression of NOS2 protein	increases expression	protein	22363694
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]]	decreases phosphorylation / decreases reaction	protein	19767878
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]	decreases phosphorylation / decreases reaction / increases abundance	protein	19767878
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	acetovanillone inhibits the reaction [Glucose results in decreased expression of NOS3 protein]	decreases expression / decreases reaction	protein	19878672
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of NOS3 protein]	decreases expression / decreases reaction	protein	19924377
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	Glucose deficiency results in decreased expression of NOS3 protein	decreases expression	protein	17855661
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	Glucose results in decreased expression of NOS3 mRNA	decreases expression	mRNA	15490108 20960276
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	Glucose results in decreased expression of NOS3 protein	decreases expression	protein	15490108 17075048 19878672 19924377
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	Glucose results in decreased phosphorylation of NOS3 protein	decreases phosphorylation	protein	11696579 19767878
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide	decreases phosphorylation / increases abundance	protein	19767878
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	Glucose results in increased expression of and results in increased activity of NOS3 protein	increases activity / increases expression	protein	15490108
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	Glucose results in increased expression of NOS3 mRNA	increases expression	mRNA	15490108
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	Glucose results in increased expression of NOS3 protein	increases expression	protein	10502298
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	Glucose results in increased O-linked glycosylation of NOS3 protein	increases O-linked glycosylation	protein	11696579
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of NOS3 protein]	decreases expression / decreases reaction	protein	17855661
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	resveratrol inhibits the reaction [Glucose results in decreased expression of NOS3 mRNA]	decreases expression / decreases reaction	mRNA	20960276
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]	decreases phosphorylation / decreases reaction	protein	19767878
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]	decreases phosphorylation / decreases reaction / increases abundance	protein	19767878
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of NOS3 mRNA]]	affects reaction / decreases expression / decreases reaction	mRNA	20960276
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]]	decreases phosphorylation / decreases reaction	protein	19767878
D005947	4846	NOS3 ECNOS eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]	decreases phosphorylation / decreases reaction / increases abundance	protein	19767878
D005947	8431	NR0B2 SHP SHP1	nuclear receptor subfamily 0, group B, member 2	[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose	affects cotreatment / decreases chemical synthesis / increases expression / increases phosphorylation	mRNA	22062806
D005947	8856	NR1I2 BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR	nuclear receptor subfamily 1, group I, member 2	Glucose results in decreased activity of NR1I2 protein	decreases activity	protein	21682256
D005947	8856	NR1I2 BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR	nuclear receptor subfamily 1, group I, member 2	Glucose results in decreased expression of NR1I2 mRNA	decreases expression	mRNA	22363694
D005947	8856	NR1I2 BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR	nuclear receptor subfamily 1, group I, member 2	Polyphenols inhibits the reaction [Glucose results in decreased activity of NR1I2 protein]	decreases activity / decreases reaction	protein	21682256
D005947	7025	NR2F1 COUP-TFI EAR-3 EAR3 ERBAL3 NR2F2 SVP44 TCFCOUP1 TFCOUP1	nuclear receptor subfamily 2, group F, member 1	Glucose affects the reaction [NR2F1 protein binds to SHBG promoter]	affects binding / affects reaction	protein	17992261
D005947	26471	NUPR1 COM1 P8	nuclear protein, transcriptional regulator, 1	NUPR1 results in decreased abundance of Glucose	decreases abundance		16822955
D005947	4973	OLR1 CLEC8A LOX1 LOXIN SCARE1 SLOX1	oxidized low density lipoprotein (lectin-like) receptor 1	acetovanillone inhibits the reaction [Glucose results in increased expression of OLR1 mRNA]	decreases reaction / increases expression	mRNA	19878672
D005947	4973	OLR1 CLEC8A LOX1 LOXIN SCARE1 SLOX1	oxidized low density lipoprotein (lectin-like) receptor 1	Glucose results in increased expression of OLR1 mRNA	increases expression	mRNA	19878672
D005947	5033	P4HA1 P4HA	prolyl 4-hydroxylase, alpha polypeptide I (EC:1.14.11.2)	Glucose deficiency results in increased expression of P4HA1 protein	increases expression	protein	22314686
D005947	51247	PAIP2 PAIP2A	poly(A) binding protein interacting protein 2	Glucose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR]	affects binding / increases reaction	protein	12820898
D005947	142	PARP1 ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	[Glucose deficiency co-treated with Acetylcysteine] results in increased cleavage of PARP1 protein	affects cotreatment / increases cleavage	protein	17309078
D005947	142	PARP1 ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	[Glucose deficiency co-treated with CAT] results in increased cleavage of PARP1 protein	affects cotreatment / increases cleavage	protein	17309078
D005947	142	PARP1 ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	[Glucose deficiency co-treated with Tetradecanoylphorbol Acetate] results in increased cleavage of PARP1 protein	affects cotreatment / increases cleavage	protein	17309078
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	calyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects localization / decreases reaction	protein	11574405
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	Glucose affects the localization of PDX1 protein	affects localization	protein	11574405 22558381
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	[Glucose co-treated with INS protein] affects the localization of PDX1 protein	affects cotreatment / affects localization	protein	11574405
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein	affects cotreatment / affects localization	protein	11574405
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	Okadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects localization / decreases reaction	protein	11574405
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	Palmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects localization / decreases reaction	protein	22558381
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	[SB 203580 co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects cotreatment / affects localization / decreases reaction	protein	11574405
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	SB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects localization / decreases reaction	protein	11574405
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]	affects cotreatment / affects localization / decreases reaction	protein	11574405
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	[wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects cotreatment / affects localization / decreases reaction	protein	11574405
D005947	3651	PDX1 GSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1	pancreatic and duodenal homeobox 1	wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]	affects localization / decreases reaction	protein	11574405
