KNApSAcK Metabolite C00007314
Metabolite
KNApSAcK Entry
| id | C00007314 |
|---|---|
| Name | Urea |
| CAS RN | 57-13-6 |
| Standard InChI | InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4) |
| Standard InChI (Main Layer) | InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 8946 |
Link
ChEMBL
| By standard InChI | CHEMBL985 |
|---|---|
| By standard InChI Main Layer | CHEMBL985 CHEMBL2096635 CHEMBL2096648 |
KEGG
| By LinkDB | C00086 |
|---|
CTD
| By CAS RN | D014508 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
7 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL985 |
CHEMBL1794524
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL985 |
CHEMBL1614544
(1)
|
11 / 10 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL985 |
CHEMBL1614458
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL985 |
CHEMBL1794401
(1)
|
0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL985 |
CHEMBL1794483
(1)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL985 |
CHEMBL2114890
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL985 |
CHEMBL1614364
(1)
|
1 / 1 |
CTD interaction (13)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D014508 | 174 |
AFP
FETA HPAFP |
alpha-fetoprotein | Urea results in increased expression of AFP protein |
increases expression
|
protein |
16966304
|
| D014508 | 213 |
ALB
PRO0883 PRO0903 PRO1341 |
albumin | Urea results in decreased folding of ALB protein |
decreases folding
|
protein |
11934277
|
| D014508 | 213 |
ALB
PRO0883 PRO0903 PRO1341 |
albumin | Urea results in decreased folding of ALB protein modified form |
decreases folding
|
protein |
11934277
|
| D014508 | 89872 |
AQP10
AQPA_HUMAN |
aquaporin 10 | AQP10 protein results in increased uptake of Urea |
increases uptake
|
protein |
12084581
|
| D014508 | 384 |
ARG2
|
arginase 2 (EC:3.5.3.1) | ARG2 protein results in increased chemical synthesis of Urea |
increases chemical synthesis
|
protein |
17680661
|
| D014508 | 567 |
B2M
|
beta-2-microglobulin | Urea promotes the reaction [Copper promotes the reaction [B2M protein binds to B2M protein]] |
affects binding
/ increases reaction |
protein |
17254602
|
| D014508 | 1374 |
CPT1A
CPT1 CPT1-L L-CPT1 |
carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) | Urea analog results in increased expression of CPT1A mRNA |
increases expression
|
mRNA |
15798002
|
| D014508 | 2260 |
FGFR1
BFGFR CD331 CEK FGFBR FGFR-1 FLG FLT-2 FLT2 HBGFR HH2 HRTFDS KAL2 N-SAM OGD bFGF-R-1 |
fibroblast growth factor receptor 1 (EC:2.7.10.1) | Urea analog results in decreased activity of FGFR1 protein |
decreases activity
|
protein |
16000000
|
| D014508 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | Urea results in increased expression of HMOX1 mRNA |
increases expression
|
mRNA |
11592956
|
| D014508 | 3791 |
KDR
CD309 FLK1 VEGFR VEGFR2 |
kinase insert domain receptor (a type III receptor tyrosine kinase) (EC:2.7.10.1) | Urea analog results in decreased activity of KDR protein |
decreases activity
|
protein |
16000000
|
| D014508 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Urea analog results in increased activity of PPARA protein |
increases activity
|
protein |
15798002
|
| D014508 | 6648 |
SOD2
IPOB MNSOD MVCD6 |
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) | SOD2 protein results in decreased abundance of Urea |
decreases abundance
|
protein |
19917352
|
| D014508 | 7276 |
TTR
CTS CTS1 HsT2651 PALB TBPA |
transthyretin | [Diflunisal binds to TTR protein mutant form] which results in decreased susceptibility to Urea |
affects binding
/ decreases response to substance |
protein |
17701470
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (12)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (11)
| KEGG | disease name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
6 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D058186 | D014508 | Acute Kidney Injury |
marker/mechanism
|
15012908
|
|
| D007024 | D014508 | Hypotension, Orthostatic |
marker/mechanism
|
127594
|
|
| D007177 | D014508 | Inappropriate ADH Syndrome |
therapeutic
|
19834406
|
|
| D007674 | D014508 | Kidney Diseases |
marker/mechanism
|
9144837
22525860 |
|
| D010243 | D014508 | Paralysis |
therapeutic
|
935180
|
|
| D011041 | D014508 | Poisoning |
marker/mechanism
|
22525860
|