KNApSAcK Metabolite C00007301
Metabolite
KNApSAcK Entry
| id | C00007301 |
|---|---|
| Name | Urate / Uric acid |
| CAS RN | 69-93-2 |
| Standard InChI | InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12) |
| Standard InChI (Main Layer) | InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 6775 |
Link
ChEMBL
| By standard InChI | CHEMBL792 |
|---|---|
| By standard InChI Main Layer | CHEMBL792 CHEMBL1951298 |
KEGG
| By LinkDB | C00366 |
|---|
CTD
| By CAS RN | D014527 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
3 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q9Y2T3 | Guanine deaminase | Enzyme | CHEMBL792 |
CHEMBL1225633
(1)
|
0 / 0 |
| Q8TCC7 | Solute carrier family 22 member 8 | Antiporter | CHEMBL792 |
CHEMBL2077090
(1)
CHEMBL2077561
(1)
CHEMBL2076651 (1) CHEMBL2076228 (1) |
0 / 0 |
| Q4U2R8 | Solute carrier family 22 member 6 | Antiporter | CHEMBL792 |
CHEMBL2077042
(1)
CHEMBL2077048
(1)
CHEMBL2077498 (1) CHEMBL2077502 (1) |
0 / 0 |
CTD interaction (85)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D014527 | 29974 |
A1CF
ACF ACF64 ACF65 APOBEC1CF ASP |
APOBEC1 complementation factor | A1CF gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | ABCC4 protein affects the export of Uric Acid |
affects export
|
protein |
15454390
|
| D014527 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | Uric Acid inhibits the reaction [ABCC4 protein affects the transport of Methotrexate] |
affects transport
/ decreases reaction |
protein |
15454390
|
| D014527 | 210 |
ALAD
ALADH PBGS |
aminolevulinate dehydratase (EC:4.2.1.24) | Uric Acid affects the reaction [ALAD polymorphism affects the susceptibility to Lead] |
affects reaction
/ affects response to substance |
polymorphism |
16263504
|
| D014527 | 126133 |
ALDH16A1
|
aldehyde dehydrogenase 16 family, member A1 | ALDH16A1 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
21983786
|
| D014527 | 358 |
AQP1
AQP-CHIP CHIP28 CO |
aquaporin 1 | AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] |
affects reaction
/ increases secretion |
mRNA |
21051542
|
| D014527 | 366 |
AQP9
AQP-9 HsT17287 SSC1 |
aquaporin 9 | AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] |
affects reaction
/ increases secretion |
mRNA |
21051542
|
| D014527 | 468 |
ATF4
CREB-2 CREB2 TAXREB67 TXREB |
activating transcription factor 4 | Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21703327
|
| D014527 | 6311 |
ATXN2
ASL13 ATX2 SCA2 TNRC13 |
ataxin 2 | ATXN2 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 79369 |
B3GNT4
B3GN-T4 beta3Gn-T4 |
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 | B3GNT4 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 9031 |
BAZ1B
WBSCR10 WBSCR9 WSTF |
bromodomain adjacent to zinc finger domain, 1B (EC:2.7.10.2) | BAZ1B gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 834 |
CASP1
ICE IL1BC P45 |
caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36) | [Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein |
affects cotreatment
/ increases cleavage |
protein |
18604214
|
| D014527 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein] |
affects cotreatment
/ decreases reaction / increases secretion |
protein |
19158351
|
| D014527 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | [Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein |
affects cotreatment
/ increases secretion |
protein |
19158351
|
| D014527 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | Uric Acid results in increased secretion of CCL2 protein |
increases secretion
|
protein |
19158351
|
| D014527 | 1356 |
CP
CP-2 |
ceruloplasmin (ferroxidase) (EC:1.16.3.1) | Uric Acid affects the activity of CP protein |
affects activity
|
protein |
10949969
|
| D014527 | 1649 |
DDIT3
CEBPZ CHOP CHOP-10 CHOP10 GADD153 |
DNA-damage-inducible transcript 3 | Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21703327
|
| D014527 | 3131 |
HLF
|
hepatic leukemia factor | HLF gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 3174 |
HNF4G
NR2A2 NR2A3 |
hepatocyte nuclear factor 4, gamma | HNF4G gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 3480 |
IGF1R
CD221 IGFIR IGFR JTK13 |
insulin-like growth factor 1 receptor (EC:2.7.10.1) | IGF1R gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | Ammonium Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] |
decreases reaction
/ increases secretion |
protein |
21051542
|
| D014527 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] |
affects reaction
/ increases secretion |
protein |
21051542
|
| D014527 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] |
affects reaction
/ increases secretion |
protein |
21051542
|
| D014527 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] |
decreases reaction
/ increases secretion |
protein |
21051542
|
| D014527 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein] |
affects cotreatment
/ decreases reaction / increases cleavage / increases secretion |
protein |
18604214
|
| D014527 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | [Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein |
affects cotreatment
/ increases cleavage / increases secretion |
protein |
18604214
|
| D014527 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | Mercuric Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] |
