PCIDB

KNApSAcK Metabolite C00000563

Metabolite

KNApSAcK Entry

id C00000563
Name Sterigmatocystin
CAS RN 10048-13-2
Standard InChI InChI=1S/C18H12O6/c1-21-11-7-12-13(8-5-6-22-18(8)24-12)17-15(11)16(20)14-9(19)3-2-4-10(14)23-17/h2-8,18-19H,1H3/t8-,18+/m0/s1
Standard InChI (Main Layer) InChI=1S/C18H12O6/c1-21-11-7-12-13(8-5-6-22-18(8)24-12)17-15(11)16(20)14-9(19)3-2-4-10(14)23-17/h2-8,18-19H,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 1133

Link

ChEMBL

By standard InChI CHEMBL524291
By standard InChI Main Layer CHEMBL524291 CHEMBL1532401

KEGG

By LinkDB C00961

CTD

By CAS RN D013241

Human Protein / Gene in interaction

CTD interaction (33)

compound gene gene name gene description interaction interaction type form reference
pmid
D013241 891 CCNB1
CCNB
cyclin B1 MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CCNB1 protein] affects reaction
/ increases expression
protein 23296099
D013241 891 CCNB1
CCNB
cyclin B1 Sterigmatocystin results in decreased expression of [CCNB1 protein binds to CDK1 protein] affects binding
/ decreases expression
protein 23296099
D013241 891 CCNB1
CCNB
cyclin B1 Sterigmatocystin results in increased expression of CCNB1 mRNA increases expression
mRNA 23296099
D013241 891 CCNB1
CCNB
cyclin B1 Sterigmatocystin results in increased expression of CCNB1 protein increases expression
protein 23296099
D013241 995 CDC25C
CDC25
PPP1R60
cell division cycle 25C (EC:3.1.3.48) MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDC25C protein] affects reaction
/ increases expression
protein 23296099
D013241 995 CDC25C
CDC25
PPP1R60
cell division cycle 25C (EC:3.1.3.48) MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDC25C protein modified form] affects reaction
/ increases expression
protein 23296099
D013241 995 CDC25C
CDC25
PPP1R60
cell division cycle 25C (EC:3.1.3.48) Sterigmatocystin results in increased expression of CDC25C mRNA increases expression
mRNA 23296099
D013241 995 CDC25C
CDC25
PPP1R60
cell division cycle 25C (EC:3.1.3.48) Sterigmatocystin results in increased expression of CDC25C protein increases expression
protein 23296099
D013241 995 CDC25C
CDC25
PPP1R60
cell division cycle 25C (EC:3.1.3.48) Sterigmatocystin results in increased expression of CDC25C protein modified form increases expression
protein 23296099
D013241 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDK1 protein] affects reaction
/ increases expression
protein 23296099
D013241 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDK1 protein modified form] affects reaction
/ increases expression
protein 23296099
D013241 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Sterigmatocystin results in decreased expression of [CCNB1 protein binds to CDK1 protein] affects binding
/ decreases expression
protein 23296099
D013241 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Sterigmatocystin results in increased expression of CDK1 mRNA increases expression
mRNA 23296099
D013241 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Sterigmatocystin results in increased expression of CDK1 protein increases expression
protein 23296099
D013241 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Sterigmatocystin results in increased expression of CDK1 protein modified form increases expression
protein 23296099
D013241 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein results in increased glutathionylation of and results in increased hydroxylation of Sterigmatocystin increases glutathionylation
/ increases hydroxylation
protein 20929267
D013241 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) [CYP1A1 protein results in increased glutathionylation of and results in increased hydroxylation of Sterigmatocystin] which results in increased chemical synthesis of Sterigmatocystin metabolite increases chemical synthesis
/ increases glutathionylation
/ increases hydroxylation
protein 20929267
D013241 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) CYP1A2 protein results in increased glutathionylation of and results in increased hydroxylation of Sterigmatocystin increases glutathionylation
/ increases hydroxylation
protein 20929267
D013241 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) [CYP1A2 protein results in increased glutathionylation of and results in increased hydroxylation of Sterigmatocystin] which results in increased chemical synthesis of Sterigmatocystin metabolite increases chemical synthesis
/ increases glutathionylation
/ increases hydroxylation
protein 20929267
D013241 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) CYP3A4 protein affects the metabolism of Sterigmatocystin affects metabolic processing
protein 2271712
2655891
D013241 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) [CYP3A4 protein results in increased glutathionylation of and results in increased hydroxylation of Sterigmatocystin] which results in increased chemical synthesis of Sterigmatocystin metabolite increases chemical synthesis
/ increases glutathionylation
/ increases hydroxylation
protein 20929267
D013241 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) CYP3A4 protein results in increased glutathionylation of Sterigmatocystin increases glutathionylation
protein 20929267
D013241 4292 MLH1
COCA2
FCC2
HNPCC
HNPCC2
hMLH1
mutL homolog 1 MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CCNB1 protein] affects reaction
/ increases expression
protein 23296099
D013241 4292 MLH1
COCA2
FCC2
HNPCC
HNPCC2
hMLH1
mutL homolog 1 MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDC25C protein] affects reaction
/ increases expression
protein 23296099
D013241 4292 MLH1
COCA2
FCC2
HNPCC
HNPCC2
hMLH1
mutL homolog 1 MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDC25C protein modified form] affects reaction
/ increases expression
protein 23296099
D013241 4292 MLH1
COCA2
FCC2
HNPCC
HNPCC2
hMLH1
mutL homolog 1 MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDK1 protein] affects reaction
/ increases expression
protein 23296099
D013241 4292 MLH1
COCA2
FCC2
HNPCC
HNPCC2
hMLH1
mutL homolog 1 MLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDK1 protein modified form] affects reaction
/ increases expression
protein 23296099
D013241 4292 MLH1
COCA2
FCC2
HNPCC
HNPCC2
hMLH1
mutL homolog 1 MLH1 protein affects the susceptibility to Sterigmatocystin affects response to substance
protein 23296099
D013241 4292 MLH1
COCA2
FCC2
HNPCC
HNPCC2
hMLH1
mutL homolog 1 Sterigmatocystin results in increased expression of MLH1 mRNA increases expression
mRNA 23296099
D013241 4292 MLH1
COCA2
FCC2
HNPCC
HNPCC2
hMLH1
mutL homolog 1 Sterigmatocystin results in increased expression of MLH1 protein increases expression
protein 23296099
D013241 4436 MSH2
COCA1
FCC1
HNPCC
HNPCC1
LCFS2
mutS homolog 2 Sterigmatocystin results in increased expression of MSH2 mRNA increases expression
mRNA 23296099
D013241 4436 MSH2
COCA1
FCC1
HNPCC
HNPCC1
LCFS2
mutS homolog 2 Sterigmatocystin results in increased expression of MSH2 protein increases expression
protein 23296099
D013241 7508 XPC
RAD4
XP3
XPCC
xeroderma pigmentosum, complementation group C Sterigmatocystin results in increased expression of XPC mRNA increases expression
mRNA 23296099

Related Disease

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D007249 D013241 Inflammation marker/mechanism
19818335
D008114 D013241 Liver Neoplasms, Experimental marker/mechanism
6191977
D011041 D013241 Poisoning marker/mechanism
20929267