KNApSAcK Metabolite C00042732
Metabolite
KNApSAcK Entry
| id | C00042732 |
|---|---|
| Name | Methamphetamine / (+)-Methamphetamine |
| CAS RN | 537-46-2 |
| Standard InChI | InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5260 |
Link
ChEMBL
| By standard InChI | CHEMBL1201201 |
|---|---|
| By standard InChI Main Layer | CHEMBL1201201 CHEMBL1927030 |
KEGG
| By LinkDB | C07164 |
|---|
CTD
| By CAS RN | D008694 |
|---|
Species
Summary
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Acacia rigidula Benth. | 205076 | Fabaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
8 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1201201 |
CHEMBL2071965
(1)
|
1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1201201 |
CHEMBL2071963
(1)
|
0 / 1 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | CHEMBL1201201 |
CHEMBL804959
(1)
|
1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1201201 |
CHEMBL2071962
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1201201 |
CHEMBL2071964
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1201201 |
CHEMBL2071966
(1)
CHEMBL2071967
(1)
|
0 / 1 |
| Q96RJ0 | Trace amine-associated receptor 1 | Trace amine receptor | CHEMBL1201201 CHEMBL1927030 |
CHEMBL1930561
(2)
CHEMBL1930659
(1)
|
0 / 0 |
| O76082 | Solute carrier family 22 member 5 | Unclassified protein | CHEMBL1201201 |
CHEMBL2078076
(1)
|
1 / 2 |
CTD interaction (138)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D008694 | 23305 |
ACSL6
ACS2 FACL6 LACS_6 LACS2 LACS5 |
acyl-CoA synthetase long-chain family member 6 (EC:6.2.1.3) | ACSL6 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 135 |
ADORA2A
A2aR ADORA2 RDC8 |
adenosine A2a receptor | ADORA2A gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
20799992
|
| D008694 | 26289 |
AK5
AK6 |
adenylate kinase 5 (EC:2.7.4.3 2.7.4.6) | AK5 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | AKT1 gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
15982448
|
| D008694 | 313 |
AOAH
|
acyloxyacyl hydrolase (neutrophil) (EC:3.1.1.77) | AOAH gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 409 |
ARRB2
ARB2 ARR2 BARR2 |
arrestin, beta 2 | ARRB2 gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
17233643
|
| D008694 | 23245 |
ASTN2
bA67K19.1 |
astrotactin 2 | ASTN2 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 627 |
BDNF
ANON2 BULN2 |
brain-derived neurotrophic factor | BDNF gene polymorphism affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
19462300
|
| D008694 | 627 |
BDNF
ANON2 BULN2 |
brain-derived neurotrophic factor | BDNF gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
20736000
|
| D008694 | 627 |
BDNF
ANON2 BULN2 |
brain-derived neurotrophic factor | Methamphetamine results in increased expression of BDNF protein |
increases expression
|
protein |
16039058
|
| D008694 | 847 |
CAT
|
catalase (EC:1.11.1.6) | Methamphetamine results in decreased expression of CAT protein |
decreases expression
|
protein |
12797468
|
| D008694 | 54535 |
CCHCR1
C6orf18 HCR SBP |
coiled-coil alpha-helical rod protein 1 | CCHCR1 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 1604 |
CD55
CR CROM DAF TC |
CD55 molecule, decay accelerating factor for complement (Cromer blood group) | CD55 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 1012 |
CDH13
CDHH P105 |
cadherin 13 (EC:3.6.1.3) | CDH13 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 1061 | CENPCP1 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
||
| D008694 | 1103 |
CHAT
CHOACTASE CMS1A CMS1A2 |
choline O-acetyltransferase (EC:2.3.1.6) | Methamphetamine results in decreased activity of CHAT protein |
decreases activity
|
protein |
10089005
|
| D008694 | 340267 |
COL28A1
COL28 |
collagen, type XXVIII, alpha 1 | COL28A1 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | COMT gene polymorphism affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
19462300
|
| D008694 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | COMT gene polymorphism results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
15274053
|
| D008694 | 64478 |
CSMD1
PPP1R24 |
CUB and Sushi multiple domains 1 | CSMD1 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 8029 |
CUBN