D005947	5037	PEBP1 HCNP HCNPpp PBP PEBP PEBP-1 RKIP	phosphatidylethanolamine binding protein 1	Glucose deficiency results in increased expression of PEBP1 protein	increases expression	protein	22314686
D005947	5295	PIK3R1 AGM7 GRB1 p85 p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Glucose promotes the reaction [PIK3R1 protein binds to IRS1 protein]	affects binding / increases reaction	protein	10430617
D005947	5315	PKM CTHBP OIP3 PK3 PKM2 TCB THBP1	pyruvate kinase, muscle (EC:2.7.1.40)	Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein]	affects binding / increases activity / increases reaction	protein	23086999
D005947	5315	PKM CTHBP OIP3 PK3 PKM2 TCB THBP1	pyruvate kinase, muscle (EC:2.7.1.40)	PKM protein results in increased uptake of Glucose	increases uptake	protein	22574221
D005947	5358	PLS3 BMND18 T-plastin	plastin 3	Glucose results in increased expression of PLS3 mRNA	increases expression	mRNA	10026205
D005947	5445	PON2	paraoxonase 2 (EC:3.1.1.2 3.1.1.81)	PON2 gene polymorphism affects the abundance of Glucose	affects abundance	gene	16185677
D005947	5465	PPARA NR1C1 PPAR PPARalpha hPPAR	peroxisome proliferator-activated receptor alpha	[Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased abundance of Glucose	affects binding / decreases abundance / increases activity	protein	20404010
D005947	5465	PPARA NR1C1 PPAR PPARalpha hPPAR	peroxisome proliferator-activated receptor alpha	Glucose results in decreased expression of PPARA mRNA	decreases expression	mRNA	16600694
D005947	5465	PPARA NR1C1 PPAR PPARalpha hPPAR	peroxisome proliferator-activated receptor alpha	Glucose results in decreased expression of PPARA protein	decreases expression	protein	16600694
D005947	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased expression of PPARG protein]]	decreases expression / decreases reaction	protein	21333731
D005947	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	Glucose results in decreased expression of PPARG protein	decreases expression	protein	21333731
D005947	5468	PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma	peroxisome proliferator-activated receptor gamma	rosiglitazone inhibits the reaction [Glucose results in decreased expression of PPARG protein]	decreases expression / decreases reaction	protein	21333731
D005947	10891	PPARGC1A LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	Glucose deficiency results in decreased expression of PPARGC1A mRNA	decreases expression	mRNA	17855661
D005947	10891	PPARGC1A LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	Glucose results in increased acetylation of PPARGC1A protein	increases acetylation	protein	19071085
D005947	10891	PPARGC1A LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of PPARGC1A mRNA]	decreases expression / decreases reaction	mRNA	17855661
D005947	10891	PPARGC1A LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	[Pyruvic Acid co-treated with Glucose] results in decreased acetylation of PPARGC1A protein	affects cotreatment / decreases acetylation	protein	19071085
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]	decreases activity / decreases phosphorylation / decreases reaction	protein	16873680
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	Apigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]	decreases activity / decreases phosphorylation / decreases reaction	protein	16873680
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein	decreases activity / decreases phosphorylation	protein	16873680 18482975
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	Metformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]	decreases activity / decreases phosphorylation / decreases reaction	protein	16873680
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	PRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]	affects reaction / decreases reaction / increases chemical synthesis	protein	16380484
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	PRKAA1 protein affects the reaction [Ribonucleosides inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]	affects reaction / decreases reaction / increases chemical synthesis	protein	16380484
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	PRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose affects the localization of NCF1 protein]]	affects localization / affects reaction / decreases reaction	protein	17916771
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	PRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose affects the localization of RAC1 protein]]	affects localization / affects reaction / decreases reaction	protein	17916771
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	PRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]	affects reaction / decreases reaction / increases abundance	protein	17916771
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]	decreases activity / decreases phosphorylation / decreases reaction	protein	16873680
D005947	5562	PRKAA1 AMPK AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]	decreases activity / decreases phosphorylation / decreases reaction / increases activity	protein	18482975
D005947	5563	PRKAA2 AMPK AMPK2 AMPKa2 PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein	decreases activity / decreases phosphorylation	protein	18482975
D005947	5563	PRKAA2 AMPK AMPK2 AMPKa2 PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	PRKAA2 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased abundance of Triglycerides]]	decreases reaction / increases abundance / increases reaction	protein	18482975
D005947	5563	PRKAA2 AMPK AMPK2 AMPKa2 PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]]	decreases phosphorylation / decreases reaction / increases reaction	protein	18482975
D005947	5563	PRKAA2 AMPK AMPK2 AMPKa2 PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]]	decreases reaction / increases abundance / increases reaction	protein	18482975
D005947	5563	PRKAA2 AMPK AMPK2 AMPKa2 PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]]	decreases reaction / increases expression / increases reaction	protein	18482975
D005947	5563	PRKAA2 AMPK AMPK2 AMPKa2 PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]	decreases activity / decreases phosphorylation / decreases reaction	protein	18482975
D005947	5563	PRKAA2 AMPK AMPK2 AMPKa2 PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides	decreases abundance / decreases activity / decreases phosphorylation / decreases reaction	protein	18482975
D005947	5563	PRKAA2 AMPK AMPK2 AMPKa2 PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]	decreases activity / decreases phosphorylation / decreases reaction / increases activity	protein	18482975
D005947	5563	PRKAA2 AMPK AMPK2 AMPKa2 PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	SIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides]	decreases abundance / decreases activity / decreases phosphorylation / decreases reaction / increases reaction	protein	18482975
D005947	5578	PRKCA AAG6 PKC-alpha PKCA PRKACA	protein kinase C, alpha (EC:2.7.11.13)	Glucose results in increased phosphorylation of PRKCA protein	increases phosphorylation	protein	22162761
D005947	5579	PRKCB PKC-beta PKCB PRKCB1 PRKCB2	protein kinase C, beta (EC:2.7.11.13)	Glucose results in increased activity of PRKCB protein	increases activity	protein	20578705
D005947	5579	PRKCB PKC-beta PKCB PRKCB1 PRKCB2	protein kinase C, beta (EC:2.7.11.13)	Glucose results in increased phosphorylation of PRKCB protein	increases phosphorylation	protein	22162761
D005947	5579	PRKCB PKC-beta PKCB PRKCB1 PRKCB2	protein kinase C, beta (EC:2.7.11.13)	resveratrol inhibits the reaction [Glucose results in increased activity of PRKCB protein]	decreases reaction / increases activity	protein	20578705
