KCF-S cluster No. 8267 (1 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (1)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count

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Cumulative family count

class name	count
Aspergillaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (1)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000565	Pravastatin	CHEMBL1144 CHEMBL1617336	D017035	103 / 43 / 33	23 / 51

Human Protein / Gene in interactions

103 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000565	1 / 0
Q9Y6L6	Solute carrier organic anion transporter family member 1B1	Electrochemical transporter	C00000565	1 / 0
O94956	Solute carrier organic anion transporter family member 2B1	Unclassified protein	C00000565	0 / 0
O95342	Bile salt export pump	drug	C00000565	2 / 1
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000565	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000565	0 / 3
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000565	2 / 2
P08246	Neutrophil elastase	S1A	C00000565	2 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00000565	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000565	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00000565	0 / 0
P29466	Caspase-1	C14	C00000565	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00000565	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00000565	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000565	2 / 2
O15245	Solute carrier family 22 member 1	Drug uniporter	C00000565	0 / 0
Q9Y694	Solute carrier family 22 member 7	Unclassified protein	C00000565	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00000565	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000565	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000565	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00000565	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00000565	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00000565	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00000565	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00000565	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000565	0 / 0
Q14534	Squalene monooxygenase	Enzyme	C00000565	0 / 0
P08183	Multidrug resistance protein 1	drug	C00000565	1 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00000565	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00000565	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00000565	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000565	0 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000565	1 / 8
P14416	D(2) dopamine receptor	Dopamine receptor	C00000565	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000565	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00000565	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000565	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00000565	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00000565	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00000565	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00000565	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00000565	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00000565	1 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000565	0 / 0
Q8TCC7	Solute carrier family 22 member 8	Antiporter	C00000565	0 / 0
P46721	Solute carrier organic anion transporter family member 1A2	Unclassified protein	C00000565	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00000565	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00000565	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00000565	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00000565	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00000565	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000565	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00000565	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00000565	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00000565	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00000565	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00000565	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00000565	0 / 0
P08311	Cathepsin G	S1A	C00000565	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00000565	1 / 0
P03956	Interstitial collagenase	M10A	C00000565	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00000565	0 / 0
Q4U2R8	Solute carrier family 22 member 6	Antiporter	C00000565	0 / 0
Q9NPD5	Solute carrier organic anion transporter family member 1B3	Electrochemical transporter	C00000565	1 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000565	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00000565	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00000565	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000565	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00000565	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00000565	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00000565	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00000565	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00000565	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00000565	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00000565	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00000565	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000565	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00000565	2 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000565	0 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00000565	2 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00000565	1 / 1
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00000565	0 / 0
P03372	Estrogen receptor	NR3A1	C00000565	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000565	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00000565	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00000565	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00000565	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00000565	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00000565	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00000565	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00000565	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00000565	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000565	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000565	0 / 1
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00000565	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00000565	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00000565	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00000565	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00000565	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00000565	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00000565	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00000565	0 / 0
Q9NSA0	Solute carrier family 22 member 11	Transporter	C00000565	0 / 0

23 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
19	ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD	ATP-binding cassette, sub-family A (ABC1), member 1	C00000565
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00000565
8647	ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP	ATP-binding cassette, sub-family B (MDR/TAP), member 11	C00000565
1244	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	C00000565
10257	ABCC4, EST170205, MOAT-B, MOATB, MRP4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	C00000565
9429	ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1	ATP-binding cassette, sub-family G (WHITE), member 2	C00000565
351	APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2	amyloid beta (A4) precursor protein	C00000565
847	CAT	catalase (EC:1.11.1.6)	C00000565
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00000565
1906	EDN1, ET1, HDLCQ7, PPET1	endothelin 1	C00000565
2222	FDFT1, DGPT, ERG9, SQS, SS	farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21)	C00000565
3156	HMGCR, LDLCQ3	3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)	C00000565
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00000565
4137	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU	microtubule-associated protein tau	C00000565
4193	MDM2, ACTFS, HDMX, hdm2	MDM2 oncogene, E3 ubiquitin protein ligase	C00000565
4314	MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1	matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17)	C00000565
2475	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1	mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)	C00000565
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00000565
6403	SELP, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL	selectin P (granule membrane protein 140kDa, antigen CD62)	C00000565
10599	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6	solute carrier organic anion transporter family, member 1B1	C00000565
28234	SLCO1B3, HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8	solute carrier organic anion transporter family, member 1B3	C00000565
11309	SLCO2B1, OATP-B, OATP2B1, OATPB, SLC21A9	solute carrier organic anion transporter family, member 2B1	C00000565
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000565

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions