PCIDB

KNApSAcK Metabolite C00000565

Metabolite

KNApSAcK Entry

id C00000565
Name Pravastatin
CAS RN 81093-37-0
Standard InChI InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16-,17+,18-,19-,20-,22-/m0/s1
Standard InChI (Main Layer) InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)

Cluster

Phytochemical cluster
KCF-S cluster No. 8267

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL1144 CHEMBL1617336

KEGG

By LinkDB C01844

CTD

By CAS RN D017035

Species

Summary

Plant class

class name count

Family

family name count
Aspergillaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Penicillium citrinum 5077 Aspergillaceae Fungi

Human Protein / Gene in interaction

103 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1144 CHEMBL1909136 (2) CHEMBL2071965 (1)
1 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL1144 CHEMBL1787888 (1) CHEMBL1786149 (1)
CHEMBL2077534 (1) CHEMBL2077535 (1)
CHEMBL2078133 (1) CHEMBL2169429 (1)
CHEMBL2169432 (2)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL1144 CHEMBL2077197 (1) CHEMBL2077206 (1)
CHEMBL2077207 (1) CHEMBL2077356 (1)
CHEMBL2169431 (1) CHEMBL2169434 (2)
0 / 0
O95342 Bile salt export pump drug CHEMBL1144 CHEMBL1743159 (1)
2 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1144 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL1144 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL1144 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL1144 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL1144 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL1144 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL1144 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL1144 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL1144 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL1144 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL1144 CHEMBL1909197 (2)
2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL1144 CHEMBL993349 (1)
0 / 0
Q9Y694 Solute carrier family 22 member 7 Unclassified protein CHEMBL1144 CHEMBL2077493 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL1144 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL1144 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL1144 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL1144 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL1144 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL1144 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL1144 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL1144 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL1144 CHEMBL1909093 (2)
0 / 0
Q14534 Squalene monooxygenase Enzyme CHEMBL1144 CHEMBL809128 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL1144 CHEMBL2078148 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL1144 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL1144 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL1144 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1144 CHEMBL1909135 (2) CHEMBL2071963 (1)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL1144 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL1144 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL1144 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL1144 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL1144 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL1144 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL1144 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL1144 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL1144 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL1144 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL1144 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL1144 CHEMBL1909133 (2)
0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter CHEMBL1144 CHEMBL2077092 (1)
0 / 0
P46721 Solute carrier organic anion transporter family member 1A2 Unclassified protein CHEMBL1144 CHEMBL2076111 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL1144 CHEMBL692133 (1) CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL1144 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL1144 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL1144 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL1144 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL1144 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL1144 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL1144 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL1144 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL1144 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL1144 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL1144 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL1144 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL1144 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL1144 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL1144 CHEMBL1909119 (2)
0 / 0
Q4U2R8 Solute carrier family 22 member 6 Antiporter CHEMBL1144 CHEMBL2077836 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL1144 CHEMBL1787889 (1) CHEMBL1786150 (1)
CHEMBL2169430 (1) CHEMBL2169433 (2)
1 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL1144 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL1144 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL1144 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL1144 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL1144 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL1144 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL1144 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL1144 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL1144 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL1144 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL1144 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL1144 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1144 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL1144 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1144 CHEMBL1909132 (2) CHEMBL2071962 (1)
0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL1144 CHEMBL2077541 (1) CHEMBL2075604 (1)
2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL1144 CHEMBL1006005 (1) CHEMBL2078137 (1)
1 / 1
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL1144 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL1144 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL1144 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL1144 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL1144 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL1144 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL1144 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL1144 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL1144 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL1144 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL1144 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1144 CHEMBL1909134 (2) CHEMBL2071964 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1144 CHEMBL1909138 (2) CHEMBL2071966 (1)
CHEMBL2071967 (1)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL1144 CHEMBL1909137 (2)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL1144 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL1144 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL1144 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL1144 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL1144 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL1144 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL1144 CHEMBL1909128 (2)
0 / 0
Q9NSA0 Solute carrier family 22 member 11 Transporter CHEMBL1144 CHEMBL2077548 (1)
0 / 0

CTD interaction (40)

compound gene gene name gene description interaction interaction type form reference
pmid
D017035 19 ABCA1
ABC-1
ABC1
CERP
HDLDT1
TGD
ATP-binding cassette, sub-family A (ABC1), member 1 Pravastatin results in decreased expression of ABCA1 decreases expression
19461118
D017035 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in increased transport of Pravastatin increases transport
protein 15616150
D017035 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in increased transport of Pravastatin analog increases transport
protein 15616150
D017035 8647 ABCB11
ABC16
BRIC2
BSEP
PFIC-2
PFIC2
PGY4
SPGP
ATP-binding cassette, sub-family B (MDR/TAP), member 11 ABCB11 protein affects the import of Pravastatin affects import
protein 15901796
D017035 8647 ABCB11
ABC16
BRIC2
BSEP
PFIC-2
PFIC2
PGY4
SPGP
ATP-binding cassette, sub-family B (MDR/TAP), member 11 Pravastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid] affects import
/ decreases reaction
protein 15901796
D017035 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ABCC2 protein affects the export of Pravastatin affects export
protein 15901800
D017035 10257 ABCC4
EST170205
MOAT-B
MOATB
MRP4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ABCC4 protein results in increased transport of Pravastatin increases transport
protein 17939016
D017035 9429 ABCG2
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR1
UAQTL1
ATP-binding cassette, sub-family G (WHITE), member 2 ABCG2 protein affects the export of Pravastatin affects export
protein 15901800
D017035 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Pravastatin results in increased expression of APP increases expression
19461118
D017035 847 CAT
catalase (EC:1.11.1.6) Pravastatin results in increased activity of CAT protein increases activity
protein 17479860
D017035 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Pravastatin inhibits the reaction [Benzo(a)pyrene results in decreased degradation of CDKN1A protein] decreases degradation
/ decreases reaction
protein 15625077
D017035 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Pravastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein] decreases degradation
/ decreases reaction
protein 15625077
D017035 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 Pravastatin results in decreased expression of EDN1 protein decreases expression
protein 12105140
D017035 2222 FDFT1
DGPT
ERG9
SQS
SS
farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21) Pravastatin affects the activity of FDFT1 protein affects activity
protein 8517861
D017035 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) HMGCR gene SNP results in decreased susceptibility to Pravastatin decreases response to substance
gene 15199031
D017035 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) Pravastatin affects the expression of HMGCR mRNA affects expression
mRNA 8517861
D017035 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) Pravastatin results in decreased activity of HMGCR protein decreases activity
protein 8593127
D017035 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor Pravastatin results in increased activity of LDLR protein increases activity
protein 8593127
D017035 4137 MAPT
DDPAC
FTDP-17
MAPTL
MSTD
MTBT1
MTBT2
PPND
TAU
microtubule-associated protein tau Pravastatin affects the expression of MAPT affects expression
19461118
D017035 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase Pravastatin results in increased phosphorylation of MDM2 protein increases phosphorylation
protein 15625077
D017035 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase [Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein increases degradation
/ increases phosphorylation
protein 15625077
D017035 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase Sirolimus inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein] decreases reaction
/ increases phosphorylation
protein 15625077
D017035 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase U 0126 inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein] decreases reaction
/ increases phosphorylation
protein 15625077
D017035 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) MMP3 promoter polymorphism affects the susceptibility to Pravastatin affects response to substance
promoter 8662692
D017035 2475 MTOR
FRAP
FRAP1
FRAP2
RAFT1
RAPT1
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) Pravastatin results in increased phosphorylation of MTOR protein increases phosphorylation
protein 15625077
D017035 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Pravastatin inhibits the reaction [[troglitazone binds to and results in increased activity of PPARG protein] which results in increased abundance of Cholesterol] affects binding
/ decreases reaction
/ increases abundance
/ increases activity
protein 12044893
D017035 6403 SELP
CD62
CD62P
GMP140
GRMP
LECAM3
PADGEM
PSEL
selectin P (granule membrane protein 140kDa, antigen CD62) Pravastatin results in decreased expression of SELP protein decreases expression
protein 11189483
D017035 10599 SLCO1B1
HBLRR
LST-1
LST1
OATP-C
OATP1B1
OATP2
OATPC
SLC21A6
solute carrier organic anion transporter family, member 1B1 Pravastatin inhibits the reaction [SLCO1B1 protein results in increased uptake of Mesalamine] decreases reaction
/ increases uptake
protein 21430235
D017035 10599 SLCO1B1
HBLRR
LST-1
LST1
OATP-C
OATP1B1
OATP2
OATPC
SLC21A6
solute carrier organic anion transporter family, member 1B1 Pravastatin inhibits the reaction [SLCO1B1 protein results in increased uptake of Sulfobromophthalein] decreases reaction
/ increases uptake
protein 21430235
D017035 10599 SLCO1B1
HBLRR
LST-1
LST1
OATP-C
OATP1B1
OATP2
OATPC
SLC21A6
solute carrier organic anion transporter family, member 1B1 SLCO1B1 gene SNP results in decreased transport of Pravastatin decreases transport
gene 15970799
D017035 10599 SLCO1B1
HBLRR
LST-1
LST1
OATP-C
OATP1B1
OATP2
OATPC
SLC21A6
solute carrier organic anion transporter family, member 1B1 SLCO1B1 gene SNP results in increased susceptibility to Pravastatin increases response to substance
gene 15681900
D017035 10599 SLCO1B1
HBLRR
LST-1
LST1
OATP-C
OATP1B1
OATP2
OATPC
SLC21A6
solute carrier organic anion transporter family, member 1B1 SLCO1B1 protein mutant form results in decreased transport of Pravastatin decreases transport
protein 19238167
D017035 10599 SLCO1B1
HBLRR
LST-1
LST1
OATP-C
OATP1B1
OATP2
OATPC
SLC21A6
solute carrier organic anion transporter family, member 1B1 SLCO1B1 protein results in increased transport of Pravastatin increases transport
protein 19238167
D017035 28234 SLCO1B3
HBLRR
LST-2
LST-3TM13
LST3
OATP-8
OATP1B3
OATP8
SLC21A8
solute carrier organic anion transporter family, member 1B3 Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine] decreases reaction
/ increases uptake
protein 21430235
D017035 28234 SLCO1B3
HBLRR
LST-2
LST-3TM13
LST3
OATP-8
OATP1B3
OATP8
SLC21A8
solute carrier organic anion transporter family, member 1B3 Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] decreases reaction
/ increases uptake
protein 21430235
D017035 11309 SLCO2B1
OATP-B
OATP2B1
OATPB
SLC21A9
solute carrier organic anion transporter family, member 2B1 Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Mesalamine] decreases reaction
/ increases uptake
protein 21430235
D017035 11309 SLCO2B1
OATP-B
OATP2B1
OATPB
SLC21A9
solute carrier organic anion transporter family, member 2B1 Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] decreases reaction
/ increases uptake
protein 21430235
D017035 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Pravastatin inhibits the reaction [Fluorouracil results in decreased degradation of TP53 protein] decreases degradation
/ decreases reaction
protein 15625077
D017035 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Pravastatin inhibits the reaction [leptomycin B results in decreased degradation of TP53 protein] decreases degradation
/ decreases reaction
protein 15625077
D017035 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 [Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein increases degradation
/ increases phosphorylation
protein 15625077

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (43)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#614490 Blood group, junior system; jr Q9UNQ0
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#605479 Cholestasis, benign recurrent intrahepatic, 2; bric2 O95342
#601847 Cholestasis, progressive familial intrahepatic, 2; pfic2 O95342
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (33)

KEGG disease name UniProt
H00624 Familial cholestasis O95342 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00208 Hyperbilirubinemia Q92887 (related)

Diseases related to CTD interactions

51 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D058186 D017035 Acute Kidney Injury therapeutic
20368269
20650967
D000236 D017035 Adenoma marker/mechanism
10813127
D000505 D017035 Alopecia marker/mechanism
1644096
D000542 D017035 Alveolitis, Extrinsic Allergic marker/mechanism
10084510
D050197 D017035 Atherosclerosis therapeutic
7586340
19330073
D006332 D017035 Cardiomegaly therapeutic
17170375
D002318 D017035 Cardiovascular Diseases therapeutic
11770708
D002561 D017035 Cerebrovascular Disorders therapeutic
12409635
D002779 D017035 Cholestasis marker/mechanism
10235223
12064992
D003324 D017035 Coronary Artery Disease therapeutic
8647574
18374337
19660595
20102908
D003327 D017035 Coronary Disease therapeutic
12409635
15771919
D003866 D017035 Depressive Disorder marker/mechanism
1357315
D003882 D017035 Dermatomyositis marker/mechanism
1640970
16154665
D003920 D017035 Diabetes Mellitus therapeutic
16472047
D003875 D017035 Drug Eruptions marker/mechanism
19323663
D056486 D017035 Drug-Induced Liver Injury marker/mechanism
1520752
D064420 D017035 Drug-Related Side Effects and Adverse Reactions therapeutic
18483861
D004401 D017035 Dysarthria marker/mechanism
15596782
D050171 D017035 Dyslipidemias therapeutic
19167588
D005355 D017035 Fibrosis therapeutic
17170375
D020275 D017035 Guillain-Barre Syndrome marker/mechanism
15389662
D006261 D017035 Headache marker/mechanism
19167588
D006331 D017035 Heart Diseases therapeutic
18483861
D006937 D017035 Hypercholesterolemia therapeutic
1682723
2492189
7909021
8172444
8238075
8593127
10027656
10751747
11189483
11770708
12409635
15199031
16029366
17188708
D006949 D017035 Hyperlipidemias therapeutic
9110123
11404165
20102918
D006938 D017035 Hyperlipoproteinemia Type II therapeutic
2492189
D006973 D017035 Hypertension therapeutic
17170375
D015228 D017035 Hypertriglyceridemia therapeutic
10751747
D006987 D017035 Hypesthesia marker/mechanism
10027656
D052456 D017035 Hypoalphalipoproteinemias therapeutic
8238075
D007565 D017035 Jaundice marker/mechanism
10235223
D020422 D017035 Mononeuropathies marker/mechanism
17133326
D009135 D017035 Muscular Diseases marker/mechanism
1644096
1904494
10217378
10799017
15681900
15914514
16218940
16433891
17600820
19238167
19323663
19833260
20102918
D009140 D017035 Musculoskeletal Diseases marker/mechanism
19167588
D009157 D017035 Myasthenia Gravis marker/mechanism
16609346
D009203 D017035 Myocardial Infarction therapeutic
7586340
8647574
17188708
D009207 D017035 Myoclonus marker/mechanism
11160978
D009220 D017035 Myositis marker/mechanism
7604176
12528328
D009222 D017035 Myotonia marker/mechanism
10367184
D010146 D017035 Pain marker/mechanism
10217378
16433891
17600820
19167588
D010292 D017035 Paresthesia marker/mechanism
8172444
10027656
12639733
D010523 D017035 Peripheral Nervous System Diseases marker/mechanism
9671841
10027656
12639733
D011111 D017035 Polymyalgia Rheumatica marker/mechanism
10084510
D017285 D017035 Polymyositis marker/mechanism
15199734
D011115 D017035 Polyneuropathies marker/mechanism
12011277
D017119 D017035 Porphyria Cutanea Tarda marker/mechanism
7631993
9801704
D011507 D017035 Proteinuria therapeutic
12105140
D012141 D017035 Respiratory Tract Infections marker/mechanism
19167588
D012852 D017035 Sinusitis marker/mechanism
19167588
D012883 D017035 Skin Ulcer marker/mechanism
19323663
D020521 D017035 Stroke therapeutic
7586340