KCF-S cluster No. 135 (40 metabolites)

Corresponding Phytochemical cluster No. 15

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (40)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

---

Cumulative plant class count

class name	count
rosids	62
asterids	2

---

Cumulative family count

class name	count
Fabaceae	61
Asteraceae	2
Moraceae	1

KEGG BRITE br08003

---

Categories (2)

br08003 Category	# of metabolite
Isoflavanes	2
Pterocarpanes	1

---

metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Isoflavanes	C10421	C00002529
Pterocarpanes	C10514	C00002559
Isoflavanes	C10515	C00002560

Metabolite list (40)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002529	Glabridin	CHEMBL480477 CHEMBL1360535	C107601	19 / 21 / 42	0 / 2
C00002559	Phaseolin / (-)-Phaseollin	CHEMBL448350
C00002560	(-)-Phaseollinisoflavan	CHEMBL465812	C053345
C00008908	7,8-(2,2-Dimethylpyrano)-3,4'-dihydroxy-5-methoxyflavan
C00008986	Hildgardtol B
C00008987	Methylhildgardtol B
C00009025	Quercetol A
C00009028	4beta-Hydroxyobovatachromene
C00009639	Neorautenol	CHEMBL1098728		1 / 0 / 0
C00009643	Hemileiocarpin
C00009649	Neorautenane / Neorautenaan / 1,2-Didehydroneorautane
C00009650	Leiocarpin	CHEMBL238610
C00009653	Edulenanol
C00009656	Neorautenanol
C00009657	Edulaan / Edulenane
C00009661	Desmodin
C00009725	2'-O-Methylphaseollinisoflavan
C00009726	4'-O-Methylglabridin	CHEMBL511536
C00009728	Leiocin	CHEMBL463484
C00009729	Leiocinol	CHEMBL518842
C00009730	3'-Methoxyglabridin	CHEMBL463948
C00009731	Neorauflavane
C00009733	Spherosinin / Sphaerosinin
C00010002	Isoneorautenol / 3-Hydroxy-6'',6''-dimethylpyrano[2'',3'':9,8]pterocarpan	CHEMBL1098729
C00013267	Xuulanin / 2H,(6R,8S)-rel-7,8-Dihydro-5,6-dimethoxy-2,2-dimethyl-8-phenyl-6H-benzo[1,2-b:5,4-b']dipyran
C00013270	3beta,4beta,5-Trimethoxy-4'-hydroxy- (6:7)-2,2-dimethylpyranoflavan
C00018880	Erythbidin A / (3R)-7,4'-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':2',3']isoflavan
C00018885	Glyasperin H / 3-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-2,6-dimethoxyphenol	CHEMBL498725
C00018911	Arizonicanol B / 2',3'-Dihydroxy-4'-methoxy-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavan
C00018979	Shinpterocarpin	CHEMBL591773		1 / 5 / 3
C00019293	Bolucarpan B / 3-Hydroxy-8,9-methylenedioxy-6',6'-dimethylpyrano[2',3':1,2]-pterocarpan
C00019295	Bolucarpan D
C00019323	Gancaonol C / 7,4'-Dihydroxy-5-methoxy-6'',6''-dimethylpyrano[2'',3'':2',3']isoflavan
C00019328	Kanzonol O / (3R)-8-Carboxyaldehyde-7,4'-dihydroxy-5-methoxy-6'',6''-dimethylpyrano[2'',3'':2',3']isoflavan
C00019338	Gancaonin X / 2'-Hydroxy-4'-methoxy-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavan
C00019339	Gancaonin Y / 7-Hydroxy-4'-methoxy-6'',6''-dimethylpyrano[2'',3'':2',3']isoflavan
C00019740	Eryvarin C / (3R)-2',4'-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavan
C00036568	4beta-Demethylxuulanin-4beta-ethyl ether
C00045612	Acutifolin C / (-)-Acutifolin C
C00050050	Daleformis / (-)-Daleformis	CHEMBL517795

Human Protein / Gene in interactions

21 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00009639	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002529	7 / 37
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002529	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002529	1 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002529	0 / 0
P20813	Cytochrome P450 2B6	Cytochrome P450 2B6	C00002529	1 / 0
P14735	Insulin-degrading enzyme	Enzyme	C00002529	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00002529	4 / 2
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002529	2 / 0
O75496	Geminin	Unclassified protein	C00002529	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002529	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002529	4 / 2
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002529	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00018979	5 / 3
O15118	Niemann-Pick C1 protein	Unclassified protein	C00002529	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002529	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002529	0 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00002529	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002529	0 / 0
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00002529	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002529	1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions