| class name | count |
|---|---|
| rosids | 1 |
| class name | count |
|---|---|
| Brassicaceae | 1 |
| Enterobacteriaceae | 1 |
| br08003 Category | # of metabolite |
|---|
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00007381
|
Quinolinic acid
|
CHEMBL286204
|
D017378
|
28 / 18 / 18 | 1 / 17 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00007381 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00007381 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00007381 | 2 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00007381 | 0 / 0 |
| P22894 | Neutrophil collagenase | M10A | C00007381 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00007381 | 2 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00007381 | 3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00007381 | 0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00007381 | 1 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00007381 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00007381 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00007381 | 0 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00007381 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00007381 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00007381 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00007381 | 1 / 3 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00007381 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00007381 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00007381 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00007381 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00007381 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00007381 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00007381 | 4 / 3 |
| P08254 | Stromelysin-1 | M10A | C00007381 | 1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00007381 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00007381 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00007381 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00007381 | 1 / 4 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 2246 | FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 | fibroblast growth factor 1 (acidic) |
C00007381
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| KEGG | name | UniProt |
|---|---|---|
| H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001321 | Autistic Disorder |
C00007381
|
| D001927 | Brain Diseases |
C00007381
|
| D001930 | Brain Injuries |
C00007381
|
| D002375 | Catalepsy |
C00007381
|
| D003072 | Cognition Disorders |
C00007381
|
| D004195 | Disease Models, Animal |
C00007381
|
| D004409 | Dyskinesia, Drug-Induced |
C00007381
|
| D004421 | Dystonia |
C00007381
|
| D020803 | Encephalitis, Herpes Simplex |
C00007381
|
| D006816 | Huntington Disease |
C00007381
|
| D008569 | Memory Disorders |
C00007381
|
| D009069 | Movement Disorders |
C00007381
|
| D009410 | Nerve Degeneration |
C00007381
|
| D009422 | Nervous System Diseases |
C00007381
|
| D020258 | Neurotoxicity Syndromes |
C00007381
|
| D012640 | Seizures |
C00007381
|
| D015431 | Weight Loss |
C00007381
|