KNApSAcK Metabolite C00007347
Metabolite
KNApSAcK Entry
| id | C00007347 |
|---|---|
| Name | S-Adenosyl-L-methionine |
| CAS RN | 29908-03-0 |
| Standard InChI | InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7?,8-,10?,11+,14-,27?/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5509 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL224120 CHEMBL1088977 CHEMBL2220241 |
KEGG
| By LinkDB | C00019 |
|---|
CTD
| By CAS RN | D012436 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
| Enterobacteriaceae | 1 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
4 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P22061 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase | Enzyme | CHEMBL1088977 |
CHEMBL766686
(1)
CHEMBL766687
(1)
|
0 / 0 |
| Q99873 | Protein arginine N-methyltransferase 1 | Enzyme | CHEMBL1088977 |
CHEMBL1115315
(1)
|
0 / 0 |
| P11086 | Phenylethanolamine N-methyltransferase | Enzyme | CHEMBL1088977 |
CHEMBL913938
(2)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL224120 |
CHEMBL1738442
(1)
|
0 / 0 |
CTD interaction (33)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D012436 | 23743 |
BHMT2
|
betaine--homocysteine S-methyltransferase 2 (EC:2.1.1.10) | S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] |
decreases reaction
/ increases metabolic processing |
protein |
18230605
|
| D012436 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
17869084
|
| D012436 | 1277 |
COL1A1
OI4 |
collagen, type I, alpha 1 | S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
16996477
|
| D012436 | 1277 |
COL1A1
OI4 |
collagen, type I, alpha 1 | S-Adenosylmethionine results in decreased expression of COL1A1 mRNA |
decreases expression
|
mRNA |
15983038
|
| D012436 | 1278 |
COL1A2
OI4 |
collagen, type I, alpha 2 | S-Adenosylmethionine results in decreased expression of COL1A2 mRNA |
decreases expression
|
mRNA |
15983038
|
| D012436 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] |
decreases activity
/ decreases reaction / increases abundance |
protein |
16758261
|
| D012436 | 1571 |
CYP2E1
CPE1 CYP2E P450-J P450C2E |
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) | S-Adenosylmethionine results in decreased activity of CYP2E1 protein |
decreases activity
|
protein |
15763544
|
| D012436 | 1644 |
DDC
AADC |
dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) | [Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine |
affects cotreatment
/ increases abundance |
11445284
|
|
| D012436 | 1786 |
DNMT1
ADCADN AIM CXXC9 DNMT HSN1E MCMT |
DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) | S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]] |
affects binding
/ decreases reaction |
protein |
22558281
|
| D012436 | 1786 |
DNMT1
ADCADN AIM CXXC9 DNMT HSN1E MCMT |
DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) | S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] |
decreases expression
/ decreases reaction |
protein |
22558281
|
| D012436 | 1788 |
DNMT3A
DNMT3A2 M.HsaIIIA |
DNA (cytosine-5-)-methyltransferase 3 alpha (EC:2.1.1.37) | S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein] |
decreases expression
/ decreases reaction |
protein |
22558281
|
| D012436 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]] |
affects binding
/ decreases reaction |
promoter |
22558281
|
| D012436 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter] |
decreases methylation
/ decreases reaction |
promoter |
22558281
|
| D012436 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22558281
|
| D012436 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] |
decreases reaction
/ increases expression |
protein |
22558281
|
| D012436 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA] |
decreases reaction
/ increases expression |
protein |
22558281
|
| D012436 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA] |
decreases reaction
/ increases expression |
protein |
22558281
|
| D012436 | 9687 |
GREB1
|
growth regulation by estrogen in breast cancer 1 | S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22558281
|
| D012436 | 9687 |
GREB1
|
growth regulation by estrogen in breast cancer 1 | S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22558281
|
| D012436 | 3952 |
LEP
LEPD OB OBS |
leptin | S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] |
decreases reaction
/ increases expression |
protein |
16996477
|
| D012436 | 3952 |
LEP
LEPD OB OBS |
leptin | S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] |
decreases reaction
/ increases expression |
mRNA |
16996477
|
| D012436 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | [1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein] |
affects cotreatment
/ decreases reaction / increases phosphorylation |
protein |
16996477
|
| D012436 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]] |
affects binding
/ decreases reaction / increases reaction |
protein |
15983038
|
| D012436 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | [1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein] |
affects cotreatment
/ decreases reaction / increases phosphorylation |
protein |
16996477
|
| D012436 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] |
affects binding
/ decreases reaction / increases reaction |
protein |
15983038
|
| D012436 | 8932 |
MBD2
DMTase NY-CO-41 |
methyl-CpG binding domain protein 2 | S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein] |
decreases reaction
/ increases expression |
protein |
22558281
|
| D012436 | 4548 |
MTR
HMAG MS cblG |
5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) | S-Adenosylmethionine binds to MTR protein |
affects binding
|
protein |
17477549
|
| D012436 | 6667 |
SP1
|
Sp1 transcription factor | S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]] |
affects binding
/ decreases reaction / increases reaction |
protein |
15983038
|
| D012436 | 6667 |
SP1
|
Sp1 transcription factor | S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] |
affects binding
/ decreases reaction / increases reaction |
protein |
15983038
|
| D012436 | 7031 |
TFF1
BCEI D21S21 HP1.A HPS2 pNR-2 pS2 |
trefoil factor 1 | S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22558281
|
| D012436 | 7031 |
TFF1
BCEI D21S21 HP1.A HPS2 pNR-2 pS2 |
trefoil factor 1 | S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22558281
|
| D012436 | 7040 |
TGFB1
CED DPD1 LAP TGFB TGFbeta |
transforming growth factor, beta 1 | S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]] |
affects binding
/ decreases reaction / increases reaction |
protein |
15983038
|
| D012436 | 7040 |
TGFB1
CED DPD1 LAP TGFB TGFbeta |
transforming growth factor, beta 1 | S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] |
affects binding
/ decreases reaction / increases reaction |
protein |
15983038
|
Related Disease
Diseases related to CTD interactions
32 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D001321 | D012436 | Autistic Disorder |
marker/mechanism
|
16917939
19056591 |
|
| D001714 | D012436 | Bipolar Disorder |
marker/mechanism
|
6367496
|
|
| D002779 | D012436 | Cholestasis |
marker/mechanism
therapeutic |
6295906
7450400 8497444 11281545 |
|
| D003072 | D012436 | Cognition Disorders |
therapeutic
|
7527320
|
|
| D003645 | D012436 | Death, Sudden |
therapeutic
|
11346894
|
|
| D003704 | D012436 | Dementia |
therapeutic
|
7527320
|
|
| D003711 | D012436 | Demyelinating Diseases |
therapeutic
|
7527320
|
|
| D003866 | D012436 | Depressive Disorder |
therapeutic
|
6367496
18824331 |
|
| D056486 | D012436 | Drug-Induced Liver Injury |
therapeutic
|
11346894
18068290 20450926 22683606 |
|
| D004409 | D012436 | Dyskinesia, Drug-Induced |
marker/mechanism
|
14643842
|
|
| D005494 | D012436 | Folic Acid Deficiency |
marker/mechanism
|
7527320
|
|
| D005705 | D012436 | Gallbladder Diseases |
therapeutic
|
18518811
|
|
| D006529 | D012436 | Hepatomegaly |
therapeutic
|
18068290
|
|
| D006948 | D012436 | Hyperkinesis |
therapeutic
|
14643842
|
|
| D018476 | D012436 | Hypokinesia |
marker/mechanism
|
1359575
8503824 10973524 |
|
| D007037 | D012436 | Hypothyroidism |
therapeutic
|
18518811
|
|
| D007565 | D012436 | Jaundice |
therapeutic
|
8497444
|
|
| D008103 | D012436 | Liver Cirrhosis |
therapeutic
|
8878782
|
|
| D008106 | D012436 | Liver Cirrhosis, Experimental |
therapeutic
|
15983038
|
|
| D008107 | D012436 | Liver Diseases |
therapeutic
|
1327655
|
|
| D008113 | D012436 | Liver Neoplasms |
therapeutic
|
12163149
|
|
| D008661 | D012436 | Metabolism, Inborn Errors |
therapeutic
|
7527320
|
|
| D009078 | D012436 | Mucocele |
therapeutic
|
18518811
|
|
| D009127 | D012436 | Muscle Rigidity |
marker/mechanism
|
1359575
8503824 10973524 |
|
| D009336 | D012436 | Necrosis |
therapeutic
|
11346894
18068290 |
|
| D009410 | D012436 | Nerve Degeneration |
marker/mechanism
|
1359575
|
|
| D020335 | D012436 | Paraparesis |
therapeutic
|
19821069
|
|
| D051437 | D012436 | Renal Insufficiency |
therapeutic
|
8497444
|
|
| D012559 | D012436 | Schizophrenia |
therapeutic
|
18824331
|
|
| D013118 | D012436 | Spinal Cord Diseases |
therapeutic
|
19821069
|
|
| D014202 | D012436 | Tremor |
marker/mechanism
|
32260
1359575 8503824 10973524 |
|
| D014806 | D012436 | Vitamin B 12 Deficiency |
marker/mechanism
|
7527320
|