KNApSAcK Metabolite C00050239
Metabolite
KNApSAcK Entry
| id | C00050239 |
|---|---|
| Name | Sulforaphane |
| CAS RN | 4478-93-7 |
| Standard InChI | InChI=1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3 |
| Standard InChI (Main Layer) | InChI=1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2731 |
Link
ChEMBL
| By standard InChI | CHEMBL48802 |
|---|---|
| By standard InChI Main Layer | CHEMBL48802 CHEMBL128136 CHEMBL1627201 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C016766 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Brassica oleracea | 3712 | Brassicaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
5 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P15559 | NAD(P)H dehydrogenase [quinone] 1 | Enzyme | CHEMBL48802 |
CHEMBL1037606
(1)
CHEMBL1109136
(1)
CHEMBL1109137 (1) CHEMBL1109138 (1) CHEMBL1109139 (1) CHEMBL1175293 (1) CHEMBL1175421 (1) CHEMBL1175422 (1) |
0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL128136 |
CHEMBL1794311
(1)
|
2 / 3 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | CHEMBL48802 |
CHEMBL2075123
(1)
CHEMBL2075127
(1)
|
1 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL128136 |
CHEMBL1614211
(1)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL48802 |
CHEMBL1112689
(1)
CHEMBL1112690
(1)
CHEMBL1804605 (1) CHEMBL1804837 (1) |
0 / 0 |
CTD interaction (216)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C016766 | 1244 |
ABCC2
ABC30 CMOAT DJS MRP2 cMRP |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | sulforafan results in increased expression of ABCC2 mRNA |
increases expression
|
mRNA |
11264000
15896333 |
| C016766 | 1244 |
ABCC2
ABC30 CMOAT DJS MRP2 cMRP |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | sulforafan results in increased expression of ABCC2 protein |
increases expression
|
protein |
11264000
|
| C016766 | 59 |
ACTA2
AAT6 ACTSA MYMY5 |
actin, alpha 2, smooth muscle, aorta | ACTA2 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 60 |
ACTB
BRWS1 PS1TP5BP1 |
actin, beta | ACTB protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | sulforafan affects the reaction [anthracene affects the localization of AHR protein] |
affects localization
/ affects reaction |
protein |
19362136
|
| C016766 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | sulforafan inhibits the reaction [1,2,5,6-dibenzanthracene affects the localization of AHR protein] |
affects localization
/ decreases reaction |
protein |
19362136
|
| C016766 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | sulforafan inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein] |
affects localization
/ decreases reaction |
protein |
19202560
|
| C016766 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | sulforafan results in increased phosphorylation of and results in increased activity of AKT1 protein |
increases activity
/ increases phosphorylation |
protein |
15896333
|
| C016766 | 216 |
ALDH1A1
ALDC ALDH-E1 ALDH1 ALDH11 PUMB1 RALDH1 |
aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36) | ALDH1A1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 216 |
ALDH1A1
ALDC ALDH-E1 ALDH1 ALDH11 PUMB1 RALDH1 |
aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36) | sulforafan promotes the reaction [gemcitabine results in decreased expression of ALDH1A1 protein] |
decreases expression
/ increases reaction |
protein |
20940707
|
| C016766 | 216 |
ALDH1A1
ALDC ALDH-E1 ALDH1 ALDH11 PUMB1 RALDH1 |
aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36) | sulforafan results in decreased expression of ALDH1A1 protein |
decreases expression
|
protein |
20940707
|
| C016766 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulforafan results in decreased expression of AR protein] |
decreases expression
/ decreases reaction |
protein |
19805354
|
| C016766 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | HDAC6 protein inhibits the reaction [sulforafan results in decreased expression of AR protein] |
decreases expression
/ decreases reaction |
protein |
19805354
|
| C016766 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | sulforafan inhibits the reaction [AR protein binds to ERG enhancer] |
affects binding
/ decreases reaction |
protein |
19805354
|
| C016766 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | sulforafan inhibits the reaction [AR protein binds to KLK3 enhancer] |
affects binding
/ decreases reaction |
protein |
19805354
|
| C016766 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | sulforafan inhibits the reaction [HSP90AA1 protein binds to AR protein] |
affects binding
/ decreases reaction |
protein |
19805354
|
| C016766 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | sulforafan results in increased degradation of and results in decreased expression of and results in decreased activity of AR protein |
decreases activity
/ decreases expression / increases degradation |
protein |
19805354
|
| C016766 | 506 |
ATP5B
ATPMB ATPSB |
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (EC:3.6.3.14) | ATP5B protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | sulforafan results in increased expression of BAX protein |
increases expression
|
protein |
16033772
|
| C016766 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | [Eugenol results in increased activity of sulforafan] which results in decreased expression of BCL2 |
decreases expression
/ increases activity |
21382956
|
|
