| class name | count |
|---|---|
| asterids | 5 |
| rosids | 1 |
| class name | count |
|---|---|
| Solanaceae | 5 |
| Schilbeidae | 1 |
| Elaeagnaceae | 1 |
| br08003 Category | # of metabolite |
|---|
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00022178
|
Anhydrovitamin A1
|
C031469
|
0 / 1 |
|
||
|
C00022184
|
Apo-15-zeaxanthinal
/ (3R)-3-Hydroxyretinal |
CHEMBL256122
|
2 / 0 / 0 |
|
||
|
C00022187
|
Apo-14'-zeaxanthinal
|
|
||||
|
C00022188
|
Apo-15-zeaxanthinal
|
CHEMBL256122
|
2 / 0 / 0 |
|
||
|
C00022189
|
Apo-13-zeaxanthinone
|
|
||||
|
C00022190
|
Apo-11-zeaxanthinal
|
|
||||
|
C00031437
|
Vitamin A
|
CHEMBL986
CHEMBL1454290 CHEMBL1595345 |
28 / 26 / 26 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00022184 C00022188 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00022184 C00022188 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00031437 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00031437 | 2 / 2 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00031437 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00031437 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00031437 | 3 / 2 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00031437 | 0 / 0 |
| P10276 | Retinoic acid receptor alpha | NR1B1 | C00031437 | 1 / 2 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00031437 | 1 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00031437 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00031437 | 0 / 0 |
| P02753 | Retinol-binding protein 4 | Secreted protein | C00031437 | 1 / 0 |
| O75496 | Geminin | Unclassified protein | C00031437 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00031437 | 3 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00031437 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00031437 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00031437 | 0 / 1 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00031437 | 5 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00031437 | 0 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00031437 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00031437 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00031437 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00031437 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00031437 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00031437 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00031437 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00031437 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00031437 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00031437 | 1 / 2 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #612376 | Acute promyelocytic leukemia; apl |
P10276
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #218800 | Crigler-najjar syndrome, type i |
P22310
|
| #606785 | Crigler-najjar syndrome, type ii |
P22310
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22310
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #601665 | Obesity |
P37231
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #615147 | Retinal dystrophy, iris coloboma, and comedogenic acne syndrome; rdccas |
P02753
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00003 | Acute myeloid leukemia (AML) |
P10276
(related)
P10276 (marker) |
| H00516 | Isolated orofacial clefts |
P10276
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|