PCIDB

KNApSAcK Metabolite C00031437

Metabolite

KNApSAcK Entry

id C00031437
Name Vitamin A
CAS RN 68-26-8
Standard InChI InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
Standard InChI (Main Layer) InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3

Cluster

Phytochemical cluster
KCF-S cluster No. 1438

Link

ChEMBL

By standard InChI CHEMBL986
By standard InChI Main Layer CHEMBL986 CHEMBL1454290 CHEMBL1595345

KEGG

By LinkDB C17276

CTD

By CAS RN

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Elaeagnaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Hippophae rhamnoides 193516 Elaeagnaceae rosids Viridiplantae

Human Protein / Gene in interaction

28 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL986 CHEMBL1908082 (1)
3 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase CHEMBL986 CHEMBL965567 (1)
0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL986 CHEMBL1794573 (1)
2 / 2
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL986 CHEMBL1794524 (1) CHEMBL1794552 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL986 CHEMBL1614331 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL986 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL986 CHEMBL1794371 (1)
0 / 0
P10276 Retinoic acid receptor alpha NR1B1 CHEMBL986 CHEMBL954844 (1)
1 / 3
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL986 CHEMBL965566 (1)
1 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL986 CHEMBL1454290 CHEMBL1794311 (2)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL986 CHEMBL1454290 CHEMBL1614458 (4)
0 / 0
P02753 Retinol-binding protein 4 Secreted protein CHEMBL986 CHEMBL1804183 (1)
1 / 0
O75496 Geminin Unclassified protein CHEMBL986 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL986 CHEMBL2114835 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL986 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL986 CHEMBL1794382 (2) CHEMBL1794456 (1)
0 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL986 CHEMBL1794510 (1)
5 / 3
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL986 CHEMBL1613808 (1)
0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL986 CHEMBL2114842 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL986 CHEMBL1794364 (1) CHEMBL1794542 (1)
1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL986 CHEMBL1614240 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL986 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL986 CHEMBL1794483 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL986 CHEMBL1454290 CHEMBL1614421 (3)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL986 CHEMBL2114890 (2)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1454290 CHEMBL1738442 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL986 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL986 CHEMBL1614531 (1)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#612376 Acute promyelocytic leukemia; apl P10276
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#609338 Carotid intimal medial thickness 1 P37231
#218800 Crigler-najjar syndrome, type i P22310
#606785 Crigler-najjar syndrome, type ii P22310
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22310
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#615147 Retinal dystrophy, iris coloboma, and comedogenic acne syndrome; rdccas P02753
#609620 Short qt syndrome 1; sqt1 Q12809
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (26)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H00003 Acute myeloid leukemia (AML) P10276 (related)
P10276 (marker)
H00516 Isolated orofacial clefts P10276 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)