D005947	5621	PRNP ASCR AltPrP CD230 CJD GSS KURU PRIP PrP PrP27-30 PrP33-35C PrPc p27-30	prion protein	[PRNP protein results in increased expression of SLC2A1 protein] which results in increased uptake of Glucose	increases expression / increases uptake	protein	21265952
D005947	5682	PSMA1 HC2 NU PROS30	proteasome (prosome, macropain) subunit, alpha type, 1 (EC:3.4.25.1)	Glucose deficiency results in decreased expression of PSMA1 protein	decreases expression	protein	22314686
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased expression of PTGS2 protein]]	decreases expression / decreases reaction	protein	21333731
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	carbonyl 3-chlorophenylhydrazone inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]	decreases reaction / increases expression	mRNA	14514642
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	carbonyl 3-chlorophenylhydrazone inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	14514642
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Catechin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Catechin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Glucose results in decreased expression of PTGS2 protein	decreases expression	protein	21333731
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Glucose results in increased expression of PTGS2 mRNA	increases expression	mRNA	14514642 19225232 19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Glucose results in increased expression of PTGS2 protein	increases expression	protein	14514642 19557821 20578705 21333731
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Luteolin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Quercetin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Quercetin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	resveratrol inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	20578705
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	rosiglitazone inhibits the reaction [Glucose results in decreased expression of PTGS2 protein]	decreases expression / decreases reaction	protein	21333731
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	19557821
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Simvastatin promotes the reaction [Glucose promotes the reaction [AGT protein results in increased expression of PTGS2 mRNA]]	increases expression / increases reaction	mRNA	19225232
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Thenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]	decreases reaction / increases expression	mRNA	14514642
D005947	5743	PTGS2 COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	Thenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	decreases reaction / increases expression	protein	14514642
D005947	5879	RAC1 Rac-1 TC-25 p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]	decreases reaction / increases localization	protein	17279352
D005947	5879	RAC1 Rac-1 TC-25 p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	bisindolylmaleimide I inhibits the reaction [Glucose affects the localization of RAC1 protein]	affects localization / decreases reaction	protein	17916771
D005947	5879	RAC1 Rac-1 TC-25 p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	geranylgeranyl pyrophosphate inhibits the reaction [atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]]	decreases reaction / increases localization	protein	17279352
D005947	5879	RAC1 Rac-1 TC-25 p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	Glucose affects the localization of RAC1 protein	affects localization	protein	17916771
D005947	5879	RAC1 Rac-1 TC-25 p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	Glucose results in increased localization of RAC1 protein	increases localization	protein	17279352
D005947	5879	RAC1 Rac-1 TC-25 p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	PRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose affects the localization of RAC1 protein]]	affects localization / affects reaction / decreases reaction	protein	17916771
D005947	5879	RAC1 Rac-1 TC-25 p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	rosiglitazone inhibits the reaction [Glucose affects the localization of RAC1 protein]	affects localization / decreases reaction	protein	17916771
D005947	5935	RBM3 IS1-RNPL RNPL	RNA binding motif (RNP1, RRM) protein 3	Glucose results in increased expression of RBM3 mRNA	increases expression	mRNA	10026205
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Aspirin inhibits the reaction [Glucose results in increased expression of RELA protein]	decreases reaction / increases expression	protein	16600694
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	bosentan inhibits the reaction [Glucose results in increased activity of RELA protein]	decreases reaction / increases activity	protein	12388107
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Catechin inhibits the reaction [Glucose affects the localization of RELA protein]	affects localization / decreases reaction	protein	19557821
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	chelerythrine inhibits the reaction [Glucose results in increased activity of RELA protein]	decreases reaction / increases activity	protein	12388107
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Clofibrate inhibits the reaction [Glucose results in increased expression of RELA protein]	decreases reaction / increases expression	protein	16600694
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Curcumin inhibits the reaction [Glucose results in increased activity of RELA protein]	decreases reaction / increases activity	protein	12388107
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	epigallocatechin gallate inhibits the reaction [Glucose affects the localization of RELA protein]	affects localization / decreases reaction	protein	19557821
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Fenofibrate inhibits the reaction [Glucose results in increased expression of RELA protein]	decreases reaction / increases expression	protein	16600694
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Glucose affects the localization of RELA protein	affects localization	protein	19557821 21367880
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Glucose results in decreased phosphorylation of RELA protein	decreases phosphorylation	protein	20200188
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Glucose results in increased activity of RELA protein	increases activity	protein	12388107
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Glucose results in increased expression of RELA protein	increases expression	protein	16600694
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Glucose results in increased phosphorylation of RELA protein	increases phosphorylation	protein	21682256
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	isoangustone A inhibits the reaction [Glucose affects the localization of RELA protein]	affects localization / decreases reaction	protein	21367880
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Luteolin inhibits the reaction [Glucose affects the localization of RELA protein]	affects localization / decreases reaction	protein	19557821
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Polyphenols inhibits the reaction [Glucose results in increased phosphorylation of RELA protein]	decreases reaction / increases phosphorylation	protein	21682256
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	pyrrolidine dithiocarbamic acid inhibits the reaction [Glucose results in increased activity of RELA protein]	decreases reaction / increases activity	protein	12388107
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Quercetin inhibits the reaction [Glucose affects the localization of RELA protein]	affects localization / decreases reaction	protein	19557821
