KNApSAcK Metabolite C00007381
Metabolite
KNApSAcK Entry
| id | C00007381 |
|---|---|
| Name | Quinolinic acid |
| CAS RN | 89-00-9 |
| Standard InChI | InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12) |
| Standard InChI (Main Layer) | InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5975 |
Link
ChEMBL
| By standard InChI | CHEMBL286204 |
|---|---|
| By standard InChI Main Layer | CHEMBL286204 |
KEGG
| By LinkDB | C03722 |
|---|
CTD
| By CAS RN | D017378 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
| Enterobacteriaceae | 1 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
28 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL286204 |
CHEMBL1741321
(1)
|
1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL286204 |
CHEMBL1738312
(1)
|
0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL286204 |
CHEMBL1794499
(1)
|
2 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | CHEMBL286204 |
CHEMBL1664429
(1)
|
0 / 0 |
| P22894 | Neutrophil collagenase | M10A | CHEMBL286204 |
CHEMBL1664434
(1)
|
0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | CHEMBL286204 |
CHEMBL1664435
(1)
|
2 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL286204 |
CHEMBL1614281
(1)
CHEMBL1614361
(1)
|
3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL286204 |
CHEMBL1741325
(1)
|
0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL286204 |
CHEMBL1614522
(1)
CHEMBL1614067
(1)
|
1 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL286204 |
CHEMBL1614458
(1)
|
0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL286204 |
CHEMBL1794486
(2)
|
0 / 0 |
| P03956 | Interstitial collagenase | M10A | CHEMBL286204 |
CHEMBL1664431
(1)
|
0 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | CHEMBL286204 |
CHEMBL1614280
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL286204 |
CHEMBL1738610
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL286204 |
CHEMBL1741322
(1)
|
0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | CHEMBL286204 |
CHEMBL1664432
(1)
|
1 / 3 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL286204 |
CHEMBL1614240
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL286204 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL286204 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
CHEMBL1741324 (1) |
0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL286204 |
CHEMBL1794483
(1)
|
0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | CHEMBL286204 |
CHEMBL1614052
(1)
|
1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | CHEMBL286204 |
CHEMBL1737991
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL286204 |
CHEMBL1614250
(3)
|
4 / 3 |
| P08254 | Stromelysin-1 | M10A | CHEMBL286204 |
CHEMBL1664433
(1)
|
1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL286204 |
CHEMBL1613914
(3)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL286204 |
CHEMBL1738442
(3)
|
0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL286204 |
CHEMBL1738090
(1)
CHEMBL1737904
(1)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL286204 |
CHEMBL1738090
(1)
CHEMBL1737904
(1)
|
1 / 6 |
CTD interaction (1)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D017378 | 2246 |
FGF1
AFGF ECGF ECGF-beta ECGFA ECGFB FGF-1 FGF-alpha FGFA GLIO703 HBGF-1 HBGF1 |
fibroblast growth factor 1 (acidic) | Quinolinic Acid results in decreased secretion of FGF1 protein |
decreases secretion
|
protein |
16392031
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (18)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (18)
| KEGG | disease name | UniProt |
|---|---|---|
| H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
Diseases related to CTD interactions
17 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D001321 | D017378 | Autistic Disorder |
marker/mechanism
|
16139734
|
|
| D001927 | D017378 | Brain Diseases |
marker/mechanism
|
2159831
7917035 |
|
| D001930 | D017378 | Brain Injuries |
marker/mechanism
|
20450929
|
|
| D002375 | D017378 | Catalepsy |
therapeutic
|
2159831
7917035 |
|
| D003072 | D017378 | Cognition Disorders |
marker/mechanism
|
11844244
|
|
| D004195 | D017378 | Disease Models, Animal |
marker/mechanism
|
7753372
11844244 |
|
| D004409 | D017378 | Dyskinesia, Drug-Induced |
marker/mechanism
|
7753372
|
|
| D004421 | D017378 | Dystonia |
marker/mechanism
|
7753372
|
|
| D020803 | D017378 | Encephalitis, Herpes Simplex |
marker/mechanism
|
17174341
|
|
| D006816 | D017378 | Huntington Disease |
marker/mechanism
|
7753372
11844244 |
|
| D008569 | D017378 | Memory Disorders |
marker/mechanism
|
17266991
|
|
| D009069 | D017378 | Movement Disorders |
marker/mechanism
|
11844244
20043943 |
|
| D009410 | D017378 | Nerve Degeneration |
marker/mechanism
|
1963345
21378209 |
|
| D009422 | D017378 | Nervous System Diseases |
marker/mechanism
|
11844244
20043943 |
|
| D020258 | D017378 | Neurotoxicity Syndromes |
marker/mechanism
|
12899943
20450929 |
|
| D012640 | D017378 | Seizures |
marker/mechanism
|
2159831
3040437 6864208 9169290 19526287 |
|
| D015431 | D017378 | Weight Loss |
marker/mechanism
|
20043943
|