| C016766 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | sulforafan results in decreased expression of BCL2 protein |
decreases expression
|
protein |
16033772
|
| C016766 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | [sulforafan results in increased activity of Eugenol] which results in decreased expression of BCL2 |
decreases expression
/ increases activity |
21382956
|
|
| C016766 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | sulforafan results in decreased expression of BCL2L1 protein |
decreases expression
|
protein |
16033772
|
| C016766 | 826 |
CAPNS1
30K CALPAIN4 CANP CANPS CAPN4 CDPS CSS1 |
calpain, small subunit 1 (EC:3.4.22.17) | CAPNS1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | sulforafan inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
19780897
|
| C016766 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | sulforafan results in increased activity of CASP3 protein |
increases activity
|
protein |
16033772
|
| C016766 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | sulforafan inhibits the reaction [Oxidopamine results in increased activity of CASP9 protein] |
decreases reaction
/ increases activity |
protein |
19780897
|
| C016766 | 874 |
CBR3
SDR21C2 hCBR3 |
carbonyl reductase 3 (EC:1.1.1.184) | sulforafan results in increased expression of CBR3 mRNA |
increases expression
|
mRNA |
20806931
|
| C016766 | 891 |
CCNB1
CCNB |
cyclin B1 | sulforafan results in increased expression of CCNB1 protein |
increases expression
|
protein |
15231455
|
| C016766 | 10576 |
CCT2
99D8.1 CCT-beta CCTB PRO1633 TCP-1-beta |
chaperonin containing TCP1, subunit 2 (beta) | CCT2 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | sulforafan results in increased expression of CDKN1A mRNA |
increases expression
|
mRNA |
17937621
|
| C016766 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | sulforafan results in increased expression of CDKN1A protein |
increases expression
|
protein |
15231455
|
| C016766 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | NFE2L2 protein affects the reaction [sulforafan results in increased expression of CES1 mRNA alternative form] |
affects reaction
/ increases expression |
mRNA |
19715681
|
| C016766 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | sulforafan promotes the reaction [NFE2L2 protein binds to CES1 promoter] |
affects binding
/ increases reaction |
promoter |
19715681
|
| C016766 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | sulforafan promotes the reaction [[NFE2L2 protein binds to CES1 promoter] which results in increased expression of CES1 mRNA alternative form] |
affects binding
/ increases expression / increases reaction |
mRNA / promoter |
19715681
|
| C016766 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | sulforafan results in increased expression of and results in increased activity of CES1 protein alternative form |
increases activity
/ increases expression |
protein |
19715681
|
| C016766 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | sulforafan results in increased expression of CES1 mRNA alternative form |
increases expression
|
mRNA |
19715681
|
| C016766 | 8452 |
CUL3
CUL-3 PHA2E |
cullin 3 | sulforafan inhibits the reaction [KEAP1 protein binds to CUL3 protein] |
affects binding
/ decreases reaction |
protein |
18417180
|
| C016766 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | sulforafan inhibits the reaction [anthracene results in increased activity of CYP1A1 protein] |
decreases reaction
/ increases activity |
protein |
19362136
|
| C016766 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | sulforafan inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein] |
decreases reaction
/ increases activity |
protein |
19202560
|
| C016766 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | sulforafan inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A2 protein] |
decreases reaction
/ increases activity |
protein |
19362136
|
| C016766 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | sulforafan inhibits the reaction [anthracene results in increased activity of CYP1A2 protein] |
decreases reaction
/ increases activity |
protein |
19362136
|
| C016766 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | sulforafan inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein] |
decreases reaction
/ increases activity |
protein |
19202560
|
| C016766 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | sulforafan results in decreased expression of CYP1A2 mRNA |
decreases expression
|
mRNA |
20442190
|
| C016766 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | [sulforafan results in increased activity of NFE2L2 protein] which results in increased expression of CYP2A6 mRNA |
increases activity
/ increases expression |
mRNA |
20887713
|
| C016766 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | sulforafan inhibits the reaction [Rifampin results in increased expression of CYP3A4] |
decreases reaction
/ increases expression |
23153560
|
|
| C016766 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | sulforafan results in decreased expression of CYP3A4 mRNA |
decreases expression
|
mRNA |
20442190
|
| C016766 | 1674 |
DES
CSM1 CSM2 LGMD2R |
desmin | DES protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 1984 |
EIF5A
EIF-5A EIF5A1 eIF5AI |
eukaryotic translation initiation factor 5A | EIF5A protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 2072 |
ERCC4
ERCC11 FANCQ RAD1 XPF |
