Species

KNApSAcK Entry

Organism name Cephalotaxus sinensis
Genus Cephalotaxus
Family Cephalotaxaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cephalotaxus sinensis
Linked NCBI taxonomy ID 89484
Linked level species

Family

Family in NCBI taxonomy Cephalotaxaceae
ID 50175

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025572 External link 512 Homoharringtonine
/ (-)-Homoharringtonine
CHEMBL46286
CHEMBL1596527
CHEMBL2360685
C001652
7 / 3 / 4 0 / 1 No. 232 No. 4
C00027319 External link 512 Cephalotaxine
/ (-)-Cephalotaxine
CHEMBL276462
CHEMBL1476895
C001597
4 / 7 / 7 No. 1451 No. 4

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025572 C00027319 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00027319 3 / 3
P42858 Huntingtin Unclassified protein C00025572 1 / 1
O75496 Geminin Unclassified protein C00025572 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00025572 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00025572 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00025572 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00025572 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00027319 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00027319 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#143100 Huntington disease; hd P42858
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (10)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D008223 Lymphoma C00025572