KCF-S cluster No. 5260 (2 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (2)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	2

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Cumulative family count

class name	count
Fabaceae	2

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (2)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00042226	Amphetamine	CHEMBL405 CHEMBL19393 CHEMBL612	D000661	10 / 7 / 4	32 / 144
C00042732	Methamphetamine / (+)-Methamphetamine	CHEMBL1201201 CHEMBL1927030	D008694	8 / 4 / 5	95 / 172

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O76082	Solute carrier family 22 member 5	Unclassified protein	C00042226 C00042732	1 / 2
Q96RJ0	Trace amine-associated receptor 1	Trace amine receptor	C00042226 C00042732	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00042226 C00042732	1 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00042226	1 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00042732	0 / 1
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00042226	0 / 0
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00042226	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00042226	1 / 1
P31645	Sodium-dependent serotonin transporter	Serotonin	C00042226	2 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00042732	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00042732	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00042732	0 / 1
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00042226	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00042226	1 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00042732	1 / 0

113 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
135	ADORA2A, A2aR, ADORA2, RDC8	adenosine A2a receptor	C00042226 C00042732
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00042226 C00042732
847	CAT	catalase (EC:1.11.1.6)	C00042226 C00042732
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00042226 C00042732
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00042226 C00042732
6531	SLC6A3, DAT, DAT1, PKDYS	solute carrier family 6 (neurotransmitter transporter), member 3	C00042226 C00042732
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00042226 C00042732
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00042226 C00042732
1813	DRD2, D2DR, D2R	dopamine receptor D2	C00042226 C00042732
6530	SLC6A2, NAT1, NET, NET1, SLC6A5	solute carrier family 6 (neurotransmitter transporter), member 2	C00042226 C00042732
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00042226 C00042732
2566	GABRG2, CAE2, ECA2, GEFSP3	gamma-aminobutyric acid (GABA) A receptor, gamma 2	C00042226 C00042732
2554	GABRA1, ECA4, EJM, EJM5	gamma-aminobutyric acid (GABA) A receptor, alpha 1	C00042226 C00042732
9568	GABBR2, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099	gamma-aminobutyric acid (GABA) B receptor, 2	C00042226 C00042732
9463	PICK1, PICK, PRKCABP	protein interacting with PRKCA 1	C00042732
2355	FOSL2, FRA2	FOS-like antigen 2	C00042226
2354	FOSB, AP-1, G0S3, GOS3, GOSB	FBJ murine osteosarcoma viral oncogene homolog B	C00042226
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00042226
2166	FAAH, FAAH-1, PSAB	fatty acid amide hydrolase (EC:3.5.1.99)	C00042226
2670	GFAP	glial fibrillary acidic protein	C00042226
692548			C00042226
2152	F3, CD142, TF, TFA	coagulation factor III (thromboplastin, tissue factor)	C00042226
3726	JUNB, AP-1	jun B proto-oncogene	C00042226
3727	JUND, AP-1	jun D proto-oncogene	C00042226
4129	MAOB	monoamine oxidase B (EC:1.4.3.4)	C00042226
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00042226
5179	PENK	proenkephalin	C00042226
2147	F2, PT, RPRGL2, THPH1	coagulation factor II (thrombin) (EC:3.4.21.5)	C00042226
1555	CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450	cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1)	C00042226
1454	CSNK1E, CKIepsilon, HCKIE	casein kinase 1, epsilon (EC:2.7.11.1)	C00042226
7035	TFPI, EPI, LACI, TFI, TFPI1	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	C00042226
250	ALPP, ALP, PALP, PLAP, PLAP-1	alkaline phosphatase, placental (EC:3.1.3.1)	C00042226
23305	ACSL6, ACS2, FACL6, LACS_6, LACS2, LACS5	acyl-CoA synthetase long-chain family member 6 (EC:6.2.1.3)	C00042732
26289	AK5, AK6	adenylate kinase 5 (EC:2.7.4.3 2.7.4.6)	C00042732
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00042732
313	AOAH	acyloxyacyl hydrolase (neutrophil) (EC:3.1.1.77)	C00042732
409	ARRB2, ARB2, ARR2, BARR2	arrestin, beta 2	C00042732
23245	ASTN2, bA67K19.1	astrotactin 2	C00042732
627	BDNF, ANON2, BULN2	brain-derived neurotrophic factor	C00042732
54535	CCHCR1, C6orf18, HCR, SBP	coiled-coil alpha-helical rod protein 1	C00042732
1604	CD55, CR, CROM, DAF, TC	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	C00042732
1012	CDH13, CDHH, P105	cadherin 13 (EC:3.6.1.3)	C00042732
1061			C00042732
1103	CHAT, CHOACTASE, CMS1A, CMS1A2	choline O-acetyltransferase (EC:2.3.1.6)	C00042732
340267	COL28A1, COL28	collagen, type XXVIII, alpha 1	C00042732
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00042732
64478	CSMD1, PPP1R24	CUB and Sushi multiple domains 1	C00042732
8029	CUBN, IFCR, MGA1, gp280	cubilin (intrinsic factor-cobalamin receptor)	C00042732
171522			C00042732
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00042732