decreases reaction
/ increases secretion |
protein |
21051542
|
| D014527 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] |
decreases reaction
/ increases secretion |
protein |
21051542
|
| D014527 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | Uric Acid results in increased secretion of IL1B protein |
increases secretion
|
protein |
21051542
|
| D014527 | 3625 |
INHBB
|
inhibin, beta B | INHBB gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 3708 |
ITPR1
INSP3R1 IP3R IP3R1 SCA15 SCA16 SCA29 |
inositol 1,4,5-trisphosphate receptor, type 1 | Uric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] |
affects localization
/ decreases reaction / increases expression |
protein |
17241155
|
| D014527 | 4094 |
MAF
CCA4 c-MAF |
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | MAF gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 10725 |
NFAT5
NF-AT5 NFATL1 NFATZ OREBP TONEBP |
nuclear factor of activated T-cells 5, tonicity-responsive | NFAT5 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 114548 |
NLRP3
AGTAVPRL AII AVP C1orf7 CIAS1 CLR1.1 FCAS FCU MWS NALP3 PYPAF1 |
NLR family, pyrin domain containing 3 | [Uric Acid co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein |
affects cotreatment
/ increases activity |
protein |
18604214
|
| D014527 | 51422 |
PRKAG2
AAKG AAKG2 CMH6 H91620p WPWS |
protein kinase, AMP-activated, gamma 2 non-catalytic subunit | PRKAG2 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 51460 |
SFMBT1
RU1 SFMBT hSFMBT |
Scm-like with four mbt domains 1 | SFMBT1 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 10786 |
SLC17A3
NPT4 |
solute carrier family 17 (organic anion transporter), member 3 | SLC17A3 gene SNP affects the transport of Uric Acid |
affects transport
|
gene |
21282933
|
| D014527 | 55867 |
SLC22A11
OAT4 hOAT4 |
solute carrier family 22 (organic anion/urate transporter), member 11 | Uric Acid inhibits the reaction [SLC22A11 protein results in increased uptake of estrone sulfate] |
decreases reaction
/ increases uptake |
protein |
16135657
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | 6-hydroxybenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | benzarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] |
affects cotreatment
/ decreases reaction / increases import |
protein |
20639259
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | [Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] |
affects cotreatment
/ decreases reaction / increases import |
protein |
20639259
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | [Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] |
affects cotreatment
/ decreases reaction / increases import |
protein |
20639259
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | [Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] |
affects cotreatment
/ decreases reaction / increases import |
protein |
20639259
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | Chlorine inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] |
decreases reaction
/ increases import |
protein |
20639259
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | Indomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | [Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid |
decreases abundance
/ decreases activity |
protein |
18670416
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | Phenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | Salicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | SLC22A12 protein results in increased import of Uric Acid |
increases import
|
protein |
20639259
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | SLC22A12 protein results in increased uptake of Uric Acid |
increases uptake
|
protein |
14694169
21272127 |
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | Sulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
21272127
|
| D014527 | 116085 |
SLC22A12
OAT4L RST URAT1 |
solute carrier family 22 (organic anion/urate transporter), member 12 | Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol] |
decreases reaction
/ increases uptake |
protein |
16135657
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] |
affects transport
/ decreases reaction |
protein |
12472777
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | alpha-ketoglutaric acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] |
affects transport
/ decreases reaction |
protein |
12472777
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | Benzbromarone inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] |
affects transport
/ decreases reaction |
protein |
12472777
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | gluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] |
affects transport
/ decreases reaction |
protein |
12472777
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | Glutarates promotes the reaction [SLC22A6 protein results in increased uptake of Uric Acid] |
increases reaction
/ increases uptake |
protein |
12472777
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Uric Acid] |
decreases reaction
/ increases uptake |
protein |
12472777
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | Probenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] |
