PCIDB

KNApSAcK Metabolite C00049230

Metabolite

KNApSAcK Entry

id C00049230
Name Mithramycin
CAS RN 18378-89-7
Standard InChI InChI=1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43-,44-,45+,49+,50+,51-,52+/m1/s1
Standard InChI (Main Layer) InChI=1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3

Cluster

Phytochemical cluster
KCF-S cluster No. 906

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL413720 CHEMBL255884 CHEMBL535101 CHEMBL1881779 CHEMBL2355736

KEGG

By LinkDB C12389

CTD

By CAS RN D008926

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces argillaceus ATCC12956 1883 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

4 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P39748 Flap endonuclease 1 Enzyme CHEMBL1881779 CHEMBL1794486 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1881779 CHEMBL1794584 (1)
2 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1881779 CHEMBL1794483 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1881779 CHEMBL1794536 (1)
0 / 0

CTD interaction (18)

compound gene gene name gene description interaction interaction type form reference
pmid
D008926 558 AXL
JTK11
UFO
AXL receptor tyrosine kinase (EC:2.7.10.1) Plicamycin results in decreased expression of AXL decreases expression
18522535
D008926 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] affects binding
/ decreases reaction
/ increases reaction
promoter 19593637
D008926 54541 DDIT4
Dig2
REDD-1
REDD1
DNA-damage-inducible transcript 4 [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA] decreases activity
/ decreases reaction
/ increases expression
mRNA 17307335
D008926 54541 DDIT4
Dig2
REDD-1
REDD1
DNA-damage-inducible transcript 4 [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein] decreases activity
/ decreases reaction
/ increases expression
protein 17307335
D008926 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] affects binding
/ decreases reaction
/ increases reaction
protein 19593637
D008926 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Plicamycin inhibits the reaction [Asbestos results in increased expression of F3 mRNA] decreases reaction
/ increases expression
mRNA 15636197
D008926 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Plicamycin results in decreased expression of F3 mRNA decreases expression
mRNA 15636197
D008926 3458 IFNG
IFG
IFI
interferon, gamma Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18953428
D008926 4128 MAOA
MAO-A
monoamine oxidase A (EC:1.4.3.4) Plicamycin inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA] decreases reaction
/ increases expression
mRNA 15946989
D008926 5320 PLA2G2A
MOM1
PLA2
PLA2B
PLA2L
PLA2S
PLAS1
sPLA2
phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18953428
D008926 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] decreases reaction
/ increases expression
mRNA 15690306
D008926 6667 SP1
Sp1 transcription factor Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter] affects binding
/ decreases reaction
protein 21603612
D008926 6667 SP1
Sp1 transcription factor [Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein affects binding
/ decreases reaction
/ increases expression
protein 21603612
D008926 6667 SP1
Sp1 transcription factor Plicamycin results in decreased activity of SP1 protein decreases activity
protein 15946989
D008926 6667 SP1
Sp1 transcription factor [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA] decreases activity
/ decreases reaction
/ increases expression
protein 17307335
D008926 6667 SP1
Sp1 transcription factor [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein] decreases activity
/ decreases reaction
/ increases expression
protein 17307335
D008926 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter] affects binding
/ decreases reaction
promoter 21603612
D008926 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 [Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein affects binding
/ decreases reaction
/ increases expression
promoter / protein 21603612

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#613795 Loeys-dietz syndrome, type 3; lds3 P84022

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D009202 D008926 Cardiomyopathies marker/mechanism
172214
D012208 D008926 Rhabdomyosarcoma therapeutic
857581