KCF-S cluster No. 1451 (7 metabolites)

Corresponding Phytochemical cluster No. 4


Plant Species


Cumulative plant class count

class name count
Spermatophyta 13

Cumulative family count

class name count
Cephalotaxaceae 13

KEGG BRITE br08003 External link 512


Categories (1)

br08003 Category # of metabolite
Isoquinoline alkaloids 1

metabolites link (2)

br08003 Category KEGG ID KNApSAcK ID
Isoquinoline alkaloids C10580 C00002324
Isoquinoline alkaloids C10580 C00027319

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00002324 External link 512 Cephalotaxine
CHEMBL276462
CHEMBL1476895
C001597
4 / 7 / 7
C00025585 External link 512 Epicephalotaxine
CHEMBL276462
CHEMBL1476895
4 / 7 / 7
C00025586 External link 512 Cephalotaxinone
C00027247 External link 512 11-Hydroxycephalotaxine
/ 11alpha-Hydroxycephalotaxine
C007992
C00027319 External link 512 Cephalotaxine
/ (-)-Cephalotaxine
CHEMBL276462
CHEMBL1476895
C001597
4 / 7 / 7
C00028395 External link 512 Isocephalotaxine
CHEMBL517319
C00044621 External link 512 Cephalotaxine beta-N-oxide
CHEMBL517318
CHEMBL464200

Human Protein / Gene in interactions

4 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002324 C00025585 C00027319 3 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002324 C00025585 C00027319 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002324 C00025585 C00027319 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002324 C00025585 C00027319 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#600274 Frontotemporal dementia; ftd P10636
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (7)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)