KCF-S cluster No. 232 (28 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (28)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Spermatophyta	36

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Cumulative family count

class name	count
Cephalotaxaceae	36

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C10597	C00002342

Metabolite list (28)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002342	Harringtonine	CHEMBL433257 CHEMBL175608 CHEMBL1565817		90 / 36 / 31
C00025572	Homoharringtonine / (-)-Homoharringtonine	CHEMBL46286 CHEMBL1596527 CHEMBL2360685	C001652	7 / 3 / 4	0 / 1
C00025573	Deoxyharringtonine	CHEMBL297877	C043095
C00025574	Nordeoxyharringtonine
C00025575	Isoharringtonine	CHEMBL369842 CHEMBL1969433	C001656
C00025577	Bishomodeoxyharringtonine	CHEMBL466998
C00025578	Neoharringtonine
C00025579	Anhydroharringtonine
C00025580	Homoneoharringtonine
C00025581	3'S-Hydroxyneoharringtonine
C00025582	5'-Des-O-methylharringtonine
C00025583	3'S-Hydroxy-5'-des-O-methylharringtonine
C00025584	5'-Des-O-methylhomoharringtonine
C00025587	Drupangtonine	CHEMBL46546
C00025588	11alpha-Hydroxyhomodeoxyharringtonine	CHEMBL465786 CHEMBL466781
C00025589	11beta-Hydroxyhomodeoxyharringtonine	CHEMBL465786 CHEMBL466781
C00027199	Cephalezomine K
C00027200	Cephalezomine L
C00027313	Cephalezomine A
C00027314	Cephalezomine B
C00027315	Cephalezomine C
C00027316	Cephalezomine D
C00027317	Cephalezomine E
C00027318	Cephalezomine F / Homoisoharringtonine	CHEMBL10308
C00027377	Homodeoxyharringtonine / Deoxyhomoharringtonine	CHEMBL275127 CHEMBL511903
C00027504	11-Hydroxydeoxyharringtonine / (-)-11alpha-Hydroxydeoxyharringtonine	CHEMBL511730
C00027574	Nordeoxyharringtonine / (-)-Nordeoxyharringtonine
C00028168	Deoxyharringtonine	CHEMBL297877	C043095

Human Protein / Gene in interactions

92 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002342 C00025572	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002342 C00025572	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002342 C00025572	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002342 C00025572	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002342 C00025572	0 / 1
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00002342	2 / 1
Q16539	Mitogen-activated protein kinase 14	p38	C00002342	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00002342	0 / 0
P29466	Caspase-1	C14	C00002342	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00002342	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00002342	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00002342	2 / 2
P00918	Carbonic anhydrase 2	Lyase	C00002342	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00002342	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00002342	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00002342	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00002342	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00002342	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00002342	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00002342	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00002342	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00002342	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00002342	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00002342	0 / 0
P08246	Neutrophil elastase	S1A	C00002342	2 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00002342	1 / 8
P14416	D(2) dopamine receptor	Dopamine receptor	C00002342	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00002342	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00002342	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00002342	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00002342	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00002342	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00002342	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00002342	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00002342	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00002342	1 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00002342	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002342	0 / 0
P42858	Huntingtin	Unclassified protein	C00025572	1 / 1
O75496	Geminin	Unclassified protein	C00025572	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00002342	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00002342	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00002342	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00002342	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00002342	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00002342	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00002342	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00002342	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00002342	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00002342	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00002342	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00002342	0 / 0
P08311	Cathepsin G	S1A	C00002342	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00002342	1 / 0
P03956	Interstitial collagenase	M10A	C00002342	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00002342	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00002342	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00002342	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00002342	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00002342	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00002342	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00002342	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00002342	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00002342	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00002342	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00002342	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00002342	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00002342	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002342	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00002342	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00002342	2 / 2
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00002342	0 / 0
P03372	Estrogen receptor	NR3A1	C00002342	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00002342	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00002342	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00002342	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00002342	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00002342	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00002342	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00002342	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00002342	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00002342	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002342	0 / 3
P21728	D(1A) dopamine receptor	Dopamine receptor	C00002342	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00002342	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00002342	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00002342	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00002342	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00002342	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00002342	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00002342	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00002342	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions