KNApSAcK Metabolite C00007267
Metabolite
KNApSAcK Entry
| id | C00007267 |
|---|---|
| Name | Ammonia |
| CAS RN | 7664-41-7 |
| Standard InChI | InChI=1S/H3N/h1H3 |
| Standard InChI (Main Layer) | InChI=1S/H3N/h1H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 8943 |
Link
ChEMBL
| By standard InChI | CHEMBL1160819 |
|---|---|
| By standard InChI Main Layer | CHEMBL1160819 CHEMBL1201189 |
KEGG
| By LinkDB | C00014 |
|---|
CTD
| By CAS RN | D000641 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
4 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL1160819 |
CHEMBL2073115
(1)
CHEMBL2073116
(1)
|
3 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | CHEMBL1160819 |
CHEMBL751863
(1)
|
1 / 1 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | CHEMBL1160819 |
CHEMBL751863
(1)
|
1 / 1 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | CHEMBL1160819 |
CHEMBL751839
(1)
|
0 / 0 |
CTD interaction (20)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D000641 | 8639 |
AOC3
HPAO SSAO VAP-1 VAP1 |
amine oxidase, copper containing 3 (EC:1.4.3.21) | AOC3 protein results in increased chemical synthesis of Ammonia |
increases chemical synthesis
|
protein |
16081681
|
| D000641 | 361 |
AQP4
HMIWC2 MIWC |
aquaporin 4 | Ammonia results in decreased expression of AQP4 mRNA |
decreases expression
|
mRNA |
20217200
|
| D000641 | 361 |
AQP4
HMIWC2 MIWC |
aquaporin 4 | IL1B protein inhibits the reaction [Ammonia results in decreased expression of AQP4 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
20217200
|
| D000641 | 2593 |
GAMT
CCDS2 PIG2 TP53I2 |
guanidinoacetate N-methyltransferase (EC:2.1.1.2) | Ammonia results in increased expression of GAMT protein |
increases expression
|
protein |
20227315
|
| D000641 | 2628 |
GATM
AGAT AT CCDS3 |
glycine amidinotransferase (L-arginine:glycine amidinotransferase) (EC:2.1.4.1) | Ammonia results in decreased activity of GATM protein |
decreases activity
|
protein |
20227315
|
| D000641 | 2670 |
GFAP
|
glial fibrillary acidic protein | Ammonia results in decreased expression of GFAP mRNA |
decreases expression
|
mRNA |
20217200
|
| D000641 | 2670 |
GFAP
|
glial fibrillary acidic protein | IL1B protein promotes the reaction [Ammonia results in decreased expression of GFAP mRNA] |
decreases expression
/ increases reaction |
mRNA |
20217200
|
| D000641 | 2752 |
GLUL
GLNS GS PIG43 PIG59 |
glutamate-ammonia ligase (EC:4.1.1.15 6.3.1.2) | GLUL affects the susceptibility to Ammonia |
affects response to substance
|
19073408
|
|
| D000641 | 2752 |
GLUL
GLNS GS PIG43 PIG59 |
glutamate-ammonia ligase (EC:4.1.1.15 6.3.1.2) | GLUL protein affects the metabolism of Ammonia |
affects metabolic processing
|
protein |
19073408
|
| D000641 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | Ammonia results in increased expression of HMOX1 mRNA |
increases expression
|
mRNA |
20217200
|
| D000641 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | IL1B protein promotes the reaction [Ammonia results in increased expression of HMOX1 mRNA] |
increases expression
/ increases reaction |
mRNA |
20217200
|
| D000641 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein inhibits the reaction [Ammonia results in decreased expression of AQP4 mRNA] |
decreases expression
/ decreases reaction |
protein |
20217200
|
| D000641 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein promotes the reaction [Ammonia results in decreased expression of GFAP mRNA] |
decreases expression
/ increases reaction |
protein |
20217200
|
| D000641 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein promotes the reaction [Ammonia results in increased expression of HMOX1 mRNA] |
increases expression
/ increases reaction |
protein |
20217200
|
| D000641 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein promotes the reaction [Ammonia results in increased expression of NOS2 mRNA] |
increases expression
/ increases reaction |
protein |
20217200
|
| D000641 | 4843 |
NOS2
HEP-NOS INOS NOS NOS2A |
nitric oxide synthase 2, inducible (EC:1.14.13.39) | Ammonia results in increased expression of NOS2 mRNA |
increases expression
|
mRNA |
20217200
|
| D000641 | 4843 |
NOS2
HEP-NOS INOS NOS NOS2A |
nitric oxide synthase 2, inducible (EC:1.14.13.39) | IL1B protein promotes the reaction [Ammonia results in increased expression of NOS2 mRNA] |
increases expression
/ increases reaction |
mRNA |
20217200
|
| D000641 | 51458 |
RHCG
C15orf6 PDRC2 RHGK SLC42A3 |
Rh family, C glycoprotein | RHCG protein affects the metabolism of Ammonia |
affects metabolic processing
|
protein |
16928804
|
| D000641 | 51458 |
RHCG
C15orf6 PDRC2 RHGK SLC42A3 |
Rh family, C glycoprotein | RHCG protein affects the secretion of Ammonia |
affects secretion
|
protein |
16928804
|
| D000641 | 6535 |
SLC6A8
CCDS1 CRT CRTR CT1 |
solute carrier family 6 (neurotransmitter transporter), member 8 | Ammonia affects the expression of SLC6A8 protein |
affects expression
|
protein |
20227315
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
Diseases related to CTD interactions
13 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D001238 | D000641 | Asphyxia Neonatorum |
marker/mechanism
|
12717664
|
|
| D001928 | D000641 | Brain Diseases, Metabolic |
marker/mechanism
|
17661800
|
|
| D001929 | D000641 | Brain Edema |
marker/mechanism
|
11481608
18688582 19393034 20217200 |
|
| D002318 | D000641 | Cardiovascular Diseases |
marker/mechanism
|
14761428
|
|
| D002493 | D000641 | Central Nervous System Diseases |
marker/mechanism
|
16382341
|
|
| D017449 | D000641 | Dermatitis, Allergic Contact |
marker/mechanism
|
16823706
|
|
| D006970 | D000641 | Disorders of Excessive Somnolence |
marker/mechanism
|
6436733
|
|
| D005756 | D000641 | Gastritis |
marker/mechanism
|
21761737
|
|
| D006501 | D000641 | Hepatic Encephalopathy |
marker/mechanism
|
3344727
12420312 16338762 20549931 |
|
| D009336 | D000641 | Necrosis |
marker/mechanism
|
2524618
|
|
| D011041 | D000641 | Poisoning |
marker/mechanism
|
1276935
|
|
| D012640 | D000641 | Seizures |
marker/mechanism
|
10776465
|
|
| D013226 | D000641 | Status Epilepticus |
marker/mechanism
|
17661800
|