excision repair cross-complementing rodent repair deficiency, complementation group 4 | sulforafan results in increased expression of ERCC4 mRNA |
increases expression
|
mRNA |
20442190
|
| C016766 | 2073 |
ERCC5
COFS3 ERCM2 UVDR XPG XPGC |
excision repair cross-complementing rodent repair deficiency, complementation group 5 | sulforafan results in increased expression of ERCC5 mRNA |
increases expression
|
mRNA |
20442190
|
| C016766 | 2078 |
ERG
erg-3 p55 |
v-ets avian erythroblastosis virus E26 oncogene homolog | sulforafan inhibits the reaction [AR protein binds to ERG enhancer] |
affects binding
/ decreases reaction |
enhancer |
19805354
|
| C016766 | 2078 |
ERG
erg-3 p55 |
v-ets avian erythroblastosis virus E26 oncogene homolog | sulforafan results in decreased expression of ERG mRNA |
decreases expression
|
mRNA |
19805354
|
| C016766 | 2078 |
ERG
erg-3 p55 |
v-ets avian erythroblastosis virus E26 oncogene homolog | sulforafan results in decreased expression of ERG protein |
decreases expression
|
protein |
19805354
|
| C016766 | 1647 |
GADD45A
DDIT1 GADD45 |
growth arrest and DNA-damage-inducible, alpha | sulforafan results in increased expression of GADD45A mRNA |
increases expression
|
mRNA |
17937621
|
| C016766 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | alpha-methylepinine promotes the reaction [sulforafan results in increased expression of GCLC mRNA] |
increases expression
/ increases reaction |
mRNA |
21871945
|
| C016766 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | sulforafan promotes the reaction [alpha-methylepinine results in increased expression of GCLC mRNA] |
increases expression
/ increases reaction |
mRNA |
21871945
|
| C016766 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | sulforafan results in increased expression of GCLC mRNA |
increases expression
|
mRNA |
20442190
21871945 |
| C016766 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | sulforafan results in increased expression of GCLC protein |
increases expression
|
protein |
22558124
|
| C016766 | 2730 |
GCLM
GLCLR |
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) | sulforafan results in increased expression of GCLM |
increases expression
|
21723306
|
|
| C016766 | 2730 |
GCLM
GLCLR |
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) | sulforafan results in increased expression of GCLM mRNA |
increases expression
|
mRNA |
20442190
|
| C016766 | 2936 |
GSR
|
glutathione reductase (EC:1.8.1.7) | sulforafan results in decreased activity of GSR protein |
decreases activity
|
protein |
17937621
|
| C016766 | 2938 |
GSTA1
GST2 GSTA1-1 GTH1 |
glutathione S-transferase alpha 1 (EC:2.5.1.18) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15090468
|
| C016766 | 2938 |
GSTA1
GST2 GSTA1-1 GTH1 |
glutathione S-transferase alpha 1 (EC:2.5.1.18) | SN50 peptide inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15090468
|
| C016766 | 2938 |
GSTA1
GST2 GSTA1-1 GTH1 |
glutathione S-transferase alpha 1 (EC:2.5.1.18) | sulforafan results in decreased expression of GSTA1 mRNA |
decreases expression
|
mRNA |
12949046
|
| C016766 | 2938 |
GSTA1
GST2 GSTA1-1 GTH1 |
glutathione S-transferase alpha 1 (EC:2.5.1.18) | sulforafan results in increased expression of GSTA1 mRNA |
increases expression
|
mRNA |
12151360
12756216 12949046 15090468 |
| C016766 | 2944 |
GSTM1
GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1 |
glutathione S-transferase mu 1 (EC:2.5.1.18) | GSTM1 gene polymorphism affects the susceptibility to sulforafan |
affects response to substance
|
gene |
15623468
|
| C016766 | 2944 |
GSTM1
GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1 |
glutathione S-transferase mu 1 (EC:2.5.1.18) | GSTM1 protein affects the metabolism of sulforafan |
affects metabolic processing
|
protein |
7826396
|
| C016766 | 2944 |
GSTM1
GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1 |
glutathione S-transferase mu 1 (EC:2.5.1.18) | sulforafan inhibits the reaction [alpha-methylepinine results in increased expression of GSTM1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21871945
|
| C016766 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | GSTP1 protein affects the metabolism of sulforafan |
affects metabolic processing
|
protein |
7826396
|
| C016766 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | GSTP1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | sulforafan results in decreased activity of GSTP1 protein |
decreases activity
|
protein |
17937621
|
| C016766 | 2952 |
GSTT1
|
glutathione S-transferase theta 1 (EC:2.5.1.18) | sulforafan results in decreased expression of GSTT1 mRNA |
decreases expression
|
mRNA |
20442190
|
| C016766 | 10013 |
HDAC6
CPBHM HD6 |
histone deacetylase 6 (EC:3.5.1.98) | HDAC6 protein inhibits the reaction [sulforafan results in decreased expression of AR protein] |
decreases expression
/ decreases reaction |
protein |
19805354
|
| C016766 | 10013 |
HDAC6
CPBHM HD6 |
histone deacetylase 6 (EC:3.5.1.98) | sulforafan results in decreased activity of HDAC6 protein |
decreases activity
|
protein |
19805354
|
| C016766 | 221613 |
HIST1H2AA
H2AA H2AFR bA317E16.2 |
histone cluster 1, H2aa | HIST1H2AA protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased expression of HMOX1 protein] |
decreases reaction
/ increases expression |
protein |
22019695
|
| C016766 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | Acetylcysteine inhibits the reaction [sulforafan results in increased expression of HMOX1 protein] |
decreases reaction
/ increases expression |
protein |
22019695
|
| C016766 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | cyanoginosin LR promotes the reaction [sulforafan results in increased expression of HMOX1 protein] |
increases expression
/ increases reaction |
protein |
20600217
|
| C016766 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | NFE2L2 mutant form inhibits the reaction [sulforafan results in increased expression of HMOX1 protein] |
decreases reaction
/ increases expression |
protein |
20600217
|
| C016766 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | NFE2L2 protein affects the reaction [sulforafan results in increased expression of HMOX1] |
affects reaction
/ increases expression |
22019695
|
|
| C016766 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | Reactive Oxygen Species affects the reaction [sulforafan promotes the reaction [NFE2L2 protein results in increased expression of HMOX1 protein]] |
affects reaction
/ increases expression / increases reaction |
protein |
22019695
|
| C016766 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | sulforafan promotes the reaction [NFE2L2 protein results in increased expression of HMOX1 protein] |
increases expression
/ increases reaction |
protein |
22019695
|
| C016766 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | sulforafan results in increased expression of HMOX1 mRNA |
increases expression
|
mRNA |
18417180
19033392 19558496 19715681 |
| C016766 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | sulforafan results in increased expression of HMOX1 protein |
increases expression
|
protein |
19558496
20600217 22019695 |
| C016766 | 3185 |
HNRNPF
HNRPF OK/SW-cl.23 mcs94-1 |
heterogeneous nuclear ribonucleoprotein F | HNRNPF protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 3187 |
HNRNPH1
HNRPH HNRPH1 hnRNPH |
heterogeneous nuclear ribonucleoprotein H1 (H) | HNRNPH1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 3190 |
HNRNPK
CSBP HNRPK TUNP |
heterogeneous nuclear ribonucleoprotein K | HNRNPK protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 3320 |
HSP90AA1
EL52 HSP86 HSP89A HSP90A HSP90N HSPC1 HSPCA HSPCAL1 HSPCAL4 HSPN Hsp89 Hsp90 LAP2 |
heat shock protein 90kDa alpha (cytosolic), class A member 1 | sulforafan inhibits the reaction [HSP90AA1 protein binds to AR protein] |
affects binding
/ decreases reaction |
protein |
19805354
|
| C016766 | 3320 |
HSP90AA1
EL52 HSP86 HSP89A HSP90A HSP90N HSPC1 HSPCA HSPCAL1 HSPCAL4 HSPN Hsp89 Hsp90 LAP2 |
heat shock protein 90kDa alpha (cytosolic), class A member 1 | sulforafan results in increased acetylation of HSP90AA1 protein |
increases acetylation
|
protein |
19805354
|
| C016766 | 3305 |
HSPA1L
HSP70-1L HSP70-HOM HSP70T hum70t |
heat shock 70kDa protein 1-like | HSPA1L protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 3308 |
HSPA4
APG-2 HS24/P52 HSPH2 RY hsp70 hsp70RY |
heat shock 70kDa protein 4 | HSPA4 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 3313 |
HSPA9
CSA GRP-75 GRP75 HSPA9B MOT MOT2 MTHSP75 PBP74 |
heat shock 70kDa protein 9 (mortalin) | HSPA9 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 3329 |
HSPD1
CPN60 GROEL HLD4 HSP-60 HSP60 HSP65 HuCHA60 SPG13 |
heat shock 60kDa protein 1 (chaperonin) | HSPD1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | [Eugenol results in increased activity of sulforafan] which results in decreased expression of IL1B |
decreases expression
/ increases activity |
21382956
|
|
| C016766 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | [sulforafan results in increased activity of Eugenol] which results in decreased expression of IL1B |
decreases expression
/ increases activity |
21382956
|
|
| C016766 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | sulforafan inhibits the reaction [Norepinephrine results in increased expression of and results in increased secretion of IL6 protein] |
decreases reaction
/ increases expression / increases secretion |
protein |
18636164
|
| C016766 | 9118 |
INA
NEF5 NF-66 TXBP-1 |
internexin neuronal intermediate filament protein, alpha | INA protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 9817 |
KEAP1
INrf2 KLHL19 |
kelch-like ECH-associated protein 1 | Iodoacetamide inhibits the reaction [sulforafan results in increased metabolism of KEAP1 protein] |
decreases reaction
/ increases metabolic processing |
protein |
21391649
|
| C016766 | 9817 |
KEAP1
INrf2 KLHL19 |
kelch-like ECH-associated protein 1 | KEAP1 protein results in increased susceptibility to sulforafan |
increases response to substance
|
protein |
22558124
|
| C016766 | 9817 |
KEAP1
INrf2 KLHL19 |
kelch-like ECH-associated protein 1 | sulforafan inhibits the reaction [KEAP1 protein binds to CUL3 protein] |
affects binding
/ decreases reaction |
protein |
18417180
|
| C016766 | 9817 |
KEAP1
INrf2 KLHL19 |
kelch-like ECH-associated protein 1 | sulforafan promotes the reaction [KEAP1 protein binds to NFE2L2 protein] |
affects binding
/ increases reaction |
protein |
18417180
|
| C016766 | 9817 |
KEAP1
INrf2 KLHL19 |
kelch-like ECH-associated protein 1 | sulforafan promotes the reaction [NFE2L2 protein binds to KEAP1 protein] |
affects binding
/ increases reaction |
protein |
22558124
|
| C016766 | 9817 |
KEAP1
INrf2 KLHL19 |
kelch-like ECH-associated protein 1 | sulforafan results in increased expression of KEAP1 protein |