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	Rutin inhibits the reaction [Glucose affects the localization of RELA protein]	affects localization / decreases reaction	protein	19557821
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	sitaxsentan inhibits the reaction [Glucose results in increased activity of RELA protein]	decreases reaction / increases activity	protein	12388107
D005947	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	SN50 peptide inhibits the reaction [Glucose results in increased activity of RELA protein]	decreases reaction / increases activity	protein	12388107
D005947	56729	RETN ADSF FIZZ3 RETN1 RSTN XCP1	resistin	RETN protein results in decreased uptake of Glucose	decreases uptake	protein	14671216
D005947	6206	RPS12 S12	ribosomal protein S12	Glucose deficiency results in decreased expression of RPS12 protein	decreases expression	protein	22314686
D005947	3921	RPSA 37LRP 67LR LAMBR LAMR1 LBP LBP/p40 LRP LRP/LR NEM/1CHD4 SA lamR p40	ribosomal protein SA	Glucose deficiency results in decreased expression of RPSA protein	decreases expression	protein	22314686
D005947	6396	SEC13 D3S1231E SEC13L1 SEC13R npp-20	SEC13 homolog (S. cerevisiae)	Glucose deficiency results in decreased expression of SEC13 protein	decreases expression	protein	22314686
D005947	6401	SELE CD62E ELAM ELAM1 ESEL LECAM2	selectin E	Glucose results in increased expression of SELE	increases expression		22074828
D005947	6401	SELE CD62E ELAM ELAM1 ESEL LECAM2	selectin E	Glucose results in increased expression of SELE mRNA	increases expression	mRNA	20960276 21682256
D005947	6401	SELE CD62E ELAM ELAM1 ESEL LECAM2	selectin E	Polyphenols inhibits the reaction [Glucose results in increased expression of SELE mRNA]	decreases reaction / increases expression	mRNA	21682256
D005947	6401	SELE CD62E ELAM ELAM1 ESEL LECAM2	selectin E	resveratrol inhibits the reaction [Glucose results in increased expression of SELE mRNA]	decreases reaction / increases expression	mRNA	20960276
D005947	6401	SELE CD62E ELAM ELAM1 ESEL LECAM2	selectin E	SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of SELE mRNA]]	affects reaction / decreases reaction / increases expression	mRNA	20960276
D005947	6403	SELP CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL	selectin P (granule membrane protein 140kDa, antigen CD62)	Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]]	decreases reaction / increases expression	protein	18413191
D005947	5054	SERPINE1 PAI PAI-1 PAI1 PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	Glucose results in increased secretion of SERPINE1 protein	increases secretion	protein	16320596
D005947	5054	SERPINE1 PAI PAI-1 PAI1 PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	Indomethacin inhibits the reaction [Glucose results in increased secretion of SERPINE1 protein]	decreases reaction / increases secretion	protein	16320596
D005947	5054	SERPINE1 PAI PAI-1 PAI1 PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	SOD2 protein inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	decreases reaction / increases expression	mRNA	11050244
D005947	6462	SHBG ABP SBP TEBG	sex hormone-binding globulin	Cerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein]	decreases expression / decreases reaction	protein	17992261
D005947	6462	SHBG ABP SBP TEBG	sex hormone-binding globulin	Glucose affects the reaction [HNF4A protein binds to SHBG promoter]	affects binding / affects reaction	promoter	17992261
D005947	6462	SHBG ABP SBP TEBG	sex hormone-binding globulin	Glucose affects the reaction [NR2F1 protein binds to SHBG promoter]	affects binding / affects reaction	promoter	17992261
D005947	6462	SHBG ABP SBP TEBG	sex hormone-binding globulin	Glucose results in decreased expression of SHBG protein	decreases expression	protein	17992261
D005947	23411	SIRT1 SIR2L1	sirtuin 1	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]	decreases reaction / increases reaction / increases secretion	protein	21163946
D005947	23411	SIRT1 SIR2L1	sirtuin 1	Glucose deficiency results in increased expression of SIRT1 mRNA	increases expression	mRNA	20195491
D005947	23411	SIRT1 SIR2L1	sirtuin 1	Glucose deficiency results in increased expression of SIRT1 protein	increases expression	protein	20195491
D005947	23411	SIRT1 SIR2L1	sirtuin 1	Glucose results in decreased expression of and results in decreased activity of SIRT1 protein	decreases activity / decreases expression	protein	19071085
D005947	23411	SIRT1 SIR2L1	sirtuin 1	Glucose results in decreased expression of SIRT1 mRNA	decreases expression	mRNA	20068143
D005947	23411	SIRT1 SIR2L1	sirtuin 1	Glucose results in decreased expression of SIRT1 protein	decreases expression	protein	20068143
D005947	23411	SIRT1 SIR2L1	sirtuin 1	PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]]	decreases phosphorylation / decreases reaction / increases reaction	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]]	decreases reaction / increases abundance / increases reaction	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]]	decreases reaction / increases expression / increases reaction	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	[Pyruvic Acid co-treated with Glucose] results in increased expression of and results in increased activity of SIRT1 protein	affects cotreatment / increases activity / increases expression	protein	19071085
D005947	23411	SIRT1 SIR2L1	sirtuin 1	[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]	decreases activity / decreases phosphorylation / decreases reaction / increases activity	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]	decreases activity / decreases phosphorylation / decreases reaction / increases activity	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides]	decreases reaction / increases abundance / increases activity / increases expression	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]	affects reaction / decreases reaction / increases secretion	protein	20960276
D005947	23411	SIRT1 SIR2L1	sirtuin 1	SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of NOS3 mRNA]]	affects reaction / decreases expression / decreases reaction	protein	20960276
D005947	23411	SIRT1 SIR2L1	sirtuin 1	SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of SELE mRNA]]	affects reaction / decreases reaction / increases expression	protein	20960276
D005947	23411	SIRT1 SIR2L1	sirtuin 1	SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]	decreases phosphorylation / decreases reaction	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]	decreases reaction / increases abundance	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]	decreases reaction / increases expression	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]	decreases reaction / increases reaction / increases secretion	protein	21163946
D005947	23411	SIRT1 SIR2L1	sirtuin 1	SIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides]	decreases abundance / decreases activity / decreases phosphorylation / decreases reaction / increases reaction	protein	18482975
D005947	23411	SIRT1 SIR2L1	sirtuin 1	SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased acetylation of TP53 protein]]	decreases reaction / increases acetylation / increases reaction	protein	20068143
D005947	4891	SLC11A2 DCT1 DMT1 NRAMP2	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 mRNA alternative form	affects cotreatment / increases expression	mRNA	22666436
D005947	4891	SLC11A2 DCT1 DMT1 NRAMP2	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 protein alternative form	affects cotreatment / increases expression	protein	22666436
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	7-hydroxyflavone inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Barbiturates inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]	decreases reaction / increases transport	protein	18455367
