KCF-S cluster No. 3747 (3 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 1 |
Cumulative family count
| class name | count |
|---|---|
| Enterobacteriaceae | 2 |
| Bacillaceae | 1 |
| Brassicaceae | 1 |
| Phycomycetaceae | 1 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000756
|
Biotin
|
CHEMBL857
CHEMBL1315356 CHEMBL1434820 CHEMBL1527083 CHEMBL1612121 |
D001710
|
22 / 21 / 27 | 12 / 3 |
|
|
C00000757
|
Dethiobiotin
|
CHEMBL1232381
|
11 / 11 / 7 |
|
||
|
C00034228
|
Selenobiotin
|
C013677
|
|
Human Protein / Gene in interactions
29 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P14735 | Insulin-degrading enzyme | Enzyme | C00000756 C00000757 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000756 C00000757 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000756 C00000757 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000756 C00000757 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000756 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000756 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000756 | 0 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00000756 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000756 | 2 / 3 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000757 | 2 / 0 |
| Q9Y5X4 | Photoreceptor-specific nuclear receptor | NR2E3 | C00000757 | 2 / 2 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000757 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00000756 | 0 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00000756 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000756 | 11 / 10 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000756 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000756 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000756 | 0 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000756 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000756 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000756 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000757 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00000756 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000756 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000756 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000756 | 1 / 4 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000757 | 5 / 3 |
| Q9Y618 | Nuclear receptor corepressor 2 | Unclassified protein | C00000757 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00000757 | 2 / 1 |
12 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 6373 | CXCL11, H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1 | chemokine (C-X-C motif) ligand 11 |
C00000756
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000756
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00000756
|
| 3039 | HBA1, CD31, HBH | hemoglobin, alpha 1 |
C00000756
|
| 26091 | HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 |
C00000756
|
| 7290 | HIRA, DGCR1, TUP1, TUPLE1 | histone cell cycle regulator |
C00000756
|
| 3500 |
C00000756
|
||
| 3916 | LAMP1, CD107a, LAMPA, LGP120 | lysosomal-associated membrane protein 1 |
C00000756
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00000756
|
| 8884 | SLC5A6, SMVT | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 |
C00000756
|
| 5651 | TMPRSS15, ENTK, PRSS7 | transmembrane protease, serine 15 (EC:3.4.21.9) |
C00000756
|
| 7175 | TPR | translocated promoter region, nuclear basket protein |
C00000756
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (32)
| OMIM | preferred title | UniProt |
|---|---|---|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #268100 | Enhanced s-cone syndrome; escs |
Q9Y5X4
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #601665 | Obesity |
P37231
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #611131 | Retinitis pigmentosa 37; rp37 |
Q9Y5X4
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (33)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
Q9Y5X4
(related)
|
| H00805 | Vitreoretinal degeneration |
Q9Y5X4
(related)
|