PCIDB

KNApSAcK Metabolite C00007313

Metabolite

KNApSAcK Entry

id C00007313
Name UDP / Uridine 5'-diphosphate
CAS RN 58-98-0
Standard InChI InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
Standard InChI (Main Layer) InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)

Cluster

Phytochemical cluster
KCF-S cluster No. 2752

Link

ChEMBL

By standard InChI CHEMBL130266
By standard InChI Main Layer CHEMBL130266 CHEMBL1625810

KEGG

By LinkDB C00015

CTD

By CAS RN D014530

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Enterobacteriaceae 1
Brassicaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Escherichia coli 562 Enterobacteriaceae Bacteria

Human Protein / Gene in interaction

14 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P47900 P2Y purinoceptor 1 Purine receptor CHEMBL130266 CHEMBL697056 (1) CHEMBL750156 (1)
0 / 0
Q15077 P2Y purinoceptor 6 Purine receptor CHEMBL130266 CHEMBL884243 (1) CHEMBL757044 (1)
CHEMBL757045 (1) CHEMBL858654 (1)
CHEMBL866173 (1) CHEMBL911821 (1)
CHEMBL958064 (1) CHEMBL1045263 (1)
CHEMBL1070825 (1) CHEMBL1119551 (1)
CHEMBL1767476 (1) CHEMBL1960467 (1)
CHEMBL2090365 (1) CHEMBL2090366 (1)
CHEMBL2090458 (1)
0 / 0
P51582 P2Y purinoceptor 4 Purine receptor CHEMBL130266 CHEMBL697060 (1) CHEMBL912410 (1)
CHEMBL1068973 (1) CHEMBL1767475 (1)
0 / 0
P22413 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Enzyme CHEMBL130266 CHEMBL2090463 (1)
4 / 4
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL130266 CHEMBL922834 (1)
0 / 0
P27708 CAD protein Enzyme CHEMBL130266 CHEMBL653964 (1)
0 / 0
P41231 P2Y purinoceptor 2 Purine receptor CHEMBL130266 CHEMBL697057 (1) CHEMBL751765 (1)
CHEMBL907213 (1) CHEMBL1068968 (1)
CHEMBL1769029 (1)
0 / 0
O14638 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 Enzyme CHEMBL130266 CHEMBL2090464 (1)
0 / 0
Q15391 P2Y purinoceptor 14 Purine receptor CHEMBL130266 CHEMBL1045264 (1) CHEMBL1119549 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL130266 CHEMBL1738675 (1)
0 / 0
O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit Enzyme CHEMBL130266 CHEMBL1670864 (1)
0 / 0
Q7LG56 Ribonucleoside-diphosphate reductase subunit M2 B Enzyme CHEMBL130266 CHEMBL857348 (1) CHEMBL796772 (1)
2 / 2
P31350 Ribonucleoside-diphosphate reductase subunit M2 Enzyme CHEMBL130266 CHEMBL857348 (1) CHEMBL796772 (1)
0 / 0
P23921 Ribonucleoside-diphosphate reductase large subunit Oxidoreductase CHEMBL130266 CHEMBL857348 (1) CHEMBL796772 (1)
0 / 0

CTD interaction (12)

compound gene gene name gene description interaction interaction type form reference
pmid
D014530 10800 CYSLTR1
CYSLT1
CYSLT1R
CYSLTR
HMTMF81
cysteinyl leukotriene receptor 1 montelukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium] affects binding
/ decreases reaction
/ increases abundance
/ increases activity
protein 20083671
D014530 10800 CYSLTR1
CYSLT1
CYSLT1R
CYSLTR
HMTMF81
cysteinyl leukotriene receptor 1 montelukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of IL8 protein] decreases reaction
/ increases activity
/ increases expression
protein 20083671
D014530 10800 CYSLTR1
CYSLT1
CYSLT1R
CYSLTR
HMTMF81
cysteinyl leukotriene receptor 1 Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein affects binding
/ increases activity
protein 20083671
D014530 10800 CYSLTR1
CYSLT1
CYSLT1R
CYSLTR
HMTMF81
cysteinyl leukotriene receptor 1 [Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium affects binding
/ increases abundance
/ increases activity
protein 20083671
D014530 10800 CYSLTR1
CYSLT1
CYSLT1R
CYSLTR
HMTMF81
cysteinyl leukotriene receptor 1 [Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased expression of IL8 protein affects binding
/ increases activity
/ increases expression
protein 20083671
D014530 10800 CYSLTR1
CYSLT1
CYSLT1R
CYSLTR
HMTMF81
cysteinyl leukotriene receptor 1 zafirlukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium] affects binding
/ decreases reaction
/ increases abundance
/ increases activity
protein 20083671
D014530 10800 CYSLTR1
CYSLT1
CYSLT1R
CYSLTR
HMTMF81
cysteinyl leukotriene receptor 1 zafirlukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of IL8 protein] decreases reaction
/ increases activity
/ increases expression
protein 20083671
D014530 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 montelukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of IL8 protein] decreases reaction
/ increases activity
/ increases expression
protein 20083671
D014530 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 [Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased expression of IL8 protein affects binding
/ increases activity
/ increases expression
protein 20083671
D014530 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 zafirlukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of IL8 protein] decreases reaction
/ increases activity
/ increases expression
protein 20083671
D014530 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Uridine Diphosphate results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 15034929
D014530 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Uridine Diphosphate results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 15034929

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#208000 Arterial calcification, generalized, of infancy, 1; gaci1 P22413
#125853 Diabetes mellitus, noninsulin-dependent; niddm P22413
#613312 Hypophosphatemic rickets, autosomal recessive, 2; arhr2 P22413
#612075 Mitochondrial dna depletion syndrome 8a (encephalomyopathic type with renal tubulopathy); mtdps8a Q7LG56
%602475 Ossification of the posterior longitudinal ligament of spine; opll P22413
#613077 Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant, 5; peoa5 Q7LG56

KEGG DISEASE (6)

KEGG disease name UniProt
H00214 Hypophosphatemic rickets P22413 (related)
H00409 Type II diabetes mellitus P22413 (related)
H00431 Ossification of the posterior longitudinal ligament of spine (OPLL) P22413 (related)
H01002 Generalized arterial calcification of infancy P22413 (related)
H00469 Mitochondrial DNA depletion syndrome (MDS) Q7LG56 (related)
H01118 Progressive external ophthalmoplegia (PEO) Q7LG56 (related)