increases expression
|
protein |
19033392
|
| C016766 | 9817 |
KEAP1
INrf2 KLHL19 |
kelch-like ECH-associated protein 1 | sulforafan results in increased metabolism of KEAP1 protein |
increases metabolic processing
|
protein |
21391649
|
| C016766 | 354 |
KLK3
APS KLK2A1 PSA hK3 |
kallikrein-related peptidase 3 (EC:3.4.21.77) | sulforafan inhibits the reaction [AR protein binds to KLK3 enhancer] |
affects binding
/ decreases reaction |
enhancer |
19805354
|
| C016766 | 354 |
KLK3
APS KLK2A1 PSA hK3 |
kallikrein-related peptidase 3 (EC:3.4.21.77) | sulforafan results in decreased expression of KLK3 mRNA |
decreases expression
|
mRNA |
19805354
|
| C016766 | 3956 |
LGALS1
GAL1 GBP |
lectin, galactoside-binding, soluble, 1 | LGALS1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | sulforafan results in increased phosphorylation of and results in increased activity of MAPK1 protein |
increases activity
/ increases phosphorylation |
protein |
15896333
|
| C016766 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | sulforafan results in increased phosphorylation of MAPK1 protein |
increases phosphorylation
|
protein |
16033772
22005276 |
| C016766 | 5602 |
MAPK10
JNK3 JNK3A PRKM10 SAPK1b p493F12 p54bSAPK |
mitogen-activated protein kinase 10 (EC:2.7.11.24) | sulforafan results in increased phosphorylation of MAPK10 protein |
increases phosphorylation
|
protein |
16033772
|
| C016766 | 1432 |
MAPK14
CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA |
mitogen-activated protein kinase 14 (EC:2.7.11.24) | sulforafan results in increased phosphorylation of MAPK14 protein |
increases phosphorylation
|
protein |
16033772
|
| C016766 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | sulforafan results in increased phosphorylation of and results in increased activity of MAPK3 protein |
increases activity
/ increases phosphorylation |
protein |
15896333
|
| C016766 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | sulforafan results in increased phosphorylation of MAPK3 protein |
increases phosphorylation
|
protein |
16033772
22005276 |
| C016766 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | sulforafan results in increased activity of MAPK8 protein |
increases activity
|
protein |
16201852
|
| C016766 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | sulforafan results in increased phosphorylation of MAPK8 protein |
increases phosphorylation
|
protein |
16033772
|
| C016766 | 5601 |
MAPK9
JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK |
mitogen-activated protein kinase 9 (EC:2.7.11.24) | sulforafan results in increased phosphorylation of MAPK9 protein |
increases phosphorylation
|
protein |
16033772
|
| C016766 | 4255 |
MGMT
|
O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) | sulforafan results in increased expression of and results in increased activity of MGMT protein |
increases activity
/ increases expression |
protein |
16950796
|
| C016766 | 4489 |
MT1A
MT1 MT1S MTC |
metallothionein 1A | sulforafan results in increased expression of MT1A mRNA |
increases expression
|
mRNA |
16033772
|
| C016766 | 4489 |
MT1A
MT1 MT1S MTC |
metallothionein 1A | sulforafan results in increased expression of MT1A protein |
increases expression
|
protein |
16033772
|
| C016766 | 4502 |
MT2A
MT2 |
metallothionein 2A | sulforafan results in increased expression of MT2A mRNA |
increases expression
|
mRNA |
16033772
|
| C016766 | 4502 |
MT2A
MT2 |
metallothionein 2A | sulforafan results in increased expression of MT2A protein |
increases expression
|
protein |
16033772
|
| C016766 | 10397 |
NDRG1
CAP43 CMT4D DRG-1 DRG1 GC4 HMSNL NDR1 NMSL PROXY1 RIT42 RTP TARG1 TDD5 |
N-myc downstream regulated 1 | sulforafan results in increased expression of NDRG1 mRNA |
increases expression
|
mRNA |
17937621
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased expression of NFE2L2 protein] |
decreases reaction
/ increases expression |
protein |
22019695
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | Acetylcysteine inhibits the reaction [sulforafan affects the localization of NFE2L2 protein] |
affects localization
/ decreases reaction |
protein |
22019695
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | Acetylcysteine inhibits the reaction [sulforafan results in increased expression of NFE2L2 protein] |
decreases reaction
/ increases expression |
protein |
22019695
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | ammonium metavanadate affects the reaction [sulforafan affects the localization of NFE2L2 mRNA] |
affects localization
/ affects reaction |
mRNA |
20599494
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [sulforafan results in increased expression of NFE2L2 protein] |
increases expression
/ increases reaction |
protein |
22019695
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | cyanoginosin LR promotes the reaction [sulforafan affects the localization of NFE2L2 protein] |
affects localization
/ increases reaction |
protein |
20600217
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | Cycloheximide inhibits the reaction [sulforafan results in increased expression of NFE2L2 protein] |
decreases reaction
/ increases expression |
protein |
22019695
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | Dactinomycin inhibits the reaction [sulforafan results in increased expression of NFE2L2 protein] |
decreases reaction
/ increases expression |
protein |
22019695