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Chloral Hydrate inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]	decreases reaction / increases transport	protein	18455367
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Cyclofenil inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Cytochalasin B inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]	decreases reaction / increases transport	protein	8457197
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	daidzein inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Diazepam inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]	decreases reaction / increases transport	protein	18455367
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Diethylstilbestrol inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Genistein inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Glucose results in increased expression of SLC2A1 mRNA	increases expression	mRNA	15864539
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Glucose results in increased stability of SLC2A1 protein	increases stability	protein	11420438
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	isoliquiritigenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	kaempferol inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	myricetin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	naringenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Phloretin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	[PRNP protein results in increased expression of SLC2A1 protein] which results in increased uptake of Glucose	increases expression / increases uptake	protein	21265952
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Quercetin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	SLC2A1 protein results in increased transport of Glucose	increases transport	protein	8457197 18455367
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Tamoxifen inhibits the reaction [SLC2A1 protein affects the transport of Glucose]	affects transport / decreases reaction	protein	14642735
D005947	6513	SLC2A1 DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED	solute carrier family 2 (facilitated glucose transporter), member 1	Valproic Acid inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]	decreases reaction / increases transport	protein	18455367
D005947	66035	SLC2A11 GLUT10 GLUT11	solute carrier family 2 (facilitated glucose transporter), member 11	SLC2A11 protein results in increased transport of Glucose	increases transport	protein	17710649
D005947	6514	SLC2A2 GLUT2	solute carrier family 2 (facilitated glucose transporter), member 2	Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]	decreases reaction / increases transport	protein	8457197
D005947	6514	SLC2A2 GLUT2	solute carrier family 2 (facilitated glucose transporter), member 2	Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]	decreases reaction / increases transport	protein	8457197
D005947	6514	SLC2A2 GLUT2	solute carrier family 2 (facilitated glucose transporter), member 2	SLC2A2 protein results in increased transport of Glucose	increases transport	protein	17710649
D005947	6515	SLC2A3 GLUT3	solute carrier family 2 (facilitated glucose transporter), member 3	Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]	decreases reaction / increases transport	protein	8457197
D005947	6515	SLC2A3 GLUT3	solute carrier family 2 (facilitated glucose transporter), member 3	Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]	decreases reaction / increases transport	protein	8457197
D005947	6518	SLC2A5 GLUT-5 GLUT5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	Colforsin promotes the reaction [Glucose results in increased expression of SLC2A5 mRNA]	increases expression / increases reaction	mRNA	12820898
D005947	6518	SLC2A5 GLUT-5 GLUT5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	Glucose promotes the reaction [PAIP2 protein binds to SLC2A5 3' UTR]	affects binding / increases reaction	3' UTR	12820898
D005947	6518	SLC2A5 GLUT-5 GLUT5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	Glucose results in increased expression of SLC2A5 mRNA	increases expression	mRNA	8554516 12820898
D005947	6518	SLC2A5 GLUT-5 GLUT5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	Glucose results in increased expression of SLC2A5 protein	increases expression	protein	8554516
D005947	6518	SLC2A5 GLUT-5 GLUT5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	SLC2A5 protein results in increased transport of Glucose	increases transport	protein	17710649
D005947	155184	SLC2A7 GLUT7	solute carrier family 2 (facilitated glucose transporter), member 7	SLC2A7 protein results in increased transport of Glucose	increases transport	protein	15033637 17710649
D005947	56606	SLC2A9 GLUT9 GLUTX UAQTL2 URATv1	solute carrier family 2 (facilitated glucose transporter), member 9	Glucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]	increases reaction / increases transport	protein	18842065
D005947	56606	SLC2A9 GLUT9 GLUTX UAQTL2 URATv1	solute carrier family 2 (facilitated glucose transporter), member 9	SLC2A9 protein results in increased transport of Glucose	increases transport	protein	17710649
D005947	169026	SLC30A8 ZNT8 ZnT-8	solute carrier family 30 (zinc transporter), member 8	SLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	16984975
D005947	6523	SLC5A1 D22S675 NAGT SGLT1	solute carrier family 5 (sodium/glucose cotransporter), member 1	Glucose inhibits the reaction [[Sodium co-treated with SLC5A1 protein] results in increased uptake of methylglucoside]	affects cotreatment / decreases reaction / increases uptake	protein	16300400
D005947	6523	SLC5A1 D22S675 NAGT SGLT1	solute carrier family 5 (sodium/glucose cotransporter), member 1	SLC5A1 protein affects the transport of Glucose	affects transport	protein	17288452
D005947	4087	SMAD2 JV18 JV18-1 MADH2 MADR2 hMAD-2 hSMAD2	SMAD family member 2	Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein	affects localization / increases phosphorylation	protein	17597607
D005947	4087	SMAD2 JV18 JV18-1 MADH2 MADR2 hMAD-2 hSMAD2	SMAD family member 2	Glucose results in increased phosphorylation of SMAD2 protein	increases phosphorylation	protein	21367880
D005947	4087	SMAD2 JV18 JV18-1 MADH2 MADR2 hMAD-2 hSMAD2	SMAD family member 2	isoangustone A inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein]	decreases reaction / increases phosphorylation	protein	21367880
D005947	4087	SMAD2 JV18 JV18-1 MADH2 MADR2 hMAD-2 hSMAD2	SMAD family member 2	protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]	affects localization / decreases reaction / increases phosphorylation	protein	17597607
D005947	4088	SMAD3 HSPC193 HsT17436 JV15-2 LDS1C LDS3 MADH3	SMAD family member 3	Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein	affects localization / increases phosphorylation	protein	17597607
D005947	4088	SMAD3 HSPC193 HsT17436 JV15-2 LDS1C LDS3 MADH3	SMAD family member 3	protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]	affects localization / decreases reaction / increases phosphorylation	protein	17597607
D005947	4089	SMAD4 DPC4 JIP MADH4 MYHRS	SMAD family member 4	Glucose results in increased expression of SMAD4 protein	increases expression	protein	21367880
D005947	4089	SMAD4 DPC4 JIP MADH4 MYHRS	SMAD family member 4	isoangustone A inhibits the reaction [Glucose results in increased expression of SMAD4 protein]	decreases reaction / increases expression	protein	21367880
D005947	6615	SNAI1 SLUGH2 SNA SNAH SNAIL SNAIL1 dJ710H13.1	snail family zinc finger 1	gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA]	decreases reaction / increases expression	mRNA	21829520
D005947	6615	SNAI1 SLUGH2 SNA SNAH SNAIL SNAIL1 dJ710H13.1	snail family zinc finger 1	Glucose results in increased expression of SNAI1 mRNA	increases expression	mRNA	21829520