affects transport
/ decreases reaction |
protein |
12472777
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] |
affects transport
/ decreases reaction |
protein |
12472777
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | Salicylates inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] |
affects transport
/ decreases reaction |
protein |
12472777
|
| D014527 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | SLC22A6 protein results in increased uptake of Uric Acid |
increases uptake
|
protein |
12472777
|
| D014527 | 9376 |
SLC22A8
OAT3 |
solute carrier family 22 (organic anion transporter), member 8 | SLC22A8 protein affects the transport of Uric Acid |
affects transport
|
protein |
11306713
|
| D014527 | 56606 |
SLC2A9
GLUT9 GLUTX UAQTL2 URATv1 |
solute carrier family 2 (facilitated glucose transporter), member 9 | Benzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid] |
decreases reaction
/ increases transport |
protein |
18842065
|
| D014527 | 56606 |
SLC2A9
GLUT9 GLUTX UAQTL2 URATv1 |
solute carrier family 2 (facilitated glucose transporter), member 9 | Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid] |
increases reaction
/ increases transport |
protein |
18842065
|
| D014527 | 56606 |
SLC2A9
GLUT9 GLUTX UAQTL2 URATv1 |
solute carrier family 2 (facilitated glucose transporter), member 9 | Glucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid] |
increases reaction
/ increases transport |
protein |
18842065
|
| D014527 | 56606 |
SLC2A9
GLUT9 GLUTX UAQTL2 URATv1 |
solute carrier family 2 (facilitated glucose transporter), member 9 | SLC2A9 gene polymorphism affects the abundance of Uric Acid |
affects abundance
|
gene |
18327257
|
| D014527 | 56606 |
SLC2A9
GLUT9 GLUTX UAQTL2 URATv1 |
solute carrier family 2 (facilitated glucose transporter), member 9 | SLC2A9 intron SNP affects the abundance of Uric Acid |
affects abundance
|
intron |
18327256
|
| D014527 | 56606 |
SLC2A9
GLUT9 GLUTX UAQTL2 URATv1 |
solute carrier family 2 (facilitated glucose transporter), member 9 | SLC2A9 protein affects the transport of Uric Acid |
affects transport
|
protein |
18327257
|
| D014527 | 56606 |
SLC2A9
GLUT9 GLUTX UAQTL2 URATv1 |
solute carrier family 2 (facilitated glucose transporter), member 9 | SLC2A9 protein alternative form results in increased transport of Uric Acid |
increases transport
|
protein |
18842065
|
| D014527 | 56606 |
SLC2A9
GLUT9 GLUTX UAQTL2 URATv1 |
solute carrier family 2 (facilitated glucose transporter), member 9 | SLC2A9 protein results in decreased secretion of Uric Acid |
decreases secretion
|
protein |
22132990
|
| D014527 | 6647 |
SOD1
ALS ALS1 IPOA SOD hSod1 homodimer |
superoxide dismutase 1, soluble (EC:1.15.1.1) | Uric Acid affects the activity of SOD1 protein |
affects activity
|
protein |
10949969
|
| D014527 | 6781 |
STC1
STC |
stanniocalcin 1 | STC1 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 134285 |
TMEM171
PRP2 |
transmembrane protein 171 | TMEM171 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 80128 |
TRIM46
GENEY TRIFIC |
tripartite motif containing 46 | TRIM46 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 92912 |
UBE2Q2
|
ubiquitin-conjugating enzyme E2Q family member 2 (EC:6.3.2.19) | UBE2Q2 gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 391051 |
UOX
UOXP URICASE |
urate oxidase, pseudogene | UOX protein results in decreased abundance of Uric Acid |
decreases abundance
|
protein |
16313266
|
| D014527 | 7422 |
VEGFA
MVCD1 VEGF VPF |
vascular endothelial growth factor A | VEGFA gene SNP affects the abundance of Uric Acid |
affects abundance
|
gene |
23263486
|
| D014527 | 7498 |
XDH
XO XOR |
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) | Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid] |
increases chemical synthesis
/ increases reaction |
protein |
19158351
|
| D014527 | 7498 |
XDH
XO XOR |
xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) | XDH protein results in increased chemical synthesis of Uric Acid |
increases chemical synthesis
|
protein |
19158351
|
Related Disease
Diseases related to CTD interactions
16 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000740 | D014527 | Anemia |
therapeutic
|
2000096
|
|
| D015210 | D014527 | Arthritis, Gouty |
marker/mechanism
|
19655406
|
|
| D002310 | D014527 | Cardiomyopathy, Alcoholic |
therapeutic
|
22497828
|
|
| D002779 | D014527 | Cholestasis |
therapeutic
|
12612912
|
|
| D003922 | D014527 | Diabetes Mellitus, Type 1 |
marker/mechanism
|
16506275
|
|
| D006073 | D014527 | Gout |
marker/mechanism
|
9500573
|
|
| D033461 | D014527 | Hyperuricemia |
marker/mechanism
|
20506124
|
|
| D007249 | D014527 | Inflammation |
marker/mechanism
|
6830329
|
|
| D007669 | D014527 | Kidney Calculi |
marker/mechanism
|
8316811
|
|
| D007674 | D014527 | Kidney Diseases |
marker/mechanism
|
16263504
|
|
| D007970 | D014527 | Leukopenia |
therapeutic
|
2000096
|
|
| D008659 | D014527 | Metabolic Diseases |
marker/mechanism
|
19131468
|
|
| D024821 | D014527 | Metabolic Syndrome X |
marker/mechanism
|
16234313
|
|
| D010146 | D014527 | Pain |
marker/mechanism
|
9882077
|
|
| D052878 | D014527 | Urolithiasis |
marker/mechanism
|
20506124
|
|
| D014652 | D014527 | Vascular Diseases |
marker/mechanism
|
18951979
|