Metabolite

KNApSAcK Entry

id C00048188
Name Taurine
CAS RN 107-35-7
Standard InChI InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)
Standard InChI (Main Layer) InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)

Cluster

Phytochemical cluster
KCF-S cluster No. 3630

Link

ChEMBL

By standard InChI CHEMBL239243
By standard InChI Main Layer CHEMBL239243

KEGG

By LinkDB C00245

CTD

By CAS RN D013654

Species

Summary

Plant class

class name count

Family

family name count
Axinellidae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Axinella polypoides 12959 Axinellidae Metazoa

Human Protein / Gene in interaction

14 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL239243 CHEMBL1741321 (1)
1 / 0
P04062 Glucosylceramidase Enzyme CHEMBL239243 CHEMBL1613818 (1)
6 / 4
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL239243 CHEMBL1794524 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL239243 CHEMBL1614544 (1)
11 / 10
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL239243 CHEMBL1741325 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL239243 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL239243 CHEMBL1741322 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL239243 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL239243 CHEMBL1741324 (1)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL239243 CHEMBL1614211 (1)
0 / 0
Q7Z2H8 Proton-coupled amino acid transporter 1 Unclassified protein CHEMBL239243 CHEMBL1919336 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL239243 CHEMBL2114890 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL239243 CHEMBL1794536 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL239243 CHEMBL2354311 (1)
1 / 0

CTD interaction (57)