IFCR MGA1 gp280 |
cubilin (intrinsic factor-cobalamin receptor) | CUBN gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | CYP1A2 protein affects the metabolism of Methamphetamine metabolite |
affects metabolic processing
|
protein |
16038959
|
| D008694 | 171522 | CYP2D4 gene polymorphism affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
20727252
|
||
| D008694 | 1565 |
CYP2D6
CPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1 |
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) | CYP2D6 protein affects the susceptibility to Methamphetamine |
affects response to substance
|
protein |
18280655
|
| D008694 | 1571 |
CYP2E1
CPE1 CYP2E P450-J P450C2E |
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) | CYP2E1 protein affects the metabolism of Methamphetamine metabolite |
affects metabolic processing
|
protein |
16038959
|
| D008694 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | CYP3A4 protein affects the metabolism of Methamphetamine metabolite |
affects metabolic processing
|
protein |
16038959
|
| D008694 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | [Methamphetamine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA |
affects binding
/ increases expression |
mRNA / promoter |
12851153
|
| D008694 | 81501 |
DCSTAMP
FIND TM7SF4 hDC-STAMP |
dendrocyte expressed seven transmembrane protein | DCSTAMP gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | Methamphetamine results in increased expression of DRD1 protein |
increases expression
|
protein |
11126397
|
| D008694 | 1813 |
DRD2
D2DR D2R |
dopamine receptor D2 | DRD2 gene polymorphism results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
18555060
|
| D008694 | 1813 |
DRD2
D2DR D2R |
dopamine receptor D2 | Methamphetamine results in decreased expression of DRD2 protein |
decreases expression
|
protein |
11126397
11729018 19940168 |
| D008694 | 1814 |
DRD3
D3DR ETM1 FET1 |
dopamine receptor D3 | Methamphetamine results in decreased expression of DRD3 protein |
decreases expression
|
protein |
19940168
|
| D008694 | 1815 |
DRD4
D4DR |
dopamine receptor D4 | DRD4 gene polymorphism affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
19462300
|
| D008694 | 1815 |
DRD4
D4DR |
dopamine receptor D4 | DRD4 gene polymorphism results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
15274053
|
| D008694 | 1978 |
EIF4EBP1
4E-BP1 4EBP1 BP-1 PHAS-I |
eukaryotic translation initiation factor 4E binding protein 1 | Methamphetamine inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19054297
|
| D008694 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | ESR1 gene polymorphism results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
19386276
|
| D008694 | 2272 |
FHIT
AP3Aase FRA3B |
fragile histidine triad (EC:3.6.1.29) | FHIT gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 23307 |
FKBP15
FKBP133 KIAA0674 PPP1R76 |
FK506 binding protein 15, 133kDa (EC:5.2.1.8) | FKBP15 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 9568 |
GABBR2
GABABR2 GPR51 GPRC3B HG20 HRIHFB2099 |
gamma-aminobutyric acid (GABA) B receptor, 2 | Methamphetamine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21729720
|
| D008694 | 2554 |
GABRA1
ECA4 EJM EJM5 |
gamma-aminobutyric acid (GABA) A receptor, alpha 1 | Methamphetamine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21729720
|
| D008694 | 2566 |
GABRG2
CAE2 ECA2 GEFSP3 |
gamma-aminobutyric acid (GABA) A receptor, gamma 2 | GABRG2 gene results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
15772696
|
| D008694 | 2566 |
GABRG2
CAE2 ECA2 GEFSP3 |
gamma-aminobutyric acid (GABA) A receptor, gamma 2 | Methamphetamine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABBR2 protein co-treated with GABRG2 protein]] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
21729720
|
| D008694 | 2912 |
GRM2
GLUR2 GPRC1B MGLUR2 mGlu2 |
glutamate receptor, metabotropic 2 | GRM2 gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
20211215
|
| D008694 | 2944 |
GSTM1
GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1 |
glutathione S-transferase mu 1 (EC:2.5.1.18) | GSTM1 gene polymorphism affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
15048646
|
| D008694 | 2944 |
GSTM1
GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1 |
glutathione S-transferase mu 1 (EC:2.5.1.18) | GSTM1 protein results in decreased susceptibility to Methamphetamine |
decreases response to substance
|
protein |
19254865
|
| D008694 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | GSTP1 exon polymorphism results in increased susceptibility to Methamphetamine |
increases response to substance
|
exon |
15729709
|
| D008694 | 2952 |
GSTT1
|
glutathione S-transferase theta 1 (EC:2.5.1.18) | GSTT1 gene polymorphism affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18186040
|
| D008694 | 2952 |
GSTT1
|
glutathione S-transferase theta 1 (EC:2.5.1.18) | GSTT1 protein affects the susceptibility to Methamphetamine |
affects response to substance
|
protein |
19254865
|
| D008694 | 9951 |
HS3ST4
3-OST-4 30ST4 3OST4 h3-OST-4 |
heparan sulfate (glucosamine) 3-O-sulfotransferase 4 (EC:2.8.2.23) | HS3ST4 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 3350 |
HTR1A
5-HT-1A 5-HT1A 5HT1a ADRB2RL1 ADRBRL1 G-21 PFMCD |
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | HTR1A gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
19747927
|
| D008694 | 3362 |
HTR6
5-HT6 5-HT6R |
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | HTR6 gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
20705401
|
| D008694 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | Methamphetamine promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
increases reaction
/ increases secretion |
protein |
19945523
|
| D008694 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | Methamphetamine results in increased activity of JUN protein |
increases activity
|
protein |
11746378
|
| D008694 | 9215 |
LARGE
MDC1D MDDGA6 MDDGB6 |
like-glycosyltransferase | LARGE gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 158038 |
LINGO2
LERN3 LRRN6C |
leucine rich repeat and Ig domain containing 2 | LINGO2 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 5607 |
MAP2K5
HsT17454 MAPKK5 MEK5 PRKMK5 |
mitogen-activated protein kinase kinase 5 (EC:2.7.12.2) | MAP2K5 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 64757 |
MARC1
MOSC1 |
mitochondrial amidoxime reducing component 1 | MARC1 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 54996 |
MARC2
MOSC2 RP11-270A6.1 |
mitochondrial amidoxime reducing component 2 | MARC2 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | [HIV Envelope Protein gp120 co-treated with Methamphetamine] promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of MMP9 mRNA] |
affects cotreatment
/ increases expression / increases reaction |
mRNA |
21425912
|
| D008694 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | [HIV Envelope Protein gp120 co-treated with Methamphetamine] promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased secretion of and results in increased activity of MMP9 protein] |
affects cotreatment
/ increases activity / increases reaction / increases secretion |
protein |
21425912
|
| D008694 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | Methamphetamine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of MMP9 mRNA] |
increases expression
/ increases reaction |
mRNA |
21425912
|
| D008694 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | Methamphetamine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased secretion of MMP9 protein] |
increases reaction
/ increases secretion |
protein |
21425912
|
| D008694 | 4502 |
MT2A
MT2 |
metallothionein 2A | Methamphetamine results in increased expression of MT2A mRNA |
increases expression
|
mRNA |
20801194
|
| D008694 | 2475 |
MTOR
FRAP FRAP1 FRAP2 RAFT1 RAPT1 |
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) | Methamphetamine inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
19054297
|
| D008694 | 2475 |
MTOR
FRAP FRAP1 FRAP2 RAFT1 RAPT1 |
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) | Methamphetamine results in decreased phosphorylation of MTOR protein |
decreases phosphorylation
|
protein |
19054297
|
| D008694 | 4645 |
MYO5B
|
myosin VB | MYO5B gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Methamphetamine results in increased activity of NFKB1 protein |
increases activity
