KNApSAcK Metabolite C00000756
Metabolite
KNApSAcK Entry
| id | C00000756 |
|---|---|
| Name | Biotin |
| CAS RN | 58-85-5 |
| Standard InChI | InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 3747 |
Link
ChEMBL
| By standard InChI | CHEMBL857 |
|---|---|
| By standard InChI Main Layer | CHEMBL857 CHEMBL1315356 CHEMBL1434820 CHEMBL1527083 CHEMBL1612121 |
KEGG
| By LinkDB | C00120 |
|---|
CTD
| By CAS RN | D001710 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
| Enterobacteriaceae | 1 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
22 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1612121 |
CHEMBL1741321
(1)
|
1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL1527083 |
CHEMBL1738312
(2)
|
0 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | CHEMBL1527083 |
CHEMBL1613996
(1)
CHEMBL1614428
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL1527083 |
CHEMBL1614544
(1)
|
11 / 10 |
| P14735 | Insulin-degrading enzyme | Enzyme | CHEMBL857 |
CHEMBL1794358
(1)
CHEMBL1794445
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1612121 |
CHEMBL1741325
(1)
|
0 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | CHEMBL1527083 |
CHEMBL1614166
(2)
CHEMBL1738096
(1)
CHEMBL1738622 (1) |
1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL857 |
CHEMBL1794311
(1)
|
2 / 3 |
| O75496 | Geminin | Unclassified protein | CHEMBL1527083 |
CHEMBL2114780
(1)
|
0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | CHEMBL1527083 |
CHEMBL1614280
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL1527083 |
CHEMBL1794401
(1)
|
0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL1527083 |
CHEMBL1613808
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1612121 |
CHEMBL1741322
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1612121 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1612121 |
CHEMBL1741324
(1)
|
0 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | CHEMBL857 CHEMBL1527083 |
CHEMBL1737991
(2)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1527083 CHEMBL1612121 |
CHEMBL1738442
(2)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL1434820 CHEMBL1527083 CHEMBL1612121 |
CHEMBL1614364
(5)
|
1 / 1 |
| O00255 | Menin | Unclassified protein | CHEMBL1527083 |
CHEMBL1614257
(1)
CHEMBL2114813
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1527083 |
CHEMBL1614257
(1)
CHEMBL2114813
(1)
|
1 / 3 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL1434820 CHEMBL1527083 |
CHEMBL1738090
(1)
CHEMBL1613933
(2)
CHEMBL1737904 (1) |
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL1434820 CHEMBL1527083 |
CHEMBL1738090
(1)
CHEMBL1613933
(2)
CHEMBL1737904 (1) |
1 / 6 |
CTD interaction (32)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D001710 | 6373 |
CXCL11
H174 I-TAC IP-9 IP9 SCYB11 SCYB9B b-R1 |
chemokine (C-X-C motif) ligand 11 | Biotin results in decreased expression of CXCL11 mRNA |
decreases expression
|
mRNA |
15219929
|
| D001710 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | Biotin results in increased expression of and results in increased activity of CYP1B1 protein |
increases activity
/ increases expression |
protein |
15333708
|
| D001710 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | Biotin results in increased expression of CYP1B1 mRNA |
increases expression
|
mRNA |
15219929
15333708 |
| D001710 | 1571 |
CYP2E1
CPE1 CYP2E P450-J P450C2E |
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) | Biotin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] |
decreases reaction
/ increases degradation |
protein |
9143349
|
| D001710 | 3039 |
HBA1
CD31 HBH |
hemoglobin, alpha 1 | [Chromium co-treated with Biotin] results in decreased expression of HBA1 protein modified form |
affects cotreatment
/ decreases expression |
protein |
17684468
|
| D001710 | 3039 |
HBA1
CD31 HBH |
hemoglobin, alpha 1 | [chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form |
affects cotreatment
/ decreases expression |
protein |
17684468
|
| D001710 | 26091 |
HERC4
|
HECT and RLD domain containing E3 ubiquitin protein ligase 4 | Biotin results in increased expression of HERC4 mRNA |
increases expression
|
mRNA |
15219929
|
| D001710 | 7290 |
HIRA
DGCR1 TUP1 TUPLE1 |
histone cell cycle regulator | Biotin results in decreased expression of HIRA mRNA |
decreases expression
|
mRNA |
15219929
|
| D001710 | 3500 | Biotin results in increased expression of IGHG1 mRNA |
increases expression
|
mRNA |
15219929
|
||
| D001710 | 3916 |
LAMP1
CD107a LAMPA LGP120 |
lysosomal-associated membrane protein 1 | Biotin results in decreased expression of LAMP1 mRNA |
decreases expression
|
mRNA |
15219929
|
| D001710 | 10891 |
PPARGC1A
LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1 |
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | Biotin results in increased expression of PPARGC1A mRNA |
increases expression
|
mRNA |
23056435
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 2,4-Dinitrophenol inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 4-Chloromercuribenzenesulfonate inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Azides inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Biotin affects the expression of SLC5A6 mRNA |
affects expression
|
mRNA |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Biotin affects the expression of SLC5A6 protein |
affects expression
|
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | calmidazolium inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | chelerythrine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Gramicidin inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Iodoacetates inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Probenecid inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | SLC5A6 protein results in increased transport of Biotin |
increases transport
|
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | SLC5A6 results in increased transport of Biotin |
increases transport
|
10329687
|
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | SLC5A6 results in increased uptake of Biotin |
increases uptake
|
12646417
|
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Sodium affects the reaction [SLC5A6 results in increased transport of Biotin] |
affects reaction
/ increases transport |
10329687
|
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Sodium promotes the reaction [SLC5A6 protein results in increased transport of Biotin] |
increases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Staurosporine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Tetradecanoylphorbol Acetate promotes the reaction [SLC5A6 protein results in increased transport of Biotin] |
increases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 8884 |
SLC5A6
SMVT |
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
decreases reaction
/ increases transport |
protein |
15561972
|
| D001710 | 5651 |
TMPRSS15
ENTK PRSS7 |
transmembrane protease, serine 15 (EC:3.4.21.9) | Biotin results in increased expression of TMPRSS15 mRNA |
increases expression
|
mRNA |
15219929
|
| D001710 | 7175 |
TPR
|
translocated promoter region, nuclear basket protein | Biotin results in increased expression of TPR mRNA |
increases expression
|
mRNA |
15219929
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (21)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (27)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|