KCF-S cluster No. 1009 (9 metabolites)

Corresponding Phytochemical cluster No. 7

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (9)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	13
asterids	8
Liliopsida	1

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Cumulative family count

class name	count
Rutaceae	13
Rubiaceae	5
Loganiaceae	2
Apocynaceae	1
Amaryllidaceae	1
Notodontidae	1

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Quinoline alkaloids	1
Quinazoline alkaloids	1

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Quinoline alkaloids	C09032	C00001685
Quinazoline alkaloids	C09238	C00001766

Metabolite list (9)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001685	Angustine		C004166
C00001766	Rutaecarpine	CHEMBL85139	C028632	35 / 47 / 67	5 / 0
C00025154	Angustoline / (-)-Angustoline		C004167
C00026551	7-Hydroxyrutaecarpine
C00027032	3-Hydroxyrutaecarpine
C00027710	1-Hydroxyrutaecarpine
C00034074	Naucleofficine E	CHEMBL1173138
C00039905	Orisuaveoline A	CHEMBL575438
C00046191	Nauclealine B / (-)-Nauclealine B

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001766	1 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00001766	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00001766	7 / 37
Q16637	Survival motor neuron protein	Unclassified protein	C00001766	4 / 1
Q99700	Ataxin-2	Unclassified protein	C00001766	1 / 1
P14618	Pyruvate kinase PKM	Enzyme	C00001766	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00001766	0 / 3
P06746	DNA polymerase beta	Enzyme	C00001766	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00001766	2 / 2
P02545	Prelamin-A/C	Unclassified protein	C00001766	11 / 10
P16473	Thyrotropin receptor	Glycohormone receptor	C00001766	3 / 2
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00001766	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001766	0 / 1
P54132	Bloom syndrome protein	Enzyme	C00001766	1 / 2
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00001766	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001766	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001766	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00001766	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001766	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00001766	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00001766	4 / 4
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001766	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001766	3 / 3
O15118	Niemann-Pick C1 protein	Unclassified protein	C00001766	1 / 1
Q01453	Peripheral myelin protein 22	Unclassified protein	C00001766	5 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001766	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001766	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001766	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00001766	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001766	0 / 0
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00001766	1 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001766	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00001766	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001766	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00001766	1 / 1

5 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00001766
57491	AHRR, AHH, AHHR, bHLHe77	aryl-hydrocarbon receptor repressor	C00001766
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00001766
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00001766
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00001766

Related Diseases

Diseases related to proteins in ChEMBL interactions