D005947	6615	SNAI1 SLUGH2 SNA SNAH SNAIL SNAIL1 dJ710H13.1	snail family zinc finger 1	MAPK14 protein promotes the reaction [Glucose results in increased expression of SNAI1 mRNA]	increases expression / increases reaction	mRNA	21829520
D005947	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	Acetylcysteine inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]	decreases reaction / increases degradation	protein	17309078
D005947	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]	decreases reaction / increases degradation	protein	17309078
D005947	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	CAT inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]	decreases reaction / increases degradation	protein	17309078
D005947	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	Glucose binds to SOD1 protein mutant form	affects binding	protein	12626432
D005947	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	Glucose deficiency results in decreased expression of and results in increased degradation of SOD1 protein	decreases expression / increases degradation	protein	17309078
D005947	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	Glucose promotes the reaction [SOD1 protein mutant form results in increased chemical synthesis of Hydrogen Peroxide]	increases chemical synthesis / increases reaction	protein	12626432
D005947	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	lactacystin inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]	decreases reaction / increases degradation	protein	17309078
D005947	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	Tetradecanoylphorbol Acetate promotes the reaction [Glucose deficiency results in decreased expression of and results in increased degradation of SOD1 protein]	decreases expression / increases degradation / increases reaction	protein	17309078
D005947	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	U 0126 inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]	decreases reaction / increases degradation	protein	17309078
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	Acetylcysteine inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein]	affects folding / decreases reaction	protein	17309078
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	CAT inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein]	affects folding / decreases reaction	protein	17309078
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	Glucose deficiency affects the folding of SOD2 protein	affects folding	protein	17309078
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	Glucose deficiency results in decreased expression of SOD2 protein	decreases expression	protein	22314686
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	decreases phosphorylation / decreases reaction	protein	11050244
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SOD2 protein inhibits the reaction [Glucose results in increased chemical synthesis of Dinoprostone]	decreases reaction / increases chemical synthesis	protein	14514642
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SOD2 protein inhibits the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]	decreases reaction / increases chemical synthesis	protein	14514642
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]	decreases activity / decreases reaction / increases chemical synthesis	protein	11050244
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SOD2 protein inhibits the reaction [Glucose results in increased expression of SERPINE1 mRNA]	decreases reaction / increases expression	protein	11050244
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SOD2 protein inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]	decreases reaction / increases expression	protein	11050244
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	decreases reaction / increases O-linked glycosylation	protein	11050244
D005947	6648	SOD2 IPOB MNSOD MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	SOD2 protein results in decreased susceptibility to Glucose	decreases response to substance	protein	11050244
D005947	6667	SP1	Sp1 transcription factor	SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein]	decreases phosphorylation / decreases reaction	protein	11050244
D005947	6667	SP1	Sp1 transcription factor	SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein]	decreases reaction / increases O-linked glycosylation	protein	11050244
D005947	6678	SPARC ON	secreted protein, acidic, cysteine-rich (osteonectin)	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of SPARC mRNA]	decreases expression / decreases reaction	mRNA	19924377
D005947	6678	SPARC ON	secreted protein, acidic, cysteine-rich (osteonectin)	Glucose results in decreased expression of SPARC mRNA	decreases expression	mRNA	19924377
D005947	6720	SREBF1 SREBP-1c SREBP1 bHLHd1	sterol regulatory element binding transcription factor 1	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]	decreases reaction / increases expression	mRNA	23319015
D005947	6720	SREBF1 SREBP-1c SREBP1 bHLHd1	sterol regulatory element binding transcription factor 1	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]	decreases reaction / increases expression	protein	23319015
D005947	6720	SREBF1 SREBP-1c SREBP1 bHLHd1	sterol regulatory element binding transcription factor 1	Glucose results in increased expression of SREBF1 mRNA	increases expression	mRNA	23319015
D005947	6720	SREBF1 SREBP-1c SREBP1 bHLHd1	sterol regulatory element binding transcription factor 1	Glucose results in increased expression of SREBF1 protein	increases expression	protein	23319015
D005947	6720	SREBF1 SREBP-1c SREBP1 bHLHd1	sterol regulatory element binding transcription factor 1	Niacinamide inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]	decreases reaction / increases expression	protein	23319015
D005947	6720	SREBF1 SREBP-1c SREBP1 bHLHd1	sterol regulatory element binding transcription factor 1	platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]	decreases reaction / increases expression	mRNA	23319015
D005947	6720	SREBF1 SREBP-1c SREBP1 bHLHd1	sterol regulatory element binding transcription factor 1	platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]	decreases reaction / increases expression	protein	23319015
D005947	6720	SREBF1 SREBP-1c SREBP1 bHLHd1	sterol regulatory element binding transcription factor 1	STO 609 inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]	decreases reaction / increases expression	mRNA	23319015
D005947	9882	TBC1D4 AS160	TBC1 domain family, member 4	GH1 protein promotes the reaction [Glucose results in increased phosphorylation of TBC1D4 protein]	increases phosphorylation / increases reaction	protein	21559284
D005947	9882	TBC1D4 AS160	TBC1 domain family, member 4	Glucose results in increased phosphorylation of TBC1D4 protein	increases phosphorylation	protein	21559284
D005947	7039	TGFA TFGA	transforming growth factor, alpha	Diazooxonorleucine inhibits the reaction [Glucose results in increased expression of TGFA mRNA]	decreases reaction / increases expression	mRNA	8638660
D005947	7039	TGFA TFGA	transforming growth factor, alpha	EGF protein promotes the reaction [Glucose results in increased expression of TGFA mRNA]	increases expression / increases reaction	mRNA	8638660
D005947	7039	TGFA TFGA	transforming growth factor, alpha	Glucose promotes the reaction [EGF protein results in increased expression of TGFA mRNA]	increases expression / increases reaction	mRNA	8638660
D005947	7039	TGFA TFGA	transforming growth factor, alpha	Glucose results in increased expression of TGFA mRNA	increases expression	mRNA	8638660
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	[Glucose co-treated with TGFB1 protein] results in decreased expression of CDH1 protein	affects cotreatment / decreases expression	protein	21829520
