PCIDB

KCF-S cluster No. 1363 (7 metabolites)

Corresponding Phytochemical cluster No. 7

Plant Species

Cumulative plant class count

class name count
rosids 9
Liliopsida 4

Cumulative family count

class name count
Rutaceae 9
Amaryllidaceae 4

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Quinoline alkaloids 2

metabolites link (2)

br08003 Category KEGG ID KNApSAcK ID
Quinoline alkaloids C10689 C00002169
Quinoline alkaloids C10713 C00002182

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00002169 External link 512 Graveoline
CHEMBL1371756
12 / 18 / 18
C00002182 External link 512 Lunamarine
C00002328 External link 512 Crinasiadine
C00024365 External link 512 Arolycoricidine
C00024366 External link 512 Arolycoricidinol
CHEMBL1980408
C00025430 External link 512 Norgraveoline
CHEMBL2335132
1 / 0 / 0
C00028697 External link 512 N-Methylcrinasiadine
CHEMBL2208201

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002169 1 / 0
P02545 Prelamin-A/C Unclassified protein C00002169 11 / 10
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002169 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00002169 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002169 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002169 0 / 0
Q9Y233 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE_10A C00025430 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002169 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002169 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002169 2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002169 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002169 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002169 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (18)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)