|
protein |
11746378
|
| D008694 | 4886 |
NPY1R
NPY1-R NPYR |
neuropeptide Y receptor Y1 | NPY1R gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
19566775
|
| D008694 | 3084 |
NRG1
ARIA GGF GGF2 HGL HRG HRG1 HRGA MST131 NDF SMDF |
neuregulin 1 | NRG1 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | OPRM1 gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
16402083
|
| D008694 | 26577 |
PCOLCE2
PCPE2 |
procollagen C-endopeptidase enhancer 2 | PCOLCE2 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 5142 |
PDE4B
DPDE4 PDE4B5 PDEIVB |
phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) | PDE4B gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 5144 |
PDE4D
ACRDYS2 DPDE3 HSPDE4D PDE43 PDE4DN2 STRK1 |
phosphodiesterase 4D, cAMP-specific (EC:3.1.4.17) | PDE4D gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 5146 |
PDE6C
ACHM5 COD4 PDEA2 |
phosphodiesterase 6C, cGMP-specific, cone, alpha prime (EC:3.1.4.35) | PDE6C gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 5173 |
PDYN
ADCA PENKB SCA23 |
prodynorphin | PDYN promoter polymorphism results in increased susceptibility to Methamphetamine |
increases response to substance
|
promoter |
16529859
|
| D008694 | 9463 |
PICK1
PICK PRKCABP |
protein interacting with PRKCA 1 | PICK1 gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
17606663
|
| D008694 | 5460 |
POU5F1
OCT3 OCT4 OTF-3 OTF3 OTF4 Oct-3 Oct-4 |
POU class 5 homeobox 1 | POU5F1 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 7799 |
PRDM2
HUMHOXY1 KMT8 MTB-ZF RIZ RIZ1 RIZ2 |
PR domain containing 2, with ZNF domain (EC:2.1.1.43) | PRDM2 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 5592 |
PRKG1
1 AAT8 PKG PRKG1B PRKGR1B cGK cGK_1 cGK1 cGKI cGKI-BETA cGKI-alpha |
protein kinase, cGMP-dependent, type I (EC:2.7.11.12) | PRKG1 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 5617 |
PRL
|
prolactin | Methamphetamine affects the expression of PRL protein |
affects expression
|
protein |
21142706
|
| D008694 | 128674 |
PROKR2
GPR73L1 GPR73b GPRg2 HH3 KAL3 PKR2 dJ680N4.3 |
prokineticin receptor 2 | PROKR2 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
20576534
|
| D008694 | 23362 |
PSD3
EFA6R HCA67 |
pleckstrin and Sec7 domain containing 3 | PSD3 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 5742 |
PTGS1
COX1 COX3 PCOX1 PES-1 PGG/HS PGHS-1 PGHS1 PHS1 PTGHS |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | [Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine |
increases activity
/ increases response to substance |
protein |
21163909
|
| D008694 | 5742 |
PTGS1
COX1 COX3 PCOX1 PES-1 PGG/HS PGHS-1 PGHS1 PHS1 PTGHS |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine |
increases abundance
/ increases activity / increases response to substance |
protein |
21163909
|
| D008694 | 5742 |
PTGS1
COX1 COX3 PCOX1 PES-1 PGG/HS PGHS-1 PGHS1 PHS1 PTGHS |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] |
decreases reaction
/ increases activity / increases response to substance |
protein |
21163909
|
| D008694 | 5742 |
PTGS1
COX1 COX3 PCOX1 PES-1 PGG/HS PGHS-1 PGHS1 PHS1 PTGHS |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | Aspirin inhibits the reaction [PTGS1 protein results in increased susceptibility to Methamphetamine] |
decreases reaction
/ increases response to substance |
protein |
21163909
|
| D008694 | 5742 |
PTGS1
COX1 COX3 PCOX1 PES-1 PGG/HS PGHS-1 PGHS1 PHS1 PTGHS |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | PTGS1 protein results in increased susceptibility to Methamphetamine |
increases response to substance
|
protein |
21163909
|
| D008694 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | [Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine |
increases activity
/ increases response to substance |
protein |
21163909
|
| D008694 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-oxo-7-hydrodeoxyguanosine |
increases abundance
/ increases activity / increases response to substance |
protein |
21163909
|
| D008694 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] |
decreases reaction
/ increases activity / increases response to substance |
protein |
21163909
|
| D008694 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | Aspirin inhibits the reaction [PTGS2 protein results in increased susceptibility to Methamphetamine] |
decreases reaction
/ increases response to substance |
protein |
21163909
|
| D008694 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | PTGS2 protein results in increased susceptibility to Methamphetamine |
increases response to substance
|
protein |
21163909
|
| D008694 | 22913 |
RALY
HNRPCL2 P542 |
RALY heterogeneous nuclear ribonucleoprotein | RALY gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 9771 |
RAPGEF5
GFR MR-GEF REPAC |
Rap guanine nucleotide exchange factor (GEF) 5 | RAPGEF5 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 26575 |
RGS17
RGS-17 RGSZ2 hRGS17 |
regulator of G-protein signaling 17 | RGS17 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 5104 |
SERPINA5
PAI-3 PAI3 PCI PCI-B PLANH3 PROCI |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | SERPINA5 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 137868 |
SGCZ
ZSG1 |
sarcoglycan, zeta | SGCZ gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 344558 |
SH3RF3
POSH2 SH3MD4 |
SH3 domain containing ring finger 3 | SH3RF3 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 6571 |
SLC18A2
SVAT SVMT VAT2 VMAT2 |
solute carrier family 18 (vesicular monoamine transporter), member 2 | Methamphetamine results in decreased expression of SLC18A2 protein |
decreases expression
|
protein |
16518646
16622715 |
| D008694 | 6518 |
SLC2A5
GLUT-5 GLUT5 |
solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | Methamphetamine results in increased expression of SLC2A5 protein |
increases expression
|
protein |
20110187
|
| D008694 | 6530 |
SLC6A2
NAT1 NET NET1 SLC6A5 |
solute carrier family 6 (neurotransmitter transporter), member 2 | Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 6530 |
SLC6A2
NAT1 NET NET1 SLC6A5 |
solute carrier family 6 (neurotransmitter transporter), member 2 | indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 6530 |
SLC6A2
NAT1 NET NET1 SLC6A5 |
solute carrier family 6 (neurotransmitter transporter), member 2 | SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein] |
increases activity
/ increases reaction |
protein |
17234900
|
| D008694 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Methamphetamine results in decreased activity of SLC6A3 protein |
decreases activity
|
protein |
16842981
|
| D008694 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Methamphetamine results in decreased expression of SLC6A3 protein |
decreases expression
|
protein |
9763484
12944350 15542729 16518646 16622715 17992686 |
| D008694 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | SLC6A3 3' UTR polymorphism results in increased susceptibility to Methamphetamine |
increases response to substance
|
3' UTR |
12931138
|
| D008694 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | SLC6A3 protein affects the abundance of Methamphetamine |
affects abundance
|
protein |
11027249
|
| D008694 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein] |
increases activity
/ increases reaction |
protein |
17234900
|
| D008694 | 6532 |
SLC6A4
5-HTT 5-HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT |
solute carrier family 6 (neurotransmitter transporter), member 4 | Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 6532 |
SLC6A4
5-HTT 5-HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT |
solute carrier family 6 (neurotransmitter transporter), member 4 | indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 6532 |
SLC6A4
5-HTT 5-HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT |
solute carrier family 6 (neurotransmitter transporter), member 4 | Methamphetamine results in decreased expression of SLC6A4 protein |
decreases expression
|
protein |
16389202
18841348 |
| D008694 | 6532 |
SLC6A4
5-HTT 5-HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT |
solute carrier family 6 (neurotransmitter transporter), member 4 | SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein] |
increases activity
/ increases reaction |
protein |
17234900
|
| D008694 | 6536 |
SLC6A9
GLYT1 |
solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | SLC6A9 gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
17582620
|
| D008694 | 64754 |
SMYD3
KMT3E ZMYND1 ZNFN3A1 bA74P14.1 |
SET and MYND domain containing 3 (EC:2.1.1.43) | SMYD3 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 6622 |
SNCA
NACP PARK1 PARK4 PD1 |
synuclein, alpha (non A4 component of amyloid precursor) | SNCA gene SNP results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
15542733
|
| D008694 | 6647 |
SOD1
ALS ALS1 IPOA SOD hSod1 homodimer |
superoxide dismutase 1, soluble (EC:1.15.1.1) | Methamphetamine results in increased activity of SOD1 protein |
increases activity
|
protein |
15189342
|
| D008694 | 6647 |
SOD1
ALS ALS1 IPOA SOD hSod1 homodimer |
superoxide dismutase 1, soluble (EC:1.15.1.1) | SOD1 protein affects the susceptibility to Methamphetamine |
affects response to substance
|
protein |
7505315
7530424 |
| D008694 | 6648 |
SOD2
IPOB MNSOD MVCD6 |
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) | SOD2 gene polymorphism results in increased susceptibility to Methamphetamine |
increases response to substance
|
gene |
16807759
|
| D008694 | 6855 |
SYP
MRXSYP |
synaptophysin | Methamphetamine results in decreased expression of SYP protein |
decreases expression
|
protein |
14657756
|
| D008694 | 134864 |
TAAR1
RP11-295F4.9 TA1 TAR1 TRAR1 |
trace amine associated receptor 1 | Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 134864 |
TAAR1
RP11-295F4.9 TA1 TAR1 TRAR1 |
trace amine associated receptor 1 | Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 134864 |
TAAR1
RP11-295F4.9 TA1 TAR1 TRAR1 |
trace amine associated receptor 1 | indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 134864 |
TAAR1
RP11-295F4.9 TA1 TAR1 TRAR1 |
trace amine associated receptor 1 | indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 134864 |
TAAR1
RP11-295F4.9 TA1 TAR1 TRAR1 |
trace amine associated receptor 1 | indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 134864 |
TAAR1
RP11-295F4.9 TA1 TAR1 TRAR1 |
trace amine associated receptor 1 | Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17234900
|
| D008694 | 134864 |
TAAR1
RP11-295F4.9 TA1 TAR1 TRAR1 |
trace amine associated receptor 1 | SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein] |
increases activity
/ increases reaction |
protein |
17234900
|
| D008694 | 134864 |
TAAR1
RP11-295F4.9 TA1 TAR1 TRAR1 |
trace amine associated receptor 1 | SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein] |
increases activity
/ increases reaction |
protein |
17234900
|
| D008694 | 134864 |
TAAR1
RP11-295F4.9 TA1 TAR1 TRAR1 |
trace amine associated receptor 1 | SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein] |
increases activity
/ increases reaction |
protein |
17234900
|
| D008694 | 7054 |
TH
DYT14 DYT5b TYH |
tyrosine hydroxylase (EC:1.14.16.2) | Methamphetamine results in decreased expression of TH protein |
decreases expression
|
protein |
16622715
|
| D008694 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Methamphetamine results in increased expression of TNF mRNA |
increases expression
|
mRNA |
11746378
|
| D008694 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | TNF protein inhibits the reaction [Methamphetamine results in decreased uptake of Dopamine] |
decreases reaction
/ decreases uptake |
protein |
14999072
|
| D008694 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | TNF protein inhibits the reaction [Methamphetamine results in increased secretion of Dopamine] |
decreases reaction
/ increases secretion |
protein |
14999072
|
| D008694 | 7137 |
TNNI3
CMD1FF CMD2A CMH7 RCM1 TNNC1 cTnI |
troponin I type 3 (cardiac) | Methamphetamine results in increased expression of TNNI3 protein |
increases expression
|
protein |
16338525
|
| D008694 | 80036 |
TRPM3
GON-2 LTRPC3 MLSN2 |
transient receptor potential cation channel, subfamily M, member 3 | TRPM3 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 84196 |
USP48
RAP1GA1 USP31 |
ubiquitin specific peptidase 48 (EC:3.4.19.12) | USP48 gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|
| D008694 | 79750 |
ZNF385D
ZNF659 |
zinc finger protein 385D | ZNF385D gene SNP affects the susceptibility to Methamphetamine |
affects response to substance
|
gene |
18316681
|