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	[Glucose co-treated with TGFB1 protein] results in decreased expression of KRT20 protein	affects cotreatment / decreases expression	protein	21829520
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	[Glucose co-treated with TGFB1 protein] results in increased expression of ACTA2 protein	affects cotreatment / increases expression	protein	21829520
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	[Glucose co-treated with TGFB1 protein] results in increased expression of VIM protein	affects cotreatment / increases expression	protein	21829520
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	Glucose results in increased expression of TGFB1 mRNA	increases expression	mRNA	17199790 17611328
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	Glucose results in increased expression of TGFB1 protein	increases expression	protein	20578705 21367880 21829520
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	Glucose results in increased secretion of TGFB1 protein	increases secretion	protein	17199790
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	isoangustone A inhibits the reaction [Glucose results in increased expression of TGFB1 protein]	decreases reaction / increases expression	protein	21367880
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in decreased expression of CDH1 protein]	affects cotreatment / decreases expression / increases reaction	protein	21829520
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in decreased expression of KRT20 protein]	affects cotreatment / decreases expression / increases reaction	protein	21829520
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of ACTA2 protein]	affects cotreatment / increases expression / increases reaction	protein	21829520
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of VIM protein]	affects cotreatment / increases expression / increases reaction	protein	21829520
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]	decreases reaction / increases expression	mRNA	17597607
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 protein]	decreases reaction / increases expression	protein	17597607
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	resveratrol inhibits the reaction [Glucose results in increased expression of TGFB1 protein]	decreases reaction / increases expression	protein	20578705
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	SOD2 protein inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]	decreases reaction / increases expression	mRNA	11050244
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	troglitazone inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]	decreases reaction / increases expression	mRNA	17199790 17611328
D005947	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	troglitazone inhibits the reaction [Glucose results in increased secretion of TGFB1 protein]	decreases reaction / increases secretion	protein	17199790
D005947	7046	TGFBR1 AAT5 ACVRLK4 ALK-5 ALK5 LDS1A LDS2A MSSE SKR4 TGFR-1	transforming growth factor, beta receptor 1 (EC:2.7.11.30)	Glucose results in increased expression of TGFBR1 protein	increases expression	protein	21367880
D005947	7046	TGFBR1 AAT5 ACVRLK4 ALK-5 ALK5 LDS1A LDS2A MSSE SKR4 TGFR-1	transforming growth factor, beta receptor 1 (EC:2.7.11.30)	isoangustone A inhibits the reaction [Glucose results in increased expression of TGFBR1 protein]	decreases reaction / increases expression	protein	21367880
D005947	7048	TGFBR2 AAT3 FAA3 LDS1B LDS2B MFS2 RIIC TAAD2 TGFR-2 TGFbeta-RII	transforming growth factor, beta receptor II (70/80kDa) (EC:2.7.11.30)	Glucose results in increased expression of TGFBR2 protein	increases expression	protein	21367880
D005947	7048	TGFBR2 AAT3 FAA3 LDS1B LDS2B MFS2 RIIC TAAD2 TGFR-2 TGFbeta-RII	transforming growth factor, beta receptor II (70/80kDa) (EC:2.7.11.30)	isoangustone A inhibits the reaction [Glucose results in increased expression of TGFBR2 protein]	decreases reaction / increases expression	protein	21367880
D005947	54974	THG1L ICF45 IHG-1	tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) (EC:2.7.7.79)	Glucose results in increased expression of THG1L mRNA	increases expression	mRNA	10026205
D005947	7077	TIMP2 CSC-21K DDC8	TIMP metallopeptidase inhibitor 2	Glucose results in increased expression of TIMP2 protein	increases expression	protein	21367880
D005947	7077	TIMP2 CSC-21K DDC8	TIMP metallopeptidase inhibitor 2	isoangustone A inhibits the reaction [Glucose results in increased expression of TIMP2 protein]	decreases reaction / increases expression	protein	21367880
D005947	7097	TLR2 CD282 TIL4	toll-like receptor 2	Glucose results in decreased expression of TLR2 protein	decreases expression	protein	20200188
D005947	7099	TLR4 ARMD10 CD284 TLR-4 TOLL	toll-like receptor 4	Glucose results in decreased expression of TLR4 protein	decreases expression	protein	20200188
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Catechin inhibits the reaction [Glucose results in increased expression of TNF mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Catechin inhibits the reaction [Glucose results in increased expression of TNF protein]	decreases reaction / increases expression	protein	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	chromic acid inhibits the reaction [[Glucose co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]	affects cotreatment / decreases reaction / increases secretion	protein	11726202
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of TNF mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	epigallocatechin gallate inhibits the reaction [Glucose results in increased expression of TNF protein]	decreases reaction / increases expression	protein	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	[Glucose co-treated with Lipopolysaccharides] results in decreased expression of TNF protein	affects cotreatment / decreases expression	protein	20200188
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	[Glucose co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TNF protein	affects cotreatment / decreases expression	protein	20200188
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	[Glucose co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein	affects cotreatment / increases secretion	protein	11726202
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glucose results in increased expression of TNF mRNA	increases expression	mRNA	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Glucose results in increased expression of TNF protein	increases expression	protein	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Luteolin inhibits the reaction [Glucose results in increased expression of TNF mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Luteolin inhibits the reaction [Glucose results in increased expression of TNF protein]	decreases reaction / increases expression	protein	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Quercetin inhibits the reaction [Glucose results in increased expression of TNF mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Quercetin inhibits the reaction [Glucose results in increased expression of TNF protein]	decreases reaction / increases expression	protein	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Rutin inhibits the reaction [Glucose results in increased expression of TNF mRNA]	decreases reaction / increases expression	mRNA	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	Rutin inhibits the reaction [Glucose results in increased expression of TNF protein]	decreases reaction / increases expression	protein	19557821
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]	decreases reaction / increases uptake	protein	7956951
D005947	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]]	decreases reaction / increases uptake	protein	7956951
