KCF-S cluster No. 1133 (8 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|
Cumulative family count
| class name | count |
|---|---|
| Aspergillaceae | 22 |
| Chaetomiaceae | 4 |
| Pleosporaceae | 1 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000563
|
Sterigmatocystin
|
CHEMBL524291
CHEMBL1532401 |
D013241
|
9 / 3 |
|
|
|
C00023633
|
Dihydrosterigmatocystin
/ 1,2-Dihydro-6-methoxy-7-hydroxyfuroxanthone |
|
||||
|
C00023634
|
O-Methylsterigmatocystin
/ 6,7-Dimethoxyfuroxanthone |
C039904
|
|
|||
|
C00023635
|
Dihydro-O-methylsterigmatocystin
/ 1,2-Dihydro-6-methoxy-7-hydroxydifuroxanthone |
C059833
|
|
|||
|
C00023636
|
Aspertoxin
/ 3-Hydroxy-6,7-dimethoxydifuroxanthone |
C054883
|
|
|||
|
C00023637
|
5-Methoxysterigmatocystin
|
CHEMBL1541017
CHEMBL1973034 |
7 / 17 / 8 |
|
||
|
C00023638
|
Sterigmatin
|
|
||||
|
C00036630
|
6-Methoxysterigmatocystin
|
|
Human Protein / Gene in interactions
7 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P37840 | Alpha-synuclein | Unclassified protein | C00023637 | 4 / 2 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00023637 | 2 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00023637 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00023637 | 7 / 3 |
| P61088 | Ubiquitin-conjugating enzyme E2 N | Enzyme | C00023637 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00023637 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00023637 | 0 / 0 |
9 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 891 | CCNB1, CCNB | cyclin B1 |
C00000563
|
| 995 | CDC25C, CDC25, PPP1R60 | cell division cycle 25C (EC:3.1.3.48) |
C00000563
|
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) |
C00000563
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000563
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00000563
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00000563
|
| 4292 | MLH1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1 | mutL homolog 1 |
C00000563
|
| 4436 | MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2 | mutS homolog 2 |
C00000563
|
| 7508 | XPC, RAD4, XP3, XPCC | xeroderma pigmentosum, complementation group C |
C00000563
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (8)
| KEGG | name | UniProt |
|---|---|---|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|