PCIDB

KNApSAcK Metabolite C00000789

Metabolite

KNApSAcK Entry

id C00000789
Name FM / MK 0955 / Fosfomycin / (-)-Phosphonomycin
CAS RN 23155-02-4
Standard InChI InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1
Standard InChI (Main Layer) InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)

Cluster

Phytochemical cluster
KCF-S cluster No. 7201

Link

ChEMBL

By standard InChI CHEMBL1757
By standard InChI Main Layer CHEMBL218627 CHEMBL1757 CHEMBL1555455 CHEMBL1616512

KEGG

By LinkDB C06454

CTD

By CAS RN D005578

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1555455 CHEMBL1738610 (1)
0 / 0
P00734 Prothrombin S1A CHEMBL1757 CHEMBL2339330 (1)
4 / 2
P53582 Methionine aminopeptidase 1 M24A CHEMBL1757 CHEMBL2339332 (1)
0 / 0
P50579 Methionine aminopeptidase 2 M24A CHEMBL1757 CHEMBL2339331 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1555455 CHEMBL1738442 (1)
0 / 0

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
D005578 1401 CRP
PTX1
C-reactive protein, pentraxin-related Fosfomycin results in decreased expression of CRP protein decreases expression
protein 12680319

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (2)

KEGG disease name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)

Diseases related to CTD interactions

29 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D005578 Abdominal Pain marker/mechanism
2709616
D058186 D005578 Acute Kidney Injury marker/mechanism
18791210
D016470 D005578 Bacteremia therapeutic
17661075
D003428 D005578 Cross Infection therapeutic
2232144
D003550 D005578 Cystic Fibrosis therapeutic
19747007
D003967 D005578 Diarrhea marker/mechanism
2709616
D015299 D005578 Discitis therapeutic
8786835
D003875 D005578 Drug Eruptions marker/mechanism
11792017
D056486 D005578 Drug-Induced Liver Injury marker/mechanism
11440232
16180681
D004697 D005578 Endocarditis, Bacterial therapeutic
2810754
3166360
D020802 D005578 Epidural Abscess therapeutic
8786835
D004927 D005578 Escherichia coli Infections therapeutic
3552693
19671590
D005921 D005578 Glomerulonephritis therapeutic
12680319
D007674 D005578 Kidney Diseases marker/mechanism
therapeutic
2962975
7461697
10217324
D007683 D005578 Kidney Tubular Necrosis, Acute therapeutic
1778857
D016920 D005578 Meningitis, Bacterial therapeutic
2232144
3850855
10349306
D008586 D005578 Meningitis, Pneumococcal therapeutic
1495831
8309909
D018410 D005578 Pneumonia, Bacterial therapeutic
17661075
D011183 D005578 Postoperative Complications therapeutic
2232144
D011507 D005578 Proteinuria therapeutic
12680319
D011704 D005578 Pyelonephritis therapeutic
7461697
D052880 D005578 Pyomyositis therapeutic
17661075
D051437 D005578 Renal Insufficiency therapeutic
1778857
D012640 D005578 Seizures marker/mechanism
17015947
D018805 D005578 Sepsis therapeutic
12845235
D012874 D005578 Skin Diseases, Infectious therapeutic
2709616
D013203 D005578 Staphylococcal Infections therapeutic
2232144
2810754
3166360
3850855
8786835
10349306
12845235
17661075
D014552 D005578 Urinary Tract Infections therapeutic
3552693
10349306
19671590
D014581 D005578 Urticaria marker/mechanism
11792017