D005947	4982	TNFRSF11B OCIF OPG TR1	tumor necrosis factor receptor superfamily, member 11b	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased secretion of TNFRSF11B protein]	decreases reaction / decreases secretion	protein	19924377
D005947	4982	TNFRSF11B OCIF OPG TR1	tumor necrosis factor receptor superfamily, member 11b	Glucose results in decreased secretion of TNFRSF11B protein	decreases secretion	protein	19924377
D005947	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	Glucose inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]	decreases reaction / increases expression	protein	21548882
D005947	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	Glucose results in increased acetylation of TP53 protein	increases acetylation	protein	20068143
D005947	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	resveratrol inhibits the reaction [Glucose results in increased acetylation of TP53 protein]	decreases reaction / increases acetylation	protein	20068143
D005947	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased acetylation of TP53 protein]]	decreases reaction / increases acetylation / increases reaction	protein	20068143
D005947	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	[Tretinoin results in increased uptake of Glucose] inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]	decreases reaction / increases expression / increases uptake	protein	21548882
D005947	10628	TXNIP EST01027 HHCPA78 THIF VDUP1	thioredoxin interacting protein	Glucose deficiency results in decreased expression of TXNIP mRNA	decreases expression	mRNA	20195491
D005947	10628	TXNIP EST01027 HHCPA78 THIF VDUP1	thioredoxin interacting protein	Glucose deficiency results in decreased expression of TXNIP protein	decreases expression	protein	20195491
D005947	7351	UCP2 BMIQ4 SLC25A8 UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	Glucose results in increased expression of UCP2 protein	increases expression	protein	18167556
D005947	7352	UCP3 SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	Glucose results in decreased expression of UCP3 protein	decreases expression	protein	18167556
D005947	7352	UCP3 SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	UCP3 protein promotes the reaction [Glucose results in increased secretion of INS protein]	increases reaction / increases secretion	protein	18167556
D005947	7412	VCAM1 CD106 INCAM-100	vascular cell adhesion molecule 1	Glucose results in increased expression of VCAM1 mRNA	increases expression	mRNA	21682256
D005947	7412	VCAM1 CD106 INCAM-100	vascular cell adhesion molecule 1	Glucose results in increased expression of VCAM1 protein	increases expression	protein	21373835
D005947	7412	VCAM1 CD106 INCAM-100	vascular cell adhesion molecule 1	Polyphenols inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]	decreases reaction / increases expression	mRNA	21682256
D005947	7412	VCAM1 CD106 INCAM-100	vascular cell adhesion molecule 1	rimonabant inhibits the reaction [Glucose results in increased expression of VCAM1 protein]	decreases reaction / increases expression	protein	21373835
D005947	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	Glucose deficiency results in increased expression of VEGFA mRNA	increases expression	mRNA	12147617
D005947	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	Glucose deficiency results in increased secretion of VEGFA protein	increases secretion	protein	12147617
D005947	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	Glucose results in increased expression of VEGFA protein	increases expression	protein	20578705
D005947	7422	VEGFA MVCD1 VEGF VPF	vascular endothelial growth factor A	resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]	decreases reaction / increases expression	protein	20578705
D005947	7431	VIM CTRCT30	vimentin	[Glucose co-treated with TGFB1 protein] results in increased expression of VIM protein	affects cotreatment / increases expression	protein	21829520
D005947	7431	VIM CTRCT30	vimentin	Glucose results in increased expression of VIM mRNA	increases expression	mRNA	21829520
D005947	7431	VIM CTRCT30	vimentin	Glucose results in increased expression of VIM protein	increases expression	protein	21829520
D005947	7431	VIM CTRCT30	vimentin	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of VIM protein]	affects cotreatment / increases expression / increases reaction	protein	21829520
D005947	7431	VIM CTRCT30	vimentin	MAPK14 protein promotes the reaction [Glucose results in increased expression of VIM mRNA]	increases expression / increases reaction	mRNA	21829520

Related Disease

Diseases related to CTD interactions

47 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D000140	D005947	Acidosis, Lactic	marker/mechanism	19427052
D000647	D005947	Amnesia	therapeutic	3146778
D000740	D005947	Anemia	marker/mechanism	20857844
D000860	D005947	Anoxia	marker/mechanism	12770949
D001929	D005947	Brain Edema	marker/mechanism	15459624
D002545	D005947	Brain Ischemia	marker/mechanism	8099768 19429140
D009202	D005947	Cardiomyopathies	marker/mechanism	21964073
D002386	D005947	Cataract	marker/mechanism	21376710
D003128	D005947	COMA	marker/mechanism therapeutic	3487333 15333503
D000013	D005947	Congenital Abnormalities	marker/mechanism	18502742
D048909	D005947	Diabetes Complications	marker/mechanism	12434198 15490108
D003921	D005947	Diabetes Mellitus, Experimental	marker/mechanism therapeutic	12123627 12137914 18266981 22056647
D003924	D005947	Diabetes Mellitus, Type 2	marker/mechanism	12914525 15531508 22056647 22244987
D003928	D005947	Diabetic Nephropathies	marker/mechanism	21439372 22245600
D003929	D005947	Diabetic Neuropathies	marker/mechanism	10780678
D050171	D005947	Dyslipidemias	marker/mechanism	12434198
D004660	D005947	Encephalitis	marker/mechanism	6424993
D005355	D005947	Fibrosis	marker/mechanism	19759273
D006461	D005947	Hemolysis	marker/mechanism	18983990 21736874
D006501	D005947	Hepatic Encephalopathy	therapeutic	20163200
D006943	D005947	Hyperglycemia	marker/mechanism	11696579 19136606
D006947	D005947	Hyperkalemia	therapeutic	20466255
D006948	D005947	Hyperkinesis	therapeutic	2173542 3202815
D015228	D005947	Hypertriglyceridemia	therapeutic	4685092
D006984	D005947	Hypertrophy	marker/mechanism	20060012
D007003	D005947	Hypoglycemia	therapeutic	6421558 8422773 18545258 19427052
D007022	D005947	Hypotension	therapeutic	7418494
D007249	D005947	Inflammation	marker/mechanism	20578705
D019586	D005947	Intracranial Hypertension	marker/mechanism	15459624
D007511	D005947	Ischemia	marker/mechanism	11108930
D007676	D005947	Kidney Failure, Chronic	therapeutic	9551423
D008545	D005947	Melanoma	therapeutic	14993021
D008569	D005947	Memory Disorders	therapeutic	9264093
D017202	D005947	Myocardial Ischemia	marker/mechanism	3812268
D009207	D005947	Myoclonus	marker/mechanism	15459624
D009336	D005947	Necrosis	marker/mechanism	17309078 19492079
D009410	D005947	Nerve Degeneration	marker/mechanism	9147382
D009461	D005947	Neurologic Manifestations	marker/mechanism	16189347
D009503	D005947	Neutropenia	marker/mechanism	20857844
D010146	D005947	Pain	marker/mechanism therapeutic	8796565 10481420
D010149	D005947	Pain, Postoperative	marker/mechanism	8610872
D010523	D005947	Peripheral Nervous System Diseases	marker/mechanism	8519711
D017118	D005947	Porphyria, Acute Intermittent	therapeutic	16871841
D012640	D005947	Seizures	marker/mechanism	65671
D012878	D005947	Skin Neoplasms	therapeutic	14993021
D013217	D005947	Starvation	therapeutic	7306070
D014202	D005947	Tremor	marker/mechanism	3202815

KNApSAcK Metabolite C00042470

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (1)

* NCBI

Human Protein / Gene in interaction

CTD interaction (861)

Related Disease

Diseases related to CTD interactions

47 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases