KCF-S cluster No. 2065 (4 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|
Cumulative family count
| class name | count |
|---|---|
| Aspergillaceae | 5 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00003133
|
Fumidil
/ Fugillin / Fumadil B / Amebacilin / Fumagillin / Fumagillin DCH / (-)-Fumagillin |
CHEMBL32838
CHEMBL117603 CHEMBL1396346 CHEMBL1522710 CHEMBL1992691 |
C026211
|
13 / 20 / 23 | 3 / 3 |
|
|
C00015154
|
Sch 528647
|
|
||||
|
C00015639
|
Fumagillin methyl ester
|
|
||||
|
C00043519
|
Fumagiringillin
|
|
Human Protein / Gene in interactions
13 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00003133 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003133 | 11 / 10 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003133 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003133 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00003133 | 0 / 0 |
| P53582 | Methionine aminopeptidase 1 | M24A | C00003133 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003133 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003133 | 0 / 0 |
| P50579 | Methionine aminopeptidase 2 | M24A | C00003133 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00003133 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00003133 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00003133 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003133 | 1 / 2 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 23173 | METAP1, MAP1A, MetAP1A | methionyl aminopeptidase 1 (EC:3.4.11.18) |
C00003133
|
| 10988 | METAP2, MAP2, MNPEP, p67, p67eIF2 | methionyl aminopeptidase 2 (EC:3.4.11.18) |
C00003133
|
| 7532 | YWHAG, 14-3-3GAMMA | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide |
C00003133
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (20)
| OMIM | preferred title | UniProt |
|---|---|---|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (23)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|