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | NFE2L2 mutant form inhibits the reaction [sulforafan results in increased expression of HMOX1 protein] |
decreases reaction
/ increases expression |
mutant form |
20600217
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | NFE2L2 mutant form inhibits the reaction [sulforafan results in increased expression of NQO1 protein] |
decreases reaction
/ increases expression |
mutant form |
20600217
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | NFE2L2 protein affects the reaction [sulforafan results in increased expression of CES1 mRNA alternative form] |
affects reaction
/ increases expression |
protein |
19715681
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | NFE2L2 protein affects the reaction [sulforafan results in increased expression of HMOX1] |
affects reaction
/ increases expression |
protein |
22019695
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | NFE2L2 protein results in increased susceptibility to sulforafan |
increases response to substance
|
protein |
20600217
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | Reactive Oxygen Species affects the reaction [sulforafan promotes the reaction [NFE2L2 protein results in increased expression of HMOX1 protein]] |
affects reaction
/ increases expression / increases reaction |
protein |
22019695
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan affects the localization of NFE2L2 mRNA |
affects localization
|
mRNA |
20599494
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan affects the localization of NFE2L2 protein |
affects localization
|
protein |
20600217
20868228 22019695 22558124 |
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan binds to and results in increased activity of NFE2L2 protein |
affects binding
/ increases activity |
protein |
20806931
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan promotes the reaction [KEAP1 protein binds to NFE2L2 protein] |
affects binding
/ increases reaction |
protein |
18417180
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan promotes the reaction [NFE2L2 protein binds to CES1 promoter] |
affects binding
/ increases reaction |
protein |
19715681
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan promotes the reaction [[NFE2L2 protein binds to CES1 promoter] which results in increased expression of CES1 mRNA alternative form] |
affects binding
/ increases expression / increases reaction |
protein |
19715681
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan promotes the reaction [NFE2L2 protein binds to KEAP1 protein] |
affects binding
/ increases reaction |
protein |
22558124
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan promotes the reaction [NFE2L2 protein results in increased expression of HMOX1 protein] |
increases expression
/ increases reaction |
protein |
22019695
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan promotes the reaction [SLC39A2 protein results in increased activity of NFE2L2 protein] |
increases activity
/ increases reaction |
protein |
18385089
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan results in increased activity of NFE2L2 protein |
increases activity
|
protein |
19715681
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | [sulforafan results in increased activity of NFE2L2 protein] which results in increased expression of CYP2A6 mRNA |
increases activity
/ increases expression |
protein |
20887713
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan results in increased expression of and results in decreased degradation of NFE2L2 protein |
decreases degradation
/ increases expression |
protein |
22558124
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan results in increased expression of and results in increased activity of NFE2L2 protein |
increases activity
/ increases expression |
protein |
22192953
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | [sulforafan results in increased expression of and results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Benzo(a)pyrene |
decreases response to substance
/ increases activity / increases expression |
protein |
22192953
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan results in increased expression of NFE2L2 mRNA |
increases expression
|
mRNA |
19558496
|
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan results in increased expression of NFE2L2 protein |
increases expression
|
protein |
16033772
22019695 |
| C016766 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | sulforafan results in increased localization of NFE2L2 protein |
increases localization
|
protein |
21723306
|
| C016766 | 4830 |
NME1
AWD GAAD NB NBS NDKA NDPK-A NDPKA NM23 NM23-H1 |
NME/NM23 nucleoside diphosphate kinase 1 (EC:2.7.4.6) | NME1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 283458 | NME2P1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
||
| C016766 | 4851 |
NOTCH1
TAN1 hN1 |
notch 1 | sulforafan inhibits the reaction [gemcitabine results in increased expression of NOTCH1 protein] |
decreases reaction
/ increases expression |
protein |
20940707
|
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | ammonium metavanadate inhibits the reaction [sulforafan results in increased expression of and results in increased activity of NQO1 protein] |
decreases reaction
/ increases activity / increases expression |
protein |
20599494
|
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | ammonium metavanadate inhibits the reaction [sulforafan results in increased expression of NQO1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20599494
|
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | cyanoginosin LR promotes the reaction [sulforafan results in increased expression of NQO1 protein] |
increases expression
/ increases reaction |
protein |
20600217
|
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | Mercuric Chloride promotes the reaction [sulforafan results in increased expression of and results in increased activity of NQO1 protein] |
increases activity
/ increases expression / increases reaction |
protein |
21843634
|
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | Mercuric Chloride promotes the reaction [sulforafan results in increased expression of NQO1 mRNA] |
increases expression
/ increases reaction |
mRNA |
21843634
|
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | NFE2L2 mutant form inhibits the reaction [sulforafan results in increased expression of NQO1 protein] |
decreases reaction
/ increases expression |
protein |
20600217
|
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | sulforafan results in increased activity of NQO1 protein |
increases activity
|
protein |
20868228
|
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | sulforafan results in increased expression of and results in increased activity of NQO1 protein |
increases activity
/ increases expression |
protein |
20599494
21843634 |
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | sulforafan results in increased expression of NQO1 mRNA |
increases expression
|
mRNA |
15672752
15896333 18417180 19033392 20442190 20599494 21464939 21843634 |
| C016766 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | sulforafan results in increased expression of NQO1 protein |
increases expression
|
protein |
20600217
22558124 |
| C016766 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | sulforafan inhibits the reaction [alpha-methylepinine results in decreased expression of NR1I2 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
21871945
|
| C016766 | 5034 |
P4HB
DSI ERBA2L GIT P4Hbeta PDI PDIA1 PHDB PO4DB PO4HB PROHB |
prolyl 4-hydroxylase, beta polypeptide (EC:5.3.4.1) | P4HB protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 5111 |
PCNA
|
proliferating cell nuclear antigen | PCNA protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 10935 |
PRDX3
AOP-1 AOP1 HBC189 MER5 PRO1748 SP-22 prx-III |
peroxiredoxin 3 (EC:1.11.1.15) | PRDX3 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 5630 |
PRPH
NEF4 PRPH1 |
peripherin | PRPH protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 5925 |
RB1
OSRC RB p105-Rb pRb pp110 |
retinoblastoma 1 | sulforafan results in increased phosphorylation of RB1 protein |
increases phosphorylation
|
protein |
15231455
|
| C016766 | 5928 |
RBBP4
NURF55 RBAP48 |
retinoblastoma binding protein 4 | RBBP4 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 5966 |
REL
C-Rel |
v-rel avian reticuloendotheliosis viral oncogene homolog | sulforafan promotes the reaction [gemcitabine results in decreased expression of REL protein] |
decreases expression
/ increases reaction |
protein |
20940707
|
| C016766 | 5966 |
REL
C-Rel |
v-rel avian reticuloendotheliosis viral oncogene homolog | sulforafan results in decreased expression of REL protein |
decreases expression
|
protein |
20940707
|
| C016766 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | sulforafan results in increased expression of RELA protein |
increases expression
|
protein |
15090468
|
| C016766 | 3921 |
RPSA
37LRP 67LR LAMBR LAMR1 LBP LBP/p40 LRP LRP/LR NEM/1CHD4 SA lamR p40 |
ribosomal protein SA | RPSA protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 710 |
SERPING1
C1IN C1INH C1NH HAE1 HAE2 |
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | SERPING1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 2810 |
SFN
YWHAS |
stratifin | SFN protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 29986 |
SLC39A2
6A1 ETI-1 ZIP-2 ZIP2 |
solute carrier family 39 (zinc transporter), member 2 | sulforafan promotes the reaction [SLC39A2 protein results in increased activity of NFE2L2 protein] |
increases activity
/ increases reaction |
protein |
18385089
|
| C016766 | 1155 |
TBCB
CG22 CKAP1 CKAPI |
tubulin folding cofactor B | TBCB protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 7168 |
TPM1
C15orf13 CMD1Y CMH3 HTM-alpha LVNC9 TMSA |
tropomyosin 1 (alpha) | TPM1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 7846 |
TUBA1A
B-ALPHA-1 LIS3 TUBA3 |
tubulin, alpha 1a | TUBA1A protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 113457 |
TUBA3D
H2-ALPHA |
tubulin, alpha 3d | TUBA3D protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 7277 |
TUBA4A
H2-ALPHA TUBA1 |
tubulin, alpha 4a | sulforafan results in increased acetylation of TUBA4A protein |
increases acetylation
|
protein |
19805354
|
| C016766 | 7277 |
TUBA4A
H2-ALPHA TUBA1 |
tubulin, alpha 4a | TUBA4A protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 81027 |
TUBB1
|
tubulin, beta 1 class VI | TUBB1 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 100691897 | TUBB2C protein binds to sulforafan |
affects binding
|
protein |
21838287
|
||
| C016766 | 7295 |
TXN
TRDX TRX TRX1 |
thioredoxin | sulforafan results in increased expression of TXN mRNA |
increases expression
|
mRNA |
19123792
20442190 |
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | 1-(5-isoquinolinylsulfonyl)-3-methylpiperazine inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
12663510
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | Buthionine Sulfoximine inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
12663510
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | Cycloheximide inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
12663510
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | Dactinomycin inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
12663510
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | Selenium promotes the reaction [sulforafan results in increased expression of and results in increased activity of TXNRD1 protein] |
increases activity
/ increases expression / increases reaction |
protein |
15740016
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | Sodium Selenite promotes the reaction [sulforafan results in increased activity of TXNRD1 protein] |
increases activity
/ increases reaction |
protein |
12663510
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | Sodium Selenite promotes the reaction [sulforafan results in increased expression of TXNRD1 mRNA] |
increases expression
/ increases reaction |
mRNA |
12663510
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | Sodium Selenite promotes the reaction [sulforafan results in increased expression of TXNRD1 protein] |
increases expression
/ increases reaction |
protein |
12663510
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | [sulforafan co-treated with Selenium] results in increased activity of TXNRD1 protein |
affects cotreatment
/ increases activity |
protein |
12949356
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | [sulforafan co-treated with Sodium Selenite] results in increased activity of TXNRD1 protein |
affects cotreatment
/ increases activity |
protein |
12949356
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | sulforafan results in decreased activity of TXNRD1 protein |
decreases activity
|
protein |
17937621
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | sulforafan results in increased activity of TXNRD1 protein |
increases activity
|
protein |
12663510
12949356 |
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | sulforafan results in increased expression of and results in increased activity of TXNRD1 protein |
increases activity
/ increases expression |
protein |
15740016
|
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | sulforafan results in increased expression of TXNRD1 mRNA |
increases expression
|
mRNA |
12663510
12949356 15740016 20442190 |
| C016766 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | sulforafan results in increased expression of TXNRD1 protein |
increases expression
|
protein |
12663510
17150329 |
| C016766 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased expression of UGT1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15090468
|
| C016766 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | [sulforafan co-treated with Apigenin] results in increased expression of UGT1A1 mRNA |
affects cotreatment
/ increases expression |
mRNA |
15090468
|
| C016766 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | sulforafan results in decreased expression of UGT1A1 mRNA |
decreases expression
|
mRNA |
12949046
|
| C016766 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | sulforafan results in increased expression of UGT1A1 mRNA |
increases expression
|
mRNA |
12151360
12756216 12949046 15090468 15896333 |
| C016766 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | sulforafan results in increased expression of UGT1A1 protein |
increases expression
|
protein |
12151360
|
| C016766 | 7415 |
VCP
ALS14 IBMPFD IBMPFD1 TERA p97 |
valosin containing protein (EC:3.6.4.6) | VCP protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 7431 |
VIM
CTRCT30 |
vimentin | VIM protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 7529 |
YWHAB
GW128 HS1 KCIP-1 YWHAA |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | YWHAB protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 7531 |
YWHAE
14-3-3E KCIP-1 MDCR MDS |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | YWHAE protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 10971 |
YWHAQ
14-3-3 1C5 HS1 |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | YWHAQ protein binds to sulforafan |
affects binding
|
protein |
21838287
|
| C016766 | 353088 |
ZNF429
|
zinc finger protein 429 | ZNF429 protein binds to sulforafan |
affects binding
|
protein |
21838287
|
Related Disease
Diseases related to proteins in ChEMBL interactions
Diseases related to CTD interactions
10 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D058186 | C016766 | Acute Kidney Injury |
therapeutic
|
19913604
|
|
| D011125 | C016766 | Adenomatous Polyposis Coli |
therapeutic
|
17942926
|
|
| D001327 | C016766 | Autoimmune Diseases |
therapeutic
|
19761891
|
|
| D006528 | C016766 | Carcinoma, Hepatocellular |
therapeutic
|
21278056
|
|
| D003928 | C016766 | Diabetic Nephropathies |
therapeutic
|
22023613
|
|
| D056486 | C016766 | Drug-Induced Liver Injury |
therapeutic
|
21575670
21684301 |
|
| D009336 | C016766 | Necrosis |
therapeutic
|
18079140
|
|
| D009369 | C016766 | Neoplasms |
therapeutic
|
21838287
|
|
| D011041 | C016766 | Poisoning |
marker/mechanism
|
22293418
|
|
| D002583 | C016766 | Uterine Cervical Neoplasms |
therapeutic
|
21382956
|