compound gene gene name gene description interaction interaction type form reference
pmid
D013654 27 ABL2
ABLL
ARG
c-abl oncogene 2, non-receptor tyrosine kinase (EC:2.7.10.2) Taurine results in increased expression of ABL2 mRNA increases expression
mRNA 16579726
D013654 55803 ADAP2
CENTA2
HSA272195
cent-b
ArfGAP with dual PH domains 2 Taurine results in increased expression of ADAP2 mRNA increases expression
mRNA 16579726
D013654 135 ADORA2A
A2aR
ADORA2
RDC8
adenosine A2a receptor Taurine results in decreased expression of ADORA2A mRNA decreases expression
mRNA 16579726
D013654 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B Taurine results in increased expression of ADRA1B mRNA increases expression
mRNA 16579726
D013654 637 BID
FP497
BH3 interacting domain death agonist Taurine results in decreased expression of BID mRNA decreases expression
mRNA 16579726
D013654 659 BMPR2
BMPR-II
BMPR3
BMR2
BRK-3
PPH1
T-ALK
bone morphogenetic protein receptor, type II (serine/threonine kinase) (EC:2.7.11.30) Taurine results in decreased expression of BMPR2 mRNA decreases expression
mRNA 16579726
D013654 10486 CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast) Taurine results in decreased expression of CAP2 mRNA decreases expression
mRNA 16579726
D013654 10486 CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast) Taurine results in increased expression of CAP2 mRNA increases expression
mRNA 16579726
D013654 1081 CGA
CG-ALPHA
FSHA
GPHA1
GPHa
HCG
LHA
TSHA
glycoprotein hormones, alpha polypeptide Taurine results in increased expression of CGA mRNA increases expression
mRNA 16579726
D013654 1123 CHN1
ARHGAP2
CHN
DURS2
NC
RHOGAP2
chimerin 1 Taurine results in decreased expression of CHN1 mRNA decreases expression
mRNA 16579726
D013654 9318 COPS2
ALIEN
CSN2
SGN2
TRIP15
COP9 signalosome subunit 2 Taurine results in increased expression of COPS2 mRNA increases expression
mRNA 16579726
D013654 2833 CXCR3
CD182
CD183
CKR-L2
CMKAR3
GPR9
IP10-R
Mig-R
MigR
chemokine (C-X-C motif) receptor 3 Taurine results in decreased expression of CXCR3 mRNA decreases expression
mRNA 16579726
D013654 23576 DDAH1
DDAH
dimethylarginine dimethylaminohydrolase 1 (EC:3.5.3.18) Taurine results in decreased expression of DDAH1 mRNA decreases expression
mRNA 16579726
D013654 8525 DGKZ
DAGK5
DAGK6
DGK-ZETA
hDGKzeta
diacylglycerol kinase, zeta (EC:2.7.1.107) Taurine results in increased expression of DGKZ mRNA increases expression
mRNA 16579726
D013654 9538 EI24
EPG4
PIG8
TP53I8
etoposide induced 2.4 Taurine results in increased expression of EI24 mRNA increases expression
mRNA 16579726
D013654 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor FAS protein results in increased secretion of Taurine increases secretion
protein 10864002
D013654 2260 FGFR1
BFGFR
CD331
CEK
FGFBR
FGFR-1
FLG
FLT-2
FLT2
HBGFR
HH2
HRTFDS
KAL2
N-SAM
OGD
bFGF-R-1
fibroblast growth factor receptor 1 (EC:2.7.10.1) Taurine results in decreased expression of FGFR1 mRNA decreases expression
mRNA 16579726
D013654 2741 GLRA1
HKPX1
STHE
glycine receptor, alpha 1 Taurine binds to and results in increased activity of GLRA1 protein affects binding
/ increases activity
protein 15081878
D013654 2917 GRM7
GLUR7
GPRC1G
MGLU7
MGLUR7
glutamate receptor, metabotropic 7 Taurine results in decreased expression of GRM7 mRNA decreases expression
mRNA 16579726
D013654 2982 GUCY1A3
GC-SA3
GUC1A3
GUCA3
GUCSA3
GUCY1A1
guanylate cyclase 1, soluble, alpha 3 (EC:4.6.1.2) Taurine results in decreased expression of GUCY1A3 mRNA decreases expression
mRNA 16579726
D013654 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 Taurine results in decreased expression of HMGB1 mRNA decreases expression
mRNA 16579726
D013654 3486 IGFBP3
BP-53
IBP3
insulin-like growth factor binding protein 3 Taurine results in decreased expression of IGFBP3 mRNA decreases expression
mRNA 16579726
D013654 889 KRIT1
CAM
CCM1
KRIT1, ankyrin repeat containing Taurine results in increased expression of KRIT1 mRNA increases expression
mRNA 16579726
D013654 10314 LANCL1
GPR69A
p40
LanC lantibiotic synthetase component C-like 1 (bacterial) Taurine results in increased expression of LANCL1 mRNA increases expression
mRNA 16579726
D013654 4067 LYN
JTK8
p53Lyn
p56Lyn
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) Taurine results in decreased expression of LYN mRNA decreases expression
mRNA 16579726
D013654 64231 MS4A6A
4SPAN3
4SPAN3.2
CD20L3
MS4A6
MST090
MSTP090
membrane-spanning 4-domains, subfamily A, member 6A Taurine results in decreased expression of MS4A6A mRNA decreases expression
mRNA 16579726
D013654 81285 OR51E2
OR51E3P
OR52A2
PSGR
olfactory receptor, family 51, subfamily E, member 2 Taurine results in decreased expression of OR51E2 mRNA decreases expression
mRNA 16579726
D013654 55824 PAG1
CBP
PAG
phosphoprotein associated with glycosphingolipid microdomains 1 Taurine results in decreased expression of PAG1 mRNA decreases expression
mRNA 16579726
D013654 10298 PAK4
p21 protein (Cdc42/Rac)-activated kinase 4 (EC:2.7.11.1) Taurine results in decreased expression of PAK4 mRNA decreases expression
mRNA 16579726
D013654 5423 POLB
polymerase (DNA directed), beta (EC:2.7.7.7) Taurine results in increased expression of POLB mRNA increases expression
mRNA 16579726
D013654 5424 POLD1
CDC2
CRCS10
MDPL
POLD
polymerase (DNA directed), delta 1, catalytic subunit (EC:2.7.7.7) Taurine results in increased expression of POLD1 mRNA increases expression
mRNA 16579726
D013654 27434 POLM
Pol_Mu
Tdt-N
polymerase (DNA directed), mu (EC:2.7.7.7) Taurine results in increased expression of POLM mRNA increases expression
mRNA 16579726
D013654 26051 PPP1R16B
ANKRD4
TIMAP
protein phosphatase 1, regulatory subunit 16B Taurine results in increased expression of PPP1R16B mRNA increases expression
mRNA 16579726
D013654 5529 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform Taurine results in decreased expression of PPP2R5E mRNA decreases expression
mRNA 16579726
D013654 5577 PRKAR2B
PRKAR2
RII-BETA
protein kinase, cAMP-dependent, regulatory, type II, beta (EC:2.7.11.1) Taurine results in decreased expression of PRKAR2B mRNA decreases expression
mRNA 16579726
D013654 5664 PSEN2
AD3L
AD4
CMD1V
PS2
STM2
presenilin 2 (Alzheimer disease 4) Taurine results in decreased expression of PSEN2 mRNA decreases expression
mRNA 16579726
D013654 5796 PTPRK
R-PTP-kappa
protein tyrosine phosphatase, receptor type, K (EC:3.1.3.48) Taurine results in decreased expression of PTPRK mRNA decreases expression
mRNA 16579726
D013654 5868 RAB5A
RAB5
RAB5A, member RAS oncogene family Taurine results in decreased expression of RAB5A mRNA decreases expression
mRNA 16579726
D013654 5889 RAD51C
BROVCA3
FANCO
R51H3
RAD51L2
RAD51 paralog C Taurine results in increased expression of RAD51C mRNA increases expression
mRNA 16579726
D013654 5883 RAD9A
RAD9
RAD9 homolog A (S. pombe) (EC:3.1.11.2) Taurine results in increased expression of RAD9A mRNA increases expression
mRNA 16579726
D013654 9693 RAPGEF2
CNrasGEF
NRAPGEP
PDZ-GEF1
PDZGEF1
RA-GEF
RA-GEF-1
Rap-GEP
nRap_GEP
Rap guanine nucleotide exchange factor (GEF) 2 Taurine results in decreased expression of RAPGEF2 mRNA decreases expression
mRNA 16579726
D013654 10125 RASGRP1
CALDAG-GEFI
CALDAG-GEFII
RASGRP
V
hRasGRP1
RAS guanyl releasing protein 1 (calcium and DAG-regulated) Taurine results in increased expression of RASGRP1 mRNA increases expression
mRNA 16579726
D013654 6196 RPS6KA2
HU-2
MAPKAPK1C
RSK
RSK3
S6K-alpha
S6K-alpha2
p90-RSK3
pp90RSK3
ribosomal protein S6 kinase, 90kDa, polypeptide 2 (EC:2.7.11.1) Taurine results in increased expression of RPS6KA2 mRNA increases expression
mRNA 16579726
D013654 6447 SCG5
7B2
P7B2
SGNE1
SgV
secretogranin V (7B2 protein) Taurine results in increased expression of SCG5 mRNA increases expression
mRNA 16579726
D013654 9126 SMC3
BAM
BMH
CDLS3
CSPG6
HCAP
SMC3L1
structural maintenance of chromosomes 3 Taurine results in increased expression of SMC3 mRNA increases expression
mRNA 16579726
D013654 10302 SNAPC5
SNAP19
small nuclear RNA activating complex, polypeptide 5, 19kDa Taurine results in increased expression of SNAPC5 mRNA increases expression
mRNA 16579726
D013654 10253 SPRY2
hSPRY2
sprouty homolog 2 (Drosophila) Taurine results in increased expression of SPRY2 mRNA increases expression
mRNA 16579726
D013654 6729 SRP54
signal recognition particle 54kDa Taurine results in decreased expression of SRP54 mRNA decreases expression
mRNA 16579726
D013654 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Taurine results in decreased expression of STAT3 mRNA decreases expression
mRNA 16579726
D013654 6869 TACR1
NK1R
NKIR
SPR
TAC1R
tachykinin receptor 1 Taurine results in decreased expression of TACR1 mRNA decreases expression
mRNA 16579726
D013654 7010 TEK
CD202B
TIE-2
TIE2
VMCM
VMCM1
TEK tyrosine kinase, endothelial (EC:2.7.10.1) Taurine results in increased expression of TEK mRNA increases expression
mRNA 16579726
D013654 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 Taurine inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 mRNA] decreases reaction
/ increases expression
mRNA 19337903
D013654 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 Taurine inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein] decreases reaction
/ increases expression
protein 19337903
D013654 9540 TP53I3
PIG3
tumor protein p53 inducible protein 3 Taurine results in decreased expression of TP53I3 mRNA decreases expression
mRNA 16579726
D013654 7297 TYK2
JTK1
tyrosine kinase 2 (EC:2.7.10.2) Taurine results in decreased expression of TYK2 mRNA decreases expression
mRNA 16579726
D013654 7415 VCP
ALS14
IBMPFD
IBMPFD1
TERA
p97
valosin containing protein (EC:3.6.4.6) Taurine results in decreased expression of VCP mRNA decreases expression
mRNA 16579726
D013654 7518 XRCC4
X-ray repair complementing defective repair in Chinese hamster cells 4 Taurine results in increased expression of XRCC4 mRNA increases expression
mRNA 16579726

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#168600 Parkinson disease, late-onset; pd P04062
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (19)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)

Diseases related to CTD interactions

38 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D055371 D013654 Acute Lung Injury therapeutic
19362168
D000860 D013654 Anoxia therapeutic
2501810
D001145 D013654 Arrhythmias, Cardiac therapeutic
125678
D001919 D013654 Bradycardia marker/mechanism
1451572
6621821
D009202 D013654 Cardiomyopathies therapeutic
15231041
D003329 D013654 Coronary Vasospasm marker/mechanism
19120009
D003921 D013654 Diabetes Mellitus, Experimental therapeutic
22138235
D003922 D013654 Diabetes Mellitus, Type 1 therapeutic
22138235
D058065 D013654 Diabetic Cardiomyopathies therapeutic
16025228
22138235
D003928 D013654 Diabetic Nephropathies therapeutic
7573492
D056486 D013654 Drug-Induced Liver Injury therapeutic
9328219
20166895
20830294
D050171 D013654 Dyslipidemias therapeutic
22138235
D004487 D013654 Edema therapeutic
15743398
D019446 D013654 Endotoxemia therapeutic
20056113
D005198 D013654 Fanconi Syndrome therapeutic
10063969
D005355 D013654 Fibrosis therapeutic
19362168
D005923 D013654 Glomerulosclerosis, Focal Segmental therapeutic
1733287
D006323 D013654 Heart Arrest marker/mechanism
19120009
D006331 D013654 Heart Diseases therapeutic
18561905
19616567
D006470 D013654 Hemorrhage therapeutic
15743398
D006943 D013654 Hyperglycemia therapeutic
22138235
D017495 D013654 Hyperpigmentation therapeutic
20804622
D006973 D013654 Hypertension therapeutic
20360751
D006984 D013654 Hypertrophy therapeutic
19553346
D007022 D013654 Hypotension marker/mechanism
1451572
6621821
D007249 D013654 Inflammation therapeutic
21470069
D007674 D013654 Kidney Diseases therapeutic
17698946
18414974
20067817
D007859 D013654 Learning Disorders therapeutic
2501810
D008106 D013654 Liver Cirrhosis, Experimental therapeutic
15893842
15931870
D009069 D013654 Movement Disorders marker/mechanism
2727012
D009133 D013654 Muscular Atrophy therapeutic
16318624
D009203 D013654 Myocardial Infarction marker/mechanism
therapeutic
16259760
19120009
D009336 D013654 Necrosis therapeutic
20166895
D009845 D013654 Oligospermia therapeutic
19429265
20498001
D011014 D013654 Pneumonia marker/mechanism
19362168
D011507 D013654 Proteinuria therapeutic
20360751
D012640 D013654 Seizures marker/mechanism
therapeutic
1276935
2501810
11140358
17728537
D013733 D013654 Testicular Diseases therapeutic
19429265