PCIDB

KNApSAcK Metabolite C00007533

Metabolite

KNApSAcK Entry

id C00007533
Name 2-Aminophenol
CAS RN 95-55-6
Standard InChI InChI=1S/C6H7NO/c7-5-3-1-2-4-6(5)8/h1-4,8H,7H2
Standard InChI (Main Layer) InChI=1S/C6H7NO/c7-5-3-1-2-4-6(5)8/h1-4,8H,7H2

Cluster

Phytochemical cluster
KCF-S cluster No. 5778

Link

ChEMBL

By standard InChI CHEMBL28319
By standard InChI Main Layer CHEMBL28319

KEGG

By LinkDB C01987

CTD

By CAS RN C027667

Species

Summary

Plant class

class name count

Family

family name count
Pseudomonadaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Pseudomonas pseudoalcaligenes 330 Pseudomonadaceae Bacteria

Human Protein / Gene in interaction

22 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL28319 CHEMBL1908082 (1)
3 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL28319 CHEMBL1908087 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL28319 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P16662 UDP-glucuronosyltransferase 2B7 Enzyme CHEMBL28319 CHEMBL1908093 (1)
0 / 0
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme CHEMBL28319 CHEMBL1908084 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL28319 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL28319 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL28319 CHEMBL2114835 (1)
0 / 0
P11308 Transcriptional regulator ERG Unclassified protein CHEMBL28319 CHEMBL2114924 (1)
1 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL28319 CHEMBL1794510 (1)
5 / 3
Q96RI1 Bile acid receptor NR1H4 CHEMBL28319 CHEMBL1794437 (1)
0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL28319 CHEMBL2114842 (1)
0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme CHEMBL28319 CHEMBL1908092 (1)
0 / 0
P36537 UDP-glucuronosyltransferase 2B10 Enzyme CHEMBL28319 CHEMBL1908089 (1)
0 / 0
Q9BY64 UDP-glucuronosyltransferase 2B28 Enzyme CHEMBL28319 CHEMBL1743335 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL28319 CHEMBL1614240 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL28319 CHEMBL1794483 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL28319 CHEMBL2114890 (1) CHEMBL2114908 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL28319 CHEMBL1794321 (1) CHEMBL1794560 (1)
3 / 4
P35869 Aryl hydrocarbon receptor Transcription Factor CHEMBL28319 CHEMBL2114849 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL28319 CHEMBL2354311 (1)
1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL28319 CHEMBL2114738 (1)
0 / 0

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
C027667 1646 AKR1C2
AKR1C-pseudo
BABP
DD
DD2
DDH2
HAKRD
HBAB
MCDR2
SRXY8
aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) 2-aminophenol results in increased expression of AKR1C2 mRNA increases expression
mRNA 20491607
C027667 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) 2-aminophenol results in increased expression of CYP1A1 mRNA increases expression
mRNA 20491607
C027667 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) 2-aminophenol results in increased expression of HMOX1 mRNA increases expression
mRNA 20491607
C027667 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 2-aminophenol results in increased expression of IL8 mRNA increases expression
mRNA 20491607
C027667 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 2-aminophenol results in increased secretion of IL8 protein increases secretion
protein 20541004
C027667 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) 2-aminophenol results in increased expression of NQO1 mRNA increases expression
mRNA 20491607
C027667 10720 UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11 (EC:2.4.1.17) UGT2B11 protein results in increased glucuronidation of 2-aminophenol increases glucuronidation
protein 8333863

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#218800 Crigler-najjar syndrome, type i P22310
#606785 Crigler-najjar syndrome, type ii P22310
#612219 Ewing sarcoma; es P11308
#143500 Gilbert syndrome P22310
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#601665 Obesity P37231
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275

KEGG DISEASE (10)

KEGG disease name UniProt
H00024 Prostate cancer P10275 (related)
P11308 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00035 Ewing's sarcoma P11308 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D006528 C027667 Carcinoma, Hepatocellular therapeutic
3621466
D011230 C027667 Precancerous Conditions therapeutic
3621466