PCIDB

KCF-S cluster No. 1467 (7 metabolites)

Corresponding Phytochemical cluster No. 7

Plant Species

Cumulative plant class count

class name count
rosids 16

Cumulative family count

class name count
Rutaceae 16

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00002141 External link 512 Balfourodinium
C00002153 External link 512 Dubinidine
CHEMBL1255737
CHEMBL1520045
CHEMBL1552847
12 / 18 / 18
C00002192 External link 512 Pteleatine
C00002194 External link 512 Ribalinium
C00002203 External link 512 Veprisinium
C034381
C00026361 External link 512 Platydesmine
/ (+)-Platydesmine
C00026371 External link 512 7,8-Dimethoxyplatydesmine
/ (2S)-(-)-7,8-Dimethoxyplatydesmine
CHEMBL463650

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002153 1 / 0
P02545 Prelamin-A/C Unclassified protein C00002153 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00002153 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002153 0 / 1
P54132 Bloom syndrome protein Enzyme C00002153 1 / 2
P42226 Signal transducer and activator of transcription 6 Unclassified protein C00002153 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002153 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002153 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002153 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002153 0 / 0
P40225 Thrombopoietin Unclassified protein C00002153 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002153 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#187950 Thrombocythemia 1; thcyt1 P40225

KEGG DISEASE (18)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)