KCF-S cluster No. 1656 (6 metabolites)

Corresponding Phytochemical cluster No. 1

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (6)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	3

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Cumulative family count

class name	count
Enterobacteriaceae	4
Brassicaceae	3

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Pyridine alkaloids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Pyridine alkaloids	C13051	C00007537

Metabolite list (6)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00007256	NAD / Nicotinamide adenine dinucleotide	CHEMBL234870 CHEMBL1234613 CHEMBL1402028 CHEMBL1454168 CHEMBL1517480	D009243	18 / 25 / 24	23 / 3
C00007537	Nicotinic acid adenine dinucleotide		C024376		1 / 0
C00007538	2'-O-Acetyl-ADP-ribose
C00019343	NADH / Dihydronicotinamide adenine dinucleotide	CHEMBL1161866		2 / 0 / 0
C00019545	TPNH / NADPH	CHEMBL407009 CHEMBL1594246 CHEMBL1619387 CHEMBL1623059		7 / 3 / 1
C00019568	Nicotinic acid dinucleotide		C018348		1 / 0

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00007256 C00019545	2 / 0
P07327	Alcohol dehydrogenase 1A	Oxidoreductase	C00007256 C00019343	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00007256 C00019545	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00007256 C00019545	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00019545	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00007256	11 / 10
P37840	Alpha-synuclein	Unclassified protein	C00007256	4 / 2
P12268	Inosine-5'-monophosphate dehydrogenase 2	Oxidoreductase	C00007256	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00007256	2 / 3
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00007256	2 / 2
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00007256	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00019343	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00019545	0 / 0
P00338	L-lactate dehydrogenase A chain	Enzyme	C00007256	1 / 5
Q99700	Ataxin-2	Unclassified protein	C00019545	1 / 1
P34981	Thyrotropin-releasing hormone receptor	Neuropeptide receptor	C00007256	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00007256	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00007256	0 / 0
P28329	Choline O-acetyltransferase	Enzyme	C00007256	1 / 1
O95544	NAD kinase	Enzyme	C00007256	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00019545	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00007256	1 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00007256	1 / 1

24 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
55191	NADSYN1	NAD synthetase 1 (EC:6.3.5.1)	C00007256 C00019568
10495	ENOX2, APK1, COVA1, tNOX	ecto-NOX disulfide-thiol exchanger 2	C00007256
10327	AKR1A1, ALDR1, ALR, ARM, DD3	aldo-keto reductase family 1, member A1 (aldehyde reductase) (EC:1.1.1.2)	C00007256
216	ALDH1A1, ALDC, ALDH-E1, ALDH1, ALDH11, PUMB1, RALDH1	aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36)	C00007256
219	ALDH1B1, ALDH5, ALDHX	aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3)	C00007256
217	ALDH2, ALDH-E2, ALDHI, ALDM	aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)	C00007256
218	ALDH3A1, ALDH3, ALDHIII	aldehyde dehydrogenase 3 family, member A1 (EC:1.2.1.5)	C00007256
581	BAX, BCL2L4	BCL2-associated X protein	C00007256
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00007256
847	CAT	catalase (EC:1.11.1.6)	C00007256
1050	CEBPA, C/EBP-alpha, CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	C00007256
1727	CYB5R3, B5R, DIA1	cytochrome b5 reductase 3 (EC:1.6.2.2)	C00007256
57192	MCOLN1, MG-2, ML4, MLIV, MST080, TRP-ML1, TRPM-L1, TRPML1	mucolipin 1	C00007537
2597	GAPDH, G3PD, GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	C00007256
3033	HADH, HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD	hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)	C00007256
15461			C00007256
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00007256
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00007256
195814	SDR16C5, RDH#2, RDH-E2, RDHE2	short chain dehydrogenase/reductase family 16C, member 5 (EC:1.1.1.105)	C00007256
23411	SIRT1, SIR2L1	sirtuin 1	C00007256
6610	SMPD2, ISC1, NSMASE, NSMASE1	sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) (EC:3.1.4.12)	C00007256
8877	SPHK1, SPHK	sphingosine kinase 1 (EC:2.7.1.91)	C00007256
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00007256
7299	TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3	tyrosinase (EC:1.14.18.1)	C00007256

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions