| id | C00048188 | 
|---|---|
| Name | Taurine | 
| CAS RN | 107-35-7 | 
| Standard InChI | InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) | 
| Standard InChI (Main Layer) | InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) | 
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 3630 | 
| By standard InChI | CHEMBL239243 | 
|---|---|
| By standard InChI Main Layer | CHEMBL239243 | 
| By LinkDB | C00245 | 
|---|
| By CAS RN | D013654 | 
|---|
| class name | count | 
|---|
| family name | count | 
|---|---|
| Axinellidae | 1 | 
| KNApSAcK organism | *ID | *family | *plant class | *kingdom | 
|---|---|---|---|---|
| Axinella polypoides | 12959 | Axinellidae | Metazoa | 
| accession | description | class description | compound | assay ID (# of activities) | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL239243 | CHEMBL1741321
                        (1) | 1 / 0 | 
| P04062 | Glucosylceramidase | Enzyme | CHEMBL239243 | CHEMBL1613818
                        (1) | 6 / 4 | 
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL239243 | CHEMBL1794524
                        (1) | 0 / 0 | 
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL239243 | CHEMBL1614544
                        (1) | 11 / 10 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL239243 | CHEMBL1741325
                        (1) | 0 / 1 | 
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL239243 | CHEMBL1614522
                        (1)
                        CHEMBL1614067
                        (1) | 1 / 2 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL239243 | CHEMBL1741322
                        (1) | 0 / 0 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL239243 | CHEMBL1613777
                        (1)
                        CHEMBL1741323
                        (1) | 1 / 1 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL239243 | CHEMBL1741324
                        (1) | 0 / 1 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL239243 | CHEMBL1614211
                        (1) | 0 / 0 | 
| Q7Z2H8 | Proton-coupled amino acid transporter 1 | Unclassified protein | CHEMBL239243 | CHEMBL1919336
                        (2) | 0 / 0 | 
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL239243 | CHEMBL2114890
                        (1) | 0 / 0 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL239243 | CHEMBL1794536
                        (1) | 0 / 0 | 
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL239243 | CHEMBL2354311
                        (1) | 1 / 0 | 
| compound | gene | gene name | gene description | interaction | interaction type | form | reference pmid | 
|---|---|---|---|---|---|---|---|
| D013654 | 27 | ABL2 ABLL ARG | c-abl oncogene 2, non-receptor tyrosine kinase (EC:2.7.10.2) | Taurine results in increased expression of ABL2 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 55803 | ADAP2 CENTA2 HSA272195 cent-b | ArfGAP with dual PH domains 2 | Taurine results in increased expression of ADAP2 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 135 | ADORA2A A2aR ADORA2 RDC8 | adenosine A2a receptor | Taurine results in decreased expression of ADORA2A mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 147 | ADRA1B ADRA1 ALPHA1BAR | adrenoceptor alpha 1B | Taurine results in increased expression of ADRA1B mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 637 | BID FP497 | BH3 interacting domain death agonist | Taurine results in decreased expression of BID mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 659 | BMPR2 BMPR-II BMPR3 BMR2 BRK-3 PPH1 T-ALK | bone morphogenetic protein receptor, type II (serine/threonine kinase) (EC:2.7.11.30) | Taurine results in decreased expression of BMPR2 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 10486 | CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | Taurine results in decreased expression of CAP2 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 10486 | CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | Taurine results in increased expression of CAP2 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 1081 | CGA CG-ALPHA FSHA GPHA1 GPHa HCG LHA TSHA | glycoprotein hormones, alpha polypeptide | Taurine results in increased expression of CGA mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 1123 | CHN1 ARHGAP2 CHN DURS2 NC RHOGAP2 | chimerin 1 | Taurine results in decreased expression of CHN1 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 9318 | COPS2 ALIEN CSN2 SGN2 TRIP15 | COP9 signalosome subunit 2 | Taurine results in increased expression of COPS2 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 2833 | CXCR3 CD182 CD183 CKR-L2 CMKAR3 GPR9 IP10-R Mig-R MigR | chemokine (C-X-C motif) receptor 3 | Taurine results in decreased expression of CXCR3 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 23576 | DDAH1 DDAH | dimethylarginine dimethylaminohydrolase 1 (EC:3.5.3.18) | Taurine results in decreased expression of DDAH1 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 8525 | DGKZ DAGK5 DAGK6 DGK-ZETA hDGKzeta | diacylglycerol kinase, zeta (EC:2.7.1.107) | Taurine results in increased expression of DGKZ mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 9538 | EI24 EPG4 PIG8 TP53I8 | etoposide induced 2.4 | Taurine results in increased expression of EI24 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 355 | FAS ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6 | Fas cell surface death receptor | FAS protein results in increased secretion of Taurine | increases secretion | protein | 10864002 | 
| D013654 | 2260 | FGFR1 BFGFR CD331 CEK FGFBR FGFR-1 FLG FLT-2 FLT2 HBGFR HH2 HRTFDS KAL2 N-SAM OGD bFGF-R-1 | fibroblast growth factor receptor 1 (EC:2.7.10.1) | Taurine results in decreased expression of FGFR1 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 2741 | GLRA1 HKPX1 STHE | glycine receptor, alpha 1 | Taurine binds to and results in increased activity of GLRA1 protein | affects binding / increases activity | protein | 15081878 | 
| D013654 | 2917 | GRM7 GLUR7 GPRC1G MGLU7 MGLUR7 | glutamate receptor, metabotropic 7 | Taurine results in decreased expression of GRM7 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 2982 | GUCY1A3 GC-SA3 GUC1A3 GUCA3 GUCSA3 GUCY1A1 | guanylate cyclase 1, soluble, alpha 3 (EC:4.6.1.2) | Taurine results in decreased expression of GUCY1A3 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 3146 | HMGB1 HMG1 HMG3 SBP-1 | high mobility group box 1 | Taurine results in decreased expression of HMGB1 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 3486 | IGFBP3 BP-53 IBP3 | insulin-like growth factor binding protein 3 | Taurine results in decreased expression of IGFBP3 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 889 | KRIT1 CAM CCM1 | KRIT1, ankyrin repeat containing | Taurine results in increased expression of KRIT1 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 10314 | LANCL1 GPR69A p40 | LanC lantibiotic synthetase component C-like 1 (bacterial) | Taurine results in increased expression of LANCL1 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 4067 | LYN JTK8 p53Lyn p56Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) | Taurine results in decreased expression of LYN mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 64231 | MS4A6A 4SPAN3 4SPAN3.2 CD20L3 MS4A6 MST090 MSTP090 | membrane-spanning 4-domains, subfamily A, member 6A | Taurine results in decreased expression of MS4A6A mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 81285 | OR51E2 OR51E3P OR52A2 PSGR | olfactory receptor, family 51, subfamily E, member 2 | Taurine results in decreased expression of OR51E2 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 55824 | PAG1 CBP PAG | phosphoprotein associated with glycosphingolipid microdomains 1 | Taurine results in decreased expression of PAG1 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 10298 | PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 (EC:2.7.11.1) | Taurine results in decreased expression of PAK4 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 5423 | POLB | polymerase (DNA directed), beta (EC:2.7.7.7) | Taurine results in increased expression of POLB mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 5424 | POLD1 CDC2 CRCS10 MDPL POLD | polymerase (DNA directed), delta 1, catalytic subunit (EC:2.7.7.7) | Taurine results in increased expression of POLD1 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 27434 | POLM Pol_Mu Tdt-N | polymerase (DNA directed), mu (EC:2.7.7.7) | Taurine results in increased expression of POLM mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 26051 | PPP1R16B ANKRD4 TIMAP | protein phosphatase 1, regulatory subunit 16B | Taurine results in increased expression of PPP1R16B mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 5529 | PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | Taurine results in decreased expression of PPP2R5E mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 5577 | PRKAR2B PRKAR2 RII-BETA | protein kinase, cAMP-dependent, regulatory, type II, beta (EC:2.7.11.1) | Taurine results in decreased expression of PRKAR2B mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 5664 | PSEN2 AD3L AD4 CMD1V PS2 STM2 | presenilin 2 (Alzheimer disease 4) | Taurine results in decreased expression of PSEN2 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 5796 | PTPRK R-PTP-kappa | protein tyrosine phosphatase, receptor type, K (EC:3.1.3.48) | Taurine results in decreased expression of PTPRK mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 5868 | RAB5A RAB5 | RAB5A, member RAS oncogene family | Taurine results in decreased expression of RAB5A mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 5889 | RAD51C BROVCA3 FANCO R51H3 RAD51L2 | RAD51 paralog C | Taurine results in increased expression of RAD51C mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 5883 | RAD9A RAD9 | RAD9 homolog A (S. pombe) (EC:3.1.11.2) | Taurine results in increased expression of RAD9A mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 9693 | RAPGEF2 CNrasGEF NRAPGEP PDZ-GEF1 PDZGEF1 RA-GEF RA-GEF-1 Rap-GEP nRap_GEP | Rap guanine nucleotide exchange factor (GEF) 2 | Taurine results in decreased expression of RAPGEF2 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 10125 | RASGRP1 CALDAG-GEFI CALDAG-GEFII RASGRP V hRasGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | Taurine results in increased expression of RASGRP1 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 6196 | RPS6KA2 HU-2 MAPKAPK1C RSK RSK3 S6K-alpha S6K-alpha2 p90-RSK3 pp90RSK3 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 (EC:2.7.11.1) | Taurine results in increased expression of RPS6KA2 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 6447 | SCG5 7B2 P7B2 SGNE1 SgV | secretogranin V (7B2 protein) | Taurine results in increased expression of SCG5 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 9126 | SMC3 BAM BMH CDLS3 CSPG6 HCAP SMC3L1 | structural maintenance of chromosomes 3 | Taurine results in increased expression of SMC3 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 10302 | SNAPC5 SNAP19 | small nuclear RNA activating complex, polypeptide 5, 19kDa | Taurine results in increased expression of SNAPC5 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 10253 | SPRY2 hSPRY2 | sprouty homolog 2 (Drosophila) | Taurine results in increased expression of SPRY2 mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 6729 | SRP54 | signal recognition particle 54kDa | Taurine results in decreased expression of SRP54 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 6774 | STAT3 APRF HIES | signal transducer and activator of transcription 3 (acute-phase response factor) | Taurine results in decreased expression of STAT3 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 6869 | TACR1 NK1R NKIR SPR TAC1R | tachykinin receptor 1 | Taurine results in decreased expression of TACR1 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 7010 | TEK CD202B TIE-2 TIE2 VMCM VMCM1 | TEK tyrosine kinase, endothelial (EC:2.7.10.1) | Taurine results in increased expression of TEK mRNA | increases expression | mRNA | 16579726 | 
| D013654 | 7040 | TGFB1 CED DPD1 LAP TGFB TGFbeta | transforming growth factor, beta 1 | Taurine inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 mRNA] | decreases reaction / increases expression | mRNA | 19337903 | 
| D013654 | 7040 | TGFB1 CED DPD1 LAP TGFB TGFbeta | transforming growth factor, beta 1 | Taurine inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein] | decreases reaction / increases expression | protein | 19337903 | 
| D013654 | 9540 | TP53I3 PIG3 | tumor protein p53 inducible protein 3 | Taurine results in decreased expression of TP53I3 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 7297 | TYK2 JTK1 | tyrosine kinase 2 (EC:2.7.10.2) | Taurine results in decreased expression of TYK2 mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 7415 | VCP ALS14 IBMPFD IBMPFD1 TERA p97 | valosin containing protein (EC:3.6.4.6) | Taurine results in decreased expression of VCP mRNA | decreases expression | mRNA | 16579726 | 
| D013654 | 7518 | XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | Taurine results in increased expression of XRCC4 mRNA | increases expression | mRNA | 16579726 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #210900 | Bloom syndrome; blm | P54132 | 
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #608013 | Gaucher disease, perinatal lethal | P04062 | 
| #230800 | Gaucher disease, type i | P04062 | 
| #230900 | Gaucher disease, type ii | P04062 | 
| #231000 | Gaucher disease, type iii | P04062 | 
| #231005 | Gaucher disease, type iiic | P04062 | 
| #137800 | Glioma susceptibility 1; glm1 | O75874 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #168600 | Parkinson disease, late-onset; pd | P04062 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| KEGG | disease name | UniProt | 
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00066 | Lewy body dementia (LBD) | P04062
                            (related) | 
| H00126 | Gaucher disease | P04062
                            (related) | 
| H00426 | Defects in the degradation of ganglioside | P04062
                            (related) | 
| H00810 | Progressive myoclonic epilepsy (PME) | P04062
                            (related) | 
| H00036 | Osteosarcoma | P08684
                            (marker) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00094 | DNA repair defects | P54132
                            (related) | 
| H00296 | Defects in RecQ helicases | P54132
                            (related) | 
| MeSH disease | OMIM | compound | disease name | evidence type | reference pmid | 
|---|---|---|---|---|---|
| D055371 | D013654 | Acute Lung Injury | therapeutic | 19362168 | |
| D000860 | D013654 | Anoxia | therapeutic | 2501810 | |
| D001145 | D013654 | Arrhythmias, Cardiac | therapeutic | 125678 | |
| D001919 | D013654 | Bradycardia | marker/mechanism | 1451572 6621821 | |
| D009202 | D013654 | Cardiomyopathies | therapeutic | 15231041 | |
| D003329 | D013654 | Coronary Vasospasm | marker/mechanism | 19120009 | |
| D003921 | D013654 | Diabetes Mellitus, Experimental | therapeutic | 22138235 | |
| D003922 | D013654 | Diabetes Mellitus, Type 1 | therapeutic | 22138235 | |
| D058065 | D013654 | Diabetic Cardiomyopathies | therapeutic | 16025228 22138235 | |
| D003928 | D013654 | Diabetic Nephropathies | therapeutic | 7573492 | |
| D056486 | D013654 | Drug-Induced Liver Injury | therapeutic | 9328219 20166895 20830294 | |
| D050171 | D013654 | Dyslipidemias | therapeutic | 22138235 | |
| D004487 | D013654 | Edema | therapeutic | 15743398 | |
| D019446 | D013654 | Endotoxemia | therapeutic | 20056113 | |
| D005198 | D013654 | Fanconi Syndrome | therapeutic | 10063969 | |
| D005355 | D013654 | Fibrosis | therapeutic | 19362168 | |
| D005923 | D013654 | Glomerulosclerosis, Focal Segmental | therapeutic | 1733287 | |
| D006323 | D013654 | Heart Arrest | marker/mechanism | 19120009 | |
| D006331 | D013654 | Heart Diseases | therapeutic | 18561905 19616567 | |
| D006470 | D013654 | Hemorrhage | therapeutic | 15743398 | |
| D006943 | D013654 | Hyperglycemia | therapeutic | 22138235 | |
| D017495 | D013654 | Hyperpigmentation | therapeutic | 20804622 | |
| D006973 | D013654 | Hypertension | therapeutic | 20360751 | |
| D006984 | D013654 | Hypertrophy | therapeutic | 19553346 | |
| D007022 | D013654 | Hypotension | marker/mechanism | 1451572 6621821 | |
| D007249 | D013654 | Inflammation | therapeutic | 21470069 | |
| D007674 | D013654 | Kidney Diseases | therapeutic | 17698946 18414974 20067817 | |
| D007859 | D013654 | Learning Disorders | therapeutic | 2501810 | |
| D008106 | D013654 | Liver Cirrhosis, Experimental | therapeutic | 15893842 15931870 | |
| D009069 | D013654 | Movement Disorders | marker/mechanism | 2727012 | |
| D009133 | D013654 | Muscular Atrophy | therapeutic | 16318624 | |
| D009203 | D013654 | Myocardial Infarction | marker/mechanism therapeutic | 16259760 19120009 | |
| D009336 | D013654 | Necrosis | therapeutic | 20166895 | |
| D009845 | D013654 | Oligospermia | therapeutic | 19429265 20498001 | |
| D011014 | D013654 | Pneumonia | marker/mechanism | 19362168 | |
| D011507 | D013654 | Proteinuria | therapeutic | 20360751 | |
| D012640 | D013654 | Seizures | marker/mechanism therapeutic | 1276935 2501810 11140358 17728537 | |
| D013733 | D013654 | Testicular Diseases | therapeutic | 19429265 |