KCF-S cluster No. 1194 (8 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 5 |
| Magnoliophyta | 1 |
Cumulative family count
| class name | count |
|---|---|
| Celastraceae | 4 |
| Nocardiaceae | 3 |
| Streptomycetaceae | 3 |
| Annonaceae | 1 |
| Euphorbiaceae | 1 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00002351
|
Maytansine
|
CHEMBL292702
CHEMBL1728226 CHEMBL1981332 |
D008453
|
3 / 2 / 1 | 0 / 1 |
|
|
C00018269
|
NSC 292222
/ Ansamitosin P 3 / Ansamitocin P 3 / Antibiotic C 15003P3 / Maytansinol isobutyrate |
CHEMBL294181
CHEMBL359364 CHEMBL507305 CHEMBL442610 CHEMBL1553400 |
7 / 5 / 5 |
|
||
|
C00018270
|
Ansamitocin P 3'
/ Maytansinol butyrate / Antibiotic C 15003P3' |
|
||||
|
C00018271
|
NSC 292223
/ Ansamitocin P 4 / Antibiotic C 15003P4 / Maytansinol isovalerate |
|
||||
|
C00018392
|
Ansamitocin P 2
/ Antibiotic C 15003P2 / Maytansinol propionate / Maytansinol-3-propionate |
|
||||
|
C00018393
|
15-Hydroxyansamitocin P-3
|
|
||||
|
C00018394
|
Antibiotic C 15003PND3
/ N-Demethylansamitocin P 3 / 22-Demethylmaytansinol 3-isobutyrate |
|
||||
|
C00047356
|
Trewiasine
|
CHEMBL506955
CHEMBL510998 CHEMBL508610 |
C060931
|
|
Human Protein / Gene in interactions
10 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00018269 | 1 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002351 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00018269 | 3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00018269 | 0 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00018269 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00018269 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00018269 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00018269 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002351 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002351 | 1 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (7)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
KEGG DISEASE (6)
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|