PCIDB

KNApSAcK Metabolite C00007382

Metabolite

KNApSAcK Entry

id C00007382
Name Anthranilic acid
CAS RN 118-92-3
Standard InChI InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)
Standard InChI (Main Layer) InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)

Cluster

Phytochemical cluster
KCF-S cluster No. 2192

Link

ChEMBL

By standard InChI CHEMBL14173
By standard InChI Main Layer CHEMBL14173

KEGG

By LinkDB C00108

CTD

By CAS RN C031385

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL14173 CHEMBL1614458 (1)
0 / 0
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase CHEMBL14173 CHEMBL939956 (1) CHEMBL939957 (1)
1 / 1
Q96RI1 Bile acid receptor NR1H4 CHEMBL14173 CHEMBL1794415 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL14173 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL14173 CHEMBL2114842 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL14173 CHEMBL2114890 (1)
0 / 0

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
C031385 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) anthranilic acid analog results in decreased activity of AKR1C1 protein decreases activity
protein 19007763
C031385 3458 IFNG
IFG
IFI
interferon, gamma anthranilic acid analog inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein] affects binding
/ decreases reaction
/ increases secretion
protein 15799959
C031385 3458 IFNG
IFG
IFI
interferon, gamma anthranilic acid analog inhibits the reaction [IL18 protein results in increased secretion of IFNG protein] decreases reaction
/ increases secretion
protein 15799959
C031385 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) anthranilic acid analog inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein] affects binding
/ decreases reaction
/ increases secretion
protein 15799959
C031385 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) anthranilic acid analog inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein] affects binding
/ decreases reaction
/ increases secretion
protein 15799959
C031385 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) anthranilic acid analog inhibits the reaction [IL18 protein results in increased secretion of IFNG protein] decreases reaction
/ increases secretion
protein 15799959
C031385 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) anthranilic acid results in decreased activity of MAP2K1 protein decreases activity
protein 18393446

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#613163 Gaba-transaminase deficiency P80404
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714

KEGG DISEASE (4)

KEGG disease name UniProt
H01257 GABA-transaminase deficiency P80404 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D019970 C031385 Cocaine-Related Disorders marker/mechanism
19649617
D008114 C031385 Liver Neoplasms, Experimental marker/mechanism
6248561
D010024 C031385 Osteoporosis marker/mechanism
17042918
D011297 C031385 Prenatal Exposure Delayed Effects marker/mechanism
6248561