KNApSAcK Metabolite C00007383
Metabolite
KNApSAcK Entry
| id | C00007383 |
|---|---|
| Name | AICAR / 5-Amino-4-imidazolecarboxamide ribonucleotide |
| CAS RN | 3031-94-5 |
| Standard InChI | InChI=1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)/t3-,5?,6+,9-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 3393 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL483849 |
KEGG
| By LinkDB | C04677 |
|---|
CTD
| By CAS RN | C031143 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
6 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P42574 | Caspase-3 | C14 | CHEMBL483849 |
CHEMBL911075
(1)
CHEMBL911076
(1)
|
0 / 0 |
| P09467 | Fructose-1,6-bisphosphatase 1 | Enzyme | CHEMBL483849 |
CHEMBL981259
(1)
CHEMBL981262
(2)
|
1 / 1 |
| P55211 | Caspase-9 | C14 | CHEMBL483849 |
CHEMBL911077
(1)
CHEMBL911078
(1)
|
0 / 0 |
| P31939 | Bifunctional purine biosynthesis protein PURH | Enzyme | CHEMBL483849 |
CHEMBL875660
(1)
CHEMBL1003209
(1)
|
1 / 1 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | CHEMBL483849 |
CHEMBL908751
(1)
CHEMBL908749
(1)
|
0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | CHEMBL483849 |
CHEMBL908751
(1)
CHEMBL908749
(1)
|
0 / 0 |
CTD interaction (42)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C031143 | 31 |
ACACA
ACAC ACACAD ACC ACC1 ACCA |
acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14) | AICA ribonucleotide results in increased phosphorylation of ACACA protein |
increases phosphorylation
|
protein |
15297373
16873680 20080969 |
| C031143 | 32 |
ACACB
ACC2 ACCB HACC275 |
acetyl-CoA carboxylase beta (EC:6.4.1.2 6.3.4.14) | AICA ribonucleotide results in increased phosphorylation of ACACB protein |
increases phosphorylation
|
protein |
16873680
|
| C031143 | 351 |
APP
AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 |
amyloid beta (A4) precursor protein | AICA ribonucleotide results in decreased expression of APP protein modified form |
decreases expression
|
protein |
20080969
|
| C031143 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP3 protein] |
decreases reaction
/ increases cleavage |
protein |
21906609
|
| C031143 | 840 |
CASP7
CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP7 protein] |
decreases reaction
/ increases cleavage |
protein |
21906609
|
| C031143 | 6348 |
CCL3
G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3 |
chemokine (C-C motif) ligand 3 | AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| C031143 | 890 |
CCNA2
CCN1 CCNA |
cyclin A2 | AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR] |
affects binding
/ decreases reaction |
3' UTR |
12730239
|
| C031143 | 890 |
CCNA2
CCN1 CCNA |
cyclin A2 | AICA ribonucleotide results in decreased expression of CCNA2 mRNA |
decreases expression
|
mRNA |
12730239
|
| C031143 | 890 |
CCNA2
CCN1 CCNA |
cyclin A2 | AICA ribonucleotide results in decreased expression of CCNA2 protein |
decreases expression
|
protein |
12730239
|
| C031143 | 891 |
CCNB1
CCNB |
cyclin B1 | AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR] |
affects binding
/ decreases reaction |
3' UTR |
12730239
|
| C031143 | 891 |
CCNB1
CCNB |
cyclin B1 | AICA ribonucleotide results in decreased expression of CCNB1 mRNA |
decreases expression
|
mRNA |
12730239
|
| C031143 | 891 |
CCNB1
CCNB |
cyclin B1 | AICA ribonucleotide results in decreased expression of CCNB1 protein |
decreases expression
|
protein |
12730239
|
| C031143 | 8529 |
CYP4F2
CPF2 |
cytochrome P450, family 4, subfamily F, polypeptide 2 (EC:1.14.13.30) | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21205922
|
| C031143 | 8529 |
CYP4F2
CPF2 |
cytochrome P450, family 4, subfamily F, polypeptide 2 (EC:1.14.13.30) | AICA ribonucleotide results in increased expression of CYP4F2 mRNA |
increases expression
|
mRNA |
21205922
|
| C031143 | 8529 |
CYP4F2
CPF2 |
cytochrome P450, family 4, subfamily F, polypeptide 2 (EC:1.14.13.30) | PRKAA1 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA] |
affects reaction
/ increases expression |
mRNA |
21205922
|
| C031143 | 8529 |
CYP4F2
CPF2 |
cytochrome P450, family 4, subfamily F, polypeptide 2 (EC:1.14.13.30) | PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA] |
affects reaction
/ increases expression |
mRNA |
21205922
|
| C031143 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | AICA ribonucleotide inhibits the reaction [EGFR protein results in increased import of Deoxyglucose] |
decreases reaction
/ increases import |
protein |
19625624
|
| C031143 | 1994 |
ELAVL1
ELAV1 HUR Hua MelG |
ELAV like RNA binding protein 1 | AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR] |
affects binding
/ decreases reaction |
protein |
12730239
|
| C031143 | 1994 |
ELAVL1
ELAV1 HUR Hua MelG |
