KNApSAcK Metabolite C00018269
Metabolite
KNApSAcK Entry
| id | C00018269 |
|---|---|
| Name | NSC 292222 / Ansamitosin P 3 / Ansamitocin P 3 / Antibiotic C 15003P3 / Maytansinol isobutyrate |
| CAS RN | 66584-72-3 |
| Standard InChI | InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28+,31+,32+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1194 |
Link
ChEMBL
| By standard InChI | CHEMBL507305 |
|---|---|
| By standard InChI Main Layer | CHEMBL294181 CHEMBL359364 CHEMBL507305 CHEMBL442610 CHEMBL1553400 |
KEGG
| By LinkDB | C12045 |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Nocardiaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Nocardia sp. No. C-15003 (N-1) | 1817 | Nocardiaceae | Bacteria |
Human Protein / Gene in interaction
7 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1553400 |
CHEMBL1614110
(1)
CHEMBL1741321
(1)
|
1 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL1553400 |
CHEMBL1614281
(1)
CHEMBL1614361
(1)
|
3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1553400 |
CHEMBL1741325
(1)
|
0 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL1553400 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1553400 |
CHEMBL1741322
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1553400 |
CHEMBL1613777
(1)
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1553400 |
CHEMBL1741324
(1)
|
0 / 1 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|