PCIDB

KNApSAcK Metabolite C00027319

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00027319
Name	Cephalotaxine / (-)-Cephalotaxine
CAS RN	24316-19-6
Standard InChI	InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1
Standard InChI (Main Layer)	InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3

Cluster

Phytochemical cluster	No. 4
KCF-S cluster	No. 1451

Link

ChEMBL

By standard InChI	CHEMBL276462
By standard InChI Main Layer	CHEMBL276462 CHEMBL1476895

KEGG

By LinkDB	C10580

CTD

By CAS RN	C001597

Species

Summary

Plant class

class name	count
Spermatophyta	4

Family

family name	count
Cephalotaxaceae	4

List (4)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Cephalotaxus drupacea	224739	Cephalotaxaceae	Spermatophyta	Viridiplantae
Cephalotaxus fortunei	66169	Cephalotaxaceae	Spermatophyta	Viridiplantae
Cephalotaxus harringtonia	58029	Cephalotaxaceae	Spermatophyta	Viridiplantae
Cephalotaxus sinensis	89484	Cephalotaxaceae	Spermatophyta	Viridiplantae

Human Protein / Gene in interaction

4 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	CHEMBL1476895	CHEMBL1613910 (1)	3 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	CHEMBL1476895	CHEMBL1614108 (1) CHEMBL1613886 (1)	0 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	CHEMBL1476895	CHEMBL1614250 (1) CHEMBL1614421 (1) CHEMBL1614502 (1)	4 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	CHEMBL1476895	CHEMBL1613914 (1)	0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM	preferred title	UniProt
#300438	17-beta-hydroxysteroid dehydrogenase x deficiency	Q99714
#600274	Frontotemporal dementia; ftd	P10636
#300705	Mental retardation, x-linked 17; mrx17	Q99714
#300220	Mental retardation, x-linked, syndromic 10; mrxs10	Q99714
#260540	Parkinson-dementia syndrome	P10636
#172700	Pick disease of brain	P10636
#601104	Supranuclear palsy, progressive, 1; psnp1	P10636

KEGG DISEASE (7)

KEGG	disease name	UniProt
H00036	Osteosarcoma	P08684 (marker)
H00058	Amyotrophic lateral sclerosis (ALS)	P10636 (related)
H00077	Progressive supranuclear palsy (PSP)	P10636 (related)
H00078	Frontotemporal lobar degeneration (FTLD)	P10636 (related)
H00480	Non-syndromic X-linked mental retardation	Q99714 (related)
H00658	Syndromic X-linked mental retardation	Q99714 (related)
H00925	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency	Q99714 (related)