ELAV like RNA binding protein 1 | AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR] |
affects binding
/ decreases reaction |
protein |
12730239
|
| C031143 | 1994 |
ELAVL1
ELAV1 HUR Hua MelG |
ELAV like RNA binding protein 1 | AICA ribonucleotide results in decreased localization of ELAVL1 protein |
decreases localization
|
protein |
12730239
|
| C031143 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21745629
|
| C031143 | 3643 |
INSR
CD220 HHF5 |
insulin receptor (EC:2.7.10.1) | 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter] |
decreases activity
/ decreases reaction |
promoter |
15694368
|
| C031143 | 3643 |
INSR
CD220 HHF5 |
insulin receptor (EC:2.7.10.1) | 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA] |
decreases expression
/ decreases reaction |
mRNA |
15694368
|
| C031143 | 3643 |
INSR
CD220 HHF5 |
insulin receptor (EC:2.7.10.1) | 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein] |
decreases expression
/ decreases reaction |
protein |
15694368
|
| C031143 | 3643 |
INSR
CD220 HHF5 |
insulin receptor (EC:2.7.10.1) | AICA ribonucleotide results in decreased activity of INSR promoter |
decreases activity
|
promoter |
15694368
|
| C031143 | 3643 |
INSR
CD220 HHF5 |
insulin receptor (EC:2.7.10.1) | AICA ribonucleotide results in decreased expression of INSR mRNA |
decreases expression
|
mRNA |
15694368
|
| C031143 | 3643 |
INSR
CD220 HHF5 |
insulin receptor (EC:2.7.10.1) | AICA ribonucleotide results in decreased expression of INSR protein |
decreases expression
|
protein |
15694368
|
| C031143 | 3643 |
INSR
CD220 HHF5 |
insulin receptor (EC:2.7.10.1) | Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter] |
decreases activity
/ decreases reaction |
promoter |
15694368
|
| C031143 | 3643 |
INSR
CD220 HHF5 |
insulin receptor (EC:2.7.10.1) | Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA] |
decreases expression
/ decreases reaction |
mRNA |
15694368
|
| C031143 | 3643 |
INSR
CD220 HHF5 |
insulin receptor (EC:2.7.10.1) | Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein] |
decreases expression
/ decreases reaction |
protein |
15694368
|
| C031143 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | AICA ribonucleotide results in decreased activity of MMP2 protein |
decreases activity
|
protein |
20590612
|
| C031143 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | AICA ribonucleotide results in decreased activity of MMP9 protein |
decreases activity
|
protein |
20590612
|
| C031143 | 2475 |
MTOR
FRAP FRAP1 FRAP2 RAFT1 RAPT1 |
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) | AICA ribonucleotide results in decreased activity of MTOR protein |
decreases activity
|
protein |
19625624
|
| C031143 | 5562 |
PRKAA1
AMPK AMPKa1 |
protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) | AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein |
increases activity
/ increases phosphorylation |
protein |
16873680
|
| C031143 | 5562 |
PRKAA1
AMPK AMPKa1 |
protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) | AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein |
increases phosphorylation
|
protein |
23266269
|
| C031143 | 5562 |
PRKAA1
AMPK AMPKa1 |
protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) | PRKAA1 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA] |
affects reaction
/ increases expression |
protein |
21205922
|
| C031143 | 5563 |
PRKAA2
AMPK AMPK2 AMPKa2 PRKAA |
protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31) | AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA2 protein |
increases activity
/ increases phosphorylation |
protein |
16873680
|
| C031143 | 5563 |
PRKAA2
AMPK AMPK2 AMPKa2 PRKAA |
protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31) | AICA ribonucleotide results in increased phosphorylation of PRKAA2 protein |
increases phosphorylation
|
protein |
18482975
|
| C031143 | 5563 |
PRKAA2
AMPK AMPK2 AMPKa2 PRKAA |
protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31) | PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA] |
affects reaction
/ increases expression |
protein |
21205922
|
| C031143 | 5728 |
PTEN
10q23del BZS CWS1 DEC GLM2 MHAM MMAC1 PTEN1 TEP1 |
phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) | PTEN protein results in increased susceptibility to AICA ribonucleotide |
increases response to substance
|
protein |
19625624
|
| C031143 | 6194 |
RPS6
S6 |
ribosomal protein S6 | AICA ribonucleotide results in decreased phosphorylation of RPS6 protein |
decreases phosphorylation
|
protein |
19625624
|
| C031143 | 6564 |
SLC15A1
HPECT1 HPEPT1 PEPT1 |
solute carrier family 15 (oligopeptide transporter), member 1 | AICA ribonucleotide results in decreased activity of SLC15A1 protein |
decreases activity
|
protein |
22108913
|