81501	DCSTAMP, FIND, TM7SF4, hDC-STAMP	dendrocyte expressed seven transmembrane protein	C00042732
1812	DRD1, DADR, DRD1A	dopamine receptor D1	C00042732
1814	DRD3, D3DR, ETM1, FET1	dopamine receptor D3	C00042732
1815	DRD4, D4DR	dopamine receptor D4	C00042732
1978	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	C00042732
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00042732
2272	FHIT, AP3Aase, FRA3B	fragile histidine triad (EC:3.6.1.29)	C00042732
23307	FKBP15, FKBP133, KIAA0674, PPP1R76	FK506 binding protein 15, 133kDa (EC:5.2.1.8)	C00042732
2912	GRM2, GLUR2, GPRC1B, MGLUR2, mGlu2	glutamate receptor, metabotropic 2	C00042732
2944	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	C00042732
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00042732
2952	GSTT1	glutathione S-transferase theta 1 (EC:2.5.1.18)	C00042732
9951	HS3ST4, 3-OST-4, 30ST4, 3OST4, h3-OST-4	heparan sulfate (glucosamine) 3-O-sulfotransferase 4 (EC:2.8.2.23)	C00042732
3350	HTR1A, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	C00042732
3362	HTR6, 5-HT6, 5-HT6R	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	C00042732
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00042732
9215	LARGE, MDC1D, MDDGA6, MDDGB6	like-glycosyltransferase	C00042732
158038	LINGO2, LERN3, LRRN6C	leucine rich repeat and Ig domain containing 2	C00042732
5607	MAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5	mitogen-activated protein kinase kinase 5 (EC:2.7.12.2)	C00042732
64757	MARC1, MOSC1	mitochondrial amidoxime reducing component 1	C00042732
54996	MARC2, MOSC2, RP11-270A6.1	mitochondrial amidoxime reducing component 2	C00042732
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00042732
4502	MT2A, MT2	metallothionein 2A	C00042732
2475	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1	mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)	C00042732
4645	MYO5B	myosin VB	C00042732
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00042732
4886	NPY1R, NPY1-R, NPYR	neuropeptide Y receptor Y1	C00042732
3084	NRG1, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, NDF, SMDF	neuregulin 1	C00042732
4988	OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM	opioid receptor, mu 1	C00042732
26577	PCOLCE2, PCPE2	procollagen C-endopeptidase enhancer 2	C00042732
5142	PDE4B, DPDE4, PDE4B5, PDEIVB	phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)	C00042732
5144	PDE4D, ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1	phosphodiesterase 4D, cAMP-specific (EC:3.1.4.17)	C00042732
5146	PDE6C, ACHM5, COD4, PDEA2	phosphodiesterase 6C, cGMP-specific, cone, alpha prime (EC:3.1.4.35)	C00042732
5173	PDYN, ADCA, PENKB, SCA23	prodynorphin	C00042732
8061	FOSL1, FRA, FRA1, fra-1	FOS-like antigen 1	C00042226
5460	POU5F1, OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4	POU class 5 homeobox 1	C00042732
7799	PRDM2, HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2	PR domain containing 2, with ZNF domain (EC:2.1.1.43)	C00042732
5592	PRKG1, 1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK_1, cGK1, cGKI, cGKI-BETA, cGKI-alpha	protein kinase, cGMP-dependent, type I (EC:2.7.11.12)	C00042732
5617	PRL	prolactin	C00042732
128674	PROKR2, GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3	prokineticin receptor 2	C00042732
23362	PSD3, EFA6R, HCA67	pleckstrin and Sec7 domain containing 3	C00042732
5742	PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00042732
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00042732
22913	RALY, HNRPCL2, P542	RALY heterogeneous nuclear ribonucleoprotein	C00042732
9771	RAPGEF5, GFR, MR-GEF, REPAC	Rap guanine nucleotide exchange factor (GEF) 5	C00042732
26575	RGS17, RGS-17, RGSZ2, hRGS17	regulator of G-protein signaling 17	C00042732
5104	SERPINA5, PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	C00042732
137868	SGCZ, ZSG1	sarcoglycan, zeta	C00042732
344558	SH3RF3, POSH2, SH3MD4	SH3 domain containing ring finger 3	C00042732
6571	SLC18A2, SVAT, SVMT, VAT2, VMAT2	solute carrier family 18 (vesicular monoamine transporter), member 2	C00042732
6518	SLC2A5, GLUT-5, GLUT5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	C00042732
6532	SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT	solute carrier family 6 (neurotransmitter transporter), member 4	C00042732
6536	SLC6A9, GLYT1	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	C00042732
64754	SMYD3, KMT3E, ZMYND1, ZNFN3A1, bA74P14.1	SET and MYND domain containing 3 (EC:2.1.1.43)	C00042732
6622	SNCA, NACP, PARK1, PARK4, PD1	synuclein, alpha (non A4 component of amyloid precursor)	C00042732
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00042732
6855	SYP, MRXSYP	synaptophysin	C00042732
134864	TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1	trace amine associated receptor 1	C00042732
7054	TH, DYT14, DYT5b, TYH	tyrosine hydroxylase (EC:1.14.16.2)	C00042732
7137	TNNI3, CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI	troponin I type 3 (cardiac)	C00042732
80036	TRPM3, GON-2, LTRPC3, MLSN2	transient receptor potential cation channel, subfamily M, member 3	C00042732
84196	USP48, RAP1GA1, USP31	ubiquitin specific peptidase 48 (EC:3.4.19.12)	C00042732
79750	ZNF385D, ZNF659	zinc finger protein 385D	C00042732

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions