PCIDB

KNApSAcK Metabolite C00007230

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00007230
Name	S-Adenosyl-L-homocysteine
CAS RN	979-92-0
Standard InChI	InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
Standard InChI (Main Layer)	InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)

Cluster

Phytochemical cluster
KCF-S cluster	No. 5509

Link

ChEMBL

By standard InChI	CHEMBL418052
By standard InChI Main Layer	CHEMBL418052 CHEMBL45041 CHEMBL142828 CHEMBL597532 CHEMBL2092997

KEGG

By LinkDB	C00021

CTD

By CAS RN	D012435

Species

Summary

Plant class

class name	count
rosids	1

Family

family name	count
Brassicaceae	1
Enterobacteriaceae	1

List (2)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Arabidopsis thaliana	3702	Brassicaceae	rosids	Viridiplantae
Escherichia coli	562	Enterobacteriaceae		Bacteria

Human Protein / Gene in interaction

10 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
Q86X55	Histone-arginine methyltransferase CARM1	Enzyme	CHEMBL418052	CHEMBL2175613 (1)	0 / 0
Q8TEK3	Histone-lysine N-methyltransferase, H3 lysine-79 specific	Enzyme	CHEMBL418052	CHEMBL2175606 (1) CHEMBL2175607 (1) CHEMBL2175616 (1) CHEMBL2350637 (1) CHEMBL2350651 (1)	0 / 0
P49327	Fatty acid synthase	Transferase	CHEMBL418052 CHEMBL45041	CHEMBL682484 (2)	0 / 0
O43463	Histone-lysine N-methyltransferase SUV39H1	Enzyme	CHEMBL418052	CHEMBL2175614 (1)	0 / 0
Q9UBC3	DNA (cytosine-5)-methyltransferase 3B	Enzyme	CHEMBL418052	CHEMBL1036409 (1) CHEMBL1036445 (1) CHEMBL1072865 (1) CHEMBL1072867 (1)	1 / 1
P50135	Histamine N-methyltransferase	Enzyme	CHEMBL418052 CHEMBL2092997	CHEMBL696454 (2)	0 / 0
Q99873	Protein arginine N-methyltransferase 1	Enzyme	CHEMBL418052	CHEMBL2175615 (1)	0 / 0
P26358	DNA (cytosine-5)-methyltransferase 1	Transferase	CHEMBL418052	CHEMBL1036408 (1) CHEMBL1036444 (1) CHEMBL1072864 (1) CHEMBL1072866 (1) CHEMBL1918222 (1) CHEMBL1918223 (1) CHEMBL2019574 (1) CHEMBL2050426 (1) CHEMBL2050428 (1)	2 / 0
O95050	Indolethylamine N-methyltransferase	Enzyme	CHEMBL418052	CHEMBL696703 (1)	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	CHEMBL597532	CHEMBL1614421 (1)	4 / 3

CTD interaction (4)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
D012435	1277	COL1A1 OI4	collagen, type I, alpha 1	S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA	decreases expression	mRNA	15983038
D012435	1278	COL1A2 OI4	collagen, type I, alpha 2	S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA	decreases expression	mRNA	15983038
D012435	1786	DNMT1 ADCADN AIM CXXC9 DNMT HSN1E MCMT	DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37)	S-Adenosylhomocysteine results in decreased activity of DNMT1 protein	decreases activity	protein	16037419
D012435	10891	PPARGC1A LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA	increases expression	mRNA	23056435

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM	preferred title	UniProt
#604121	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant; adcadn	P26358
#600274	Frontotemporal dementia; ftd	P10636
#242860	Immunodeficiency-centromeric instability-facial anomalies syndrome 1; icf1	Q9UBC3
#614116	Neuropathy, hereditary sensory, type ie; hsn1e	P26358
#260540	Parkinson-dementia syndrome	P10636
#172700	Pick disease of brain	P10636
#601104	Supranuclear palsy, progressive, 1; psnp1	P10636

KEGG DISEASE (4)

KEGG	disease name	UniProt
H00058	Amyotrophic lateral sclerosis (ALS)	P10636 (related)
H00077	Progressive supranuclear palsy (PSP)	P10636 (related)
H00078	Frontotemporal lobar degeneration (FTLD)	P10636 (related)
H00087	Other humoral immunodeficiencies	Q9UBC3 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease	OMIM	compound	disease name	evidence type	reference pmid
D001321		D012435	Autistic Disorder	marker/mechanism	16917939 20468076
D009361		D012435	Neoplasm Invasiveness	marker/mechanism	19770485